| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | 0.107352 |
| DST | dystonin | 0.0650801 |
| CADM2 | cell adhesion molecule 2 | 0.0646327 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0606946 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.057368 |
| HLA-B | major histocompatibility complex, class I, B | 0.0562114 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0479196 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0461883 |
| PRELID2 | PRELI domain containing 2 | 0.0425367 |
| RNF213 | ring finger protein 213 | 0.0362479 |
| EPHA4 | EPH receptor A4 | 0.0358055 |
| TNS3 | tensin 3 | 0.0350472 |
| SP100 | SP100 nuclear antigen | 0.0314733 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0313145 |
| EGFR | epidermal growth factor receptor | 0.0303033 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0286444 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0278053 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.027367 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0271169 |
| COL5A2 | collagen, type V, alpha 2 | 0.026688 |
| INTS6 | integrator complex subunit 6 | 0.0264871 |
| TXNIP | thioredoxin interacting protein | 0.0264097 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0252936 |
| MYOF | myoferlin | 0.0246703 |
| PLSCR1 | phospholipid scramblase 1 | 0.0243342 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0239853 |
| AEBP2 | AE binding protein 2 | 0.0237042 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0235658 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0234636 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0233847 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0233734 |
| NEK10 | NIMA-related kinase 10 | 0.0230167 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0228503 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0227902 |
| TRIM56 | tripartite motif containing 56 | 0.022634 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0223741 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.022347 |
| LYST | lysosomal trafficking regulator | 0.0219125 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0211209 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.021111 |
| MT1E | metallothionein 1E | 0.0209403 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207408 |
| PMP22 | peripheral myelin protein 22 | 0.0206754 |
| VEGFA | vascular endothelial growth factor A | 0.0202456 |
| EFNA5 | ephrin-A5 | 0.0195926 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0195616 |
| HOMER1 | homer scaffolding protein 1 | 0.0192151 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0192072 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0186477 |
| TGM2 | transglutaminase 2 | 0.0186457 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0182059 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0180648 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.01787 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0172729 |
| CEP250 | centrosomal protein 250kDa | 0.0172398 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0172151 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0169567 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0168918 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0168841 |
| PLEC | plectin | 0.0166742 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0164858 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0164149 |
| RAD51B | RAD51 paralog B | 0.0163134 |
| BEGAIN | brain-enriched guanylate kinase-associated | 0.0161765 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0156009 |
| HLA-E | major histocompatibility complex, class I, E | 0.0155703 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0155191 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.015445 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0154073 |
| SEPTIN9 | septin 9 | 0.0152748 |
| ECE1 | endothelin converting enzyme 1 | 0.0152718 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0151881 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.0150071 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0149871 |
| RPS12 | ribosomal protein S12 | 0.0148597 |
| WDR27 | WD repeat domain 27 | 0.0145577 |
| PRKCE | protein kinase C, epsilon | 0.0143997 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0142617 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0140238 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0139561 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0137298 |
| RPS23 | ribosomal protein S23 | 0.0134504 |
| CTTN | cortactin | 0.0134408 |
| TPRG1 | tumor protein p63 regulated 1 | 0.0134294 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0132944 |
| RPS3 | ribosomal protein S3 | 0.0130506 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0128467 |
| TMF1 | TATA element modulatory factor 1 | 0.0128065 |
| RIGI | RNA sensor RIG-I | 0.0127497 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.0124828 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0124687 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0123881 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0123573 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.012354 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0123516 |
| PDE10A | phosphodiesterase 10A | 0.0122217 |
| TMEM14B | transmembrane protein 14B | 0.0119415 |
| INSR | insulin receptor | 0.011859 |
| SMAD9 | SMAD family member 9 | 0.0118146 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | 0.0117468 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.291181 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.174911 |
| TXNRD1 | thioredoxin reductase 1 | -0.150629 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.127796 |
| VIM | vimentin | -0.111301 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.105452 |
| RAI1 | retinoic acid induced 1 | -0.0955059 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0904256 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0779032 |
| RTN4 | reticulon 4 | -0.0774737 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0754526 |
| ACTG1 | actin gamma 1 | -0.0686407 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.068045 |
| CENPF | centromere protein F, 350/400kDa | -0.0674476 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0669489 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0625757 |
| PGK1 | phosphoglycerate kinase 1 | -0.0612848 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0612347 |
| AHNAK | AHNAK nucleoprotein | -0.0608815 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0566132 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0565796 |
| APP | amyloid beta (A4) precursor protein | -0.0552892 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0548701 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0539644 |
| FTL | ferritin, light polypeptide | -0.0531815 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0527146 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0523995 |
| SPAG9 | sperm associated antigen 9 | -0.0520366 |
| LDHA | lactate dehydrogenase A | -0.0520166 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0513995 |
| SRGN | serglycin | -0.0511201 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0508902 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0508488 |
| ZNF292 | zinc finger protein 292 | -0.0488377 |
| EZR | ezrin | -0.0475662 |
| ANXA1 | annexin A1 | -0.0475241 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0471216 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0452798 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0451307 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0451294 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0448693 |
| TMSB10 | thymosin beta 10 | -0.0447021 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0441866 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0441431 |
| PTMA | prothymosin, alpha | -0.0440054 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0438248 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0432996 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0431193 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0431034 |
| WDR45B | WD repeat domain 45B | -0.0423284 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0420867 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.041488 |
| MKI67 | marker of proliferation Ki-67 | -0.0410412 |
| ZNF217 | zinc finger protein 217 | -0.0410166 |
| TMEM41B | transmembrane protein 41B | -0.0407957 |
| ENO1 | enolase 1, (alpha) | -0.0400198 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0399256 |
| ANLN | anillin, actin binding protein | -0.0390236 |
| TMSB4X | thymosin beta 4, X-linked | -0.0385655 |
| TOP1 | topoisomerase (DNA) I | -0.0382502 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0380286 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0379867 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.037319 |
| RBM39 | RNA binding motif protein 39 | -0.0371066 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.036403 |
| SMC4 | structural maintenance of chromosomes 4 | -0.036156 |
| SBF2 | SET binding factor 2 | -0.0357952 |
| ECT2 | epithelial cell transforming 2 | -0.035634 |
| NUP58 | nucleoporin 58 | -0.0347438 |
| USP34 | ubiquitin specific peptidase 34 | -0.0346771 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0345884 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0345318 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0344323 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0340621 |
| YBX1 | Y box binding protein 1 | -0.0336816 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0335856 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0335594 |
| RLF | rearranged L-myc fusion | -0.0334066 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0333689 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0332761 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0331419 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0331026 |
| TMEM123 | transmembrane protein 123 | -0.0330746 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0330288 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0330102 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0329641 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0328681 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0327342 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0327216 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0322766 |
| CEP170 | centrosomal protein 170kDa | -0.032207 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0321302 |
| MATR3 | matrin 3 | -0.0319899 |
| KIF5B | kinesin family member 5B | -0.0319126 |
| SEPTIN7 | septin 7 | -0.0319069 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0315853 |
| WDR26 | WD repeat domain 26 | -0.0313124 |
| TNPO1 | transportin 1 | -0.0312088 |
| SRPK2 | SRSF protein kinase 2 | -0.030787 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0306504 |
