| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.176156 |
| COL6A3 | collagen, type VI, alpha 3 | 0.141312 |
| CALR | calreticulin | 0.111918 |
| VIM | vimentin | 0.105239 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0855688 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0806102 |
| FLNA | filamin A, alpha | 0.0803642 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0705096 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0648249 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0557572 |
| ZNF395 | zinc finger protein 395 | 0.0552962 |
| PLEC | plectin | 0.0479358 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0458252 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0423328 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0419075 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0401836 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0396892 |
| ARRDC3 | arrestin domain containing 3 | 0.0394837 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.037646 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0345238 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0340573 |
| ACTN4 | actinin, alpha 4 | 0.0332614 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.032203 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0310427 |
| COL5A1 | collagen, type V, alpha 1 | 0.0309209 |
| KYNU | kynureninase | 0.0299891 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0298195 |
| PPL | periplakin | 0.0294308 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0290154 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0289866 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0286879 |
| VEGFA | vascular endothelial growth factor A | 0.0279833 |
| GOLGB1 | golgin B1 | 0.027946 |
| HYOU1 | hypoxia up-regulated 1 | 0.0278722 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0278242 |
| FAT1 | FAT atypical cadherin 1 | 0.0277056 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0272119 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0270053 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0267561 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.026579 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261519 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0261099 |
| ATF4 | activating transcription factor 4 | 0.0259339 |
| FN1 | fibronectin 1 | 0.025626 |
| MYLK | myosin light chain kinase | 0.0246794 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0246745 |
| EGFR | epidermal growth factor receptor | 0.0238838 |
| GSE1 | Gse1 coiled-coil protein | 0.0235214 |
| TNS3 | tensin 3 | 0.023365 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0232378 |
| RPS4X | ribosomal protein S4, X-linked | 0.0231719 |
| CA12 | carbonic anhydrase XII | 0.0230685 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0229749 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0227277 |
| CALD1 | caldesmon 1 | 0.0227191 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0226337 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0224112 |
| EXOC4 | exocyst complex component 4 | 0.0222706 |
| JPH2 | junctophilin 2 | 0.0222535 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0222324 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0219099 |
| PRELID2 | PRELI domain containing 2 | 0.0219041 |
| DSPP | dentin sialophosphoprotein | 0.0218083 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0214128 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0213999 |
| C3 | complement component 3 | 0.0213383 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0210231 |
| STK38L | serine/threonine kinase 38 like | 0.0208912 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0208863 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.0207414 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0206168 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0203675 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0199971 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.019984 |
| L1CAM | L1 cell adhesion molecule | 0.0198346 |
| APP | amyloid beta (A4) precursor protein | 0.019762 |
| TRIOBP | TRIO and F-actin binding protein | 0.0194748 |
| AOPEP | aminopeptidase O (putative) | 0.0193079 |
| MYO1E | myosin IE | 0.0192542 |
| EZR | ezrin | 0.0188757 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0188716 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0187689 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.0186047 |
| STC2 | stanniocalcin 2 | 0.0185579 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0185058 |
| RSF1 | remodeling and spacing factor 1 | 0.0184747 |
| RNF19B | ring finger protein 19B | 0.0184717 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0184208 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0183887 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0182938 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0180795 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0180786 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0180352 |
| RPL3 | ribosomal protein L3 | 0.0180101 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.017822 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0177989 |
| DIAPH1 | diaphanous-related formin 1 | 0.0176911 |
| KIAA1191 | KIAA1191 | 0.0176869 |
| ZNF608 | zinc finger protein 608 | 0.0175975 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0175906 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.203738 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.18419 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.151952 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.137714 |
| TMSB10 | thymosin beta 10 | -0.110603 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.107842 |
| HLA-B | major histocompatibility complex, class I, B | -0.10405 |
| COL1A1 | collagen, type I, alpha 1 | -0.0982508 |
| STC1 | stanniocalcin 1 | -0.0908787 |
| POTEF | POTE ankyrin domain family, member F | -0.0847344 |
| COL1A2 | collagen, type I, alpha 2 | -0.0828249 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0813849 |
| CDH13 | cadherin 13 | -0.0800179 |
| MT1X | metallothionein 1X | -0.072444 |
| PRSS23 | protease, serine, 23 | -0.0612744 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0609851 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0588507 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0542382 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0539807 |
| B2M | beta-2-microglobulin | -0.0537259 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0515129 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0514425 |
| HLA-C | major histocompatibility complex, class I, C | -0.0509774 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0497939 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0496979 |
| GLIS3 | GLIS family zinc finger 3 | -0.0490866 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0479217 |
| HLA-A | major histocompatibility complex, class I, A | -0.0464857 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0460171 |
| LOX | lysyl oxidase | -0.0449071 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0435797 |
| ANXA2 | annexin A2 | -0.0434248 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0433023 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0425947 |
| HMGA2 | high mobility group AT-hook 2 | -0.0423211 |
| SDC4 | syndecan 4 | -0.0421921 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0419712 |
| VCL | vinculin | -0.0419603 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0416912 |
| SEPTIN7 | septin 7 | -0.0409335 |
| CCNI | cyclin I | -0.0407629 |
| VDAC1 | voltage-dependent anion channel 1 | -0.040202 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0399579 |
| RTN4 | reticulon 4 | -0.0397272 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0392328 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0387158 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0380732 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0380583 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0379983 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0379132 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0369415 |
| CALU | calumenin | -0.0367949 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0367412 |
| NDRG1 | N-myc downstream regulated 1 | -0.0361773 |
| VEGFC | vascular endothelial growth factor C | -0.0357696 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0350586 |
| ANLN | anillin, actin binding protein | -0.0339726 |
| CDK6 | cyclin-dependent kinase 6 | -0.0333984 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0326118 |
| NRP1 | neuropilin 1 | -0.0323865 |
| RPL28 | ribosomal protein L28 | -0.0322652 |
| NRXN3 | neurexin 3 | -0.0317177 |
| SRP54 | signal recognition particle 54kDa | -0.0312287 |
| FUS | FUS RNA binding protein | -0.0308898 |
| WTAP | Wilms tumor 1 associated protein | -0.0306384 |
| EGR1 | early growth response 1 | -0.0303807 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0302301 |
| ARF1 | ADP-ribosylation factor 1 | -0.0301221 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0298811 |
| PTMA | prothymosin, alpha | -0.0298395 |
| FTL | ferritin, light polypeptide | -0.0296546 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0289062 |
| S100A10 | S100 calcium binding protein A10 | -0.0288369 |
| COL5A2 | collagen, type V, alpha 2 | -0.0286658 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0286235 |
| HMGB1 | high mobility group box 1 | -0.0285623 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0284635 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0277397 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0277311 |
| FOSL1 | FOS-like antigen 1 | -0.027706 |
| COG5 | component of oligomeric golgi complex 5 | -0.0275756 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0274079 |
| RHEB | Ras homolog enriched in brain | -0.0273822 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0273662 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0273327 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0272344 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0270873 |
| DIAPH3 | diaphanous-related formin 3 | -0.0268413 |
| RBM39 | RNA binding motif protein 39 | -0.0267595 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0266524 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0263183 |
| SRGN | serglycin | -0.0256884 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0256839 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0255244 |
| EXT1 | exostosin glycosyltransferase 1 | -0.025167 |
| KAZN | kazrin, periplakin interacting protein | -0.0251104 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0250074 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0249452 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0248589 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0247832 |
