| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.221232 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0935286 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0852723 |
| VIM | vimentin | 0.0734385 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0706464 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.063506 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0481997 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0459746 |
| KYNU | kynureninase | 0.043444 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0409007 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0408153 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0400265 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0395502 |
| CALR | calreticulin | 0.037324 |
| MYOF | myoferlin | 0.03685 |
| FLNA | filamin A, alpha | 0.0360557 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0358956 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347579 |
| FGA | fibrinogen alpha chain | 0.0335305 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0330856 |
| ATF4 | activating transcription factor 4 | 0.0303577 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0289947 |
| PLEC | plectin | 0.0280799 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0254703 |
| NTN4 | netrin 4 | 0.0252625 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0248047 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0238455 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0237375 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.023304 |
| AHNAK | AHNAK nucleoprotein | 0.0232367 |
| FGG | fibrinogen gamma chain | 0.0229023 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0219401 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0216891 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0215035 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0208671 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0208468 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0208177 |
| CAVIN1 | caveolae associated protein 1 | 0.0205794 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0204306 |
| KRT18 | keratin 18, type I | 0.0204267 |
| FAM107B | family with sequence similarity 107, member B | 0.0200147 |
| MRTFA | myocardin related transcription factor A | 0.019998 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0198061 |
| INTS6 | integrator complex subunit 6 | 0.0197566 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.019317 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0192723 |
| CEP250 | centrosomal protein 250kDa | 0.0187123 |
| KIAA0319 | KIAA0319 | 0.0185642 |
| RHOA | ras homolog family member A | 0.0185347 |
| FOXO3 | forkhead box O3 | 0.0178563 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0175474 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0175121 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0174432 |
| CABIN1 | calcineurin binding protein 1 | 0.0172272 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0170601 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0169892 |
| PSEN1 | presenilin 1 | 0.0169856 |
| CUX1 | cut-like homeobox 1 | 0.0168608 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0166963 |
| RPS9 | ribosomal protein S9 | 0.0166708 |
| CMIP | c-Maf inducing protein | 0.0165354 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0162039 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0160365 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0160124 |
| RHOB | ras homolog family member B | 0.0159178 |
| RPL13A | ribosomal protein L13a | 0.0157168 |
| PDE10A | phosphodiesterase 10A | 0.0154686 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0154129 |
| HYOU1 | hypoxia up-regulated 1 | 0.0153513 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0151753 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0147992 |
| CASC3 | cancer susceptibility candidate 3 | 0.0147291 |
| EFNA1 | ephrin-A1 | 0.0147272 |
| H1-2 | H1.2 linker histone, cluster member | 0.0146896 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0146133 |
| HDAC5 | histone deacetylase 5 | 0.0141867 |
| RORA | RAR-related orphan receptor A | 0.0137428 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0136298 |
| APP | amyloid beta (A4) precursor protein | 0.0135972 |
| RBM8A | RNA binding motif protein 8A | 0.0132323 |
| RPS4X | ribosomal protein S4, X-linked | 0.0131289 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.012934 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0128761 |
| RNF10 | ring finger protein 10 | 0.0127451 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0127299 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0127121 |
| RPL4 | ribosomal protein L4 | 0.0124642 |
| TPD52L2 | tumor protein D52-like 2 | 0.0124588 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0123574 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0123213 |
| USF1 | upstream transcription factor 1 | 0.0123101 |
| RBM5 | RNA binding motif protein 5 | 0.0122387 |
| VCL | vinculin | 0.0121964 |
| HMGB2 | high mobility group box 2 | 0.012073 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0120645 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0119843 |
| RHOV | ras homolog family member V | 0.0119613 |
| CDK13 | cyclin-dependent kinase 13 | 0.0119433 |
| CANX | calnexin | 0.0119306 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0118399 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.27832 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.236429 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170008 |
| IGF2 | insulin-like growth factor 2 | -0.154782 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.119995 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.112851 |
| TXNRD1 | thioredoxin reductase 1 | -0.111793 |
| GRAMD1B | GRAM domain containing 1B | -0.0999898 |
| ACTG1 | actin gamma 1 | -0.0971218 |
| FTL | ferritin, light polypeptide | -0.0901262 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0827452 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0821188 |
| IER3 | immediate early response 3 | -0.0821151 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0774661 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0717662 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0715182 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0659376 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0652168 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0644124 |
| POTEF | POTE ankyrin domain family, member F | -0.0627774 |
| RTN4 | reticulon 4 | -0.0611075 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0578556 |
| KIF5B | kinesin family member 5B | -0.0548234 |
| STC1 | stanniocalcin 1 | -0.0519994 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0498795 |
| RPS6 | ribosomal protein S6 | -0.045878 |
| PKM | pyruvate kinase, muscle | -0.0448196 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.044514 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0436548 |
| NAV3 | neuron navigator 3 | -0.0433275 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0431743 |
| ENO1 | enolase 1, (alpha) | -0.0422132 |
| RPL37A | ribosomal protein L37a | -0.0418777 |
| ASPH | aspartate beta-hydroxylase | -0.0415843 |
| EGR1 | early growth response 1 | -0.0396902 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0395215 |
| CLTC | clathrin, heavy chain (Hc) | -0.0385896 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0383676 |
| RBM25 | RNA binding motif protein 25 | -0.0369628 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0364472 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0363994 |
| ZNF207 | zinc finger protein 207 | -0.0362999 |
| MKI67 | marker of proliferation Ki-67 | -0.0360727 |
| NRG1 | neuregulin 1 | -0.0353417 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0349912 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0349908 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0340871 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0338753 |
| RBM39 | RNA binding motif protein 39 | -0.0336188 |
| DST | dystonin | -0.0335403 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0333958 |
| RPS27A | ribosomal protein S27a | -0.0333891 |
| IL6 | interleukin 6 | -0.0329665 |
| RPS25 | ribosomal protein S25 | -0.0327442 |
| USP34 | ubiquitin specific peptidase 34 | -0.0326928 |
| S100A6 | S100 calcium binding protein A6 | -0.0326825 |
| CENPF | centromere protein F, 350/400kDa | -0.0325985 |
| TPM4 | tropomyosin 4 | -0.0325828 |
| AK1 | adenylate kinase 1 | -0.0320852 |
| VMP1 | vacuole membrane protein 1 | -0.0317385 |
| RPS2 | ribosomal protein S2 | -0.0315529 |
| RPL35A | ribosomal protein L35a | -0.0310251 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0306389 |
| S100A11 | S100 calcium binding protein A11 | -0.0303933 |
| SEPTIN7 | septin 7 | -0.0297503 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.029711 |
| ECT2 | epithelial cell transforming 2 | -0.0296724 |
| RPS12 | ribosomal protein S12 | -0.0296719 |
| PRDX1 | peroxiredoxin 1 | -0.0295747 |
| HMGA1 | high mobility group AT-hook 1 | -0.0295441 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0294783 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0293416 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0292448 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0292389 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0287481 |
| PFN1 | profilin 1 | -0.0287395 |
| NUP58 | nucleoporin 58 | -0.0286565 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0286546 |
| TPM3 | tropomyosin 3 | -0.0280884 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0280762 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0278693 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0277395 |
| FMNL2 | formin-like 2 | -0.0275546 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0272227 |
| CDCP1 | CUB domain containing protein 1 | -0.027098 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0270517 |
| DENND4A | DENN/MADD domain containing 4A | -0.0269502 |
| RPL31 | ribosomal protein L31 | -0.0268077 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0267703 |
| PYGL | phosphorylase, glycogen, liver | -0.0267082 |
| SNX14 | sorting nexin 14 | -0.0266332 |
| S100A10 | S100 calcium binding protein A10 | -0.0264934 |
| PARD3 | par-3 family cell polarity regulator | -0.026393 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0263779 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0262586 |
| PTMA | prothymosin, alpha | -0.0259666 |
| SRGN | serglycin | -0.0259414 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0257963 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0253635 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0253074 |
