| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Encorafenib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.253059 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.192019 |
| NLGN1 | neuroligin 1 | 0.127499 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.117412 |
| VIM | vimentin | 0.094833 |
| TENM3 | teneurin transmembrane protein 3 | 0.0894689 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0772529 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0715406 |
| NEBL | nebulette | 0.0594185 |
| MMP12 | matrix metallopeptidase 12 | 0.0575401 |
| HMGA2 | high mobility group AT-hook 2 | 0.0566704 |
| DST | dystonin | 0.0559302 |
| PDGFC | platelet derived growth factor C | 0.0553786 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0496419 |
| JMJD1C | jumonji domain containing 1C | 0.0485021 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0464855 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.04382 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0430778 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0430711 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0418631 |
| HDAC9 | histone deacetylase 9 | 0.0412977 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0404993 |
| DPYD | dihydropyrimidine dehydrogenase | 0.039651 |
| NRXN3 | neurexin 3 | 0.0394847 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0374865 |
| VMP1 | vacuole membrane protein 1 | 0.0373019 |
| YAP1 | Yes-associated protein 1 | 0.0372265 |
| AHR | aryl hydrocarbon receptor | 0.0367486 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.035307 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0346231 |
| ADIPOR2 | adiponectin receptor 2 | 0.0339422 |
| EHBP1 | EH domain binding protein 1 | 0.0334677 |
| ANXA1 | annexin A1 | 0.0329562 |
| ANK2 | ankyrin 2, neuronal | 0.0328685 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0322753 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0321823 |
| CEP112 | centrosomal protein 112kDa | 0.0317318 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0311119 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0292195 |
| CALR | calreticulin | 0.0277412 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0274641 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0274131 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0273616 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0273531 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0268562 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0261009 |
| RPS12 | ribosomal protein S12 | 0.0248685 |
| EPHA5 | EPH receptor A5 | 0.0248096 |
| RPS2 | ribosomal protein S2 | 0.0247168 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0245123 |
| TMEM41B | transmembrane protein 41B | 0.0242009 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0242006 |
| FHIT | fragile histidine triad | 0.0240228 |
| EGR1 | early growth response 1 | 0.023829 |
| INTS6 | integrator complex subunit 6 | 0.023813 |
| RNF213 | ring finger protein 213 | 0.0236629 |
| MAP1B | microtubule-associated protein 1B | 0.0236545 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0232455 |
| XPOT | exportin, tRNA | 0.0228721 |
| ACTG1 | actin gamma 1 | 0.0228015 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0226113 |
| PCDH7 | protocadherin 7 | 0.0225345 |
| NEGR1 | neuronal growth regulator 1 | 0.0224161 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0223558 |
| PRR16 | proline rich 16 | 0.022251 |
| TXNRD1 | thioredoxin reductase 1 | 0.0221128 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0219903 |
| FNIP1 | folliculin interacting protein 1 | 0.0219338 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0215357 |
| PCDH9 | protocadherin 9 | 0.0215008 |
| EXOC4 | exocyst complex component 4 | 0.0213901 |
| CMIP | c-Maf inducing protein | 0.0212566 |
| DTNA | dystrobrevin, alpha | 0.021017 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0208392 |
| MYPN | myopalladin | 0.020821 |
| RPL37A | ribosomal protein L37a | 0.0206318 |
| BCHE | butyrylcholinesterase | 0.0203644 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0202648 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0200898 |
| WWOX | WW domain containing oxidoreductase | 0.0198561 |
| SYT1 | synaptotagmin I | 0.0198117 |
| RTN4 | reticulon 4 | 0.0197474 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0196175 |
| R3HDM2 | R3H domain containing 2 | 0.0194879 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0193786 |
| PEG10 | paternally expressed 10 | 0.0193376 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0192698 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0191123 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0190387 |
| NFIB | nuclear factor I/B | 0.0190093 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0184974 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0181192 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0177467 |
| TPM3 | tropomyosin 3 | 0.0176777 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0173796 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0173753 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0172055 |
| CUX1 | cut-like homeobox 1 | 0.0171715 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0171588 |
| ERBIN | erbb2 interacting protein | 0.0171503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.0501189 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0421703 |
| PTMA | prothymosin, alpha | -0.0405622 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0310275 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0301796 |
| H1-0 | H1.0 linker histone | -0.0296906 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0273041 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0270865 |
| TMSB10 | thymosin beta 10 | -0.0267255 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0260624 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0252703 |
| ECT2 | epithelial cell transforming 2 | -0.024561 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0230052 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0228075 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0226035 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0219748 |
| RPS24 | ribosomal protein S24 | -0.0215881 |
| RPL8 | ribosomal protein L8 | -0.020739 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0204548 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0203263 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0202746 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0200133 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0196737 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0193562 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0191892 |
| YBX3 | Y box binding protein 3 | -0.018007 |
| CEP192 | centrosomal protein 192kDa | -0.018 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.017814 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0177393 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0177191 |
| YBX1 | Y box binding protein 1 | -0.0170317 |
| RPL38 | ribosomal protein L38 | -0.0169005 |
| RPS21 | ribosomal protein S21 | -0.0167499 |
| RPLP1 | ribosomal protein, large, P1 | -0.0162965 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.016286 |
| CENPF | centromere protein F, 350/400kDa | -0.0162289 |
| EDN1 | endothelin 1 | -0.0161616 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0160561 |
| MATR3 | matrin 3 | -0.0155499 |
| BTG3 | BTG family, member 3 | -0.0154731 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0152385 |
| HMGB2 | high mobility group box 2 | -0.0152244 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0148388 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0143263 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0140045 |
| XPO1 | exportin 1 | -0.0139004 |
| RPS6 | ribosomal protein S6 | -0.0138468 |
| WDR45B | WD repeat domain 45B | -0.0138041 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0137177 |
| DEK | DEK proto-oncogene | -0.0135903 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0133289 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0133133 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0131647 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0130484 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0129992 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0129769 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0129502 |
| RPS16 | ribosomal protein S16 | -0.0128904 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0128564 |
| CENPE | centromere protein E, 312kDa | -0.0126543 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0123433 |
| RPS15 | ribosomal protein S15 | -0.0122715 |
| RPL32 | ribosomal protein L32 | -0.012184 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0121497 |
| TPX2 | TPX2, microtubule-associated | -0.0121274 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0120972 |
| RLF | rearranged L-myc fusion | -0.0119898 |
| CPOX | coproporphyrinogen oxidase | -0.0118381 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0117988 |
| R3HDM1 | R3H domain containing 1 | -0.0117489 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0117443 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.011677 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.011638 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0115503 |
| OGA | O-GlcNAcase | -0.0113534 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0113532 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0113291 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0111874 |
| CDK19 | cyclin-dependent kinase 19 | -0.0111629 |
| RPL12 | ribosomal protein L12 | -0.0111383 |
| RPL34 | ribosomal protein L34 | -0.0110645 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0110199 |
| TMEM131 | transmembrane protein 131 | -0.0109865 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0109382 |
| THOC2 | THO complex 2 | -0.0109022 |
| THOC1 | THO complex 1 | -0.0108699 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0108129 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.01078 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0106973 |
| NPR2 | natriuretic peptide receptor 2 | -0.0106595 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.010585 |
| SRP72 | signal recognition particle 72kDa | -0.0105763 |
| PRR11 | proline rich 11 | -0.010561 |
| RPLP2 | ribosomal protein, large, P2 | -0.0105525 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0104257 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0103747 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0103712 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0103609 |
| NDC80 | NDC80 kinetochore complex component | -0.0103433 |
| PBK | PDZ binding kinase | -0.0103171 |
