| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.227162 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0953701 |
| FLNA | filamin A, alpha | 0.0760807 |
| CANX | calnexin | 0.0729279 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0653029 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0633817 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0630787 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.056611 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0536642 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0532369 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0483202 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0479305 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0460283 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0450156 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.044664 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0442786 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0427527 |
| CENPF | centromere protein F, 350/400kDa | 0.0425137 |
| ACTN4 | actinin, alpha 4 | 0.042096 |
| GOLGB1 | golgin B1 | 0.0413306 |
| RPS4X | ribosomal protein S4, X-linked | 0.0382719 |
| RRBP1 | ribosome binding protein 1 | 0.0365492 |
| ATF4 | activating transcription factor 4 | 0.0349802 |
| LMNA | lamin A/C | 0.0344394 |
| SERINC1 | serine incorporator 1 | 0.0343507 |
| CEP250 | centrosomal protein 250kDa | 0.0339553 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0335899 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0330831 |
| SP100 | SP100 nuclear antigen | 0.0326795 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0313081 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0311386 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0309363 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.030119 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0284991 |
| RNF213 | ring finger protein 213 | 0.028043 |
| AHNAK | AHNAK nucleoprotein | 0.0277107 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0273441 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0270023 |
| TAOK1 | TAO kinase 1 | 0.0268102 |
| SORT1 | sortilin 1 | 0.0258255 |
| KLF6 | Kruppel-like factor 6 | 0.0257878 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0256269 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0255252 |
| OGA | O-GlcNAcase | 0.0254015 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 0.0251188 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0249754 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0247113 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0246205 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0245337 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.024484 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0244353 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.02396 |
| ANXA2 | annexin A2 | 0.0234518 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0234256 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0233357 |
| ZNF608 | zinc finger protein 608 | 0.023106 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.022874 |
| FAM219A | family with sequence similarity 219, member A | 0.0226582 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0224826 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0224127 |
| RPL14 | ribosomal protein L14 | 0.0222347 |
| TPM3 | tropomyosin 3 | 0.0221539 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0220776 |
| CTTN | cortactin | 0.0219718 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0219627 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0218701 |
| TENM1 | teneurin transmembrane protein 1 | 0.0218621 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.021859 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0217016 |
| ADAR | adenosine deaminase, RNA-specific | 0.0216452 |
| CALR | calreticulin | 0.0215457 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0215091 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0214937 |
| SFTPA2 | surfactant protein A2 | 0.0213942 |
| YME1L1 | YME1-like 1 ATPase | 0.0212961 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0210909 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0210665 |
| RLIM | ring finger protein, LIM domain interacting | 0.0204843 |
| UBC | ubiquitin C | 0.0204476 |
| RPL19 | ribosomal protein L19 | 0.020356 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0202847 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.0202778 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0201329 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0200924 |
| MYO9A | myosin IXA | 0.0198124 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0197787 |
| ANK2 | ankyrin 2, neuronal | 0.019644 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.019379 |
| CABIN1 | calcineurin binding protein 1 | 0.0193391 |
| CORO1C | coronin, actin binding protein, 1C | 0.0192822 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | 0.019034 |
| RASAL2 | RAS protein activator like 2 | 0.0187266 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0186785 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0186587 |
| CREBRF | CREB3 regulatory factor | 0.0184855 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.018399 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0183283 |
| EMP1 | epithelial membrane protein 1 | 0.0182911 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0182814 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0182445 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG3 | neuregulin 3 | -0.251008 |
| LSAMP | limbic system-associated membrane protein | -0.234004 |
| FN1 | fibronectin 1 | -0.218508 |
| NLGN1 | neuroligin 1 | -0.175023 |
| FRMD4A | FERM domain containing 4A | -0.152426 |
| FMN1 | formin 1 | -0.107336 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.101425 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0971783 |
| FNDC3B | fibronectin type III domain containing 3B | -0.08334 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0757937 |
| MSI2 | musashi RNA-binding protein 2 | -0.0637969 |
| CADM1 | cell adhesion molecule 1 | -0.0562023 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.055252 |
| FTL | ferritin, light polypeptide | -0.0546212 |
| FHIT | fragile histidine triad | -0.0536771 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0516767 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.051092 |
| TNNC1 | troponin C type 1 (slow) | -0.0487387 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0481424 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0466802 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0450558 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0440758 |
| POTEF | POTE ankyrin domain family, member F | -0.0436962 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0425351 |
| ARMC9 | armadillo repeat containing 9 | -0.0400675 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0394676 |
| WDR45B | WD repeat domain 45B | -0.0382372 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0363324 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0362348 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0354875 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0349439 |
| SQSTM1 | sequestosome 1 | -0.0344287 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0341412 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.034022 |
| CNKSR3 | CNKSR family member 3 | -0.033466 |
| APOD | apolipoprotein D | -0.0321578 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0320348 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0311989 |
| IER3 | immediate early response 3 | -0.0310256 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0307576 |
| ZNF292 | zinc finger protein 292 | -0.0304561 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0302704 |
| CALD1 | caldesmon 1 | -0.0301515 |
| MMP12 | matrix metallopeptidase 12 | -0.0298131 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0297831 |
| RPS12 | ribosomal protein S12 | -0.0296791 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0294128 |
| RPL37A | ribosomal protein L37a | -0.0287671 |
| PRAME | preferentially expressed antigen in melanoma | -0.0286288 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0283733 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0280458 |
| HMGA1 | high mobility group AT-hook 1 | -0.0279672 |
| DOCK7 | dedicator of cytokinesis 7 | -0.027771 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0275774 |
| RGS5 | regulator of G-protein signaling 5 | -0.027502 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0274083 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0271549 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0270212 |
| CFAP20DC | CFAP20 domain containing | -0.0269089 |
| CTSD | cathepsin D | -0.0268435 |
| THOC2 | THO complex 2 | -0.0266951 |
| HLA-B | major histocompatibility complex, class I, B | -0.0257157 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0255773 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.0247718 |
| RPL35A | ribosomal protein L35a | -0.024348 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0235126 |
| RAD51B | RAD51 paralog B | -0.0230318 |
| NF1 | neurofibromin 1 | -0.0230151 |
| SRPK2 | SRSF protein kinase 2 | -0.0229988 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0228426 |
| CDH13 | cadherin 13 | -0.0227889 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0227406 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0224685 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0224516 |
| RPS14 | ribosomal protein S14 | -0.0224185 |
| CCNL1 | cyclin L1 | -0.0221962 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0221128 |
| ENO1 | enolase 1, (alpha) | -0.0220109 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0219764 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0219234 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0218758 |
| TMSB10 | thymosin beta 10 | -0.0218635 |
| RPS29 | ribosomal protein S29 | -0.0215293 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0214977 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.0214597 |
| IGF2 | insulin-like growth factor 2 | -0.021364 |
| RPL9 | ribosomal protein L9 | -0.021108 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0208685 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0207056 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0204435 |
| RPL31 | ribosomal protein L31 | -0.0202146 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0202096 |
| B2M | beta-2-microglobulin | -0.0201609 |
| SEC24A | SEC24 family member A | -0.0201333 |
| VMP1 | vacuole membrane protein 1 | -0.0200503 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | -0.0191153 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0190968 |
| FSTL5 | follistatin-like 5 | -0.0190362 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0190055 |
| FOXJ3 | forkhead box J3 | -0.0186002 |
