| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.169926 |
| VEGFA | vascular endothelial growth factor A | 0.0922591 |
| FN1 | fibronectin 1 | 0.081797 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0813844 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0790103 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0784444 |
| SVIL | supervillin | 0.0725522 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0615235 |
| IFI44L | interferon-induced protein 44-like | 0.0601266 |
| SP100 | SP100 nuclear antigen | 0.0544335 |
| SMAD3 | SMAD family member 3 | 0.0524741 |
| HDAC9 | histone deacetylase 9 | 0.0504309 |
| TMEM178B | transmembrane protein 178B | 0.0496726 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0489405 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0447548 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0439909 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0437618 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0431298 |
| HLA-E | major histocompatibility complex, class I, E | 0.0424856 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0402616 |
| NAV2 | neuron navigator 2 | 0.0401962 |
| TGM2 | transglutaminase 2 | 0.0384594 |
| ANGPTL4 | angiopoietin-like 4 | 0.036725 |
| ARRDC3 | arrestin domain containing 3 | 0.0366695 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0362043 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0354603 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0349322 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0344881 |
| FLNA | filamin A, alpha | 0.0335798 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0335627 |
| RNF213 | ring finger protein 213 | 0.0332142 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0331634 |
| ADAR | adenosine deaminase, RNA-specific | 0.033034 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0328992 |
| COL5A3 | collagen, type V, alpha 3 | 0.0320168 |
| ZNF395 | zinc finger protein 395 | 0.0319906 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0315908 |
| COL5A1 | collagen, type V, alpha 1 | 0.0311407 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0302125 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0301496 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0295144 |
| FAT1 | FAT atypical cadherin 1 | 0.0288218 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0284775 |
| ACTN4 | actinin, alpha 4 | 0.0283779 |
| PLEC | plectin | 0.0281328 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0279626 |
| OPTN | optineurin | 0.02755 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0273487 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0271827 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0269076 |
| CALR | calreticulin | 0.0265072 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0260472 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0259112 |
| AFAP1 | actin filament associated protein 1 | 0.0254692 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0253186 |
| PLSCR1 | phospholipid scramblase 1 | 0.0250222 |
| CEP250 | centrosomal protein 250kDa | 0.0246926 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0246568 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0244539 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0242336 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0241496 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0240368 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0239963 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0237912 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0237238 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0235817 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0226853 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0220294 |
| EHD4 | EH-domain containing 4 | 0.0213711 |
| ATF4 | activating transcription factor 4 | 0.0213634 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0210925 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0210401 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0208128 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.020744 |
| PML | promyelocytic leukemia | 0.0206524 |
| KYNU | kynureninase | 0.0205256 |
| CLEC11A | C-type lectin domain family 11, member A | 0.0202354 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0199805 |
| UTRN | utrophin | 0.0198144 |
| FNIP1 | folliculin interacting protein 1 | 0.0195826 |
| APP | amyloid beta (A4) precursor protein | 0.0195425 |
| CUL3 | cullin 3 | 0.0195373 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0193787 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0193502 |
| AHR | aryl hydrocarbon receptor | 0.019304 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0190308 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.019 |
| MYOF | myoferlin | 0.0187292 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.018656 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0186369 |
| SAMHD1 | SAM domain and HD domain 1 | 0.0184938 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0184411 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0182167 |
| TRIM22 | tripartite motif containing 22 | 0.0181996 |
| OGA | O-GlcNAcase | 0.0181849 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | 0.0181318 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0179051 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.01789 |
| TOP1 | topoisomerase (DNA) I | 0.0178363 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0178239 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.243299 |
| COL1A1 | collagen, type I, alpha 1 | -0.131761 |
| TPM4 | tropomyosin 4 | -0.0949625 |
| HLA-B | major histocompatibility complex, class I, B | -0.0936832 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0935307 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0824778 |
| CADM1 | cell adhesion molecule 1 | -0.0824125 |
| NDRG1 | N-myc downstream regulated 1 | -0.0808094 |
| CDH13 | cadherin 13 | -0.0729596 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0727693 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.072248 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0672157 |
| MTSS1 | metastasis suppressor 1 | -0.0654241 |
| CD44 | CD44 molecule (Indian blood group) | -0.0652643 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0638177 |
| MMP12 | matrix metallopeptidase 12 | -0.0622449 |
| IER3 | immediate early response 3 | -0.0515595 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0510526 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0510119 |
| TMSB10 | thymosin beta 10 | -0.050077 |
| IL1B | interleukin 1, beta | -0.0495358 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0485264 |
| POTEF | POTE ankyrin domain family, member F | -0.0478552 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0477896 |
| RPL37A | ribosomal protein L37a | -0.0468647 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0467619 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0465741 |
| CALU | calumenin | -0.0449465 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0446173 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0435982 |
| RTN4 | reticulon 4 | -0.0435913 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.043442 |
| ARMC9 | armadillo repeat containing 9 | -0.0433691 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0421937 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0409749 |
| MAP4 | microtubule-associated protein 4 | -0.0408868 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0396376 |
| RPL35A | ribosomal protein L35a | -0.0393232 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0389826 |
| GNAS | GNAS complex locus | -0.0389631 |
| GOLGA4 | golgin A4 | -0.0385034 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0381514 |
| ACTG1 | actin gamma 1 | -0.0372165 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0370473 |
| PGK1 | phosphoglycerate kinase 1 | -0.0367474 |
| EGR1 | early growth response 1 | -0.0365078 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0352791 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.034283 |
| HM13 | histocompatibility (minor) 13 | -0.0342802 |
| FAM20C | family with sequence similarity 20, member C | -0.0340395 |
| ATP13A3 | ATPase type 13A3 | -0.0340063 |
| PCBP3 | poly(rC) binding protein 3 | -0.0339612 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0338591 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.033705 |
| RRBP1 | ribosome binding protein 1 | -0.0335467 |
| RPL37 | ribosomal protein L37 | -0.0334518 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0328211 |
| ZNF292 | zinc finger protein 292 | -0.0322788 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0321599 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0318707 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0309677 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0305723 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0301915 |
| RAB2A | RAB2A, member RAS oncogene family | -0.030136 |
| RPS6 | ribosomal protein S6 | -0.0297759 |
| ENO1 | enolase 1, (alpha) | -0.0297139 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0296736 |
| RUNX2 | runt-related transcription factor 2 | -0.0294625 |
| RAI14 | retinoic acid induced 14 | -0.0294376 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0292558 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0291036 |
| STC1 | stanniocalcin 1 | -0.0288957 |
| NRP1 | neuropilin 1 | -0.0286345 |
| GLIS3 | GLIS family zinc finger 3 | -0.02854 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0281231 |
| TNNC1 | troponin C type 1 (slow) | -0.0280703 |
| MEF2A | myocyte enhancer factor 2A | -0.0280438 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0277456 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0276715 |
| CLMP | CXADR-like membrane protein | -0.0276249 |
| EGFR | epidermal growth factor receptor | -0.0273291 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0273256 |
| SEC61G | Sec61 gamma subunit | -0.0272715 |
| NREP | neuronal regeneration related protein | -0.0267411 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0267375 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0266775 |
| COL5A2 | collagen, type V, alpha 2 | -0.0264569 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0263378 |
| MT2A | metallothionein 2A | -0.0263185 |
| RPS12 | ribosomal protein S12 | -0.0262588 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0261798 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0260611 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0260132 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0253561 |
| PXDN | peroxidasin | -0.0252694 |
| ITGA1 | integrin, alpha 1 | -0.0252091 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0251432 |
| SBF2 | SET binding factor 2 | -0.025108 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0245621 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0243799 |
