| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0950429 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0774268 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0766724 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0738548 |
| KRT18 | keratin 18, type I | 0.0577122 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0566554 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0561633 |
| ADAR | adenosine deaminase, RNA-specific | 0.0513902 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0509721 |
| PDE10A | phosphodiesterase 10A | 0.0455906 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0452435 |
| GOLGB1 | golgin B1 | 0.0422633 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0421867 |
| TXNRD1 | thioredoxin reductase 1 | 0.0421445 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0416975 |
| ATF6 | activating transcription factor 6 | 0.0411335 |
| BRD2 | bromodomain containing 2 | 0.0405152 |
| YBX3 | Y box binding protein 3 | 0.0379082 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0374145 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0356608 |
| YAP1 | Yes-associated protein 1 | 0.0339026 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.033817 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0337439 |
| CTTN | cortactin | 0.0327701 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0323611 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0320771 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0311027 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0310961 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0309099 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0307201 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0302702 |
| CPNE1 | copine I | 0.0297783 |
| XPO1 | exportin 1 | 0.0293225 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.028326 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0281009 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0274103 |
| COPA | coatomer protein complex, subunit alpha | 0.0269841 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0268625 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0264133 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0257822 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0249898 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0248738 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0244304 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0243303 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.024074 |
| CMIP | c-Maf inducing protein | 0.0235863 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0235422 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.023499 |
| OGA | O-GlcNAcase | 0.0227695 |
| MSH6 | mutS homolog 6 | 0.0226836 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0225963 |
| PLEC | plectin | 0.022358 |
| USP36 | ubiquitin specific peptidase 36 | 0.0222541 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0222532 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0221142 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0220061 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0218622 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0215854 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0214945 |
| GRAMD1B | GRAM domain containing 1B | 0.0213286 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0212235 |
| BRD4 | bromodomain containing 4 | 0.0210417 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0209021 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0203386 |
| RPS4X | ribosomal protein S4, X-linked | 0.0203153 |
| FOXP1 | forkhead box P1 | 0.0202959 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0200373 |
| PCBP2 | poly(rC) binding protein 2 | 0.0200091 |
| TLN1 | talin 1 | 0.0199475 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0197706 |
| AMOTL2 | angiomotin like 2 | 0.0197619 |
| MAGEA4 | melanoma antigen family A4 | 0.0196212 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0194644 |
| TPM3 | tropomyosin 3 | 0.0193362 |
| CANX | calnexin | 0.0192559 |
| HDAC4 | histone deacetylase 4 | 0.0186958 |
| INTS6 | integrator complex subunit 6 | 0.0186078 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0184825 |
| HOMER1 | homer scaffolding protein 1 | 0.0183793 |
| PHF3 | PHD finger protein 3 | 0.0178888 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0178579 |
| CALR | calreticulin | 0.0176684 |
| RNF145 | ring finger protein 145 | 0.0176059 |
| BMP5 | bone morphogenetic protein 5 | 0.0175234 |
| CEP250 | centrosomal protein 250kDa | 0.0174436 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0172808 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0171165 |
| USP22 | ubiquitin specific peptidase 22 | 0.0170411 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.016777 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.016728 |
| CRY1 | cryptochrome circadian clock 1 | 0.0167091 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0166124 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0163897 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0163293 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0161924 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0161843 |
| RPL3 | ribosomal protein L3 | 0.0159533 |
| PREPL | prolyl endopeptidase-like | 0.0159118 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0158012 |
| SKI | SKI proto-oncogene | 0.0157949 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.133881 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.117611 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0952399 |
| RPS3 | ribosomal protein S3 | -0.086286 |
| RPL37A | ribosomal protein L37a | -0.0859268 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0783256 |
| TMSB10 | thymosin beta 10 | -0.077241 |
| EGR1 | early growth response 1 | -0.0750187 |
| RPS12 | ribosomal protein S12 | -0.0725295 |
| HMGA2 | high mobility group AT-hook 2 | -0.0709861 |
| FTL | ferritin, light polypeptide | -0.0690086 |
| RPL37 | ribosomal protein L37 | -0.0651096 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0642626 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0641774 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0626276 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0621271 |
| RPL26 | ribosomal protein L26 | -0.0588869 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0577487 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0573356 |
| VIM | vimentin | -0.0560732 |
| OSMR | oncostatin M receptor | -0.0560246 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0548848 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.05485 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0532687 |
| RPL11 | ribosomal protein L11 | -0.052223 |
| RPS19 | ribosomal protein S19 | -0.0515533 |
| RPL31 | ribosomal protein L31 | -0.0513887 |
| POTEF | POTE ankyrin domain family, member F | -0.0492947 |
| RYR3 | ryanodine receptor 3 | -0.0467766 |
| ACTG1 | actin gamma 1 | -0.0461027 |
| STC1 | stanniocalcin 1 | -0.0447981 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0438485 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0437864 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0434986 |
| RTN4 | reticulon 4 | -0.0431075 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0427766 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0425022 |
| FMNL2 | formin-like 2 | -0.0422827 |
| RPLP2 | ribosomal protein, large, P2 | -0.0411912 |
| RPL36 | ribosomal protein L36 | -0.039 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0383329 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0378484 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.037751 |
| EGFR | epidermal growth factor receptor | -0.0376612 |
| RPS25 | ribosomal protein S25 | -0.0373588 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0365277 |
| CDK17 | cyclin-dependent kinase 17 | -0.0361446 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0356415 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.035272 |
| HLA-B | major histocompatibility complex, class I, B | -0.0348644 |
| DST | dystonin | -0.0345151 |
| RPS27A | ribosomal protein S27a | -0.0339268 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0338425 |
| RPL35A | ribosomal protein L35a | -0.0329382 |
| PTK2 | protein tyrosine kinase 2 | -0.0324308 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0321596 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0316006 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0313831 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0313337 |
| RPL30 | ribosomal protein L30 | -0.0313252 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0313038 |
| CCDC91 | coiled-coil domain containing 91 | -0.0311243 |
| IER3 | immediate early response 3 | -0.031109 |
| RPL12 | ribosomal protein L12 | -0.0310476 |
| RPL36A | ribosomal protein L36a | -0.0309731 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0309701 |
| RPL28 | ribosomal protein L28 | -0.0306855 |
| RPL9 | ribosomal protein L9 | -0.0303205 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0302068 |
| MMP12 | matrix metallopeptidase 12 | -0.029807 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0294634 |
| TPM4 | tropomyosin 4 | -0.0290141 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0288722 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0284491 |
| RACK1 | receptor for activated C kinase 1 | -0.0284466 |
| SBF2 | SET binding factor 2 | -0.0278995 |
| USP34 | ubiquitin specific peptidase 34 | -0.0277651 |
| RPL13A | ribosomal protein L13a | -0.0277576 |
| RSF1 | remodeling and spacing factor 1 | -0.027704 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0275444 |
| RPS8 | ribosomal protein S8 | -0.0274582 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0272216 |
| IGF2 | insulin-like growth factor 2 | -0.0272038 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.026975 |
| NABP1 | nucleic acid binding protein 1 | -0.0267617 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0263151 |
| ATXN1 | ataxin 1 | -0.0262226 |
| RPS29 | ribosomal protein S29 | -0.0262157 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0260529 |
| EPAS1 | endothelial PAS domain protein 1 | -0.025807 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0256651 |
| RPS27 | ribosomal protein S27 | -0.0255869 |
| CDCP1 | CUB domain containing protein 1 | -0.0254704 |
| ATP13A3 | ATPase type 13A3 | -0.0251241 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0249481 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.024938 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0244934 |
| CD2AP | CD2-associated protein | -0.0244489 |
| RPS6 | ribosomal protein S6 | -0.0244469 |
| ENO1 | enolase 1, (alpha) | -0.0244132 |
