| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.20069 |
| FN1 | fibronectin 1 | 0.176816 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.151811 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.131454 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0732736 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.073269 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0729078 |
| RNF213 | ring finger protein 213 | 0.07237 |
| CANX | calnexin | 0.0723129 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0722426 |
| DSPP | dentin sialophosphoprotein | 0.0665318 |
| PLEC | plectin | 0.0636412 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0631864 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.057427 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0553143 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0528506 |
| MX1 | MX dynamin-like GTPase 1 | 0.0524415 |
| FLNA | filamin A, alpha | 0.050562 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0493778 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0486614 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0468697 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0463559 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0455896 |
| TUFT1 | tuftelin 1 | 0.0451907 |
| VEGFA | vascular endothelial growth factor A | 0.0450945 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0430643 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0429245 |
| ADAR | adenosine deaminase, RNA-specific | 0.0426978 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0420099 |
| FBXO32 | F-box protein 32 | 0.0400926 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0397377 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0389215 |
| BRD2 | bromodomain containing 2 | 0.0387348 |
| MYOF | myoferlin | 0.0385573 |
| KRT18 | keratin 18, type I | 0.0383271 |
| CALR | calreticulin | 0.0380199 |
| CTBP2 | C-terminal binding protein 2 | 0.0377715 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0377366 |
| CTSB | cathepsin B | 0.0371665 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.037099 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0369898 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0364161 |
| RPL4 | ribosomal protein L4 | 0.0362375 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0360745 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0348531 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0345468 |
| TXNIP | thioredoxin interacting protein | 0.0343479 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0339476 |
| RPS4X | ribosomal protein S4, X-linked | 0.0337796 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0330575 |
| FLNB | filamin B, beta | 0.0328411 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0327014 |
| SEPTIN9 | septin 9 | 0.0326922 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0326628 |
| XPO1 | exportin 1 | 0.0326241 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0325255 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.031676 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0314719 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0314532 |
| HMGB2 | high mobility group box 2 | 0.0314239 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0314178 |
| ACTN4 | actinin, alpha 4 | 0.0310248 |
| MYO1E | myosin IE | 0.0309755 |
| PGBD5 | piggyBac transposable element derived 5 | 0.030662 |
| KLHL24 | kelch-like family member 24 | 0.0305149 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0304181 |
| GOLGB1 | golgin B1 | 0.0300049 |
| TMF1 | TATA element modulatory factor 1 | 0.0294396 |
| TMSB4X | thymosin beta 4, X-linked | 0.0291595 |
| PCBP2 | poly(rC) binding protein 2 | 0.0290366 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0290241 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0287829 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0283931 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0281133 |
| HLA-E | major histocompatibility complex, class I, E | 0.0280028 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.027771 |
| VCL | vinculin | 0.027419 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0271711 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.027119 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0270598 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0268095 |
| RAB10 | RAB10, member RAS oncogene family | 0.026761 |
| SGMS2 | sphingomyelin synthase 2 | 0.026644 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0263019 |
| SP100 | SP100 nuclear antigen | 0.0262924 |
| RPL3 | ribosomal protein L3 | 0.0261993 |
| MED13 | mediator complex subunit 13 | 0.0261603 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0252588 |
| CFB | complement factor B | 0.0252002 |
| LMNA | lamin A/C | 0.025198 |
| OPTN | optineurin | 0.0251136 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.024925 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0247786 |
| EFNA1 | ephrin-A1 | 0.0246794 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0245551 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0241708 |
| PLSCR1 | phospholipid scramblase 1 | 0.0239299 |
| TJP1 | tight junction protein 1 | 0.0239251 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0238636 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0238401 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | -0.163651 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.16099 |
| FTL | ferritin, light polypeptide | -0.156075 |
| NDRG1 | N-myc downstream regulated 1 | -0.15175 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.121872 |
| ASPH | aspartate beta-hydroxylase | -0.107555 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0999976 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0885422 |
| TMSB10 | thymosin beta 10 | -0.088331 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0845339 |
| HMGA1 | high mobility group AT-hook 1 | -0.079922 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0696091 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0695615 |
| RPL35A | ribosomal protein L35a | -0.0676568 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0676411 |
| ACTG1 | actin gamma 1 | -0.0633918 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0632224 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0629168 |
| RPL37A | ribosomal protein L37a | -0.0600815 |
| CCND1 | cyclin D1 | -0.0598981 |
| FAM3C | family with sequence similarity 3, member C | -0.0570726 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0527682 |
| RPLP2 | ribosomal protein, large, P2 | -0.0517399 |
| RPS25 | ribosomal protein S25 | -0.0513662 |
| PTK2 | protein tyrosine kinase 2 | -0.050849 |
| TOP1 | topoisomerase (DNA) I | -0.0498735 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0490512 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0466935 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0465893 |
| RPS19 | ribosomal protein S19 | -0.0457602 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0453163 |
| MXD1 | MAX dimerization protein 1 | -0.0425178 |
| CSTB | cystatin B (stefin B) | -0.0420661 |
| FAM162A | family with sequence similarity 162, member A | -0.0416219 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0413928 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.041096 |
| RPS3 | ribosomal protein S3 | -0.0395982 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0390985 |
| RPS12 | ribosomal protein S12 | -0.0384616 |
| RPL31 | ribosomal protein L31 | -0.0384305 |
| TMEM123 | transmembrane protein 123 | -0.0380452 |
| TXNRD1 | thioredoxin reductase 1 | -0.0364942 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0354947 |
| RPL9 | ribosomal protein L9 | -0.0351049 |
| RPL37 | ribosomal protein L37 | -0.0342173 |
| FOSL1 | FOS-like antigen 1 | -0.0339933 |
| RTN4 | reticulon 4 | -0.0335039 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0328764 |
| CD2AP | CD2-associated protein | -0.0327083 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0326815 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0318773 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0317741 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.031689 |
| RPS24 | ribosomal protein S24 | -0.0315244 |
| FNDC3B | fibronectin type III domain containing 3B | -0.031244 |
| RPS29 | ribosomal protein S29 | -0.0310997 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0310118 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0308803 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0308536 |
| RPL5 | ribosomal protein L5 | -0.0308167 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0304249 |
| TFG | TRK-fused gene | -0.030311 |
| S100A10 | S100 calcium binding protein A10 | -0.0302082 |
| PGK1 | phosphoglycerate kinase 1 | -0.0299219 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0298425 |
| ZNF292 | zinc finger protein 292 | -0.0297879 |
| USP3 | ubiquitin specific peptidase 3 | -0.0294357 |
| RPL28 | ribosomal protein L28 | -0.02917 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0290577 |
| PLAU | plasminogen activator, urokinase | -0.0288996 |
| MEF2A | myocyte enhancer factor 2A | -0.0286777 |
| DTNA | dystrobrevin, alpha | -0.0286256 |
| RPL36 | ribosomal protein L36 | -0.0286236 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0282933 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0278336 |
| MT2A | metallothionein 2A | -0.0275763 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0275143 |
| S100A6 | S100 calcium binding protein A6 | -0.0273705 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0273212 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0271716 |
| COX6C | cytochrome c oxidase subunit VIc | -0.026813 |
| RPS14 | ribosomal protein S14 | -0.0266787 |
| RASA2 | RAS p21 protein activator 2 | -0.0264579 |
| AREG | amphiregulin | -0.0260569 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0260252 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.026022 |
| QKI | QKI, KH domain containing, RNA binding | -0.0256574 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0255837 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0255553 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0255111 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0252891 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0251267 |
| RPS8 | ribosomal protein S8 | -0.0251095 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.025054 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0248637 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0246445 |
| RPL15 | ribosomal protein L15 | -0.0243298 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0242447 |
| RPL23 | ribosomal protein L23 | -0.0239581 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0238791 |
