| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.318874 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.116039 |
| HMGA2 | high mobility group AT-hook 2 | 0.0987158 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0857547 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0738035 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.063579 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0591509 |
| PRELID2 | PRELI domain containing 2 | 0.0576588 |
| VEGFA | vascular endothelial growth factor A | 0.0566245 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.054141 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0521394 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0491438 |
| VCL | vinculin | 0.0460888 |
| INTS6 | integrator complex subunit 6 | 0.0444472 |
| NAV2 | neuron navigator 2 | 0.0409197 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0388377 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0383559 |
| HDAC9 | histone deacetylase 9 | 0.0375284 |
| HLA-E | major histocompatibility complex, class I, E | 0.0343148 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0332997 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0332705 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0327824 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0317838 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0316632 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0304523 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0301109 |
| MCL1 | myeloid cell leukemia 1 | 0.0300701 |
| FMNL2 | formin-like 2 | 0.0300216 |
| CALR | calreticulin | 0.0290016 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0288838 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0285876 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.028433 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0281111 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0276171 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0272834 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0271678 |
| MYO1E | myosin IE | 0.0269172 |
| FLNA | filamin A, alpha | 0.0266552 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0258987 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0255546 |
| PLEC | plectin | 0.0253511 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0251676 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0243932 |
| ATF4 | activating transcription factor 4 | 0.0242186 |
| RUNX1 | runt-related transcription factor 1 | 0.0241341 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0240782 |
| MT2A | metallothionein 2A | 0.0234513 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0233784 |
| NOTCH2 | notch 2 | 0.023273 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0231986 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0230433 |
| FERMT2 | fermitin family member 2 | 0.022958 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0225899 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0225034 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0221914 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0220784 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0220698 |
| TNS1 | tensin 1 | 0.0217569 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0215586 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0212326 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0209488 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0204431 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0200955 |
| SVIL | supervillin | 0.0196803 |
| KIAA1217 | KIAA1217 | 0.0196569 |
| FLNB | filamin B, beta | 0.0196221 |
| NAV1 | neuron navigator 1 | 0.0194341 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0188945 |
| AEBP2 | AE binding protein 2 | 0.018814 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0184604 |
| MYO9A | myosin IXA | 0.0180084 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0175688 |
| CLIC4 | chloride intracellular channel 4 | 0.0170881 |
| CABIN1 | calcineurin binding protein 1 | 0.0170203 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0165099 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0164574 |
| FAM219A | family with sequence similarity 219, member A | 0.0164045 |
| SMYD3 | SET and MYND domain containing 3 | 0.0163727 |
| SNX14 | sorting nexin 14 | 0.016363 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0163122 |
| RCAN1 | regulator of calcineurin 1 | 0.0162607 |
| RPS4X | ribosomal protein S4, X-linked | 0.0161203 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0161168 |
| MSN | moesin | 0.0160107 |
| EGFR | epidermal growth factor receptor | 0.0159447 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0159381 |
| RAD51B | RAD51 paralog B | 0.015848 |
| EXOC6B | exocyst complex component 6B | 0.0158269 |
| PCBP2 | poly(rC) binding protein 2 | 0.0155777 |
| KIF1B | kinesin family member 1B | 0.0155619 |
| ATG7 | autophagy related 7 | 0.0154393 |
| FNIP1 | folliculin interacting protein 1 | 0.0152469 |
| SEPTIN9 | septin 9 | 0.0151764 |
| TLE4 | transducin-like enhancer of split 4 | 0.0150029 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.014938 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0149235 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0149092 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0148147 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0145796 |
| PHF3 | PHD finger protein 3 | 0.0145537 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MMP1 | matrix metallopeptidase 1 | -0.358487 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.173207 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.151971 |
| INHBA | inhibin, beta A | -0.149275 |
| FTL | ferritin, light polypeptide | -0.136251 |
| COL1A1 | collagen, type I, alpha 1 | -0.13533 |
| STC1 | stanniocalcin 1 | -0.135233 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.115391 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0983802 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0932189 |
| ATP13A3 | ATPase type 13A3 | -0.0846527 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0839107 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0770928 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0724573 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0715382 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0681499 |
| CAVIN1 | caveolae associated protein 1 | -0.0679821 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0647149 |
| NDRG1 | N-myc downstream regulated 1 | -0.0641319 |
| COL1A2 | collagen, type I, alpha 2 | -0.0610437 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0582278 |
| OXR1 | oxidation resistance 1 | -0.0570053 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0555142 |
| IER3 | immediate early response 3 | -0.0485157 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0480669 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0471872 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0468868 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0460757 |
| EMP1 | epithelial membrane protein 1 | -0.0459924 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0425298 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.041501 |
| CLMP | CXADR-like membrane protein | -0.0412857 |
| CDH13 | cadherin 13 | -0.040017 |
| SEPTIN11 | septin 11 | -0.039568 |
| CALU | calumenin | -0.0391963 |
| FAM13A | family with sequence similarity 13, member A | -0.0388694 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0377191 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0368017 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0362209 |
| KIAA1549L | KIAA1549-like | -0.035872 |
| TPM4 | tropomyosin 4 | -0.0357603 |
| RPLP1 | ribosomal protein, large, P1 | -0.0347082 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0347004 |
| ANXA2 | annexin A2 | -0.034634 |
| INSIG1 | insulin induced gene 1 | -0.0346304 |
| TMSB10 | thymosin beta 10 | -0.034441 |
| CCDC102B | coiled-coil domain containing 102B | -0.033561 |
| RPL37A | ribosomal protein L37a | -0.0331124 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0329939 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0328032 |
| SPAG9 | sperm associated antigen 9 | -0.0326088 |
| YBX3 | Y box binding protein 3 | -0.0324388 |
| TXNRD1 | thioredoxin reductase 1 | -0.0322069 |
| COL5A3 | collagen, type V, alpha 3 | -0.0319438 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0309236 |
| FRMD4A | FERM domain containing 4A | -0.0308101 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0306693 |
| PRRX1 | paired related homeobox 1 | -0.0301547 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0298872 |
| USP3 | ubiquitin specific peptidase 3 | -0.0298484 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0297272 |
| HAS2 | hyaluronan synthase 2 | -0.0292735 |
| GOLGA4 | golgin A4 | -0.0289939 |
| ACTG1 | actin gamma 1 | -0.0285739 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0283603 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0282891 |
| S100A6 | S100 calcium binding protein A6 | -0.0278272 |
| SEC24D | SEC24 family member D | -0.0275423 |
| RRBP1 | ribosome binding protein 1 | -0.0271379 |
| RPS19 | ribosomal protein S19 | -0.0268605 |
| VCAN | versican | -0.0264395 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0263753 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0262405 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0258716 |
| TFG | TRK-fused gene | -0.0254297 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0253763 |
| NCKAP5 | NCK-associated protein 5 | -0.0251474 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.025062 |
| RPL34 | ribosomal protein L34 | -0.0250599 |
| CLINT1 | clathrin interactor 1 | -0.024959 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.024819 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -0.0248163 |
| TMEM165 | transmembrane protein 165 | -0.0241075 |
| RPL35A | ribosomal protein L35a | -0.0238647 |
| RAI14 | retinoic acid induced 14 | -0.02377 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0236768 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0235597 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0235505 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0233157 |
| IL1B | interleukin 1, beta | -0.0229899 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.022958 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0226157 |
| GLIS3 | GLIS family zinc finger 3 | -0.0226078 |
| DIAPH2 | diaphanous-related formin 2 | -0.0224535 |
| LOC112694756 | uncharaterized LOC112694756 | -0.022446 |
| NPTX1 | neuronal pentraxin I | -0.0223185 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.022167 |
| RPS3 | ribosomal protein S3 | -0.0221651 |
| RPS24 | ribosomal protein S24 | -0.0218365 |
| PTMA | prothymosin, alpha | -0.0218226 |
