Elimusertib hydrochloride_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elimusertib hydrochloride_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF213 ring finger protein 213 0.0917903
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0711888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.070318
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0682301
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0672808
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0646146
IRS2 insulin receptor substrate 2 0.0607242
ADAR adenosine deaminase, RNA-specific 0.0606566
RALYL RALY RNA binding protein-like 0.0586291
INHBA inhibin, beta A 0.0584099
MAP7 microtubule-associated protein 7 0.0556931
CHGB chromogranin B 0.0549936
FAT1 FAT atypical cadherin 1 0.0542088
NFIB nuclear factor I/B 0.0526475
PABPC1 poly(A) binding protein, cytoplasmic 1 0.05249
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0511182
CNKSR3 CNKSR family member 3 0.0478282
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0472455
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0450674
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0429971
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0426855
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0414257
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0412873
CANX calnexin 0.0406716
MX2 MX dynamin-like GTPase 2 0.0395008
EEF2 eukaryotic translation elongation factor 2 0.0389329
VEGFA vascular endothelial growth factor A 0.0382609
MYH9 myosin, heavy chain 9, non-muscle 0.0373126
WWOX WW domain containing oxidoreductase 0.0371388
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0371345
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0365914
TOX thymocyte selection-associated high mobility group box 0.0365647
FOXP2 forkhead box P2 0.0365416
MBNL2 muscleblind-like splicing regulator 2 0.0355654
BACE2 beta-site APP-cleaving enzyme 2 0.0355267
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.035426
HYOU1 hypoxia up-regulated 1 0.0348412
KDM5C lysine (K)-specific demethylase 5C 0.0342495
UNC13B unc-13 homolog B (C. elegans) 0.034003
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0339438
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0337413
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0333679
RIGI RNA sensor RIG-I 0.0330428
RPL4 ribosomal protein L4 0.0328326
SMAD9 SMAD family member 9 0.0322001
GRAMD4 GRAM domain containing 4 0.0320691
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0318229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311163
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308795
SIK2 salt-inducible kinase 2 0.0305685
CAMTA1 calmodulin binding transcription activator 1 0.0305635
B2M beta-2-microglobulin 0.0301138
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0293498
SP100 SP100 nuclear antigen 0.0291479
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.0289225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0287172
KTN1 kinectin 1 (kinesin receptor) 0.0285262
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0280957
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0280735
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.028044
CRACD capping protein inhibiting regulator of actin dynamics 0.0280243
SCFD1 sec1 family domain containing 1 0.0277929
PCSK2 proprotein convertase subtilisin/kexin type 2 0.0275907
TTC3 tetratricopeptide repeat domain 3 0.0274608
XBP1 X-box binding protein 1 0.0271084
TSHZ2 teashirt zinc finger homeobox 2 0.0263533
DST dystonin 0.026338
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0256596
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0255382
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0252746
RPS8 ribosomal protein S8 0.0252173
RPS4X ribosomal protein S4, X-linked 0.025211
NFE2L1 nuclear factor, erythroid 2-like 1 0.0251869
KDM2A lysine (K)-specific demethylase 2A 0.0250967
TMEM178B transmembrane protein 178B 0.0250726
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0247725
TRIO trio Rho guanine nucleotide exchange factor 0.0247113
CABIN1 calcineurin binding protein 1 0.0246964
RSAD2 radical S-adenosyl methionine domain containing 2 0.024674
ADGRV1 adhesion G protein-coupled receptor V1 0.024672
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0246311
BRD2 bromodomain containing 2 0.0245283
FOXN3 forkhead box N3 0.024463
MACF1 microtubule-actin crosslinking factor 1 0.0244302
LDHA lactate dehydrogenase A 0.0243315
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0242431
RPL7 ribosomal protein L7 0.0241588
ZFHX3 zinc finger homeobox 3 0.0240263
MACROD2 MACRO domain containing 2 0.0239529
CNTNAP2 contactin associated protein-like 2 0.0239203
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0238698
RPL3 ribosomal protein L3 0.0236124
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0235709
MED13L mediator complex subunit 13-like 0.0235539
CALR calreticulin 0.0233851
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0233755
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0233515
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0233358
LRPPRC leucine-rich pentatricopeptide repeat containing 0.023284
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0232614

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.178328
NALF1 NALCN channel auxiliary factor 1 -0.13906
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.110235
TENM1 teneurin transmembrane protein 1 -0.0983109
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0942233
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0907355
GPC6 glypican 6 -0.0840411
EGR1 early growth response 1 -0.0825208
STC1 stanniocalcin 1 -0.0824372
RORA RAR-related orphan receptor A -0.0737629
PTCHD4 patched domain containing 4 -0.0712244
VGF VGF nerve growth factor inducible -0.0640417
PDE10A phosphodiesterase 10A -0.0598875
CALCA calcitonin-related polypeptide alpha -0.0561206
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0463183
MCL1 myeloid cell leukemia 1 -0.0459615
EFNA5 ephrin-A5 -0.045945
MCTP1 multiple C2 domains, transmembrane 1 -0.0449209
PDE4B phosphodiesterase 4B, cAMP-specific -0.0446767
SNTG1 syntrophin, gamma 1 -0.0444299
RIT2 Ras-like without CAAX 2 -0.0441755
KIF26B kinesin family member 26B -0.0418021
DOCK5 dedicator of cytokinesis 5 -0.0414438
ADGRL2 adhesion G protein-coupled receptor L2 -0.0394823
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0391452
RIMS2 regulating synaptic membrane exocytosis 2 -0.0387276
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0372021
NDRG1 N-myc downstream regulated 1 -0.0340657
ASIC2 acid sensing (proton gated) ion channel 2 -0.034065
COL22A1 collagen, type XXII, alpha 1 -0.0339835
ARHGAP26 Rho GTPase activating protein 26 -0.0332449
TUSC3 tumor suppressor candidate 3 -0.0329536
SLC35F4 solute carrier family 35, member F4 -0.0320611
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0319001
NAV2 neuron navigator 2 -0.0313032
FGF14 fibroblast growth factor 14 -0.0310544
ZC3H12B zinc finger CCCH-type containing 12B -0.0310417
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0304278
MAP1B microtubule-associated protein 1B -0.0296427
DTNA dystrobrevin, alpha -0.0294816
PSD3 pleckstrin and Sec7 domain containing 3 -0.029481
MIS18BP1 MIS18 binding protein 1 -0.028731
LSAMP limbic system-associated membrane protein -0.0286059
CADM1 cell adhesion molecule 1 -0.0275628
ACTG1 actin gamma 1 -0.0275163
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0275023
STXBP5L syntaxin binding protein 5-like -0.0251148
ESRRG estrogen-related receptor gamma -0.0247468
CCDC88A coiled-coil domain containing 88A -0.0243345
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0242976
SGO2 shugoshin 2 -0.0241765
ZBTB20 zinc finger and BTB domain containing 20 -0.0239314
POTEF POTE ankyrin domain family, member F -0.0238562
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0237999
RTN4 reticulon 4 -0.0233512
ZBTB7C zinc finger and BTB domain containing 7C -0.0232479
CENPF centromere protein F, 350/400kDa -0.0230417
MKI67 marker of proliferation Ki-67 -0.0228524
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0225617
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0224901
SMC4 structural maintenance of chromosomes 4 -0.0223153
SYT1 synaptotagmin I -0.0223102
PFN1 profilin 1 -0.0222948
IGFBP5 insulin-like growth factor binding protein 5 -0.0222324
ANKRD36C ankyrin repeat domain 36C -0.0218351
LIFR leukemia inhibitory factor receptor alpha -0.0218153
ECT2 epithelial cell transforming 2 -0.0217953
ANKRD10 ankyrin repeat domain 10 -0.0216546
NUF2 NUF2, NDC80 kinetochore complex component -0.0214912
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0214731
DGKD diacylglycerol kinase, delta 130kDa -0.0213703
NCKAP5 NCK-associated protein 5 -0.0212829
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0212465
NF1 neurofibromin 1 -0.0211199
ETV1 ets variant 1 -0.0209966
TOP1 topoisomerase (DNA) I -0.0204085
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0202261
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.020187
RGS17 regulator of G-protein signaling 17 -0.0200114
MMP26 matrix metallopeptidase 26 -0.0198784
SMYD3 SET and MYND domain containing 3 -0.0197837
MT2A metallothionein 2A -0.0195957
FANCL Fanconi anemia, complementation group L -0.01959
RPTOR regulatory associated protein of MTOR, complex 1 -0.0195205
PHF14 PHD finger protein 14 -0.0194717
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0192522
RGS7 regulator of G-protein signaling 7 -0.018785
DNAH5 dynein, axonemal, heavy chain 5 -0.0186129
GLCCI1 glucocorticoid induced 1 -0.0185368
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0185112
TUBA1B tubulin, alpha 1b -0.0179514
SINHCAF SIN3-HDAC complex associated factor -0.01795
RAB30 RAB30, member RAS oncogene family -0.017686
CEP152 centrosomal protein 152kDa -0.0175729
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0174981
TRPS1 trichorhinophalangeal syndrome I -0.0172513
U2SURP U2 snRNP-associated SURP domain containing -0.0172362
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0170228
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0168861
RSRC1 arginine/serine-rich coiled-coil 1 -0.0166479