Emphysema Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A subcategory of chronic obstructive pulmonary disease (COPD). It occurs in people who smoke and suffer from chronic bronchitis. It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing. (Experimental Factor Ontology, EFO_0000464)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D004646
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Genes

378 genes/proteins associated with the disease Emphysema from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 2.88009
NOS2 nitric oxide synthase 2, inducible 2.88009
APOE apolipoprotein E 2.88009
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 2.88009
NFE2L2 nuclear factor, erythroid 2-like 2 2.88009
TP53 tumor protein p53 2.88009
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.88009
FBLN5 fibulin 5 2.88009
KL klotho 2.88009
CLU clusterin 1.79598
GSR glutathione reductase 1.70265
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.65864
CCL2 chemokine (C-C motif) ligand 2 1.62468
GPX1 glutathione peroxidase 1 1.62312
VEGFA vascular endothelial growth factor A 1.59007
COL1A1 collagen, type I, alpha 1 1.57378
SOD1 superoxide dismutase 1, soluble 1.57138
IGF1 insulin-like growth factor 1 (somatomedin C) 1.52938
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.5254
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.51632
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.50146
IL1B interleukin 1, beta 1.49482
SPP1 secreted phosphoprotein 1 1.48941
TIMP1 TIMP metallopeptidase inhibitor 1 1.48864
PDIA3 protein disulfide isomerase family A, member 3 1.48556
TNF tumor necrosis factor 1.48454
ELN elastin 1.47711
CTGF connective tissue growth factor 1.47556
LOX lysyl oxidase 1.47452
CAT catalase 1.47167
PLAT plasminogen activator, tissue 1.46961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.46356
IL6 interleukin 6 1.46304
VCAM1 vascular cell adhesion molecule 1 1.45883
TFRC transferrin receptor 1.45697
IFNG interferon, gamma 1.45273
ICAM1 intercellular adhesion molecule 1 1.45009
PTK2 protein tyrosine kinase 2 1.45009
GSTM1 glutathione S-transferase mu 1 1.44845
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.44817
CYBB cytochrome b-245, beta polypeptide 1.44681
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.4449
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.44327
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.43755
HSPA1A heat shock 70kDa protein 1A 1.437
HSPB1 heat shock 27kDa protein 1 1.43591
FOS FBJ murine osteosarcoma viral oncogene homolog 1.43212
COL3A1 collagen, type III, alpha 1 1.42723
GPX3 glutathione peroxidase 3 1.42562
EDN1 endothelin 1 1.42211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.42101
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.41938
BCL2 B-cell CLL/lymphoma 2 1.4164
NQO1 NAD(P)H dehydrogenase, quinone 1 1.41424
MMP13 matrix metallopeptidase 13 1.41368
CXCR4 chemokine (C-X-C motif) receptor 4 1.41229
DDIT3 DNA-damage-inducible transcript 3 1.40925
TPM3 tropomyosin 3 1.4087
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.4065
EP300 E1A binding protein p300 1.4065
LCN2 lipocalin 2 1.40623
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.40595
ATF3 activating transcription factor 3 1.40568
SP1 Sp1 transcription factor 1.40486
NOS3 nitric oxide synthase 3 (endothelial cell) 1.39591
EGFR epidermal growth factor receptor 1.39591
CREB1 cAMP responsive element binding protein 1 1.3903
JAK1 Janus kinase 1 1.3903
ACO2 aconitase 2, mitochondrial 1.38584
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.38384
CP ceruloplasmin (ferroxidase) 1.38242
JUN jun proto-oncogene 1.38015
CCND1 cyclin D1 1.37561
STEAP4 STEAP family member 4 1.37446
NOS1 nitric oxide synthase 1 (neuronal) 1.37189
SOD2 superoxide dismutase 2, mitochondrial 1.37103
CXCL2 chemokine (C-X-C motif) ligand 2 1.36961
KLF4 Kruppel-like factor 4 (gut) 1.36848
COX5B cytochrome c oxidase subunit Vb 1.35934
PRKCA protein kinase C, alpha 1.35676
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1.35444
CCL11 chemokine (C-C motif) ligand 11 1.35242
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.35213
COX5A cytochrome c oxidase subunit Va 1.35213
CDH13 cadherin 13 1.35213
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.35069
MAP2K1 mitogen-activated protein kinase kinase 1 1.34926
NGF nerve growth factor (beta polypeptide) 1.34926
CD36 CD36 molecule (thrombospondin receptor) 1.34082
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.33346
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.33022
APP amyloid beta (A4) precursor protein 1.32103
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.31897
ARG1 arginase 1 1.31746
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.31746
SFTPB surfactant protein B 1.31596
DUSP1 dual specificity phosphatase 1 1.31476
EGR1 early growth response 1 1.31267
CXCL8 chemokine (C-X-C motif) ligand 8 1.31237
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.31178
MMP9 matrix metallopeptidase 9 1.3103
LPL lipoprotein lipase 1.30604
ACTA2 actin, alpha 2, smooth muscle, aorta 1.29533
MPO myeloperoxidase 1.29471
TGFB1 transforming growth factor, beta 1 1.29317
ANGPTL4 angiopoietin-like 4 1.29256
TMC5 transmembrane channel-like 5 1.29041
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.28456
CKM creatine kinase, muscle 1.28425
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.28395
IL1RN interleukin 1 receptor antagonist 1.28303
TGFB2 transforming growth factor, beta 2 1.28149
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1.27875
IL12B interleukin 12B 1.27502
FN1 fibronectin 1 1.27409
NCF1 neutrophil cytosolic factor 1 1.27378
IL4 interleukin 4 1.27224
CRYAB crystallin, alpha B 1.27224
MMP2 matrix metallopeptidase 2 1.27224
MAPK3 mitogen-activated protein kinase 3 1.27162
RGS4 regulator of G-protein signaling 4 1.27101
CTSB cathepsin B 1.26359
MAPK1 mitogen-activated protein kinase 1 1.26329
HMOX1 heme oxygenase 1 1.26298
ATF4 activating transcription factor 4 1.26083
PECAM1 platelet/endothelial cell adhesion molecule 1 1.25868
CAV1 caveolin 1, caveolae protein, 22kDa 1.25651
TF transferrin 1.25494
POMC proopiomelanocortin 1.25463
CD44 CD44 molecule (Indian blood group) 1.25369
IGF1R insulin-like growth factor 1 receptor 1.25245
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.2509
BAX BCL2-associated X protein 1.25028
GPNMB glycoprotein (transmembrane) nmb 1.24905
CTSD cathepsin D 1.24812
IL33R interleukin 33 receptor 1.24687
LDHB lactate dehydrogenase B 1.24433
IRS2 insulin receptor substrate 2 1.24433
IL1R2 interleukin 1 receptor, type II 1.24433
GALK1 galactokinase 1 1.2437
GSK3B glycogen synthase kinase 3 beta 1.2437
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.24275
CXCL12 chemokine (C-X-C motif) ligand 12 1.24275
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.24181
NCF2 neutrophil cytosolic factor 2 1.23775
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.23552
LTF lactotransferrin 1.23552
HSPA4 heat shock 70kDa protein 4 1.23328
FABP3 fatty acid binding protein 3, muscle and heart 1.23106
CXCL9 chemokine (C-X-C motif) ligand 9 1.23106
FST follistatin 1.23106
BCL2L1 BCL2-like 1 1.22948
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.22884
FABP5 fatty acid binding protein 5 (psoriasis-associated) 1.22884
ADRB2 adrenoceptor beta 2, surface 1.22469
IGFBP3 insulin-like growth factor binding protein 3 1.22436
MT2A metallothionein 2A 1.22436
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.22242
SIRT1 sirtuin 1 1.22209
IL10 interleukin 10 1.22145
GSTP1 glutathione S-transferase pi 1 1.2208
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.22048
TGFB3 transforming growth factor, beta 3 1.22016
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.21823
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.21759
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) 1.2137
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.21337
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 1.21337
GSTT1 glutathione S-transferase theta 1 1.21206
GSN gelsolin 1.21173
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.21043
IL2RA interleukin 2 receptor, alpha 1.21011
FOXO1 forkhead box O1 1.20978
ALDOA aldolase A, fructose-bisphosphate 1.20784
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.20622
ARG2 arginase 2 1.20394
HSPA8 heat shock 70kDa protein 8 1.20361
MMP1 matrix metallopeptidase 1 1.20229
PRDX6 peroxiredoxin 6 1.20196
FSCN1 fascin actin-bundling protein 1 1.20163
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.19802
IL18 interleukin 18 1.19639
ZFP36 ZFP36 ring finger protein 1.19607
G6PD glucose-6-phosphate dehydrogenase 1.19542
CYCS cytochrome c, somatic 1.19477
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.19412
TLR4 toll-like receptor 4 1.19312
GJA1 gap junction protein, alpha 1, 43kDa 1.1908
STAT1 signal transducer and activator of transcription 1, 91kDa 1.1908
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.19014
COX2 1.19014
VIM vimentin 1.18849
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.18849
FGF2 fibroblast growth factor 2 (basic) 1.18718
ALB albumin 1.18554
CTH cystathionine gamma-lyase 1.18456
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.18159
SREBF1 sterol regulatory element binding transcription factor 1 1.18159
ILK integrin-linked kinase 1.17959
ENDOG endonuclease G 1.17959
IL1A interleukin 1, alpha 1.17728
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.17728
PPARG peroxisome proliferator-activated receptor gamma 1.17695
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.17629
ADIPOQ adiponectin, C1Q and collagen domain containing 1.1753
EDNRA endothelin receptor type A 1.17202
MB myoglobin 1.16967
AR androgen receptor 1.16933
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.16866
HBEGF heparin-binding EGF-like growth factor 1.16666
MTF1 metal-regulatory transcription factor 1 1.166
TH tyrosine hydroxylase 1.16567
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.16467
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.16335
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.16269
CCL17 chemokine (C-C motif) ligand 17 1.16269
RGS2 regulator of G-protein signaling 2 1.16001
ACKR3 atypical chemokine receptor 3 1.15967
LHB luteinizing hormone beta polypeptide 1.15933
TIMP3 TIMP metallopeptidase inhibitor 3 1.15661
PPARA peroxisome proliferator-activated receptor alpha 1.15458
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.15357
GPX2 glutathione peroxidase 2 1.15324
THBS1 thrombospondin 1 1.15156
AHR aryl hydrocarbon receptor 1.15055
ACTG2 actin, gamma 2, smooth muscle, enteric 1.15022
ARNT aryl hydrocarbon receptor nuclear translocator 1.15022
ADM adrenomedullin 1.15022
EGF epidermal growth factor 1.14919
CCL3 chemokine (C-C motif) ligand 3 1.14816
FABP1 fatty acid binding protein 1, liver 1.1437
NPPB natriuretic peptide B 1.1437
GADD45B growth arrest and DNA-damage-inducible, beta 1.1437
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.14302
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.14234
MAP2K2 mitogen-activated protein kinase kinase 2 1.142
GEM GTP binding protein overexpressed in skeletal muscle 1.14098
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1.14098
ACSL1 acyl-CoA synthetase long-chain family member 1 1.1403
TXN thioredoxin 1.1403
IER3 immediate early response 3 1.13895
ACHE acetylcholinesterase (Yt blood group) 1.13621
KRT8 keratin 8, type II 1.13586
IGF2 insulin-like growth factor 2 1.13586
ANXA1 annexin A1 1.13415
CCND3 cyclin D3 1.13415
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.13347
TNNI3 troponin I type 3 (cardiac) 1.13313
MGST1 microsomal glutathione S-transferase 1 1.13279
MAPK14 mitogen-activated protein kinase 14 1.13245
CCL26 chemokine (C-C motif) ligand 26 1.13177
SLPI secretory leukocyte peptidase inhibitor 1.1294
EDNRB endothelin receptor type B 1.12805
HSPA1B heat shock 70kDa protein 1B 1.12668
MAOA monoamine oxidase A 1.12357
NDRG1 N-myc downstream regulated 1 1.12219
DGAT1 diacylglycerol O-acyltransferase 1 1.12151
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 1.12117
DBP D site of albumin promoter (albumin D-box) binding protein 1.12117
SGK1 serum/glucocorticoid regulated kinase 1 1.11775
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.11639
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.11639
XBP1 X-box binding protein 1 1.1136
ENO1 enolase 1, (alpha) 1.1136
NDRG2 NDRG family member 2 1.11325
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.10942
RND3 Rho family GTPase 3 1.10803
MGST3 microsomal glutathione S-transferase 3 1.10803
GSTM3 glutathione S-transferase mu 3 (brain) 1.10803
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.10527
KLF2 Kruppel-like factor 2 1.10317
CD14 CD14 molecule 1.10104
SCARB1 scavenger receptor class B, member 1 1.10104
NEFM neurofilament, medium polypeptide 1.09541
TCF4 transcription factor 4 1.09541
LITAF lipopolysaccharide-induced TNF factor 1.09541
CXCL3 chemokine (C-X-C motif) ligand 3 1.09297
SQSTM1 sequestosome 1 1.09297
FOSL1 FOS-like antigen 1 1.09297
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.09083
FBXO32 F-box protein 32 1.09083
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.09047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.09011
TACR1 tachykinin receptor 1 1.08833
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.08619
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.08513
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.08372
SPHK1 sphingosine kinase 1 1.08372
KLF5 Kruppel-like factor 5 (intestinal) 1.08337
GADD45A growth arrest and DNA-damage-inducible, alpha 1.08301
PLAU plasminogen activator, urokinase 1.08231
IL13 interleukin 13 1.08231
HAMP hepcidin antimicrobial peptide 1.07911
ACAA2 acetyl-CoA acyltransferase 2 1.07875
PLCG1 phospholipase C, gamma 1 1.07875
GSTM5 glutathione S-transferase mu 5 1.07875
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.0784
PLG plasminogen 1.07696
IL11 interleukin 11 1.0766
GDNF glial cell derived neurotrophic factor 1.07447
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.07234
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.06987
CCNB1 cyclin B1 1.06952
ABHD1 abhydrolase domain containing 1 1.06917
HADH hydroxyacyl-CoA dehydrogenase 1.06808
AGTR1 angiotensin II receptor, type 1 1.06808
IL6ST interleukin 6 signal transducer 1.06771
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.06771
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.06734
CSF1 colony stimulating factor 1 (macrophage) 1.06552
MT3 metallothionein 3 1.06333
RB1 retinoblastoma 1 1.06225
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.06116
GAP43 growth associated protein 43 1.06116
MCM5 minichromosome maintenance complex component 5 1.059
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.059
KCNK2 potassium channel, two pore domain subfamily K, member 2 1.05864
CRP C-reactive protein, pentraxin-related 1.05535
MGLL monoglyceride lipase 1.05498
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 1.05461
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 1.05386
VLDLR very low density lipoprotein receptor 1.05274
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.05274
CXCL5 chemokine (C-X-C motif) ligand 5 1.05089
CDKN2A cyclin-dependent kinase inhibitor 2A 1.05052
PCNA proliferating cell nuclear antigen 1.05015
JAG2 jagged 2 1.04978
GCK glucokinase (hexokinase 4) 1.04868
NRN1 neuritin 1 1.04501
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.04465
APOA1 apolipoprotein A-I 1.04352
GDF15 growth differentiation factor 15 1.04352
SMAD2 SMAD family member 2 1.04276
BAD BCL2-associated agonist of cell death 1.04239
RPL32 ribosomal protein L32 1.04126
FAS Fas cell surface death receptor 1.04088
CREM cAMP responsive element modulator 1.04051
BHLHE40 basic helix-loop-helix family, member e40 1.04051
LIF leukemia inhibitory factor 1.04051
G0S2 G0/G1 switch 2 1.03864
IL2 interleukin 2 1.0353
OCLN occludin 1.03456
NOX4 NADPH oxidase 4 1.03308
KITLG KIT ligand 1.03197
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.02933
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.02783
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.02783
MBD1 methyl-CpG binding domain protein 1 1.02783
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 1.02783
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.02671
NOTCH1 notch 1 1.02522
A2M alpha-2-macroglobulin 1.02522
GPX4 glutathione peroxidase 4 1.02522
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.02485
EMB embigin 1.0241
CBR1 carbonyl reductase 1 1.02336
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.02262
FMO1 flavin containing monooxygenase 1 1.02188
MBP myelin basic protein 1.02151
INHBA inhibin, beta A 1.02151
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.02151
STAR steroidogenic acute regulatory protein 1.0204
RRAS related RAS viral (r-ras) oncogene homolog 1.02003
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1.01966
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.01928
AQP1 aquaporin 1 (Colton blood group) 1.01814
TK1 thymidine kinase 1, soluble 1.01776
TAGLN transgelin 1.01776
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.01625
FKBP5 FK506 binding protein 5 1.01587
AQP3 aquaporin 3 (Gill blood group) 1.01587
FASN fatty acid synthase 1.01324
PFN2 profilin 2 1.01249
TAC1 tachykinin, precursor 1 1.01212
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.01212
FBXO30 F-box protein 30 1.01212
GSTA1 glutathione S-transferase alpha 1 1.01099
FOXO3 forkhead box O3 1.01062