| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.12513 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0910813 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.083811 |
| KRT18 | keratin 18, type I | 0.0619214 |
| DSPP | dentin sialophosphoprotein | 0.0595678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0558968 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0512129 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0510473 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0496768 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0490685 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0480268 |
| FLNA | filamin A, alpha | 0.0474393 |
| SMAD3 | SMAD family member 3 | 0.0463273 |
| RPS4X | ribosomal protein S4, X-linked | 0.0441824 |
| MYO1E | myosin IE | 0.040642 |
| VCL | vinculin | 0.0388525 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0386807 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0376071 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0371803 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0357967 |
| FAM107B | family with sequence similarity 107, member B | 0.0355067 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0344367 |
| RPL13A | ribosomal protein L13a | 0.0343069 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0336222 |
| PLEC | plectin | 0.0335075 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0332594 |
| SP100 | SP100 nuclear antigen | 0.0326764 |
| RPS6 | ribosomal protein S6 | 0.0315702 |
| RNF213 | ring finger protein 213 | 0.0313945 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0311871 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0309151 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0306563 |
| CANX | calnexin | 0.0305147 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0294801 |
| ATF4 | activating transcription factor 4 | 0.0292513 |
| RPL19 | ribosomal protein L19 | 0.0291486 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0276853 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.025704 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0256122 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0250911 |
| KRT19 | keratin 19, type I | 0.024951 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.024495 |
| STC2 | stanniocalcin 2 | 0.0243617 |
| STX5 | syntaxin 5 | 0.0235198 |
| RIGI | RNA sensor RIG-I | 0.0234277 |
| HYOU1 | hypoxia up-regulated 1 | 0.0234111 |
| HKDC1 | hexokinase domain containing 1 | 0.0234026 |
| RPLP1 | ribosomal protein, large, P1 | 0.0233099 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0232005 |
| WWOX | WW domain containing oxidoreductase | 0.0229661 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0229587 |
| CTBP2 | C-terminal binding protein 2 | 0.0228581 |
| RPL14 | ribosomal protein L14 | 0.0224208 |
| NEBL | nebulette | 0.0222949 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.022147 |
| CEP250 | centrosomal protein 250kDa | 0.022121 |
| INTS6 | integrator complex subunit 6 | 0.0213105 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0211392 |
| BLCAP | bladder cancer associated protein | 0.0210218 |
| PPP6R1 | protein phosphatase 6, regulatory subunit 1 | 0.0208639 |
| VEGFA | vascular endothelial growth factor A | 0.0207642 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0206198 |
| OGFR | opioid growth factor receptor | 0.0205393 |
| RPL4 | ribosomal protein L4 | 0.0204253 |
| SIK3 | SIK family kinase 3 | 0.0203862 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0201934 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.020186 |
| SEPTIN9 | septin 9 | 0.0201734 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0199838 |
| GOLGB1 | golgin B1 | 0.0198911 |
| RPS26 | ribosomal protein S26 | 0.0198032 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0197529 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.019521 |
| ETV6 | ets variant 6 | 0.0194369 |
| LIMA1 | LIM domain and actin binding 1 | 0.0192239 |
| RPS2 | ribosomal protein S2 | 0.0191642 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0191374 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0189584 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0189434 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0186626 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0183921 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0183207 |
| RND3 | Rho family GTPase 3 | 0.0182745 |
| TUFT1 | tuftelin 1 | 0.0181558 |
| DIAPH1 | diaphanous-related formin 1 | 0.018141 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0180761 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0180394 |
| SMAD2 | SMAD family member 2 | 0.0175911 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0175821 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.0171276 |
| UBAP2 | ubiquitin associated protein 2 | 0.0170947 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0169243 |
| PTGES2 | prostaglandin E synthase 2 | 0.0168728 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0168383 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0166614 |
| RPL12 | ribosomal protein L12 | 0.0165145 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.016495 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0164922 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0164839 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0164632 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.145484 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.132988 |
| PTMA | prothymosin, alpha | -0.125111 |
| TMSB10 | thymosin beta 10 | -0.122902 |
| UBC | ubiquitin C | -0.107612 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.104247 |
| KRT8 | keratin 8, type II | -0.101777 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0926432 |
| EZR | ezrin | -0.0810633 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0727903 |
| VMP1 | vacuole membrane protein 1 | -0.072555 |
| SNX9 | sorting nexin 9 | -0.0687817 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0682119 |
| TMEM123 | transmembrane protein 123 | -0.0669493 |
| CCND1 | cyclin D1 | -0.0635324 |
| FAM3C | family with sequence similarity 3, member C | -0.0612435 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0586226 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.056459 |
| ANXA2 | annexin A2 | -0.0560382 |
| EGR1 | early growth response 1 | -0.055902 |
| FTL | ferritin, light polypeptide | -0.0555199 |
| PUM2 | pumilio RNA-binding family member 2 | -0.055009 |
| AHNAK | AHNAK nucleoprotein | -0.0549486 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0548472 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0546615 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0538768 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0536695 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0533584 |
| ITGA6 | integrin, alpha 6 | -0.0527366 |
| THOC2 | THO complex 2 | -0.0522725 |
| TOP1 | topoisomerase (DNA) I | -0.0514612 |
| FRMD5 | FERM domain containing 5 | -0.0513264 |
| PERP | PERP, TP53 apoptosis effector | -0.0500769 |
| RPS27A | ribosomal protein S27a | -0.0492646 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0488017 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0478639 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0477843 |
| BCL2L1 | BCL2-like 1 | -0.0451483 |
| CCNL1 | cyclin L1 | -0.0450088 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0449215 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0449138 |
| NFIA | nuclear factor I/A | -0.0437037 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0431174 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0428913 |
| IER3 | immediate early response 3 | -0.0423874 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0419572 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0414302 |
| S100A6 | S100 calcium binding protein A6 | -0.0405851 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0395204 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.039209 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0391777 |
| ANKRD28 | ankyrin repeat domain 28 | -0.039112 |
| NDRG1 | N-myc downstream regulated 1 | -0.0390628 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0381798 |
| ZNF207 | zinc finger protein 207 | -0.0380657 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0372144 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0369222 |
| TCERG1 | transcription elongation regulator 1 | -0.0367444 |
| EHBP1 | EH domain binding protein 1 | -0.0366906 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.036421 |
| POTEF | POTE ankyrin domain family, member F | -0.0363655 |
| RBM39 | RNA binding motif protein 39 | -0.0362426 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0359889 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0358663 |
| NF1 | neurofibromin 1 | -0.0357786 |
| RTN4 | reticulon 4 | -0.0357108 |
| ITGB4 | integrin, beta 4 | -0.0353928 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0352917 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0348794 |
| PKM | pyruvate kinase, muscle | -0.0347484 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0344151 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.034246 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0341667 |
| ECT2 | epithelial cell transforming 2 | -0.0340618 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0340103 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.033905 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.033781 |
| CD2AP | CD2-associated protein | -0.0333725 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0333264 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0320122 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.031511 |
| SBF2 | SET binding factor 2 | -0.0314793 |
| SRPK2 | SRSF protein kinase 2 | -0.0313514 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0313148 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0312365 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0310689 |
| RNF43 | ring finger protein 43 | -0.0310677 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0310673 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0307611 |
| PCBP2 | poly(rC) binding protein 2 | -0.0307416 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0305537 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0303878 |
| SETD5 | SET domain containing 5 | -0.0302243 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0300519 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0299103 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0297212 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0294744 |
| USP34 | ubiquitin specific peptidase 34 | -0.0293041 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0291959 |
| S100A10 | S100 calcium binding protein A10 | -0.0290559 |
