| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.161118 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.107404 |
| VIM | vimentin | 0.0993432 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.064445 |
| VEGFA | vascular endothelial growth factor A | 0.0572433 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0536473 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0513313 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0511261 |
| PCBP2 | poly(rC) binding protein 2 | 0.0464723 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0447777 |
| CEP250 | centrosomal protein 250kDa | 0.0438975 |
| SMAD3 | SMAD family member 3 | 0.043801 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0417764 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0403058 |
| RNF213 | ring finger protein 213 | 0.0402286 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0368134 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0366096 |
| ANGPTL4 | angiopoietin-like 4 | 0.033841 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0333513 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0297093 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.029649 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0283037 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0282167 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0266813 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0265459 |
| FN1 | fibronectin 1 | 0.0258889 |
| RAD51B | RAD51 paralog B | 0.0257427 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0253839 |
| PLIN2 | perilipin 2 | 0.0252484 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0252308 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0250157 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0249894 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0243925 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.023438 |
| MX1 | MX dynamin-like GTPase 1 | 0.0234223 |
| LDHA | lactate dehydrogenase A | 0.022819 |
| CFB | complement factor B | 0.0227621 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0226738 |
| CA12 | carbonic anhydrase XII | 0.0226171 |
| TGM2 | transglutaminase 2 | 0.0224532 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0221259 |
| NAV2 | neuron navigator 2 | 0.0221179 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0212341 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0211006 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0208652 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0199436 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0198365 |
| ADAR | adenosine deaminase, RNA-specific | 0.0185296 |
| OPTN | optineurin | 0.0183899 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0180918 |
| HDAC9 | histone deacetylase 9 | 0.0179716 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.017592 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.017177 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.016941 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.01687 |
| SUMF1 | sulfatase modifying factor 1 | 0.0167152 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0166211 |
| FLNA | filamin A, alpha | 0.0163441 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0162401 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0162147 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0161635 |
| ADM | adrenomedullin | 0.0161258 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0160212 |
| PFKP | phosphofructokinase, platelet | 0.0160071 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0158817 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0158421 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0157519 |
| IFI44L | interferon-induced protein 44-like | 0.0156749 |
| RPL3 | ribosomal protein L3 | 0.0155569 |
| ARRDC3 | arrestin domain containing 3 | 0.0155322 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0151985 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0151156 |
| TXNIP | thioredoxin interacting protein | 0.0147378 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0146473 |
| KIAA1217 | KIAA1217 | 0.0144952 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0144557 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0143872 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0142264 |
| PCDH7 | protocadherin 7 | 0.0138331 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0137658 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0137607 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.0135041 |
| MX2 | MX dynamin-like GTPase 2 | 0.013462 |
| C1R | complement component 1, r subcomponent | 0.0133639 |
| PLEC | plectin | 0.0133441 |
| LOXL2 | lysyl oxidase-like 2 | 0.0133083 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0132684 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.013244 |
| RPL7 | ribosomal protein L7 | 0.0132015 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0129902 |
| WWOX | WW domain containing oxidoreductase | 0.0129887 |
| JUN | jun proto-oncogene | 0.0129354 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0129094 |
| MLPH | melanophilin | 0.0129077 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | 0.012893 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0128635 |
| RND3 | Rho family GTPase 3 | 0.0128633 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0128269 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0125838 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0125816 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.16442 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.146708 |
| CD44 | CD44 molecule (Indian blood group) | -0.125066 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.115 |
| CDH13 | cadherin 13 | -0.106748 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.105758 |
| HMGA2 | high mobility group AT-hook 2 | -0.10532 |
| FTL | ferritin, light polypeptide | -0.102058 |
| STC1 | stanniocalcin 1 | -0.0987053 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0893057 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0874998 |
| RBM39 | RNA binding motif protein 39 | -0.0805133 |
| NRG1 | neuregulin 1 | -0.0803458 |
| USP34 | ubiquitin specific peptidase 34 | -0.0803029 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0761275 |
| GLCCI1 | glucocorticoid induced 1 | -0.0757901 |
| LOX | lysyl oxidase | -0.0749907 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0739963 |
| OSMR | oncostatin M receptor | -0.0725537 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0722958 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0718899 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0690376 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0676076 |
| EFNA5 | ephrin-A5 | -0.0658787 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0655 |
| MTSS1 | metastasis suppressor 1 | -0.0653149 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0647699 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.06346 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0626595 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0572055 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0558444 |
| TMSB10 | thymosin beta 10 | -0.0531572 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0512967 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0510322 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0499258 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0488668 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0478246 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0460082 |
| VRK2 | vaccinia related kinase 2 | -0.0454772 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0450171 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0447756 |
| RPL37A | ribosomal protein L37a | -0.0430659 |
| JMJD1C | jumonji domain containing 1C | -0.0402036 |
| DNER | delta/notch-like EGF repeat containing | -0.0393415 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0392006 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0389535 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0388346 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0387436 |
| GOLGA4 | golgin A4 | -0.0384022 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0382723 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0377778 |
| NF1 | neurofibromin 1 | -0.0377455 |
| CDK14 | cyclin-dependent kinase 14 | -0.0373755 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0372963 |
| MEF2A | myocyte enhancer factor 2A | -0.0371706 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0367193 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0356053 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0354226 |
| RAI14 | retinoic acid induced 14 | -0.0353737 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0351427 |
| NRP1 | neuropilin 1 | -0.0349303 |
| NUMB | numb homolog (Drosophila) | -0.0347299 |
| PARD3 | par-3 family cell polarity regulator | -0.0346205 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0341319 |
| VMP1 | vacuole membrane protein 1 | -0.0335674 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0334864 |
| RPLP1 | ribosomal protein, large, P1 | -0.0333727 |
| CLMP | CXADR-like membrane protein | -0.0333265 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0333086 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0331462 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0330069 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0328851 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0326626 |
| IER3 | immediate early response 3 | -0.0326611 |
| RPL31 | ribosomal protein L31 | -0.0326029 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.032435 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0323947 |
| RPS12 | ribosomal protein S12 | -0.0319673 |
| RUNX2 | runt-related transcription factor 2 | -0.031667 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0313934 |
| RPL35A | ribosomal protein L35a | -0.0309007 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0307152 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0304517 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0302343 |
| NAV3 | neuron navigator 3 | -0.0302097 |
| RPS25 | ribosomal protein S25 | -0.0301295 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.030087 |
| RPL37 | ribosomal protein L37 | -0.0300601 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0300571 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0298243 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0295683 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0292427 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0291688 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0288869 |
| ETV6 | ets variant 6 | -0.0285774 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0284977 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.028337 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.028266 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0282463 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0281769 |
