| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.142078 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.14182 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.111334 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.109901 |
| EGFR | epidermal growth factor receptor | 0.0927132 |
| MYOF | myoferlin | 0.0890738 |
| RNF213 | ring finger protein 213 | 0.074933 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0696841 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0633259 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0621883 |
| DSPP | dentin sialophosphoprotein | 0.0615442 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.059887 |
| GRAMD1B | GRAM domain containing 1B | 0.0539209 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0498386 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0467939 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0459355 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0452891 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0419756 |
| HSPA8 | heat shock 70kDa protein 8 | 0.041751 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0401988 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0387117 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.038114 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0376283 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.03699 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0367145 |
| IRS2 | insulin receptor substrate 2 | 0.0366125 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0354207 |
| CPE | carboxypeptidase E | 0.0349898 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0348052 |
| KRT18 | keratin 18, type I | 0.034532 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0331971 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.032354 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0308653 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0303675 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0302652 |
| MAP7 | microtubule-associated protein 7 | 0.0298904 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0297289 |
| ENO1 | enolase 1, (alpha) | 0.0296429 |
| RAD51B | RAD51 paralog B | 0.0291691 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0290973 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0289337 |
| AHR | aryl hydrocarbon receptor | 0.0289106 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0282894 |
| YBX3 | Y box binding protein 3 | 0.0278811 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0277296 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0276948 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0275072 |
| FAM13A | family with sequence similarity 13, member A | 0.0269323 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0256115 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0256082 |
| CP | ceruloplasmin (ferroxidase) | 0.0250568 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0246902 |
| HOMER1 | homer scaffolding protein 1 | 0.0245156 |
| DST | dystonin | 0.0242814 |
| MX1 | MX dynamin-like GTPase 1 | 0.0239534 |
| FAM107B | family with sequence similarity 107, member B | 0.0237778 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0237554 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0235725 |
| ARRDC3 | arrestin domain containing 3 | 0.0234003 |
| CANX | calnexin | 0.0229267 |
| KIAA1217 | KIAA1217 | 0.0228079 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0222951 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0220973 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0220266 |
| DTNB | dystrobrevin, beta | 0.0219293 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0219045 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0217423 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0216678 |
| WWOX | WW domain containing oxidoreductase | 0.0207876 |
| HYOU1 | hypoxia up-regulated 1 | 0.02063 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0205139 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0204843 |
| APP | amyloid beta (A4) precursor protein | 0.0201194 |
| KYNU | kynureninase | 0.0195161 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0193781 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0192608 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0185278 |
| PGK1 | phosphoglycerate kinase 1 | 0.0184935 |
| TTC39C | tetratricopeptide repeat domain 39C | 0.0182087 |
| RPS4X | ribosomal protein S4, X-linked | 0.0181614 |
| TPI1 | triosephosphate isomerase 1 | 0.0181167 |
| ANGPTL4 | angiopoietin-like 4 | 0.0178696 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0178068 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0177191 |
| ATF6 | activating transcription factor 6 | 0.017553 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.017128 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0171189 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0167833 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.016559 |
| DNASE1 | deoxyribonuclease I | 0.0165012 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0164451 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0163529 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0163406 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0162337 |
| LDHA | lactate dehydrogenase A | 0.0159881 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0159714 |
| CABIN1 | calcineurin binding protein 1 | 0.0159333 |
| TUFT1 | tuftelin 1 | 0.0156918 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0156173 |
| SMAD3 | SMAD family member 3 | 0.0155343 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMC2 | laminin, gamma 2 | -0.133402 |
| TMSB10 | thymosin beta 10 | -0.103469 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0967671 |
| FTL | ferritin, light polypeptide | -0.0958082 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0908707 |
| LAMA4 | laminin, alpha 4 | -0.0760122 |
| ACTG1 | actin gamma 1 | -0.0751944 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0710623 |
| NDRG1 | N-myc downstream regulated 1 | -0.0706802 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0639629 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0619877 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0618889 |
| STC1 | stanniocalcin 1 | -0.0613846 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0586898 |
| OSMR | oncostatin M receptor | -0.0575138 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0574193 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0511339 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0495917 |
| EGR1 | early growth response 1 | -0.0481737 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0467427 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0460746 |
| LAMB3 | laminin, beta 3 | -0.045587 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0451485 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0434484 |
| MT2A | metallothionein 2A | -0.0407111 |
| ABLIM1 | actin binding LIM protein 1 | -0.0389788 |
| ASPH | aspartate beta-hydroxylase | -0.0383836 |
| CDCP1 | CUB domain containing protein 1 | -0.0371444 |
| SCEL | sciellin | -0.0361725 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0358137 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0355684 |
| TMEM165 | transmembrane protein 165 | -0.035044 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.034336 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0342513 |
| RPS25 | ribosomal protein S25 | -0.0339838 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0330318 |
| FBXO11 | F-box protein 11 | -0.032693 |
| RAB10 | RAB10, member RAS oncogene family | -0.0323507 |
| H1-0 | H1.0 linker histone | -0.0314677 |
| S100A11 | S100 calcium binding protein A11 | -0.0311605 |
| PRDX1 | peroxiredoxin 1 | -0.0307531 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0307317 |
| HMGA1 | high mobility group AT-hook 1 | -0.0303839 |
| WASF2 | WAS protein family, member 2 | -0.0301645 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0299822 |
| RPL37A | ribosomal protein L37a | -0.0298911 |
| MCL1 | myeloid cell leukemia 1 | -0.0298552 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0293704 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0290986 |
| TXNRD1 | thioredoxin reductase 1 | -0.0289823 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0286294 |
| NABP1 | nucleic acid binding protein 1 | -0.0285469 |
| S100A10 | S100 calcium binding protein A10 | -0.02819 |
| RIN2 | Ras and Rab interactor 2 | -0.0278121 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0277638 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0271773 |
| RPL35A | ribosomal protein L35a | -0.0271166 |
| ATG7 | autophagy related 7 | -0.0270174 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0268474 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0267162 |
| MYO1D | myosin ID | -0.0266901 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0265418 |
| RPS24 | ribosomal protein S24 | -0.0264183 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0259317 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0258886 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.025755 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0256867 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0254827 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0254378 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0253891 |
| POTEF | POTE ankyrin domain family, member F | -0.0250969 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0250561 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0249662 |
| RASA2 | RAS p21 protein activator 2 | -0.0249509 |
| USP34 | ubiquitin specific peptidase 34 | -0.0249007 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0248162 |
| PERP | PERP, TP53 apoptosis effector | -0.0247615 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.024613 |
| RPL31 | ribosomal protein L31 | -0.0245171 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0242502 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0240932 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0238774 |
| IER3 | immediate early response 3 | -0.0237744 |
| AHNAK | AHNAK nucleoprotein | -0.0236691 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0231996 |
| RCOR1 | REST corepressor 1 | -0.0231382 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0229653 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0228894 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0227177 |
| CCNI | cyclin I | -0.0224017 |
| RPS3 | ribosomal protein S3 | -0.0221212 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0217176 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0217085 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0215857 |
| DSG2 | desmoglein 2 | -0.0214225 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0211406 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0209679 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0208744 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0208374 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0208171 |
