| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Encorafenib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.520393 |
| C3 | complement component 3 | 0.162311 |
| APOB | apolipoprotein B | 0.105314 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0976496 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0949835 |
| ENO1 | enolase 1, (alpha) | 0.0936829 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.090124 |
| TF | transferrin | 0.0828412 |
| CP | ceruloplasmin (ferroxidase) | 0.0800944 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0790719 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0775488 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0696254 |
| FN1 | fibronectin 1 | 0.0643222 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0633672 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0577575 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0566029 |
| DSPP | dentin sialophosphoprotein | 0.0522145 |
| FTL | ferritin, light polypeptide | 0.0521871 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0497421 |
| EGR1 | early growth response 1 | 0.0486173 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.048557 |
| RPS8 | ribosomal protein S8 | 0.0466104 |
| GPC3 | glypican 3 | 0.0458117 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0453601 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.043726 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0435147 |
| RPL23 | ribosomal protein L23 | 0.0434189 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0431112 |
| LDHA | lactate dehydrogenase A | 0.0425645 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0418117 |
| RPL37 | ribosomal protein L37 | 0.0410789 |
| YME1L1 | YME1-like 1 ATPase | 0.0404072 |
| RPL37A | ribosomal protein L37a | 0.0389887 |
| RPS12 | ribosomal protein S12 | 0.0385449 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0379406 |
| TXNRD1 | thioredoxin reductase 1 | 0.036177 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0361206 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0358693 |
| FOXP1 | forkhead box P1 | 0.0357838 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0357321 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0356291 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0351665 |
| A2M | alpha-2-macroglobulin | 0.034344 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0340988 |
| ARFGEF3 | ARFGEF family member 3 | 0.0337378 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.033512 |
| CFB | complement factor B | 0.0330216 |
| RPL31 | ribosomal protein L31 | 0.0327048 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0323612 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0321469 |
| AHSG | alpha-2-HS-glycoprotein | 0.0320398 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0318899 |
| GK | glycerol kinase | 0.0314456 |
| PTMA | prothymosin, alpha | 0.0311148 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0307537 |
| SQSTM1 | sequestosome 1 | 0.0307037 |
| RAD51B | RAD51 paralog B | 0.0306825 |
| AEBP2 | AE binding protein 2 | 0.0305382 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.030448 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0295289 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0293777 |
| ZFR | zinc finger RNA binding protein | 0.0291186 |
| JMJD1C | jumonji domain containing 1C | 0.0288272 |
| RACK1 | receptor for activated C kinase 1 | 0.0288223 |
| RPL30 | ribosomal protein L30 | 0.0284752 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0284516 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0277126 |
| CLIC4 | chloride intracellular channel 4 | 0.0276976 |
| RPLP0 | ribosomal protein, large, P0 | 0.027495 |
| PTCHD4 | patched domain containing 4 | 0.0274042 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0271893 |
| CADM1 | cell adhesion molecule 1 | 0.0271581 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0271554 |
| SEPTIN9 | septin 9 | 0.0271114 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0267001 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0265494 |
| RPL5 | ribosomal protein L5 | 0.026421 |
| KIF5B | kinesin family member 5B | 0.0263544 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0262641 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0262177 |
| SDC4 | syndecan 4 | 0.0261357 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0260753 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0256732 |
| RPL26 | ribosomal protein L26 | 0.0255235 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0252034 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0251486 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0250347 |
| JAK1 | Janus kinase 1 | 0.0247321 |
| RBBP4 | retinoblastoma binding protein 4 | 0.0244638 |
| MRTFA | myocardin related transcription factor A | 0.0242574 |
| CCNY | cyclin Y | 0.0241801 |
| RPL19 | ribosomal protein L19 | 0.0240912 |
| SLC23A1 | solute carrier family 23 (ascorbic acid transporter), member 1 | 0.0237678 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0236544 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.023355 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0228917 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0228109 |
| PCBP2 | poly(rC) binding protein 2 | 0.0227468 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0226533 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0226501 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.188828 |
| EHBP1 | EH domain binding protein 1 | -0.109743 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0932428 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0810809 |
| ASPH | aspartate beta-hydroxylase | -0.0658737 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0632365 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0616578 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0601588 |
| FRMD5 | FERM domain containing 5 | -0.0590453 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0453155 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.04 |
| MT2A | metallothionein 2A | -0.0393297 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0391274 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.032722 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0297485 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0294975 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0273664 |
| FAT1 | FAT atypical cadherin 1 | -0.0268574 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0267737 |
| ITGA1 | integrin, alpha 1 | -0.0244812 |
| ITGA6 | integrin, alpha 6 | -0.0233743 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0225985 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0223781 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.021285 |
| RAI14 | retinoic acid induced 14 | -0.0211118 |
| ITGB5 | integrin, beta 5 | -0.0210567 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0204216 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.020202 |
| VCAN | versican | -0.0194453 |
| FERMT1 | fermitin family member 1 | -0.0194084 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0193177 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0189258 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0189058 |
| RNASET2 | ribonuclease T2 | -0.0184833 |
| DTNA | dystrobrevin, alpha | -0.0183752 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0179033 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0178024 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0176771 |
| MALT1 | MALT1 paracaspase | -0.0168317 |
| ACTN1 | actinin, alpha 1 | -0.0166886 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0163105 |
| NHSL1 | NHS-like 1 | -0.0161579 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0159983 |
| STK17A | serine/threonine kinase 17a | -0.0159551 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0154209 |
| LAMB1 | laminin, beta 1 | -0.0153566 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0151224 |
| NBAS | neuroblastoma amplified sequence | -0.015106 |
| DSTN | destrin (actin depolymerizing factor) | -0.015071 |
| SNX9 | sorting nexin 9 | -0.0149922 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0149718 |
| CNKSR3 | CNKSR family member 3 | -0.0148228 |
| DIDO1 | death inducer-obliterator 1 | -0.0147698 |
| KIF1B | kinesin family member 1B | -0.014753 |
| SEPTIN10 | septin 10 | -0.0147449 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0147059 |
| TPD52 | tumor protein D52 | -0.0146429 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0145402 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0143372 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.014245 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0142289 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0142095 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0142089 |
| CYTH1 | cytohesin 1 | -0.0141729 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0141669 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0141334 |
| CAPRIN2 | caprin family member 2 | -0.0140512 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0139475 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0138263 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0137096 |
| H1-0 | H1.0 linker histone | -0.0135825 |
| STK39 | serine threonine kinase 39 | -0.0135455 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0134085 |
| KIF26B | kinesin family member 26B | -0.0133344 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0132352 |
| AHNAK | AHNAK nucleoprotein | -0.0132268 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0130961 |
| PKP4 | plakophilin 4 | -0.0128494 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.012842 |
| ZNF804A | zinc finger protein 804A | -0.0128353 |
| HDAC4 | histone deacetylase 4 | -0.0126633 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0125206 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0124916 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.0122429 |
| NUP58 | nucleoporin 58 | -0.0121983 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0121899 |
| PATJ | PATJ crumbs cell polarity complex component | -0.012104 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0119013 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0118878 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0118072 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0118054 |
| TPM3 | tropomyosin 3 | -0.0116555 |
| PMM2 | phosphomannomutase 2 | -0.0116301 |
| MPZL2 | myelin protein zero-like 2 | -0.0116298 |
| BRD2 | bromodomain containing 2 | -0.0115988 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0115939 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0115742 |
| FMNL2 | formin-like 2 | -0.0115253 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0115138 |
| CLTC | clathrin, heavy chain (Hc) | -0.0114737 |
