Elimusertib hydrochloride_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elimusertib hydrochloride_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.141537
NKD1 naked cuticle homolog 1 (Drosophila) 0.0842017
BACE2 beta-site APP-cleaving enzyme 2 0.0827182
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0782064
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.073498
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0726485
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0658836
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0631075
IGF2 insulin-like growth factor 2 0.0618747
KYNU kynureninase 0.05539
RPS6 ribosomal protein S6 0.0531316
ANKIB1 ankyrin repeat and IBR domain containing 1 0.052441
STRN3 striatin, calmodulin binding protein 3 0.0500113
RIGI RNA sensor RIG-I 0.0493561
ENO1 enolase 1, (alpha) 0.0492778
IFIH1 interferon induced with helicase C domain 1 0.0484286
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0477918
RACK1 receptor for activated C kinase 1 0.0466441
RPL11 ribosomal protein L11 0.045795
SH3KBP1 SH3-domain kinase binding protein 1 0.045351
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0439728
TGFBI transforming growth factor, beta-induced, 68kDa 0.0435077
TRIO trio Rho guanine nucleotide exchange factor 0.0430772
RPL37A ribosomal protein L37a 0.0426574
ARGLU1 arginine and glutamate rich 1 0.0425633
ZBTB38 zinc finger and BTB domain containing 38 0.0423298
MYOF myoferlin 0.0422981
CANX calnexin 0.0421331
VCL vinculin 0.0419852
FNDC3B fibronectin type III domain containing 3B 0.0419788
RNF213 ring finger protein 213 0.0413635
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0413016
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0412514
TNS3 tensin 3 0.0403919
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0403285
MYO1E myosin IE 0.0399888
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0391954
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0388431
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0387425
INHBA inhibin, beta A 0.0379029
CMIP c-Maf inducing protein 0.0375478
NEBL nebulette 0.0372178
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0369792
SP100 SP100 nuclear antigen 0.0367628
EEF2 eukaryotic translation elongation factor 2 0.036473
KMT2C lysine (K)-specific methyltransferase 2C 0.0364595
HLA-B major histocompatibility complex, class I, B 0.0362701
PLAUR plasminogen activator, urokinase receptor 0.0357737
RPS19 ribosomal protein S19 0.0356478
ADAM9 ADAM metallopeptidase domain 9 0.0350617
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0346767
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0340282
DOCK1 dedicator of cytokinesis 1 0.033959
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0339363
LPP LIM domain containing preferred translocation partner in lipoma 0.0331981
FHIT fragile histidine triad 0.0328333
SPAG9 sperm associated antigen 9 0.0327478
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.032519
RPS12 ribosomal protein S12 0.0319463
PDGFC platelet derived growth factor C 0.0318436
FBL fibrillarin 0.0317271
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0316734
RPS16 ribosomal protein S16 0.0313853
PDZD8 PDZ domain containing 8 0.0310133
FERMT2 fermitin family member 2 0.0308674
NRIP1 nuclear receptor interacting protein 1 0.0307734
GPATCH8 G patch domain containing 8 0.0305809
EIF1 eukaryotic translation initiation factor 1 0.0301363
MYH9 myosin, heavy chain 9, non-muscle 0.0300139
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0298105
CDK6 cyclin-dependent kinase 6 0.0297671
CALR calreticulin 0.0297398
RPTOR regulatory associated protein of MTOR, complex 1 0.0295153
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0292876
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0292446
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0291918
MACC1 metastasis associated in colon cancer 1 0.0290002
ETNK1 ethanolamine kinase 1 0.0289123
WWOX WW domain containing oxidoreductase 0.0288661
RPL15 ribosomal protein L15 0.0288165
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0286859
OSBPL8 oxysterol binding protein-like 8 0.0284576
NAV1 neuron navigator 1 0.0284286
TPM4 tropomyosin 4 0.0283775
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0281894
PHIP pleckstrin homology domain interacting protein 0.028127
PARD3 par-3 family cell polarity regulator 0.0279521
YBX1 Y box binding protein 1 0.0279232
TMEM131 transmembrane protein 131 0.0276224
AHNAK AHNAK nucleoprotein 0.0275471
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0273297
ADIPOR2 adiponectin receptor 2 0.0272677
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0271436
ATP11A ATPase, class VI, type 11A 0.0269924
TTC3 tetratricopeptide repeat domain 3 0.0267317
RPL5 ribosomal protein L5 0.0266236
TPT1 tumor protein, translationally-controlled 1 0.0266026
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0264301
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0261134
EML4 echinoderm microtubule associated protein like 4 0.0259075

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.161402
PDE4D phosphodiesterase 4D, cAMP-specific -0.0814044
VMP1 vacuole membrane protein 1 -0.0717081
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0691222
RORA RAR-related orphan receptor A -0.0643445
ANXA2 annexin A2 -0.0634185
CSNK1A1 casein kinase 1, alpha 1 -0.0631966
ATOSA atos homolog A -0.0608382
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0600129
PTK2 protein tyrosine kinase 2 -0.0576718
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0558947
STAU1 staufen double-stranded RNA binding protein 1 -0.0558416
CEMIP cell migration inducing protein, hyaluronan binding -0.0528083
SETD5 SET domain containing 5 -0.0514638
ASPH aspartate beta-hydroxylase -0.0513205
SAMD4A sterile alpha motif domain containing 4A -0.0502619
ZMYND8 zinc finger, MYND-type containing 8 -0.0478852
ZNF207 zinc finger protein 207 -0.045038
FTL ferritin, light polypeptide -0.0445851
NCOA3 nuclear receptor coactivator 3 -0.0430479
OSMR oncostatin M receptor -0.0429068
FN1 fibronectin 1 -0.0428307
LOC112694756 uncharaterized LOC112694756 -0.0425294
TFG TRK-fused gene -0.0418312
MBD5 methyl-CpG binding domain protein 5 -0.0417189
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0415409
PIBF1 progesterone immunomodulatory binding factor 1 -0.0412338
POTEF POTE ankyrin domain family, member F -0.0411978
KDM2A lysine (K)-specific demethylase 2A -0.0397194
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0391243
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0382421
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.038115
PUM2 pumilio RNA-binding family member 2 -0.038005
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0375003
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.036812
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.036493
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0359459
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0356032
TAOK3 TAO kinase 3 -0.0354306
S100A10 S100 calcium binding protein A10 -0.0344603
NF1 neurofibromin 1 -0.0344129
UBAC2 UBA domain containing 2 -0.0340657
BAIAP2L1 BAI1-associated protein 2-like 1 -0.033845
GRB10 growth factor receptor-bound protein 10 -0.0337867
MCL1 myeloid cell leukemia 1 -0.0334589
ARHGAP5 Rho GTPase activating protein 5 -0.033384
MSI2 musashi RNA-binding protein 2 -0.0332858
TMSB10 thymosin beta 10 -0.0330849
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0330293
TMEM41B transmembrane protein 41B -0.0328942
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0328237
MYO6 myosin VI -0.0325185
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0323623
MAML2 mastermind-like 2 (Drosophila) -0.0317879
EGR1 early growth response 1 -0.0315138
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0312156
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0312044
COPA coatomer protein complex, subunit alpha -0.0311953
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0311802
FTH1 ferritin, heavy polypeptide 1 -0.0311521
GPR107 G protein-coupled receptor 107 -0.0311419
MBD4 methyl-CpG binding domain protein 4 -0.0310692
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0309602
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0309096
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.030684
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0306202
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0303237
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0302414
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0301849
TRA2A transformer 2 alpha homolog (Drosophila) -0.0300932
RASA2 RAS p21 protein activator 2 -0.0300889
LSAMP limbic system-associated membrane protein -0.0300318
SEC24A SEC24 family member A -0.0299665
KMT2E lysine (K)-specific methyltransferase 2E -0.0298578
INTS6 integrator complex subunit 6 -0.0298238
RNF145 ring finger protein 145 -0.0298196
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0297518
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0296399
ANKRD17 ankyrin repeat domain 17 -0.029381
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0293067
FAM13B family with sequence similarity 13, member B -0.0291028
ADNP activity-dependent neuroprotector homeobox -0.0290663
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0290598
SMAD3 SMAD family member 3 -0.028765
MATR3 matrin 3 -0.0285487
NAP1L4 nucleosome assembly protein 1-like 4 -0.0285267
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0284639
ITCH itchy E3 ubiquitin protein ligase -0.0284172
ZC3H11A zinc finger CCCH-type containing 11A -0.028337
NDRG1 N-myc downstream regulated 1 -0.0279853
BIRC6 baculoviral IAP repeat containing 6 -0.0277851
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.027709
TM9SF2 transmembrane 9 superfamily member 2 -0.0276261
KDM7A lysine (K)-specific demethylase 7A -0.0276084
HBS1L HBS1-like translational GTPase -0.0274138
SEPTIN7 septin 7 -0.0269939
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0269501
MYL12B myosin, light chain 12B, regulatory -0.0268236
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0267715
TRPS1 trichorhinophalangeal syndrome I -0.0266482