Elimusertib hydrochloride_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elimusertib hydrochloride_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0629581
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0625315
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0560459
SOD2 superoxide dismutase 2, mitochondrial 0.049296
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0486107
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0465319
TXNRD1 thioredoxin reductase 1 0.0438117
CEP250 centrosomal protein 250kDa 0.0431959
MBNL2 muscleblind-like splicing regulator 2 0.0418849
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0411428
ZSWIM6 zinc finger, SWIM-type containing 6 0.0402661
INTS6 integrator complex subunit 6 0.0389337
FLNA filamin A, alpha 0.0375236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0343227
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0341307
TRIO trio Rho guanine nucleotide exchange factor 0.0332606
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.033178
CPNE1 copine I 0.0312284
AHNAK2 AHNAK nucleoprotein 2 0.0293401
SMAD3 SMAD family member 3 0.0271069
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0269489
ATF3 activating transcription factor 3 0.0267955
CFB complement factor B 0.0263219
TENM2 teneurin transmembrane protein 2 0.0263081
CNOT12 CCR4-NOT transcription complex subunit 12 0.0254612
OXSR1 oxidative stress responsive 1 0.0254003
HSPA8 heat shock 70kDa protein 8 0.0240887
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0238273
NUMA1 nuclear mitotic apparatus protein 1 0.0237224
CALR calreticulin 0.0237103
CCL5 chemokine (C-C motif) ligand 5 0.0235778
NFE2L1 nuclear factor, erythroid 2-like 1 0.023423
APLP2 amyloid beta (A4) precursor-like protein 2 0.0234079
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.023251
CMIP c-Maf inducing protein 0.0226061
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.02258
ACTN4 actinin, alpha 4 0.0220334
TOM1L2 target of myb1-like 2 (chicken) 0.0218866
SEPTIN9 septin 9 0.0216077
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0215719
CANX calnexin 0.0214116
KIF1B kinesin family member 1B 0.0210764
NFE2L2 nuclear factor, erythroid 2-like 2 0.0209234
RCOR1 REST corepressor 1 0.0207861
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0202891
RHOBTB3 Rho-related BTB domain containing 3 0.0202754
NOP56 NOP56 ribonucleoprotein 0.0201894
SYNM synemin, intermediate filament protein 0.0199963
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.019971
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0197457
FN1 fibronectin 1 0.0196615
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0195628
MYOF myoferlin 0.0194813
SIK2 salt-inducible kinase 2 0.0193867
LOC102724023 ES1 protein homolog, mitochondrial 0.0193332
FAT1 FAT atypical cadherin 1 0.0191903
JARID2 jumonji, AT rich interactive domain 2 0.0190618
YME1L1 YME1-like 1 ATPase 0.0186076
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0181746
TIMP3 TIMP metallopeptidase inhibitor 3 0.0181232
MYH9 myosin, heavy chain 9, non-muscle 0.0180556
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.01803
KMT2D lysine (K)-specific methyltransferase 2D 0.0179722
FHIT fragile histidine triad 0.0178473
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0173026
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0172627
KLF10 Kruppel-like factor 10 0.0171084
SLFN5 schlafen family member 5 0.0170451
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0170283
PDIA4 protein disulfide isomerase family A, member 4 0.0170256
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0169913
APOLD1 apolipoprotein L domain containing 1 0.0167337
IRF1 interferon regulatory factor 1 0.0166359
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0166341
RAD23B RAD23 homolog B (S. cerevisiae) 0.0166176
LNPK lunapark, ER junction formation factor 0.0164504
FOSL2 FOS-like antigen 2 0.0164048
FBXL3 F-box and leucine-rich repeat protein 3 0.01634
RPL3 ribosomal protein L3 0.0161631
HP1BP3 heterochromatin protein 1, binding protein 3 0.0161622
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.016075
SFTPA2 surfactant protein A2 0.0160069
FAM120A family with sequence similarity 120A 0.0159998
RPL7 ribosomal protein L7 0.0159887
WHRN whirlin 0.0159664
MED13L mediator complex subunit 13-like 0.0159534
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.015929
ACIN1 apoptotic chromatin condensation inducer 1 0.0158664
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0158596
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.015814
SYTL2 synaptotagmin-like 2 0.0157704
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0156683
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0156654
FBXL7 F-box and leucine-rich repeat protein 7 0.0155315
CHD4 chromodomain helicase DNA binding protein 4 0.0153811
RDX radixin 0.0152641
USP9X ubiquitin specific peptidase 9, X-linked 0.0151347
SIL1 SIL1 nucleotide exchange factor 0.0151019
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0150895
USO1 USO1 vesicle transport factor 0.0150702

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.269585
FNDC3B fibronectin type III domain containing 3B -0.17633
TMSB10 thymosin beta 10 -0.133936
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.11214
CD44 CD44 molecule (Indian blood group) -0.109093
HMGA2 high mobility group AT-hook 2 -0.107761
TPT1 tumor protein, translationally-controlled 1 -0.0953742
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0905383
NT5E 5'-nucleotidase, ecto (CD73) -0.0905167
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0864253
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0840192
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0790757
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0781162
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0765623
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0765399
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0747822
RBM39 RNA binding motif protein 39 -0.073472
ANGPTL4 angiopoietin-like 4 -0.0719933
NF1 neurofibromin 1 -0.0715787
MACF1 microtubule-actin crosslinking factor 1 -0.07093
TM4SF1 transmembrane 4 L six family member 1 -0.0696257
TAS2R14 taste receptor, type 2, member 14 -0.0695482
AHNAK AHNAK nucleoprotein -0.0687694
AKAP13 A kinase (PRKA) anchor protein 13 -0.0624325
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0619909
MT2A metallothionein 2A -0.060327
FLNB filamin B, beta -0.0599574
LOC112694756 uncharaterized LOC112694756 -0.0589815
ZMYND8 zinc finger, MYND-type containing 8 -0.0585602
THSD4 thrombospondin, type I, domain containing 4 -0.0585493
FMNL2 formin-like 2 -0.0575671
BIRC6 baculoviral IAP repeat containing 6 -0.0574962
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0572505
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0572223
OSMR oncostatin M receptor -0.0572
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0555383
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0548602
ERBIN erbb2 interacting protein -0.0546486
ANKRD11 ankyrin repeat domain 11 -0.054319
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0541481
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0540177
BIRC3 baculoviral IAP repeat containing 3 -0.0531038
VIM vimentin -0.0524562
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.052273
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0518002
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0516918
CAPRIN2 caprin family member 2 -0.0514279
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0508334
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0506338
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0504139
ZBTB20 zinc finger and BTB domain containing 20 -0.0501674
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0501145
MCTP1 multiple C2 domains, transmembrane 1 -0.0500364
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0490344
SDC4 syndecan 4 -0.0489099
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0487459
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0483241
PTK2 protein tyrosine kinase 2 -0.0481131
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0471538
DNER delta/notch-like EGF repeat containing -0.0466986
PBX3 pre-B-cell leukemia homeobox 3 -0.0466406
SH3KBP1 SH3-domain kinase binding protein 1 -0.0464361
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0464092
WAC WW domain containing adaptor with coiled-coil -0.0463913
PCED1B PC-esterase domain containing 1B -0.0461068
AKAP12 A kinase (PRKA) anchor protein 12 -0.0453118
LDHA lactate dehydrogenase A -0.0451963
RIGI RNA sensor RIG-I -0.0448932
SVIL supervillin -0.0436347
CDCP1 CUB domain containing protein 1 -0.0434695
ATM ATM serine/threonine kinase -0.0431751
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0431525
EGR1 early growth response 1 -0.0430953
YBX3 Y box binding protein 3 -0.0426951
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0418976
PRR16 proline rich 16 -0.0418769
RAB7A RAB7A, member RAS oncogene family -0.0417927
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0413989
IGF2 insulin-like growth factor 2 -0.0412752
IL1RAP interleukin 1 receptor accessory protein -0.0412112
NPAS2 neuronal PAS domain protein 2 -0.0407341
ASPH aspartate beta-hydroxylase -0.0400507
NKTR natural killer cell triggering receptor -0.0395367
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0393285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.039293
RIN2 Ras and Rab interactor 2 -0.0392788
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0392788
POTEF POTE ankyrin domain family, member F -0.039104
PARD3 par-3 family cell polarity regulator -0.0386164
GNAS GNAS complex locus -0.038521
ATG7 autophagy related 7 -0.0376946
FUS FUS RNA binding protein -0.0373843
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0373504
ATXN1 ataxin 1 -0.0371259
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0365463
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0364325
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0360883
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0358969
FAM3C family with sequence similarity 3, member C -0.0358774
RPL35A ribosomal protein L35a -0.035808