| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Encorafenib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0595014 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0484719 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0430415 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0418833 |
| PDE10A | phosphodiesterase 10A | 0.0413796 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0380933 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0296884 |
| WWOX | WW domain containing oxidoreductase | 0.0295237 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0273629 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0264372 |
| RNF213 | ring finger protein 213 | 0.0252154 |
| AEBP2 | AE binding protein 2 | 0.0239854 |
| RPS3 | ribosomal protein S3 | 0.023576 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0219612 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0216928 |
| BMP5 | bone morphogenetic protein 5 | 0.0216793 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0212393 |
| DENND5B | DENN/MADD domain containing 5B | 0.0206981 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0204423 |
| FNDC3B | fibronectin type III domain containing 3B | 0.019775 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0177102 |
| INTS6 | integrator complex subunit 6 | 0.0174476 |
| HLA-B | major histocompatibility complex, class I, B | 0.0174109 |
| RPL37A | ribosomal protein L37a | 0.0172486 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0168217 |
| MACROD2 | MACRO domain containing 2 | 0.0167585 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0165687 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0164544 |
| RPS12 | ribosomal protein S12 | 0.0161862 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.016167 |
| EGR1 | early growth response 1 | 0.0160887 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.015818 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0158003 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0157845 |
| ATF6 | activating transcription factor 6 | 0.0157489 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0150313 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0149824 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0147682 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.014116 |
| VIM | vimentin | 0.0134323 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0134084 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0129578 |
| BPTF | bromodomain PHD finger transcription factor | 0.0129525 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0127154 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0124635 |
| RPL37 | ribosomal protein L37 | 0.0124135 |
| SIK3 | SIK family kinase 3 | 0.0123832 |
| RPS8 | ribosomal protein S8 | 0.012375 |
| PRELID2 | PRELI domain containing 2 | 0.012328 |
| SFTPA2 | surfactant protein A2 | 0.0121007 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0119799 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0118768 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0117149 |
| ATXN1 | ataxin 1 | 0.0116065 |
| ADAR | adenosine deaminase, RNA-specific | 0.0115194 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0114954 |
| HOMER1 | homer scaffolding protein 1 | 0.0113826 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0110619 |
| VCL | vinculin | 0.0109188 |
| ANK2 | ankyrin 2, neuronal | 0.0106762 |
| RPS17 | ribosomal protein S17 | 0.0106712 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0106679 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.010523 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0104352 |
| PCDH7 | protocadherin 7 | 0.0103897 |
| RPS27 | ribosomal protein S27 | 0.0103417 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0102611 |
| TAPBP | TAP binding protein (tapasin) | 0.0100655 |
| IGF2 | insulin-like growth factor 2 | 0.0100153 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.00992721 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0098812 |
| FTL | ferritin, light polypeptide | 0.00977604 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.00965541 |
| NLGN1 | neuroligin 1 | 0.00959738 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00954545 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.00949081 |
| RPS2 | ribosomal protein S2 | 0.0094637 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00938622 |
| MRTFA | myocardin related transcription factor A | 0.00931511 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.00914015 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.00913422 |
| ADA | adenosine deaminase | 0.00912182 |
| DST | dystonin | 0.00905581 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.00901786 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0089955 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.00896992 |
| NRDC | nardilysin convertase | 0.00896612 |
| RSU1 | Ras suppressor protein 1 | 0.00889967 |
| TENM3 | teneurin transmembrane protein 3 | 0.00882152 |
| CALR | calreticulin | 0.00875368 |
| PCBP1 | poly(rC) binding protein 1 | 0.00872085 |
| XPOT | exportin, tRNA | 0.0084872 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0084784 |
| DSPP | dentin sialophosphoprotein | 0.00847315 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00844096 |
| CREBBP | CREB binding protein | 0.00843911 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.00839709 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.00829227 |
| B2M | beta-2-microglobulin | 0.00815398 |
| RPL31 | ribosomal protein L31 | 0.00810151 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.122172 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0900198 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0403728 |
| RTN4 | reticulon 4 | -0.0379284 |
| YBX3 | Y box binding protein 3 | -0.0370954 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0316314 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0304262 |
| PHIP | pleckstrin homology domain interacting protein | -0.0296365 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0293449 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0286931 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0260135 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0254004 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0252428 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0248222 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0245189 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0243774 |
| OGA | O-GlcNAcase | -0.0237768 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0237485 |
| TXNRD1 | thioredoxin reductase 1 | -0.0235736 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0226116 |
| PTMA | prothymosin, alpha | -0.0221387 |
| XPO1 | exportin 1 | -0.0219048 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0218033 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0217169 |
| GRAMD1B | GRAM domain containing 1B | -0.0210923 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.020889 |
| RBM25 | RNA binding motif protein 25 | -0.0206849 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0205309 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0205232 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0200777 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0198552 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0196167 |
| FMNL2 | formin-like 2 | -0.0187061 |
| SBF2 | SET binding factor 2 | -0.0186816 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0186589 |
| PTK2 | protein tyrosine kinase 2 | -0.0183283 |
| RPS21 | ribosomal protein S21 | -0.018091 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0175692 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.01752 |
| BBX | bobby sox homolog (Drosophila) | -0.0173689 |
| CDK17 | cyclin-dependent kinase 17 | -0.0172778 |
| TMSB10 | thymosin beta 10 | -0.0171587 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0170383 |
| SRPK1 | SRSF protein kinase 1 | -0.0169547 |
| RBM39 | RNA binding motif protein 39 | -0.0169466 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0167888 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0165639 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0164284 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0161927 |
| PCNX1 | pecanex 1 | -0.0161616 |
| AHNAK | AHNAK nucleoprotein | -0.0160208 |
| TPI1 | triosephosphate isomerase 1 | -0.0160114 |
| MMP12 | matrix metallopeptidase 12 | -0.0159028 |
| ZNF292 | zinc finger protein 292 | -0.0158982 |
| RASA2 | RAS p21 protein activator 2 | -0.015722 |
| TMEM165 | transmembrane protein 165 | -0.0157034 |
| SRPK2 | SRSF protein kinase 2 | -0.0156653 |
| ZFR | zinc finger RNA binding protein | -0.0154044 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0153906 |
| ANO6 | anoctamin 6 | -0.0153396 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0151846 |
| CCND2 | cyclin D2 | -0.0150671 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0148752 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0147471 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0147197 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0146641 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0146062 |
| CTTN | cortactin | -0.0146005 |
| NABP1 | nucleic acid binding protein 1 | -0.0144016 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.014312 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0141221 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0141083 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0140683 |
| PFKP | phosphofructokinase, platelet | -0.0139627 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0138606 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0137919 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0137796 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0136511 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0134472 |
| GOLGA4 | golgin A4 | -0.0134397 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0134338 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0134071 |
| KRT18 | keratin 18, type I | -0.0133599 |
| SEPTIN10 | septin 10 | -0.013268 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0132405 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0131789 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0131477 |
| RRM2 | ribonucleotide reductase M2 | -0.0128553 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0128401 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0127863 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0127764 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0127615 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0126507 |
| CDYL | chromodomain protein, Y-like | -0.0124504 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0124171 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0124088 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0124036 |
| ANXA5 | annexin A5 | -0.0123657 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0123613 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0123595 |
