| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0780174 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0562617 |
| SMAD3 | SMAD family member 3 | 0.0470744 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0454616 |
| TXNRD1 | thioredoxin reductase 1 | 0.0353128 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.034595 |
| PLEC | plectin | 0.0342793 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0332795 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0324617 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.0311126 |
| RNF213 | ring finger protein 213 | 0.0288898 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0268619 |
| TNS3 | tensin 3 | 0.0262793 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0262284 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0261366 |
| RPL4 | ribosomal protein L4 | 0.0256863 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0247143 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0247024 |
| RPS4X | ribosomal protein S4, X-linked | 0.022651 |
| SEPTIN9 | septin 9 | 0.0224863 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0218311 |
| FLNA | filamin A, alpha | 0.0209465 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0204907 |
| INTS6 | integrator complex subunit 6 | 0.0204775 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0199266 |
| CANX | calnexin | 0.0196045 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0194527 |
| RPL7 | ribosomal protein L7 | 0.0188685 |
| OGA | O-GlcNAcase | 0.0183883 |
| ARRDC3 | arrestin domain containing 3 | 0.0182381 |
| ATF6 | activating transcription factor 6 | 0.0181829 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0180301 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.0179782 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0177959 |
| ZNF146 | zinc finger protein 146 | 0.017414 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0169645 |
| RPS12 | ribosomal protein S12 | 0.0168384 |
| BRD2 | bromodomain containing 2 | 0.0166697 |
| KRT18 | keratin 18, type I | 0.0162794 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0162572 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0160952 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.016046 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0158478 |
| ABLIM1 | actin binding LIM protein 1 | 0.0157191 |
| ACTN4 | actinin, alpha 4 | 0.015105 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0149631 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0148542 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.0144719 |
| MAP3K10 | mitogen-activated protein kinase kinase kinase 10 | 0.0144439 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0142348 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0140115 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0138506 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0136905 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0134974 |
| CEP250 | centrosomal protein 250kDa | 0.013481 |
| UTRN | utrophin | 0.013477 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.013462 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0134153 |
| SQSTM1 | sequestosome 1 | 0.0134079 |
| RPL13A | ribosomal protein L13a | 0.0133689 |
| SERINC1 | serine incorporator 1 | 0.013217 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0131189 |
| MRTFA | myocardin related transcription factor A | 0.0129085 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0128441 |
| JAK1 | Janus kinase 1 | 0.0128309 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0126862 |
| APP | amyloid beta (A4) precursor protein | 0.012679 |
| FLNB | filamin B, beta | 0.012485 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0124593 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0124555 |
| FAT1 | FAT atypical cadherin 1 | 0.0123352 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0123121 |
| ATXN1 | ataxin 1 | 0.0122284 |
| RPS3 | ribosomal protein S3 | 0.0121689 |
| MYPN | myopalladin | 0.0121453 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0119714 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0119588 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0118349 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0118055 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0117467 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0117135 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0116731 |
| PHF3 | PHD finger protein 3 | 0.0116564 |
| SP100 | SP100 nuclear antigen | 0.0116003 |
| XPO1 | exportin 1 | 0.0115754 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0113919 |
| STAT5B | signal transducer and activator of transcription 5B | 0.011039 |
| ATF3 | activating transcription factor 3 | 0.0110158 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0109908 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0109136 |
| HLA-E | major histocompatibility complex, class I, E | 0.0108875 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.010798 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.01076 |
| RPS7 | ribosomal protein S7 | 0.0107335 |
| MED13L | mediator complex subunit 13-like | 0.0106804 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.010654 |
| ZNF608 | zinc finger protein 608 | 0.0106104 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0104916 |
| CABIN1 | calcineurin binding protein 1 | 0.0101327 |
| CASC3 | cancer susceptibility candidate 3 | 0.0100598 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.31983 |
| VIM | vimentin | -0.2592 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.251897 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.200136 |
| RPS16 | ribosomal protein S16 | -0.197823 |
| TMSB10 | thymosin beta 10 | -0.133901 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.126613 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.10732 |
| PTMA | prothymosin, alpha | -0.101925 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.101157 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.101064 |
| VCL | vinculin | -0.0990108 |
| CD44 | CD44 molecule (Indian blood group) | -0.0834129 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0807798 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0790662 |
| ACTG1 | actin gamma 1 | -0.0785777 |
| RTN4 | reticulon 4 | -0.0774942 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0769923 |
| EGR1 | early growth response 1 | -0.0715583 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0670186 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0655269 |
| HMGA2 | high mobility group AT-hook 2 | -0.0651074 |
| HMGA1 | high mobility group AT-hook 1 | -0.0603036 |
| MT2A | metallothionein 2A | -0.0582795 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0565475 |
| MAP1B | microtubule-associated protein 1B | -0.0557622 |
| FOSL1 | FOS-like antigen 1 | -0.0555077 |
| PFN1 | profilin 1 | -0.0547877 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0529629 |
| AHNAK | AHNAK nucleoprotein | -0.0520492 |
| S100A6 | S100 calcium binding protein A6 | -0.0519329 |
| ZFP36 | ZFP36 ring finger protein | -0.0493564 |
| MCL1 | myeloid cell leukemia 1 | -0.0487355 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0486029 |
| RPL35A | ribosomal protein L35a | -0.0485763 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0482744 |
| PDE10A | phosphodiesterase 10A | -0.0471854 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0468853 |
| ATG7 | autophagy related 7 | -0.0464719 |
| CDCP1 | CUB domain containing protein 1 | -0.0461006 |
| JMJD1C | jumonji domain containing 1C | -0.0455876 |
| POTEF | POTE ankyrin domain family, member F | -0.0444649 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0443927 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0443474 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0442836 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.043588 |
| ASPH | aspartate beta-hydroxylase | -0.0429792 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.042736 |
| PTK2 | protein tyrosine kinase 2 | -0.0425888 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0421895 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0421378 |
| TMEM123 | transmembrane protein 123 | -0.0419935 |
| RPLP0 | ribosomal protein, large, P0 | -0.0416112 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0411896 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0393145 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0392244 |
| CENPF | centromere protein F, 350/400kDa | -0.0385685 |
| CTSD | cathepsin D | -0.0371191 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0369602 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0368254 |
| CBX3 | chromobox homolog 3 | -0.0365259 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0357831 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0355784 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0355628 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0355407 |
| NHSL1 | NHS-like 1 | -0.0353672 |
| MYO10 | myosin X | -0.0351709 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.035048 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0350258 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0346828 |
| FMNL2 | formin-like 2 | -0.033445 |
| NAV2 | neuron navigator 2 | -0.0333492 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0324855 |
| ANGPTL4 | angiopoietin-like 4 | -0.0322827 |
| CCND1 | cyclin D1 | -0.0322693 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0322562 |
| SBF2 | SET binding factor 2 | -0.0315668 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0314933 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0313241 |
| ATP13A3 | ATPase type 13A3 | -0.0312554 |
| MYADM | myeloid-associated differentiation marker | -0.0312418 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0311178 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0308013 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0307467 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0305672 |
| NF1 | neurofibromin 1 | -0.0304287 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0297205 |
| THOC2 | THO complex 2 | -0.0294011 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0292402 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.0291855 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0290993 |
| EHBP1 | EH domain binding protein 1 | -0.0282897 |
| VMP1 | vacuole membrane protein 1 | -0.0280308 |
| CD109 | CD109 molecule | -0.0277258 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0276293 |
| RPS21 | ribosomal protein S21 | -0.0274966 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0273922 |
| RPLP2 | ribosomal protein, large, P2 | -0.0269619 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.0268278 |
| RNF220 | ring finger protein 220 | -0.0267596 |
