| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0774696 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0759408 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0668815 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0540354 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0514117 |
| STC2 | stanniocalcin 2 | 0.0492767 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0429635 |
| VEGFA | vascular endothelial growth factor A | 0.0413015 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0410574 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0399629 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0398032 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0375746 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0369762 |
| MYOF | myoferlin | 0.0368236 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0361801 |
| CFB | complement factor B | 0.0358962 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0340516 |
| FLNA | filamin A, alpha | 0.0337453 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0332219 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0329139 |
| VIM | vimentin | 0.0325787 |
| AOPEP | aminopeptidase O (putative) | 0.0319901 |
| TGFB2 | transforming growth factor, beta 2 | 0.0310258 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0310248 |
| SIRT1 | sirtuin 1 | 0.0310146 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0290724 |
| SFTPA2 | surfactant protein A2 | 0.02804 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0272937 |
| ENAH | enabled homolog (Drosophila) | 0.0259344 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0248475 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0231926 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0229909 |
| CD109 | CD109 molecule | 0.0228576 |
| NXN | nucleoredoxin | 0.0218859 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0217538 |
| RAB10 | RAB10, member RAS oncogene family | 0.0212923 |
| RNF213 | ring finger protein 213 | 0.0210291 |
| SIK3 | SIK family kinase 3 | 0.0207184 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.020287 |
| FOSL2 | FOS-like antigen 2 | 0.0199841 |
| CALR | calreticulin | 0.0197919 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0194858 |
| ATF3 | activating transcription factor 3 | 0.0189645 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0188715 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0188345 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.018299 |
| TNS3 | tensin 3 | 0.018115 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.018085 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0179057 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0178657 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0177347 |
| FAT1 | FAT atypical cadherin 1 | 0.0174674 |
| RASAL2 | RAS protein activator like 2 | 0.0170231 |
| ATF4 | activating transcription factor 4 | 0.016968 |
| ARRDC3 | arrestin domain containing 3 | 0.0164889 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0164079 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.016114 |
| HYOU1 | hypoxia up-regulated 1 | 0.0160881 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0158782 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0158012 |
| DUSP16 | dual specificity phosphatase 16 | 0.0155604 |
| IRS2 | insulin receptor substrate 2 | 0.0154943 |
| CANX | calnexin | 0.0154701 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0153913 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0151636 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0151349 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0150703 |
| DSTN | destrin (actin depolymerizing factor) | 0.0150225 |
| SIK2 | salt-inducible kinase 2 | 0.0150046 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0149332 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0147156 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0145781 |
| CEP250 | centrosomal protein 250kDa | 0.0144205 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0144135 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0143571 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.014078 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0139881 |
| SEPTIN9 | septin 9 | 0.013926 |
| FAM13A | family with sequence similarity 13, member A | 0.0139085 |
| GLUL | glutamate-ammonia ligase | 0.0138791 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.0138105 |
| ZNF608 | zinc finger protein 608 | 0.013699 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0135925 |
| SH3BP4 | SH3-domain binding protein 4 | 0.0133697 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0133629 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.013331 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0132833 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0132747 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.012836 |
| DST | dystonin | 0.0128341 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0127674 |
| ADAR | adenosine deaminase, RNA-specific | 0.0126846 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0125921 |
| TUFT1 | tuftelin 1 | 0.0125414 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0124758 |
| PLK2 | polo-like kinase 2 | 0.012432 |
| MMP13 | matrix metallopeptidase 13 | 0.0124181 |
| RASEF | RAS and EF-hand domain containing | 0.0123107 |
| PLPP3 | phospholipid phosphatase 3 | 0.012301 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0122764 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.346347 |
| NRG1 | neuregulin 1 | -0.303899 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.296733 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.23932 |
| HMGA2 | high mobility group AT-hook 2 | -0.238357 |
| ITGA1 | integrin, alpha 1 | -0.154456 |
| FN1 | fibronectin 1 | -0.137018 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.136957 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.120073 |
| ASPH | aspartate beta-hydroxylase | -0.089164 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0822948 |
| TMSB10 | thymosin beta 10 | -0.0724971 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0694965 |
| MT2A | metallothionein 2A | -0.0669224 |
| SYT1 | synaptotagmin I | -0.0646756 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0645176 |
| FTL | ferritin, light polypeptide | -0.0628716 |
| SQSTM1 | sequestosome 1 | -0.0576983 |
| TMEM156 | transmembrane protein 156 | -0.056094 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0552307 |
| NDRG1 | N-myc downstream regulated 1 | -0.0535482 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0519247 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0500947 |
| GLIS3 | GLIS family zinc finger 3 | -0.0491531 |
| PTMA | prothymosin, alpha | -0.0490869 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0487429 |
| S100A6 | S100 calcium binding protein A6 | -0.0484085 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0468277 |
| IER3 | immediate early response 3 | -0.0451769 |
| HLA-B | major histocompatibility complex, class I, B | -0.0437839 |
| TMSB4X | thymosin beta 4, X-linked | -0.0427206 |
| RPL35A | ribosomal protein L35a | -0.0423842 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0414907 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0414253 |
| EFNA5 | ephrin-A5 | -0.0409368 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0404693 |
| ETV1 | ets variant 1 | -0.0400513 |
| HMGA1 | high mobility group AT-hook 1 | -0.0394826 |
| EGR1 | early growth response 1 | -0.038008 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0373033 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0372903 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0364178 |
| GNAS | GNAS complex locus | -0.0352123 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0351424 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0340546 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0338886 |
| ACTG1 | actin gamma 1 | -0.0337074 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0336034 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0334984 |
| RPS24 | ribosomal protein S24 | -0.0334432 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0333173 |
| EREG | epiregulin | -0.0331858 |
| DUSP6 | dual specificity phosphatase 6 | -0.0325252 |
| PELO | pelota homolog (Drosophila) | -0.0320502 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0319301 |
| RAI14 | retinoic acid induced 14 | -0.031291 |
| RPL26 | ribosomal protein L26 | -0.0311414 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0306246 |
| RPL31 | ribosomal protein L31 | -0.0304743 |
| PTK2 | protein tyrosine kinase 2 | -0.0294511 |
| SPAG9 | sperm associated antigen 9 | -0.0292561 |
| HPCAL1 | hippocalcin-like 1 | -0.029035 |
| TOP1 | topoisomerase (DNA) I | -0.028563 |
| RPS21 | ribosomal protein S21 | -0.028563 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0281336 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0280058 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0278001 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0277244 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0271768 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0265383 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0264311 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.026199 |
| RBM39 | RNA binding motif protein 39 | -0.0260313 |
| RPL34 | ribosomal protein L34 | -0.0255518 |
| TGFA | transforming growth factor, alpha | -0.0255192 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0253278 |
| RPL37A | ribosomal protein L37a | -0.0250227 |
| FNBP1 | formin binding protein 1 | -0.02445 |
| RPLP1 | ribosomal protein, large, P1 | -0.0243145 |
| FAM20C | family with sequence similarity 20, member C | -0.0242405 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0242377 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0240855 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0239395 |
| POTEF | POTE ankyrin domain family, member F | -0.023803 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0237465 |
| TMEM263 | transmembrane protein 263 | -0.0237086 |
| CDCP1 | CUB domain containing protein 1 | -0.0235868 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0234725 |
| ZNF217 | zinc finger protein 217 | -0.0233101 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0231467 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.022834 |
| RPL9 | ribosomal protein L9 | -0.0227815 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0226971 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0226619 |
| VMP1 | vacuole membrane protein 1 | -0.022562 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0225259 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0224951 |
| TENM4 | teneurin transmembrane protein 4 | -0.02226 |
| ARF1 | ADP-ribosylation factor 1 | -0.0218076 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0216958 |
