| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Encorafenib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.243595 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.126425 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.125225 |
| EGFR | epidermal growth factor receptor | 0.119528 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0910269 |
| NDRG1 | N-myc downstream regulated 1 | 0.0846599 |
| STC1 | stanniocalcin 1 | 0.0767301 |
| GPC5 | glypican 5 | 0.0734059 |
| RPS3 | ribosomal protein S3 | 0.0732592 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0726524 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0712936 |
| EGR1 | early growth response 1 | 0.0703578 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.058135 |
| SLTM | SAFB-like, transcription modulator | 0.0580947 |
| RNF213 | ring finger protein 213 | 0.057446 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0551582 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0533267 |
| MT2A | metallothionein 2A | 0.0525093 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0511096 |
| JMJD1C | jumonji domain containing 1C | 0.0465995 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0463183 |
| LAMC2 | laminin, gamma 2 | 0.043308 |
| LDHA | lactate dehydrogenase A | 0.0431458 |
| RPL37A | ribosomal protein L37a | 0.0427598 |
| RPS12 | ribosomal protein S12 | 0.0425703 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0423542 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.042324 |
| B2M | beta-2-microglobulin | 0.04188 |
| RPS8 | ribosomal protein S8 | 0.0397929 |
| FAM107B | family with sequence similarity 107, member B | 0.0373657 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0370912 |
| RACK1 | receptor for activated C kinase 1 | 0.0368975 |
| LAMA4 | laminin, alpha 4 | 0.0354024 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0349271 |
| PKM | pyruvate kinase, muscle | 0.0344303 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0336046 |
| SLC38A2 | solute carrier family 38, member 2 | 0.033341 |
| RPS2 | ribosomal protein S2 | 0.0332787 |
| HDAC9 | histone deacetylase 9 | 0.0332371 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0332081 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0327221 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0323879 |
| RPL35A | ribosomal protein L35a | 0.0321353 |
| RPLP1 | ribosomal protein, large, P1 | 0.0313682 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0312192 |
| MCL1 | myeloid cell leukemia 1 | 0.0311184 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0310974 |
| S100P | S100 calcium binding protein P | 0.0306888 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0306658 |
| AREG | amphiregulin | 0.0306512 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0306395 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0303433 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0294366 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0291844 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0290308 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0289398 |
| RPS27 | ribosomal protein S27 | 0.0288659 |
| RAD51B | RAD51 paralog B | 0.0282205 |
| IRS2 | insulin receptor substrate 2 | 0.0281978 |
| RPS17 | ribosomal protein S17 | 0.0280532 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0280378 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0280196 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0279706 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0276007 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0274191 |
| CAV2 | caveolin 2 | 0.0273279 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0269862 |
| FTL | ferritin, light polypeptide | 0.0263538 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0260376 |
| RPL37 | ribosomal protein L37 | 0.0259823 |
| ENO1 | enolase 1, (alpha) | 0.0257357 |
| HOMER1 | homer scaffolding protein 1 | 0.0255854 |
| MYO6 | myosin VI | 0.0253744 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0253466 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0250997 |
| SP100 | SP100 nuclear antigen | 0.0249907 |
| RPL11 | ribosomal protein L11 | 0.0248807 |
| RPL7 | ribosomal protein L7 | 0.0248272 |
| YBX3 | Y box binding protein 3 | 0.0248192 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0245251 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0243191 |
| CST3 | cystatin C | 0.024088 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0236301 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0234206 |
| RPS25 | ribosomal protein S25 | 0.0233593 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0232015 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0230642 |
| RPL30 | ribosomal protein L30 | 0.0227558 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.022645 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0224998 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0223375 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0223077 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0220894 |
| LAMB3 | laminin, beta 3 | 0.021957 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0219366 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0217654 |
| RPS14 | ribosomal protein S14 | 0.0217122 |
| ERLEC1 | endoplasmic reticulum lectin 1 | 0.0216218 |
| WASF2 | WAS protein family, member 2 | 0.0215871 |
| DISC1 | disrupted in schizophrenia 1 | 0.0213563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.117932 |
| ASPH | aspartate beta-hydroxylase | -0.111578 |
| H1-0 | H1.0 linker histone | -0.0683583 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0577032 |
| AHNAK | AHNAK nucleoprotein | -0.0550645 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0528599 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0469623 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0371359 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0345661 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0340423 |
| VCL | vinculin | -0.0324933 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0319817 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.030402 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0294287 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0281201 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0272792 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0268869 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0264661 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0251241 |
| PDE8A | phosphodiesterase 8A | -0.0250751 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0240531 |
| FAM13A | family with sequence similarity 13, member A | -0.023382 |
| RNF145 | ring finger protein 145 | -0.023279 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0231749 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0222743 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0222689 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0222215 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0220095 |
| RBM39 | RNA binding motif protein 39 | -0.0213935 |
| TMEM165 | transmembrane protein 165 | -0.0212562 |
| CUX1 | cut-like homeobox 1 | -0.0212481 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0211194 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0207694 |
| PARD3 | par-3 family cell polarity regulator | -0.0204693 |
| OGA | O-GlcNAcase | -0.0202031 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0200706 |
| SBF2 | SET binding factor 2 | -0.0199797 |
| SLMAP | sarcolemma associated protein | -0.0199013 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0198264 |
| SCEL | sciellin | -0.0192681 |
| UVRAG | UV radiation resistance associated | -0.0187693 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0187081 |
| SETD5 | SET domain containing 5 | -0.0183288 |
| FLNB | filamin B, beta | -0.0181562 |
| KRT8 | keratin 8, type II | -0.0177529 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0176716 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0175649 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0174374 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0173765 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0172214 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0171817 |
| UBAC2 | UBA domain containing 2 | -0.0166833 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0165557 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0164953 |
| RIN2 | Ras and Rab interactor 2 | -0.0162633 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0162262 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0161922 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0161823 |
| PTK2 | protein tyrosine kinase 2 | -0.0161379 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0160935 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0156832 |
| GPC6 | glypican 6 | -0.0155912 |
| TPD52 | tumor protein D52 | -0.0149451 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0147692 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.01474 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0146359 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0146267 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0142195 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0141563 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.0141092 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0139122 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.013787 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0137624 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0137408 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0136709 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0135164 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.01346 |
| EHBP1 | EH domain binding protein 1 | -0.0134326 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0133814 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0132751 |
| OSMR | oncostatin M receptor | -0.0132594 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0129876 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0129468 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0128279 |
| CERT1 | ceramide transporter 1 | -0.0127843 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.012682 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0126346 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0125643 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0124063 |
| CTBP2 | C-terminal binding protein 2 | -0.0123688 |
| NGLY1 | N-glycanase 1 | -0.0122776 |
| ANO6 | anoctamin 6 | -0.0122713 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0122332 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0121903 |
| SUCO | SUN domain containing ossification factor | -0.0121817 |
| SMAD2 | SMAD family member 2 | -0.01204 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0120335 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | -0.0118325 |
| GLG1 | golgi glycoprotein 1 | -0.01174 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0117399 |
