| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.207477 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.168592 |
| FLNA | filamin A, alpha | 0.130929 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0934669 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0810848 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0686919 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0681489 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0559304 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0555924 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0542087 |
| RNF213 | ring finger protein 213 | 0.0535398 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0498437 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0490655 |
| L1CAM | L1 cell adhesion molecule | 0.0485976 |
| LDHA | lactate dehydrogenase A | 0.0462748 |
| ATXN1 | ataxin 1 | 0.0458703 |
| DST | dystonin | 0.0444403 |
| FLNB | filamin B, beta | 0.0430867 |
| CANX | calnexin | 0.0429134 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.042813 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0394421 |
| TLE4 | transducin-like enhancer of split 4 | 0.0393578 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0380202 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0375804 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0375453 |
| CEP250 | centrosomal protein 250kDa | 0.0373816 |
| SEPTIN9 | septin 9 | 0.0373236 |
| KRT18 | keratin 18, type I | 0.0372931 |
| RIGI | RNA sensor RIG-I | 0.0369709 |
| INTS6 | integrator complex subunit 6 | 0.0369484 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0364477 |
| COL5A1 | collagen, type V, alpha 1 | 0.0361674 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0358777 |
| PLSCR1 | phospholipid scramblase 1 | 0.0357258 |
| PLEC | plectin | 0.034605 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0341966 |
| SMAD3 | SMAD family member 3 | 0.0327867 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0326644 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0326514 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0324291 |
| STC2 | stanniocalcin 2 | 0.0319906 |
| VEGFA | vascular endothelial growth factor A | 0.0315176 |
| ACTN4 | actinin, alpha 4 | 0.0311466 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0299215 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0296237 |
| CALD1 | caldesmon 1 | 0.0289112 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0289014 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.02783 |
| MX1 | MX dynamin-like GTPase 1 | 0.0277842 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0273872 |
| MSN | moesin | 0.0271718 |
| TPM3 | tropomyosin 3 | 0.0269369 |
| VCL | vinculin | 0.0264033 |
| ASPH | aspartate beta-hydroxylase | 0.0263659 |
| IFI44L | interferon-induced protein 44-like | 0.0262818 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0258966 |
| MAP1B | microtubule-associated protein 1B | 0.0256663 |
| NAV2 | neuron navigator 2 | 0.0252562 |
| SP100 | SP100 nuclear antigen | 0.024875 |
| FAM219A | family with sequence similarity 219, member A | 0.0248694 |
| PKM | pyruvate kinase, muscle | 0.0247762 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0247174 |
| FAM107B | family with sequence similarity 107, member B | 0.0243646 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0242049 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0241277 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0235229 |
| MYO1E | myosin IE | 0.0228744 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0224991 |
| EZR | ezrin | 0.0224229 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0217047 |
| OPTN | optineurin | 0.0217016 |
| TENM3 | teneurin transmembrane protein 3 | 0.021658 |
| APP | amyloid beta (A4) precursor protein | 0.0215588 |
| RHOA | ras homolog family member A | 0.0214298 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0210468 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0207548 |
| DIO2 | deiodinase, iodothyronine, type II | 0.0205108 |
| RND3 | Rho family GTPase 3 | 0.020433 |
| COL3A1 | collagen, type III, alpha 1 | 0.0200827 |
| TUFT1 | tuftelin 1 | 0.0199546 |
| HLA-E | major histocompatibility complex, class I, E | 0.0196041 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0195439 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0192933 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0191508 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.018996 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0188253 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0187171 |
| SQSTM1 | sequestosome 1 | 0.0186492 |
| LASP1 | LIM and SH3 protein 1 | 0.0184791 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0184695 |
| ANO6 | anoctamin 6 | 0.0183711 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0183104 |
| CLIC4 | chloride intracellular channel 4 | 0.0182383 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0181118 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0180458 |
| HDAC9 | histone deacetylase 9 | 0.0179289 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0177049 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0176689 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0176192 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0176192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | -0.215003 |
| FTL | ferritin, light polypeptide | -0.203051 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.161053 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.154871 |
| MT2A | metallothionein 2A | -0.154391 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.1232 |
| CD44 | CD44 molecule (Indian blood group) | -0.0965034 |
| MT1X | metallothionein 1X | -0.0948291 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0919184 |
| ATP13A3 | ATPase type 13A3 | -0.086781 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0865477 |
| RPL35A | ribosomal protein L35a | -0.0732285 |
| DEK | DEK proto-oncogene | -0.0727172 |
| GOLGA4 | golgin A4 | -0.064487 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0595417 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0577434 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0563527 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0534675 |
| ARF4 | ADP-ribosylation factor 4 | -0.05217 |
| TMSB10 | thymosin beta 10 | -0.0516499 |
| RPS6 | ribosomal protein S6 | -0.0503029 |
| FN1 | fibronectin 1 | -0.0489515 |
| B2M | beta-2-microglobulin | -0.0476208 |
| PTMA | prothymosin, alpha | -0.0475567 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0467091 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.046565 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0458609 |
| RBM39 | RNA binding motif protein 39 | -0.0443909 |
| RPLP2 | ribosomal protein, large, P2 | -0.0437425 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0425372 |
| GLIS3 | GLIS family zinc finger 3 | -0.0422788 |
| PFN1 | profilin 1 | -0.0419667 |
| NOP58 | NOP58 ribonucleoprotein | -0.0417297 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0410264 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0402412 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0398548 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0389403 |
| HMGB1 | high mobility group box 1 | -0.0386842 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0378055 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0377126 |
| S100A10 | S100 calcium binding protein A10 | -0.0373545 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0363141 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0361319 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0356834 |
| ADM | adrenomedullin | -0.0354474 |
| RPL12 | ribosomal protein L12 | -0.0353674 |
| ZNF292 | zinc finger protein 292 | -0.035326 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0352325 |
| USP3 | ubiquitin specific peptidase 3 | -0.034923 |
| CUL4B | cullin 4B | -0.0345744 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0344474 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.034426 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0344094 |
| PLCB4 | phospholipase C, beta 4 | -0.0342747 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0338801 |
| NUP58 | nucleoporin 58 | -0.0337138 |
| RLF | rearranged L-myc fusion | -0.0329659 |
| IER3 | immediate early response 3 | -0.0329314 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0327272 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.032428 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0323219 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0318426 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0316065 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0315207 |
| CTSD | cathepsin D | -0.0314578 |
| TMEM41B | transmembrane protein 41B | -0.0313368 |
| RPS8 | ribosomal protein S8 | -0.0312047 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0306676 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0306437 |
| MPZL1 | myelin protein zero-like 1 | -0.0304437 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0304063 |
| ZFR | zinc finger RNA binding protein | -0.0303263 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0301833 |
| RBM25 | RNA binding motif protein 25 | -0.0301512 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0301445 |
| TFG | TRK-fused gene | -0.0301238 |
| LMAN1 | lectin, mannose-binding, 1 | -0.030055 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0295205 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0293186 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0292967 |
| SRP54 | signal recognition particle 54kDa | -0.029178 |
| RPS24 | ribosomal protein S24 | -0.0290022 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0289338 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0289192 |
| RPS21 | ribosomal protein S21 | -0.0284396 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0283765 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0283559 |
| THOC2 | THO complex 2 | -0.0279792 |
| GNAS | GNAS complex locus | -0.0278651 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0278628 |
| RPL34 | ribosomal protein L34 | -0.0273511 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0271162 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0270988 |
| FOSL1 | FOS-like antigen 1 | -0.0270391 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0269861 |
| WDR45B | WD repeat domain 45B | -0.0269292 |
| RTN4 | reticulon 4 | -0.0268808 |
| PDS5B | PDS5 cohesin associated factor B | -0.0268659 |
| RPLP1 | ribosomal protein, large, P1 | -0.0267843 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0267596 |
