| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Encorafenib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0551773 |
| IGF2 | insulin-like growth factor 2 | 0.0485639 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.047308 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0354049 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0308024 |
| RPS12 | ribosomal protein S12 | 0.027306 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0257828 |
| RPS2 | ribosomal protein S2 | 0.0247483 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0232564 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0212582 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0208621 |
| PCBP2 | poly(rC) binding protein 2 | 0.0182638 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0178518 |
| FLNA | filamin A, alpha | 0.0172327 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0164439 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0163283 |
| MCL1 | myeloid cell leukemia 1 | 0.0158981 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0153955 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0142095 |
| NCKAP1 | NCK-associated protein 1 | 0.0141043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0134226 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0133656 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0133357 |
| HLA-A | major histocompatibility complex, class I, A | 0.0133341 |
| NDRG1 | N-myc downstream regulated 1 | 0.0130397 |
| SIK3 | SIK family kinase 3 | 0.0125077 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0121483 |
| BRD2 | bromodomain containing 2 | 0.0118746 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0118068 |
| SFTPA2 | surfactant protein A2 | 0.0115608 |
| PCBP1 | poly(rC) binding protein 1 | 0.0114409 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0113437 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.01133 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0112891 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.011153 |
| IL6 | interleukin 6 | 0.0104981 |
| MT1X | metallothionein 1X | 0.0103045 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0102324 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00981274 |
| ICAM1 | intercellular adhesion molecule 1 | 0.00945065 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.00907005 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.00906211 |
| RCOR1 | REST corepressor 1 | 0.00886265 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00884263 |
| UBAP2L | ubiquitin associated protein 2-like | 0.00877276 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.00857712 |
| LRRC23 | leucine rich repeat containing 23 | 0.00850041 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00845911 |
| NUP58 | nucleoporin 58 | 0.00844934 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.00835162 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.00833975 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.00820195 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00817858 |
| CD68 | CD68 molecule | 0.00805709 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.00798527 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.00787759 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.00781801 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.00781743 |
| RPS27 | ribosomal protein S27 | 0.0077599 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.00766242 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.00764522 |
| LAMA5 | laminin, alpha 5 | 0.00763295 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00762107 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0075288 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.00748332 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.00744563 |
| RUNX1 | runt-related transcription factor 1 | 0.00740233 |
| MYO10 | myosin X | 0.00734775 |
| CCNL1 | cyclin L1 | 0.00722913 |
| AXL | AXL receptor tyrosine kinase | 0.00715622 |
| FGF18 | fibroblast growth factor 18 | 0.00713882 |
| TUBB4B | tubulin, beta 4B class IVb | 0.00707304 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00706655 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.00705795 |
| SKI | SKI proto-oncogene | 0.00699409 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.00697944 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | 0.00684272 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.00676851 |
| CRLF2 | cytokine receptor-like factor 2 | 0.00672142 |
| CCDC138 | coiled-coil domain containing 138 | 0.00661168 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.00653023 |
| NXF1 | nuclear RNA export factor 1 | 0.00652758 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.00649858 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.00641171 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.00639109 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.00633102 |
| SNX31 | sorting nexin 31 | 0.00622384 |
| TMF1 | TATA element modulatory factor 1 | 0.00621956 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.00619505 |
| SPX | spexin hormone | 0.00618696 |
| PDE4C | phosphodiesterase 4C, cAMP-specific | 0.00608783 |
| BTRC | beta-transducin repeat containing E3 ubiquitin protein ligase | 0.00604792 |
| PSEN1 | presenilin 1 | 0.00604215 |
| TESK2 | testis-specific kinase 2 | 0.00595876 |
| BAIAP2 | BAI1-associated protein 2 | 0.00594058 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.00592808 |
| MLF1 | myeloid leukemia factor 1 | 0.00592371 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.00589511 |
| B2M | beta-2-microglobulin | 0.00588075 |
| KCMF1 | potassium channel modulatory factor 1 | 0.00586931 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.412063 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.162152 |
| TMSB10 | thymosin beta 10 | -0.150681 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128605 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.128127 |
| VIM | vimentin | -0.118547 |
| PTMA | prothymosin, alpha | -0.0979614 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.094422 |
| AHNAK | AHNAK nucleoprotein | -0.0923608 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0859168 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0835694 |
| ACTG1 | actin gamma 1 | -0.0834224 |
| RPL19 | ribosomal protein L19 | -0.0790857 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0786679 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0784974 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0717323 |
| IER3 | immediate early response 3 | -0.0710103 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.064674 |
| CMIP | c-Maf inducing protein | -0.0634871 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0631683 |
| S100A6 | S100 calcium binding protein A6 | -0.0622531 |
| S100A10 | S100 calcium binding protein A10 | -0.0584722 |
| ASPH | aspartate beta-hydroxylase | -0.0571887 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0567663 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0565936 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0560709 |
| CAVIN1 | caveolae associated protein 1 | -0.0554186 |
| TPM4 | tropomyosin 4 | -0.0552752 |
| DST | dystonin | -0.0545312 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.054411 |
| RPS21 | ribosomal protein S21 | -0.0528001 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0515082 |
| FTL | ferritin, light polypeptide | -0.0506981 |
| BICC1 | BicC family RNA binding protein 1 | -0.0493217 |
| ERBIN | erbb2 interacting protein | -0.0487519 |
| RPS6 | ribosomal protein S6 | -0.0475753 |
| TXNRD1 | thioredoxin reductase 1 | -0.0458209 |
| ENO1 | enolase 1, (alpha) | -0.0453816 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0449126 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0439094 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0429049 |
| CANX | calnexin | -0.0427705 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0423706 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0415328 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0404473 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0403413 |
| ANXA2 | annexin A2 | -0.0402221 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0396951 |
| GRAMD1B | GRAM domain containing 1B | -0.0396109 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0391807 |
| NEGR1 | neuronal growth regulator 1 | -0.0390779 |
| SRGN | serglycin | -0.0389562 |
| SVIL | supervillin | -0.0383333 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0378595 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0376003 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0375944 |
| EFNA5 | ephrin-A5 | -0.0374061 |
| VCL | vinculin | -0.03713 |
| S100A9 | S100 calcium binding protein A9 | -0.0367872 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0363501 |
| PKM | pyruvate kinase, muscle | -0.0363166 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0359762 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0354057 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0353209 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0351321 |
| UTRN | utrophin | -0.0350878 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0348355 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0343814 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0341617 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0339206 |
| APP | amyloid beta (A4) precursor protein | -0.0338808 |
| FMNL2 | formin-like 2 | -0.0337554 |
| LDHA | lactate dehydrogenase A | -0.0334946 |
| RPS15 | ribosomal protein S15 | -0.0334488 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.033356 |
| PDE8A | phosphodiesterase 8A | -0.0331547 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.032961 |
| RPS25 | ribosomal protein S25 | -0.0325851 |
| RPS24 | ribosomal protein S24 | -0.0325728 |
| RPL8 | ribosomal protein L8 | -0.0322261 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0321466 |
| RPS29 | ribosomal protein S29 | -0.0320903 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0320744 |
| CFDP1 | craniofacial development protein 1 | -0.0320641 |
| STC1 | stanniocalcin 1 | -0.0319954 |
| TPI1 | triosephosphate isomerase 1 | -0.0312422 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0311658 |
| RPS23 | ribosomal protein S23 | -0.0311303 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0311263 |
| PYGL | phosphorylase, glycogen, liver | -0.0307398 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0306467 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0305057 |
| MYOF | myoferlin | -0.030405 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0302928 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0302649 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0300154 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0297311 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0297126 |
| RPLP0 | ribosomal protein, large, P0 | -0.0296596 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0292995 |
