Encephalitis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. The usual cause is a viral infection, but bacteria can also cause it. Cases can range from mild to severe. For mild cases, you could have flu-like symptoms. Serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures. (Human Disease Ontology, DOID_9588)
External Link https://www.disgenet.org/browser/0/1/0/C0014038
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Genes

304 genes associated with the disease Encephalitis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACE2 angiotensin I converting enzyme 2
ADAM9 ADAM metallopeptidase domain 9
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2A adenosine A2a receptor
AGA aspartylglucosaminidase
AGER advanced glycosylation end product-specific receptor
AGRP agouti related neuropeptide
ALB albumin
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
ALOX5 arachidonate 5-lipoxygenase
AMPH amphiphysin
ANXA1 annexin A1
ANXA13 annexin A13
AOC2 amine oxidase, copper containing 2 (retina-specific)
AOC3 amine oxidase, copper containing 3
APOD apolipoprotein D
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARG1 arginase 1
ARRB2 arrestin, beta 2
ARSA arylsulfatase A
ARTN artemin
ATN1 atrophin 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATRX alpha thalassemia/mental retardation syndrome X-linked
AVP arginine vasopressin
B2M beta-2-microglobulin
BCAP31 B-cell receptor-associated protein 31
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BEST1 bestrophin 1
BSG basigin (Ok blood group)
BTK Bruton agammaglobulinemia tyrosine kinase
C4A complement component 4A (Rodgers blood group)
CABIN1 calcineurin binding protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL7 chemokine (C-C motif) ligand 7
CCL8 chemokine (C-C motif) ligand 8
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD163 CD163 molecule
CD38 CD38 molecule
CD40LG CD40 ligand
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CDSN corneodesmosin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP2 contactin associated protein-like 2
COX2
CPT2 carnitine palmitoyltransferase 2
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNND2 catenin (cadherin-associated protein), delta 2
CTSB cathepsin B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR5 chemokine (C-X-C motif) receptor 5
CYBB cytochrome b-245, beta polypeptide
DBR1 debranching RNA lariats 1
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DLL4 delta-like 4 (Drosophila)
DNALI1 dynein, axonemal, light intermediate chain 1
DPYSL5 dihydropyrimidinase-like 5
EDN1 endothelin 1
EEF2K eukaryotic elongation factor 2 kinase
EGR1 early growth response 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELF4 E74-like factor 4 (ets domain transcription factor)
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERVW-1 endogenous retrovirus group W, member 1
F2R coagulation factor II (thrombin) receptor
FAS Fas cell surface death receptor
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGF2 fibroblast growth factor 2 (basic)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GDNF glial cell derived neurotrophic factor
GFAP glial fibrillary acidic protein
GLP1R glucagon-like peptide 1 receptor
GMFB glia maturation factor, beta
GORASP1 golgi reassembly stacking protein 1, 65kDa
GOSR1 golgi SNAP receptor complex member 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRK1 G protein-coupled receptor kinase 1
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM5 glutamate receptor, metabotropic 5
GRN granulin
GSN gelsolin
GSR glutathione reductase
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
HAMP hepcidin antimicrobial peptide
HAVCR2 hepatitis A virus cellular receptor 2
HDAC6 histone deacetylase 6
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HSPA4 heat shock 70kDa protein 4
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGLON5 IgLON family member 5
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL12A interleukin 12A
IL13 interleukin 13
IL15 interleukin 15
IL16 interleukin 16
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27 interleukin 27
IL33 interleukin 33
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
ISYNA1 inositol-3-phosphate synthase 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KCTD16 potassium channel tetramerization domain containing 16
KLHL2 kelch-like family member 2
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KNG1 kininogen 1
KRT20 keratin 20, type I
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMC2 laminin, gamma 2
LBR lamin B receptor
LCN2 lipocalin 2
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LGI1 leucine-rich, glioma inactivated 1
LIG4 ligase IV, DNA, ATP-dependent
LRRK2 leucine-rich repeat kinase 2
MALT1 MALT1 paracaspase
MAP2 microtubule-associated protein 2
MAPT microtubule-associated protein tau
MBP myelin basic protein
MECP2 methyl CpG binding protein 2
MEFV Mediterranean fever
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
MPO myeloperoxidase
MRC1 mannose receptor, C type 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MST1 macrophage stimulating 1
NEFL neurofilament, light polypeptide
NES nestin
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGB neuroglobin
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
NOTCH2 notch 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRTN neurturin
NTF3 neurotrophin 3
NTN1 netrin 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OGA O-GlcNAcase
OPRM1 opioid receptor, mu 1
ORM2 orosomucoid 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAOX polyamine oxidase (exo-N4-amino)
PDCD1 programmed cell death 1
PDGFB platelet-derived growth factor beta polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAT plasminogen activator, tissue
PLB1 phospholipase B1
PLG plasminogen
POLG polymerase (DNA directed), gamma
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRNP prion protein
PRODH proline dehydrogenase (oxidase) 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPN persephin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
RAB32 RAB32, member RAS oncogene family
RANBP2 RAN binding protein 2
RBBP6 retinoblastoma binding protein 6
RBM45 RNA binding motif protein 45
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RFXANK regulatory factor X-associated ankyrin-containing protein
RFXAP regulatory factor X-associated protein
RTN1 reticulon 1
S100A12 S100 calcium binding protein A12
SAMHD1 SAM domain and HD domain 1
SARS1 seryl-tRNA synthetase 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDC1 syndecan 1
SH2D1A SH2 domain containing 1A
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMOC1 SPARC related modular calcium binding 1
SMOX spermine oxidase
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCB synuclein, beta
SPP1 secreted phosphoprotein 1
SST somatostatin
STAG2 stromal antigen 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STS steroid sulfatase (microsomal), isozyme S
SYF2 SYF2 pre-mRNA-splicing factor
SYT1 synaptotagmin I
TBK1 TANK-binding kinase 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THPO thrombopoietin
TIMP1 TIMP metallopeptidase inhibitor 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TJP1 tight junction protein 1
TLK2 tousled-like kinase 2
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM70 transmembrane protein 70
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TPP2 tripeptidyl peptidase II
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPO translocator protein (18kDa)
TYRO3 TYRO3 protein tyrosine kinase
UBAC2 UBA domain containing 2
UBE3B ubiquitin protein ligase E3B
UNC93B1 unc-93 homolog B1 (C. elegans)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VTN vitronectin
WNK1 WNK lysine deficient protein kinase 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YME1L1 YME1-like 1 ATPase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBP1 Z-DNA binding protein 1
ZNF175 zinc finger protein 175
ZNF415 zinc finger protein 415