Encephalomalacia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

244 genes co-occuring with the disease Encephalomalacia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MBP myelin basic protein 2.627
OLIG2 oligodendrocyte lineage transcription factor 2 2.292
IL6 interleukin 6 2.257
IL1B interleukin 1, beta 2.196
MOCS1 molybdenum cofactor synthesis 1 2.165
MOCS2 molybdenum cofactor synthesis 2 2.16
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.129
SUOX sulfite oxidase 2.117
GFAP glial fibrillary acidic protein 2.103
CRP C-reactive protein, pentraxin-related 2.068
AIF1 allograft inflammatory factor 1 2.062
EPO erythropoietin 2.06
TNF tumor necrosis factor 2.034
GPR17 G protein-coupled receptor 17 1.96
OLIG1 oligodendrocyte transcription factor 1 1.954
MOCS3 molybdenum cofactor synthesis 3 1.932
S100B S100 calcium binding protein B 1.931
BDNF brain-derived neurotrophic factor 1.883
COL4A1 collagen, type IV, alpha 1 1.876
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.867
GALC galactosylceramidase 1.834
CXCL8 chemokine (C-X-C motif) ligand 8 1.819
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 1.789
IGF1 insulin-like growth factor 1 (somatomedin C) 1.774
GPX4 glutathione peroxidase 4 1.769
IL10 interleukin 10 1.747
CD68 CD68 molecule 1.719
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.707
TLR4 toll-like receptor 4 1.699
COL4A2 collagen, type IV, alpha 2 1.697
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.674
LTF lactotransferrin 1.669
IFNG interferon, gamma 1.666
PLP1 proteolipid protein 1 1.666
ALB albumin 1.661
MAG myelin associated glycoprotein 1.599
PLAT plasminogen activator, tissue 1.597
F2 coagulation factor II (thrombin) 1.597
MOG myelin oligodendrocyte glycoprotein 1.594
INS insulin 1.593
PVALB parvalbumin 1.581
IL1A interleukin 1, alpha 1.576
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 1.57
NES nestin 1.57
CPVL carboxypeptidase, vitellogenic-like 1.569
FGF2 fibroblast growth factor 2 (basic) 1.568
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.556
PXDNL peroxidasin-like 1.548
PXDN peroxidasin 1.546
POMC proopiomelanocortin 1.534
APP amyloid beta (A4) precursor protein 1.531
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 1.53
GPX6 glutathione peroxidase 6 1.524
GPX3 glutathione peroxidase 3 1.523
GPX8 glutathione peroxidase 8 (putative) 1.523
GPX7 glutathione peroxidase 7 1.52
GPX5 glutathione peroxidase 5 1.516
GPX2 glutathione peroxidase 2 1.51
SCN1A sodium channel, voltage gated, type I alpha subunit 1.504
CDKL5 cyclin-dependent kinase-like 5 1.491
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.483
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.465
OXT oxytocin/neurophysin I prepropeptide 1.454
ITK IL2-inducible T-cell kinase 1.454
CNTF ciliary neurotrophic factor 1.449
CKM creatine kinase, muscle 1.448
ENO2 enolase 2 (gamma, neuronal) 1.436
CKB creatine kinase, brain 1.435
EPOR erythropoietin receptor 1.435
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.431
CKMT1B creatine kinase, mitochondrial 1B 1.43
CD4 CD4 molecule 1.417
FGR FGR proto-oncogene, Src family tyrosine kinase 1.409
TGFB1 transforming growth factor, beta 1 1.408
DCX doublecortin 1.408
GMDS GDP-mannose 4,6-dehydratase 1.407
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.406
SOX10 SRY (sex determining region Y)-box 10 1.404
CP ceruloplasmin (ferroxidase) 1.398
PGF placental growth factor 1.393
F3 coagulation factor III (thromboplastin, tissue factor) 1.382
GDNF glial cell derived neurotrophic factor 1.38
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.373
GSR glutathione reductase 1.372
CALB1 calbindin 1, 28kDa 1.365
CCL2 chemokine (C-C motif) ligand 2 1.365
ACSL4 acyl-CoA synthetase long-chain family member 4 1.359
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.356
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.356
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 1.355
SHH sonic hedgehog 1.354
NKX2-2 NK2 homeobox 2 1.354
ACTB actin, beta 1.353
IL4 interleukin 4 1.349
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.347
STXBP1 syntaxin binding protein 1 1.34
ALOX15 arachidonate 15-lipoxygenase 1.338
MYT1 myelin transcription factor 1 1.33
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.326
OCLN occludin 1.319
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.315
IL17A interleukin 17A 1.313
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.312
POLG polymerase (DNA directed), gamma 1.311
LOX lysyl oxidase 1.308
LPCAT3 lysophosphatidylcholine acyltransferase 3 1.304
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.301
TLR2 toll-like receptor 2 1.297
EPRS1 glutamyl-prolyl-tRNA synthetase 1 1.295
PTPRC protein tyrosine phosphatase, receptor type, C 1.294
KCNT1 potassium channel, sodium activated subfamily T, member 1 1.286
MAP2 microtubule-associated protein 2 1.284
SPAST spastin 1.278
OXTR oxytocin receptor 1.274
MAGEA8 melanoma antigen family A8 1.273
CD8A CD8a molecule 1.27
NGF nerve growth factor (beta polypeptide) 1.267
TFRC transferrin receptor 1.267
MOBP myelin-associated oligodendrocyte basic protein 1.259
CNTNAP2 contactin associated protein-like 2 1.255
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.245
NOS3 nitric oxide synthase 3 (endothelial cell) 1.245
HMOX1 heme oxygenase 1 1.24
TIMP1 TIMP metallopeptidase inhibitor 1 1.24
IREB2 iron-responsive element binding protein 2 1.239
OPALIN oligodendrocytic myelin paranodal and inner loop protein 1.237
IL2 interleukin 2 1.233
CYCS cytochrome c, somatic 1.228
SZT2 seizure threshold 2 homolog (mouse) 1.225
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.225
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.224
CSF3 colony stimulating factor 3 (granulocyte) 1.222
EGF epidermal growth factor 1.219
SYP synaptophysin 1.215
CCL3 chemokine (C-C motif) ligand 3 1.211
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.209
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 1.205
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 1.204
GPHN gephyrin 1.201
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 1.198
SCN2A sodium channel, voltage gated, type II alpha subunit 1.197
ATP5MC3 ATP synthase membrane subunit c locus 3 1.197
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.191
BAX BCL2-associated X protein 1.189
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.188
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.187
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.186
MMP8 matrix metallopeptidase 8 1.185
IL18 interleukin 18 1.184
PPP1R21 protein phosphatase 1, regulatory subunit 21 1.183
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 1.179
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.179
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.178
APOE apolipoprotein E 1.173
ACE2 angiotensin I converting enzyme 2 1.171
CD34 CD34 molecule 1.169
HVCN1 hydrogen voltage gated channel 1 1.167
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.166
CCL4 chemokine (C-C motif) ligand 4 1.165
DES desmin 1.165
PMM2 phosphomannomutase 2 1.16
NEFL neurofilament, light polypeptide 1.157
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.153
PC pyruvate carboxylase 1.153
EMC2 ER membrane protein complex subunit 2 1.15
MECP2 methyl CpG binding protein 2 1.15
EDN1 endothelin 1 1.149
TTN titin 1.148
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 1.147
ACSF2 acyl-CoA synthetase family member 2 1.145
AOX1 aldehyde oxidase 1 1.145
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.141
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.14
MMP9 matrix metallopeptidase 9 1.14
MAGEA12 melanoma antigen family A12 1.138
ATL1 atlastin GTPase 1 1.137
STEAP3 STEAP family member 3, metalloreductase 1.133
NOS1 nitric oxide synthase 1 (neuronal) 1.133
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.13
GAMT guanidinoacetate N-methyltransferase 1.125
CCL5 chemokine (C-C motif) ligand 5 1.117
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.117
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 1.114
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.112
BTD biotinidase 1.111
MYRF myelin regulatory factor 1.11
NTF3 neurotrophin 3 1.11
RPL8 ribosomal protein L8 1.107
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.106
CARS1 cysteinyl-tRNA synthetase 1 1.105
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 1.105
LINGO1 leucine rich repeat and Ig domain containing 1 1.1
NEFH neurofilament, heavy polypeptide 1.097
CXCL10 chemokine (C-X-C motif) ligand 10 1.096
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.095
RELN reelin 1.095
IGFBP1 insulin-like growth factor binding protein 1 1.092
FN1 fibronectin 1 1.092
HP haptoglobin 1.092
PURA purine-rich element binding protein A 1.091
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 1.09
TBR1 T-box, brain, 1 1.088
IL13 interleukin 13 1.087
TLR3 toll-like receptor 3 1.082
RANBP2 RAN binding protein 2 1.075
FGF13 fibroblast growth factor 13 1.075
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 1.074
PNPO pyridoxamine 5'-phosphate oxidase 1.073
FTH1 ferritin, heavy polypeptide 1 1.071
ARSA arylsulfatase A 1.069
SYN1 synapsin I 1.068
AP4M1 adaptor-related protein complex 4, mu 1 subunit 1.066
JUN jun proto-oncogene 1.065
CYREN cell cycle regulator of NHEJ 1.062
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.062
MAGEA9B melanoma antigen family A9B 1.058
CPLX3 complexin 3 1.057
FGF7 fibroblast growth factor 7 1.052
MAPK3 mitogen-activated protein kinase 3 1.052
ENG endoglin 1.051
NCAM1 neural cell adhesion molecule 1 1.051
LGI1 leucine-rich, glioma inactivated 1 1.049
AMPD2 adenosine monophosphate deaminase 2 1.049
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.043
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.041
MAGEA9 melanoma antigen family A9 1.04
PRRT2 proline-rich transmembrane protein 2 1.039
LAS1L LAS1-like (S. cerevisiae) 1.038
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.036
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.035
XDH xanthine dehydrogenase 1.034
PAX6 paired box 6 1.031
PNMA2 paraneoplastic Ma antigen 2 1.03
BCL2 B-cell CLL/lymphoma 2 1.029
FOXRED1 FAD-dependent oxidoreductase domain containing 1 1.028
DNAH8 dynein, axonemal, heavy chain 8 1.028
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.025
PDHX pyruvate dehydrogenase complex, component X 1.015
CS citrate synthase 1.011
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 1.01
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.008
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.006
NFE2L2 nuclear factor, erythroid 2-like 2 1.003
GCDH glutaryl-CoA dehydrogenase 1.001