| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Encorafenib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0618697 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0538999 |
| FN1 | fibronectin 1 | 0.053605 |
| CDH13 | cadherin 13 | 0.051423 |
| LOX | lysyl oxidase | 0.0508373 |
| HMGA2 | high mobility group AT-hook 2 | 0.0445129 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0434039 |
| CD44 | CD44 molecule (Indian blood group) | 0.0389633 |
| NTN4 | netrin 4 | 0.0384689 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.038227 |
| NRG1 | neuregulin 1 | 0.0337162 |
| AADAC | arylacetamide deacetylase | 0.0323591 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0323374 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0300821 |
| SYT1 | synaptotagmin I | 0.0297621 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0296551 |
| IFI44L | interferon-induced protein 44-like | 0.0285349 |
| DST | dystonin | 0.0278179 |
| RAD51B | RAD51 paralog B | 0.0272812 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0271522 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0267769 |
| RNF213 | ring finger protein 213 | 0.0253447 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0251839 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0250618 |
| INTS6 | integrator complex subunit 6 | 0.0242595 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0242523 |
| SP100 | SP100 nuclear antigen | 0.0240342 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0238728 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0238171 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0237753 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0236719 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0232857 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0221092 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0208141 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.020708 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0206189 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0201252 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0200891 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.019452 |
| EGR1 | early growth response 1 | 0.0192753 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0191482 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0190187 |
| ASPH | aspartate beta-hydroxylase | 0.0189949 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0185016 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0182321 |
| GPC6 | glypican 6 | 0.0180604 |
| MTSS1 | metastasis suppressor 1 | 0.0179061 |
| TGM2 | transglutaminase 2 | 0.0178037 |
| VIM | vimentin | 0.0175615 |
| FAM20C | family with sequence similarity 20, member C | 0.017387 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.017179 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0171665 |
| PRKCA | protein kinase C, alpha | 0.0171624 |
| SEPTIN9 | septin 9 | 0.0170743 |
| TGFB1 | transforming growth factor, beta 1 | 0.0170393 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0169679 |
| FBN1 | fibrillin 1 | 0.0169476 |
| RAI14 | retinoic acid induced 14 | 0.0164399 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0163611 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0162873 |
| MYO10 | myosin X | 0.016135 |
| SVIL | supervillin | 0.0161117 |
| HDAC9 | histone deacetylase 9 | 0.0161102 |
| SQSTM1 | sequestosome 1 | 0.0160166 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0159785 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0157224 |
| NRP1 | neuropilin 1 | 0.0153534 |
| RASAL2 | RAS protein activator like 2 | 0.0150427 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0150201 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0148639 |
| ZNF804A | zinc finger protein 804A | 0.0147885 |
| ECE1 | endothelin converting enzyme 1 | 0.0147767 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0147308 |
| GLCCI1 | glucocorticoid induced 1 | 0.014689 |
| NEBL | nebulette | 0.0145801 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0145801 |
| HMGA1 | high mobility group AT-hook 1 | 0.0143655 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0142986 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0140609 |
| ATXN1 | ataxin 1 | 0.0140307 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0139918 |
| NAV2 | neuron navigator 2 | 0.013903 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0138324 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0134939 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0133903 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0132804 |
| MECOM | MDS1 and EVI1 complex locus | 0.0132675 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0132046 |
| WLS | wntless Wnt ligand secretion mediator | 0.0130464 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0128405 |
| SLFN5 | schlafen family member 5 | 0.0127922 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0126935 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0126712 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.012641 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.012619 |
| RIGI | RNA sensor RIG-I | 0.0125466 |
| CDK14 | cyclin-dependent kinase 14 | 0.0125403 |
| NAV1 | neuron navigator 1 | 0.0125372 |
| PRSS23 | protease, serine, 23 | 0.0125226 |
| SUMF1 | sulfatase modifying factor 1 | 0.0124394 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.116805 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.104105 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10011 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0572533 |
| TMSB10 | thymosin beta 10 | -0.0564117 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0528222 |
| MT2A | metallothionein 2A | -0.049753 |
| GOLGA4 | golgin A4 | -0.0495064 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0464806 |
| RBM39 | RNA binding motif protein 39 | -0.0461777 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0426087 |
| PTMA | prothymosin, alpha | -0.0365123 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0348473 |
| FTL | ferritin, light polypeptide | -0.0332847 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0325991 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0324522 |
| OGA | O-GlcNAcase | -0.0295524 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0285213 |
| FAM13A | family with sequence similarity 13, member A | -0.0276743 |
| IER3 | immediate early response 3 | -0.0258876 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0257813 |
| RPLP1 | ribosomal protein, large, P1 | -0.025755 |
| ZNF292 | zinc finger protein 292 | -0.0257507 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0252178 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0233408 |
| OSMR | oncostatin M receptor | -0.0223105 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0221167 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0219117 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0212645 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0208439 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0205703 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0204589 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0204293 |
| RPS21 | ribosomal protein S21 | -0.0203963 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0203932 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0200585 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0197431 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0196514 |
| YBX3 | Y box binding protein 3 | -0.0194039 |
| SRP54 | signal recognition particle 54kDa | -0.0189092 |
| SBF2 | SET binding factor 2 | -0.0188548 |
| SETD5 | SET domain containing 5 | -0.0188338 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0187306 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0183813 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0182136 |
| RPS6 | ribosomal protein S6 | -0.0175455 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0172912 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0170735 |
| USP3 | ubiquitin specific peptidase 3 | -0.0169849 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0169366 |
| RPL32 | ribosomal protein L32 | -0.0168747 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0167581 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0167143 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0164671 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0163694 |
| RNF145 | ring finger protein 145 | -0.0159284 |
| RPLP2 | ribosomal protein, large, P2 | -0.0158565 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0156277 |
| RPS19 | ribosomal protein S19 | -0.0155559 |
| RBM25 | RNA binding motif protein 25 | -0.0152475 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0152292 |
| NGLY1 | N-glycanase 1 | -0.0146087 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0145566 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0145116 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.014496 |
| RPL12 | ribosomal protein L12 | -0.0143869 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0143788 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0143685 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0143419 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0141018 |
| CANX | calnexin | -0.0140473 |
| FOXO3 | forkhead box O3 | -0.0138803 |
| WDR45B | WD repeat domain 45B | -0.013841 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.013815 |
| YBX1 | Y box binding protein 1 | -0.0136813 |
| ATP13A3 | ATPase type 13A3 | -0.013516 |
| COG5 | component of oligomeric golgi complex 5 | -0.0133251 |
| RIOK3 | RIO kinase 3 | -0.0132356 |
| PHIP | pleckstrin homology domain interacting protein | -0.0132188 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0131998 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0131468 |
| ARF4 | ADP-ribosylation factor 4 | -0.0131459 |
| MORF4L2 | mortality factor 4 like 2 | -0.0131381 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0130262 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0129917 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0129052 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0128789 |
| RPS24 | ribosomal protein S24 | -0.0127575 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0126301 |
| CD109 | CD109 molecule | -0.0125943 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0125916 |
| RPL35A | ribosomal protein L35a | -0.0125019 |
| COPA | coatomer protein complex, subunit alpha | -0.0124989 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0123528 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0122926 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.012214 |
| SPAG9 | sperm associated antigen 9 | -0.0122037 |
| POM121 | POM121 transmembrane nucleoporin | -0.0121835 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0121783 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.012092 |
