| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Encorafenib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.111357 |
| PODXL | podocalyxin-like | 0.10021 |
| CDH13 | cadherin 13 | 0.0909795 |
| HDAC9 | histone deacetylase 9 | 0.0887435 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0757028 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0753278 |
| CD44 | CD44 molecule (Indian blood group) | 0.072366 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0668586 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0636025 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0623823 |
| FLNA | filamin A, alpha | 0.0599056 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0574078 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0554576 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0508411 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0496505 |
| RNF213 | ring finger protein 213 | 0.042387 |
| ASPH | aspartate beta-hydroxylase | 0.0387162 |
| SMYD3 | SET and MYND domain containing 3 | 0.0384161 |
| EFNA5 | ephrin-A5 | 0.0382882 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0377089 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0372139 |
| SP100 | SP100 nuclear antigen | 0.0353641 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.03387 |
| CSTB | cystatin B (stefin B) | 0.0336235 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0324267 |
| SQSTM1 | sequestosome 1 | 0.0302156 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0300535 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0294631 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0289554 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.028695 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0280884 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0271087 |
| ANK2 | ankyrin 2, neuronal | 0.0270776 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0269035 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0260223 |
| RPS2 | ribosomal protein S2 | 0.0259983 |
| RIGI | RNA sensor RIG-I | 0.0251497 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0250634 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0245488 |
| THBS2 | thrombospondin 2 | 0.0240945 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0238042 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0237119 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0233779 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 0.0230295 |
| PRKCE | protein kinase C, epsilon | 0.0226602 |
| SLFN5 | schlafen family member 5 | 0.022599 |
| FSTL1 | follistatin-like 1 | 0.0224727 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0224382 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0221735 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0220287 |
| RND3 | Rho family GTPase 3 | 0.0220286 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0212702 |
| TUSC3 | tumor suppressor candidate 3 | 0.0212265 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0212047 |
| PRELID2 | PRELI domain containing 2 | 0.0208974 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0207741 |
| CCND1 | cyclin D1 | 0.0207621 |
| EGFR | epidermal growth factor receptor | 0.0206696 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.020581 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0203762 |
| E2F7 | E2F transcription factor 7 | 0.0203414 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0202473 |
| RPS12 | ribosomal protein S12 | 0.0198634 |
| TRABD2B | TraB domain containing 2B | 0.0198096 |
| PMP22 | peripheral myelin protein 22 | 0.019713 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0197052 |
| TXNRD1 | thioredoxin reductase 1 | 0.0195673 |
| SET | SET nuclear proto-oncogene | 0.0194773 |
| ITGA6 | integrin, alpha 6 | 0.0194524 |
| APP | amyloid beta (A4) precursor protein | 0.019339 |
| KIAA1549L | KIAA1549-like | 0.0192008 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0191613 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0190773 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0190109 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.01885 |
| NAV3 | neuron navigator 3 | 0.0188195 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0187782 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0183373 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0182622 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0182427 |
| VCL | vinculin | 0.0181673 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0181251 |
| KLF12 | Kruppel-like factor 12 | 0.0179012 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0179009 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0176962 |
| PCDH7 | protocadherin 7 | 0.017663 |
| RACK1 | receptor for activated C kinase 1 | 0.0176329 |
| NCKAP1 | NCK-associated protein 1 | 0.0175886 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0174167 |
| CRYM | crystallin, mu | 0.0174077 |
| BCL2L1 | BCL2-like 1 | 0.0170923 |
| FAT1 | FAT atypical cadherin 1 | 0.0169585 |
| ERBIN | erbb2 interacting protein | 0.016921 |
| LMO7 | LIM domain 7 | 0.0167598 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0166417 |
| RPL37A | ribosomal protein L37a | 0.0165885 |
| RPLP1 | ribosomal protein, large, P1 | 0.0165437 |
| MYOF | myoferlin | 0.0162972 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0161989 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0160577 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.301177 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.277022 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.234387 |
| VIM | vimentin | -0.162077 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.131277 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.117252 |
| TMSB10 | thymosin beta 10 | -0.114657 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.110802 |
| LOX | lysyl oxidase | -0.105469 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0856343 |
| FBN1 | fibrillin 1 | -0.085202 |
| COL1A2 | collagen, type I, alpha 2 | -0.084278 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0832217 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0727184 |
| MYADM | myeloid-associated differentiation marker | -0.0725477 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0716304 |
| UBC | ubiquitin C | -0.0702887 |
| PLAT | plasminogen activator, tissue | -0.069424 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0663735 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0613063 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0612215 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0599099 |
| COL5A2 | collagen, type V, alpha 2 | -0.0589258 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0565269 |
| NDRG1 | N-myc downstream regulated 1 | -0.0526583 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0487385 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0486095 |
| LOXL2 | lysyl oxidase-like 2 | -0.0484157 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0475662 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0472309 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0471606 |
| TAGLN2 | transgelin 2 | -0.0467364 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0437446 |
| STC1 | stanniocalcin 1 | -0.0402856 |
| MEIS2 | Meis homeobox 2 | -0.0399151 |
| INSIG1 | insulin induced gene 1 | -0.0383659 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0376192 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0371671 |
| CD99 | CD99 molecule | -0.0367323 |
| COPA | coatomer protein complex, subunit alpha | -0.0366022 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0361352 |
| GOLGA4 | golgin A4 | -0.0358035 |
| PTMA | prothymosin, alpha | -0.0355508 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0338102 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0337512 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0330401 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0329203 |
| SBF2 | SET binding factor 2 | -0.0326795 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0324363 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0319207 |
| JAZF1 | JAZF zinc finger 1 | -0.0318022 |
| MMP12 | matrix metallopeptidase 12 | -0.0316723 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.030703 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.02997 |
| S100A6 | S100 calcium binding protein A6 | -0.0298918 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0289117 |
| SETD5 | SET domain containing 5 | -0.028724 |
| FN1 | fibronectin 1 | -0.0285183 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0284704 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0282992 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0277851 |
| GOLGA2 | golgin A2 | -0.0274895 |
| SPAG9 | sperm associated antigen 9 | -0.0273113 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0271249 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0268529 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.026426 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0262632 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0260776 |
| MT2A | metallothionein 2A | -0.0259356 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0257604 |
| OGA | O-GlcNAcase | -0.0256985 |
| B2M | beta-2-microglobulin | -0.0255629 |
| LMNA | lamin A/C | -0.0255519 |
| CLU | clusterin | -0.0248452 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0246166 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0243993 |
| NBEAL1 | neurobeachin-like 1 | -0.0243738 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.02437 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0243695 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0242318 |
| FRMD4A | FERM domain containing 4A | -0.0241647 |
| INSIG2 | insulin induced gene 2 | -0.0239486 |
| HDLBP | high density lipoprotein binding protein | -0.0238548 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.023779 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0236055 |
| FRMD5 | FERM domain containing 5 | -0.0235089 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0234198 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0230875 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0228438 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0227594 |
| ADM | adrenomedullin | -0.022639 |
| HLA-E | major histocompatibility complex, class I, E | -0.0224438 |
| COL6A1 | collagen, type VI, alpha 1 | -0.022404 |
| NKTR | natural killer cell triggering receptor | -0.0223349 |
| MSI2 | musashi RNA-binding protein 2 | -0.0223099 |
| WTAP | Wilms tumor 1 associated protein | -0.0220716 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0220387 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0216579 |
| TMOD1 | tropomodulin 1 | -0.0216046 |
| FNBP1 | formin binding protein 1 | -0.0215679 |
