| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Encorafenib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.12211 |
| LAMC2 | laminin, gamma 2 | 0.0609105 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0600977 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0479041 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0423162 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0418538 |
| EFNA5 | ephrin-A5 | 0.0387522 |
| DTNA | dystrobrevin, alpha | 0.0350057 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0340174 |
| LMO7 | LIM domain 7 | 0.0337188 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0325512 |
| LAMB3 | laminin, beta 3 | 0.0276823 |
| MAP1B | microtubule-associated protein 1B | 0.0268462 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0254715 |
| ERBIN | erbb2 interacting protein | 0.0243494 |
| FBXO32 | F-box protein 32 | 0.0242339 |
| NAV2 | neuron navigator 2 | 0.0235274 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0234536 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0214554 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0208512 |
| TJP1 | tight junction protein 1 | 0.0200226 |
| EGFR | epidermal growth factor receptor | 0.0199088 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.019787 |
| VGLL3 | vestigial-like family member 3 | 0.0196351 |
| HDAC9 | histone deacetylase 9 | 0.0188468 |
| ACTG1 | actin gamma 1 | 0.018761 |
| RCOR1 | REST corepressor 1 | 0.01865 |
| ATXN1 | ataxin 1 | 0.0183802 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0183788 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0182345 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0179402 |
| CD44 | CD44 molecule (Indian blood group) | 0.0176821 |
| CCND1 | cyclin D1 | 0.0174544 |
| MYO1E | myosin IE | 0.0174518 |
| SVIL | supervillin | 0.0174341 |
| MYO5B | myosin VB | 0.017293 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0168708 |
| FNIP1 | folliculin interacting protein 1 | 0.0165093 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0163871 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0162783 |
| RASAL2 | RAS protein activator like 2 | 0.0159401 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0158391 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0155522 |
| DST | dystonin | 0.0152886 |
| FLNA | filamin A, alpha | 0.0151893 |
| PLEC | plectin | 0.015075 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0148711 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0148271 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0145494 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.014462 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0142436 |
| DSPP | dentin sialophosphoprotein | 0.0141271 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0140609 |
| ATP11A | ATPase, class VI, type 11A | 0.0140168 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0138564 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0137438 |
| PEG10 | paternally expressed 10 | 0.0136334 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0135497 |
| CLTC | clathrin, heavy chain (Hc) | 0.0134428 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0134323 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.013202 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0131426 |
| TUBB4B | tubulin, beta 4B class IVb | 0.013138 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0130693 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0130313 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0130287 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0128642 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.012681 |
| SBF2 | SET binding factor 2 | 0.0126639 |
| NUMB | numb homolog (Drosophila) | 0.012427 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.012421 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0121515 |
| FN1 | fibronectin 1 | 0.0121183 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.0121083 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0119927 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0119315 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0118657 |
| PRKCA | protein kinase C, alpha | 0.0118449 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0117372 |
| JUP | junction plakoglobin | 0.0117035 |
| EGR1 | early growth response 1 | 0.0116681 |
| NF1 | neurofibromin 1 | 0.0115917 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0114875 |
| GOLGB1 | golgin B1 | 0.011406 |
| KLF6 | Kruppel-like factor 6 | 0.0111807 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0110815 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0110644 |
| KLF12 | Kruppel-like factor 12 | 0.0110572 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.011053 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0109697 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0107216 |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides | 0.0105844 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0105541 |
| CAB39 | calcium binding protein 39 | 0.0105514 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0104222 |
| MAP4 | microtubule-associated protein 4 | 0.0103887 |
| SCFD1 | sec1 family domain containing 1 | 0.0103879 |
| ANO6 | anoctamin 6 | 0.0102365 |
| INTS6 | integrator complex subunit 6 | 0.0101542 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0101395 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.168383 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.134881 |
| FTL | ferritin, light polypeptide | -0.106543 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0841947 |
| PTMA | prothymosin, alpha | -0.0799913 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0762978 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.060361 |
| S100A6 | S100 calcium binding protein A6 | -0.0544053 |
| FAM13A | family with sequence similarity 13, member A | -0.0457431 |
| POTEF | POTE ankyrin domain family, member F | -0.0445075 |
| TMSB10 | thymosin beta 10 | -0.0390827 |
| NDRG1 | N-myc downstream regulated 1 | -0.0377443 |
| RPS6 | ribosomal protein S6 | -0.0375521 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0369783 |
| UBC | ubiquitin C | -0.0362176 |
| G0S2 | G0/G1 switch 2 | -0.0358219 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0353818 |
| FAM162A | family with sequence similarity 162, member A | -0.0342656 |
| S100A10 | S100 calcium binding protein A10 | -0.0327238 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0326969 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0326295 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.032095 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.031848 |
| RNF145 | ring finger protein 145 | -0.031193 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0305782 |
| RPL8 | ribosomal protein L8 | -0.0295245 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0278984 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0252972 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0247853 |
| PKM | pyruvate kinase, muscle | -0.0245929 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0240102 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0238815 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0237798 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0237699 |
| CANX | calnexin | -0.0236807 |
| RPLP1 | ribosomal protein, large, P1 | -0.0235333 |
| SQSTM1 | sequestosome 1 | -0.0234294 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0232747 |
| QKI | QKI, KH domain containing, RNA binding | -0.0226264 |
| DSTN | destrin (actin depolymerizing factor) | -0.0225741 |
| LDHA | lactate dehydrogenase A | -0.0225151 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0222005 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0220697 |
| TPI1 | triosephosphate isomerase 1 | -0.0220064 |
| RLF | rearranged L-myc fusion | -0.022 |
| TFG | TRK-fused gene | -0.0219944 |
| RPS23 | ribosomal protein S23 | -0.0219109 |
| RHOA | ras homolog family member A | -0.0217683 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0214536 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0211517 |
| RYBP | RING1 and YY1 binding protein | -0.0211432 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0209973 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0208656 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0208382 |
| USP3 | ubiquitin specific peptidase 3 | -0.0208367 |
| PGK1 | phosphoglycerate kinase 1 | -0.0207621 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0205648 |
| PCBP2 | poly(rC) binding protein 2 | -0.0205463 |
| MT2A | metallothionein 2A | -0.0205248 |
| ZNF292 | zinc finger protein 292 | -0.0200942 |
| RPLP0 | ribosomal protein, large, P0 | -0.0198441 |
| RHEB | Ras homolog enriched in brain | -0.0198385 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0196961 |
| SDC4 | syndecan 4 | -0.0193009 |
| RBM39 | RNA binding motif protein 39 | -0.0192793 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0191285 |
| FOSL1 | FOS-like antigen 1 | -0.0187105 |
| B2M | beta-2-microglobulin | -0.0184226 |
| RPL28 | ribosomal protein L28 | -0.0182628 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0180805 |
| RPLP2 | ribosomal protein, large, P2 | -0.0180183 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0178629 |
| MXD1 | MAX dimerization protein 1 | -0.0178108 |
| SETD5 | SET domain containing 5 | -0.017454 |
| TOP1 | topoisomerase (DNA) I | -0.0172024 |
| HLA-A | major histocompatibility complex, class I, A | -0.0171811 |
| CCNL1 | cyclin L1 | -0.0170736 |
| RPL32 | ribosomal protein L32 | -0.0170138 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0169401 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0167545 |
| AREG | amphiregulin | -0.0165555 |
| DEK | DEK proto-oncogene | -0.0165551 |
| RPS19 | ribosomal protein S19 | -0.0165101 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0162575 |
| S100A9 | S100 calcium binding protein A9 | -0.0160267 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0159842 |
| RPL35A | ribosomal protein L35a | -0.0159789 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0158542 |
| ENO1 | enolase 1, (alpha) | -0.0156376 |
| GNAS | GNAS complex locus | -0.0155349 |
| RPL19 | ribosomal protein L19 | -0.0154289 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.015324 |
| RPL11 | ribosomal protein L11 | -0.0151313 |
| RPL27A | ribosomal protein L27a | -0.015073 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0149767 |
| RPS13 | ribosomal protein S13 | -0.0149241 |
| YBX1 | Y box binding protein 1 | -0.0149064 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0148213 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.014659 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0145306 |
