Encorafenib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Encorafenib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Encorafenib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.100172
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0763777
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0750935
MYOF myoferlin 0.0724862
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0717768
WARS1 tryptophanyl-tRNA synthetase 1 0.0639405
KYNU kynureninase 0.0623115
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0604969
PDE4D phosphodiesterase 4D, cAMP-specific 0.0573094
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0569071
PDE10A phosphodiesterase 10A 0.0537131
EEF2 eukaryotic translation elongation factor 2 0.0527613
PSD3 pleckstrin and Sec7 domain containing 3 0.0516439
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0504794
DST dystonin 0.050215
FAT1 FAT atypical cadherin 1 0.0500091
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0487769
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0469533
CHD1 chromodomain helicase DNA binding protein 1 0.0464587
PLCB4 phospholipase C, beta 4 0.0443984
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0443226
ANTXR1 anthrax toxin receptor 1 0.0442794
COL5A2 collagen, type V, alpha 2 0.0420853
TMEM178B transmembrane protein 178B 0.0414795
PDLIM5 PDZ and LIM domain 5 0.0401984
CD109 CD109 molecule 0.0385082
RASAL2 RAS protein activator like 2 0.0370316
TBXT T-box transcription factor T 0.0367319
KIF16B kinesin family member 16B 0.0364943
CDH13 cadherin 13 0.0363873
FN1 fibronectin 1 0.0358928
MAP7 microtubule-associated protein 7 0.03497
AGTPBP1 ATP/GTP binding protein 1 0.0340281
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0336663
PM20D1 peptidase M20 domain containing 1 0.033396
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0331879
MARCHF1 membrane associated ring-CH-type finger 1 0.033094
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0330743
COL8A1 collagen, type VIII, alpha 1 0.0326931
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0321572
NEK7 NIMA-related kinase 7 0.0313388
NRXN3 neurexin 3 0.0313268
CTIF CBP80/20-dependent translation initiation factor 0.0313046
ZEB2 zinc finger E-box binding homeobox 2 0.0312319
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0310758
CLIP1 CAP-GLY domain containing linker protein 1 0.030716
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.030596
ADGRD1 adhesion G protein-coupled receptor D1 0.0295888
ATAD2B ATPase family, AAA domain containing 2B 0.0292286
TUSC3 tumor suppressor candidate 3 0.0285839
FNIP1 folliculin interacting protein 1 0.0281604
ZNF804A zinc finger protein 804A 0.027998
CADM2 cell adhesion molecule 2 0.0277962
PALLD palladin, cytoskeletal associated protein 0.0273894
FBXL7 F-box and leucine-rich repeat protein 7 0.027375
SPAG9 sperm associated antigen 9 0.0273744
SLC38A2 solute carrier family 38, member 2 0.0267482
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0263976
ZMIZ1 zinc finger, MIZ-type containing 1 0.0263331
EGR1 early growth response 1 0.0258199
IARS1 isoleucyl-tRNA synthetase 1 0.0256164
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0255193
ERBIN erbb2 interacting protein 0.0251241
CLU clusterin 0.0251149
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.025111
NT5E 5'-nucleotidase, ecto (CD73) 0.0250344
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0250241
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0250097
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.024937
RETREG1 reticulophagy regulator 1 0.0249166
NFE2L1 nuclear factor, erythroid 2-like 1 0.0248594
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0248425
SQSTM1 sequestosome 1 0.0247252
STC2 stanniocalcin 2 0.0243704
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0240475
CARD16 caspase recruitment domain family, member 16 0.0239146
GARS1 glycyl-tRNA synthetase 1 0.0237795
ZFYVE16 zinc finger, FYVE domain containing 16 0.0236629
FTH1 ferritin, heavy polypeptide 1 0.0233484
ENAH enabled homolog (Drosophila) 0.022876
PTEN phosphatase and tensin homolog 0.0228346
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0227217
CTBP2 C-terminal binding protein 2 0.0226633
ESYT2 extended synaptotagmin-like protein 2 0.0223851
RAD51B RAD51 paralog B 0.0223642
JMJD1C jumonji domain containing 1C 0.0221942
FLRT2 fibronectin leucine rich transmembrane protein 2 0.021986
ZC3H11A zinc finger CCCH-type containing 11A 0.0219728
TGFBR1 transforming growth factor, beta receptor 1 0.0219192
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0215313
ABLIM1 actin binding LIM protein 1 0.021527
PCDH15 protocadherin-related 15 0.0213632
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0212821
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0212712
TSC22D1 TSC22 domain family, member 1 0.0211034
TXNRD1 thioredoxin reductase 1 0.0209303
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0208839
EIF5 eukaryotic translation initiation factor 5 0.0203316
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0202684
FLNA filamin A, alpha 0.0201705

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149237
PTMA prothymosin, alpha -0.125204
TPT1 tumor protein, translationally-controlled 1 -0.115711
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.104901
RPS6 ribosomal protein S6 -0.0957483
TMSB10 thymosin beta 10 -0.0904678
RPLP1 ribosomal protein, large, P1 -0.0867032
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0863942
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0827594
RPS24 ribosomal protein S24 -0.0789405
VIM vimentin -0.0785256
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0688874
RPL35A ribosomal protein L35a -0.0638641
EFNA5 ephrin-A5 -0.060181
RPL34 ribosomal protein L34 -0.0565233
STC1 stanniocalcin 1 -0.056227
RPL37A ribosomal protein L37a -0.0547052
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0545559
RPS29 ribosomal protein S29 -0.0542799
RPL31 ribosomal protein L31 -0.051767
MCL1 myeloid cell leukemia 1 -0.0507698
RPS23 ribosomal protein S23 -0.0487758
RPS19 ribosomal protein S19 -0.0482372
RPS27A ribosomal protein S27a -0.0475596
RPL26 ribosomal protein L26 -0.0472541
FTL ferritin, light polypeptide -0.0465432
RPS25 ribosomal protein S25 -0.0462489
MAML3 mastermind-like 3 (Drosophila) -0.0439742
RPL19 ribosomal protein L19 -0.0421071
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0414698
RPL12 ribosomal protein L12 -0.0405879
RPS13 ribosomal protein S13 -0.0399344
RPL9 ribosomal protein L9 -0.0394029
RPL11 ribosomal protein L11 -0.0391959
RPL38 ribosomal protein L38 -0.0379007
RPS8 ribosomal protein S8 -0.036885
HLA-B major histocompatibility complex, class I, B -0.0367791
INHBA inhibin, beta A -0.0361236
RPL36A ribosomal protein L36a -0.0352047
RPS21 ribosomal protein S21 -0.0346305
RPLP2 ribosomal protein, large, P2 -0.0339917
ACTG1 actin gamma 1 -0.0322726
NALF1 NALCN channel auxiliary factor 1 -0.0321693
NRCAM neuronal cell adhesion molecule -0.0314062
WSB1 WD repeat and SOCS box containing 1 -0.0304428
SOX4 SRY (sex determining region Y)-box 4 -0.029748
VCL vinculin -0.0297394
GNAS GNAS complex locus -0.0291021
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0290328
RPS27 ribosomal protein S27 -0.0289913
PRKN parkin RBR E3 ubiquitin protein ligase -0.0280723
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0279649
RPL23 ribosomal protein L23 -0.0277803
RPL36 ribosomal protein L36 -0.0276297
RPL13A ribosomal protein L13a -0.0271899
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0269599
RPL37 ribosomal protein L37 -0.0267767
RPL35 ribosomal protein L35 -0.0264136
RPL7A ribosomal protein L7a -0.0263695
FNDC3B fibronectin type III domain containing 3B -0.0258823
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0256799
RPS3 ribosomal protein S3 -0.0255841
BMERB1 bMERB domain containing 1 -0.0252329
UNC5D unc-5 homolog D (C. elegans) -0.0247732
NPAS2 neuronal PAS domain protein 2 -0.0245838
RPS16 ribosomal protein S16 -0.0244427
GLIS3 GLIS family zinc finger 3 -0.0239544
GDA guanine deaminase -0.0236571
RPS10 ribosomal protein S10 -0.0236558
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0234866
EIF1 eukaryotic translation initiation factor 1 -0.0234844
OGA O-GlcNAcase -0.0234193
RPS14 ribosomal protein S14 -0.0234167
TFPI2 tissue factor pathway inhibitor 2 -0.0233823
RPS11 ribosomal protein S11 -0.0233696
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0233295
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0232433
PCBP3 poly(rC) binding protein 3 -0.0229426
RPL28 ribosomal protein L28 -0.0222871
S100A10 S100 calcium binding protein A10 -0.0218629
RPS12 ribosomal protein S12 -0.0216948
RPL32 ribosomal protein L32 -0.0216758
PDGFA platelet-derived growth factor alpha polypeptide -0.0210384
RPLP0 ribosomal protein, large, P0 -0.0209845
HLA-A major histocompatibility complex, class I, A -0.0209362
KPNB1 karyopherin (importin) beta 1 -0.0203173
NCKAP5 NCK-associated protein 5 -0.0202001
RPL8 ribosomal protein L8 -0.019889
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0198732
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0197448
THSD4 thrombospondin, type I, domain containing 4 -0.0196637
RPS15 ribosomal protein S15 -0.0196453
ISG15 ISG15 ubiquitin-like modifier -0.019534
GLCCI1 glucocorticoid induced 1 -0.0191848
GOLGA4 golgin A4 -0.0189592
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0186971
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0182572
CENPF centromere protein F, 350/400kDa -0.0178507
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0177638
RPL27A ribosomal protein L27a -0.0176631