Eltrombopag Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/135449332
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Genes

199 proteins with high or low expression in Eltrombopag relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1.23
COL12A1 collagen, type XII, alpha 1 1.21
COL18A1 collagen, type XVIII, alpha 1 1.04
CCNE2 cyclin E2 1.02
ENO1 enolase 1, (alpha) 0.76
COQ4 coenzyme Q4 0.68
PMFBP1 polyamine modulated factor 1 binding protein 1 0.66
TULP4 tubby like protein 4 0.63
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.57
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 0.53
PCLAF PCNA clamp associated factor 0.52
LYRM4 LYR motif containing 4 0.51
KDM3A lysine (K)-specific demethylase 3A 0.5
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.5
COX19 COX19 cytochrome c oxidase assembly factor 0.5
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.5
PCSK5 proprotein convertase subtilisin/kexin type 5 0.49
CASKIN1 CASK interacting protein 1 0.48
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.48
RRM2 ribonucleotide reductase M2 0.47
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.46
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 0.45
RNF220 ring finger protein 220 0.44
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.43
ANLN anillin, actin binding protein 0.43
GMNN geminin, DNA replication inhibitor 0.43
IFT43 intraflagellar transport 43 0.43
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.42
KLF10 Kruppel-like factor 10 0.42
METAP2 methionyl aminopeptidase 2 0.41
MB21D2 Mab-21 domain containing 2 0.41
MRPL50 mitochondrial ribosomal protein L50 0.4
SKA2 spindle and kinetochore associated complex subunit 2 0.4
SP100 SP100 nuclear antigen 0.4
AEBP2 AE binding protein 2 0.39
WNT16 wingless-type MMTV integration site family, member 16 0.38
JAG2 jagged 2 0.38
CALU calumenin 0.38
CLSPN claspin 0.38
CCNB1 cyclin B1 0.38
TMX4 thioredoxin-related transmembrane protein 4 0.38
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 0.38
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.38
ZBTB43 zinc finger and BTB domain containing 43 0.37
ZBTB24 zinc finger and BTB domain containing 24 0.37
MAD2L1BP MAD2L1 binding protein 0.37
SUMO2 small ubiquitin-like modifier 2 0.37
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.37
CCNA2 cyclin A2 0.37
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.37
ZNF292 zinc finger protein 292 0.37
AASS aminoadipate-semialdehyde synthase 0.36
CCNE1 cyclin E1 0.36
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 0.36
DONSON downstream neighbor of SON 0.36
JAK2 Janus kinase 2 0.36
TM7SF3 transmembrane 7 superfamily member 3 0.35
TACC3 transforming, acidic coiled-coil containing protein 3 0.35
RELT RELT tumor necrosis factor receptor 0.35
C15ORF61 chromosome 15 open reading frame 61 0.35
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 0.35
RNF166 ring finger protein 166 0.35
TFR2 transferrin receptor 2 0.35
VCAN versican 0.35
EFHD2 EF-hand domain family, member D2 0.35
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.34
AEN apoptosis enhancing nuclease 0.34
MADD MAP-kinase activating death domain 0.34
FANCC Fanconi anemia, complementation group C 0.34
TLCD4 TLC domain containing 4 0.34
CDC7 cell division cycle 7 0.34
ATXN7L3B ataxin 7-like 3B 0.34
MEF2D myocyte enhancer factor 2D 0.34
MEGF8 multiple EGF-like-domains 8 0.34
RNFT2 ring finger protein, transmembrane 2 0.34
NAF1 nuclear assembly factor 1 ribonucleoprotein 0.33
FANCM Fanconi anemia, complementation group M 0.33
KIF22 kinesin family member 22 0.33
KAT6B K(lysine) acetyltransferase 6B 0.33
TK1 thymidine kinase 1, soluble 0.33
RAD51 RAD51 recombinase 0.33
RPL26 ribosomal protein L26 0.33
TIPIN TIMELESS interacting protein 0.33
CBX2 chromobox homolog 2 0.33
UBE2T ubiquitin-conjugating enzyme E2T 0.33
EIF5A2 eukaryotic translation initiation factor 5A2 0.33
ZNF624 zinc finger protein 624 0.33
CDCA5 cell division cycle associated 5 0.33
BICRA BRD4 interacting chromatin remodeling complex associated protein 0.32
SLBP stem-loop binding protein 0.32
ALDOC aldolase C, fructose-bisphosphate 0.32
PLD6 phospholipase D family, member 6 0.32
CPA4 carboxypeptidase A4 0.32
JMJD8 jumonji domain containing 8 0.32
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.32
SIMC1 SUMO-interacting motifs containing 1 0.32
NCAM1 neural cell adhesion molecule 1 0.32
MIS18A MIS18 kinetochore protein A 0.32
ANKRD16 ankyrin repeat domain 16 0.31

low expression

Symbol Name Standardized Value
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.42
NTHL1 nth endonuclease III-like 1 (E. coli) -1.43
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.3
CISD3 CDGSH iron sulfur domain 3 -1.22
METTL17 methyltransferase like 17 -1.13
FECH ferrochelatase -1.11
MUTYH mutY homolog -1.07
CIAO3 cytosolic iron-sulfur assembly component 3 -1.04
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -0.95
PPAT phosphoribosyl pyrophosphate amidotransferase -0.9
FTH1 ferritin, heavy polypeptide 1 -0.85
PIF1 PIF1 5'-to-3' DNA helicase -0.8
ELP3 elongator acetyltransferase complex subunit 3 -0.77
SLC39A11 solute carrier family 39, member 11 -0.74
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -0.73
NPHP3 nephronophthisis 3 (adolescent) -0.7
E2F7 E2F transcription factor 7 -0.7
ZBTB41 zinc finger and BTB domain containing 41 -0.69
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.67
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.67
FTL ferritin, light polypeptide -0.66
PIP prolactin-induced protein -0.65
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -0.64
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -0.63
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.6
CISD1 CDGSH iron sulfur domain 1 -0.57
LIAS lipoic acid synthetase -0.56
CKM creatine kinase, muscle -0.55
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.54
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.54
HMOX1 heme oxygenase 1 -0.53
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -0.52
PLD1 phospholipase D1, phosphatidylcholine-specific -0.52
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.51
IFITM3 interferon induced transmembrane protein 3 -0.51
ALAS1 5'-aminolevulinate synthase 1 -0.51
CD63 CD63 molecule -0.5
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -0.5
PNKD paroxysmal nonkinesigenic dyskinesia -0.5
HIPK1 homeodomain interacting protein kinase 1 -0.5
HM13 histocompatibility (minor) 13 -0.5
APOB apolipoprotein B -0.49
MAK16 MAK16 homolog (S. cerevisiae) -0.49
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.49
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.49
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -0.49
BPTF bromodomain PHD finger transcription factor -0.47
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -0.47
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -0.47
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -0.46
TEX15 testis expressed 15 -0.46
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -0.45
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -0.45
POLE polymerase (DNA directed), epsilon, catalytic subunit -0.45
FDX1 ferredoxin 1 -0.45
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -0.45
ZNF513 zinc finger protein 513 -0.44
TMCC3 transmembrane and coiled-coil domain family 3 -0.44
CCAR2 cell cycle and apoptosis regulator 2 -0.44
ERICH5 glutamate-rich 5 -0.44
DPH1 diphthamide biosynthesis 1 -0.44
ZBTB45 zinc finger and BTB domain containing 45 -0.43
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -0.43
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene -0.43
MRPS21 mitochondrial ribosomal protein S21 -0.43
KIAA1107 KIAA1107 -0.42
TAPT1 transmembrane anterior posterior transformation 1 -0.41
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.41
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.41
STEAP2 STEAP family member 2, metalloreductase -0.41
ANAPC11 anaphase promoting complex subunit 11 -0.41
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -0.41
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -0.41
TOR3A torsin family 3, member A -0.4
CYCS cytochrome c, somatic -0.4
MT-ND5 NADH dehydrogenase, subunit 5 (complex I) -0.4
MRPS18C mitochondrial ribosomal protein S18C -0.4
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.4
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -0.39
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -0.38
FBXL4 F-box and leucine-rich repeat protein 4 -0.38
MTRES1 mitochondrial transcription rescue factor 1 -0.38
PPARD peroxisome proliferator-activated receptor delta -0.38
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -0.38
ZDHHC23 zinc finger, DHHC-type containing 23 -0.38
EPHA5 EPH receptor A5 -0.37
MKX mohawk homeobox -0.37
APOLTP apolipoprotein lipid transfer particle homolog -0.37
S100A5 S100 calcium binding protein A5 -0.37
MID1IP1 MID1 interacting protein 1 -0.36
AKNA AT-hook transcription factor -0.36
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.36
MTERF2 mitochondrial transcription termination factor 2 -0.36
TYMP thymidine phosphorylase -0.36
SAYSD1 SAYSVFN motif domain containing 1 -0.36
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -0.36
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) -0.36
TMEM208 transmembrane protein 208 -0.36
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -0.36