Encorafenib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Encorafenib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

193 genes differentially expressed following the Encorafenib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.148099
LPP LIM domain containing preferred translocation partner in lipoma 0.125743
DST dystonin 0.108162
EXT1 exostosin glycosyltransferase 1 0.107013
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.103207
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0936873
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0922075
EFNA5 ephrin-A5 0.0910053
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0876532
PDE4D phosphodiesterase 4D, cAMP-specific 0.085203
EEF2 eukaryotic translation elongation factor 2 0.0790115
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0781927
NALF1 NALCN channel auxiliary factor 1 0.0780182
RNF213 ring finger protein 213 0.0769197
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0757315
VCL vinculin 0.0751202
HMGA2 high mobility group AT-hook 2 0.0721764
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0694995
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0656469
SMYD3 SET and MYND domain containing 3 0.0650497
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0642839
HDLBP high density lipoprotein binding protein 0.0637766
RAD51B RAD51 paralog B 0.0623737
PRRC2C proline-rich coiled-coil 2C 0.0622888
MYO1E myosin IE 0.0606181
ACTG1 actin gamma 1 0.0586051
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0582086
ATXN1 ataxin 1 0.0567929
TRIO trio Rho guanine nucleotide exchange factor 0.0554007
LOC112694756 uncharaterized LOC112694756 0.0544082
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0532188
SMAD3 SMAD family member 3 0.0529662
BIRC6 baculoviral IAP repeat containing 6 0.0513417
CDK6 cyclin-dependent kinase 6 0.0495881
EGFR epidermal growth factor receptor 0.0495092
ZSWIM6 zinc finger, SWIM-type containing 6 0.0475802
MYOF myoferlin 0.0471966
FNDC3B fibronectin type III domain containing 3B 0.0440583
ASPH aspartate beta-hydroxylase 0.044044
ZBTB20 zinc finger and BTB domain containing 20 0.043422
TOP1 topoisomerase (DNA) I 0.0428829
TRIP12 thyroid hormone receptor interactor 12 0.0413302
JMJD1C jumonji domain containing 1C 0.0392442
NDRG1 N-myc downstream regulated 1 0.0376324
VMP1 vacuole membrane protein 1 0.0375627
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0371252
AKAP13 A kinase (PRKA) anchor protein 13 0.0369587
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0353976
FTH1 ferritin, heavy polypeptide 1 0.0349043
RBM39 RNA binding motif protein 39 0.0341316
CD44 CD44 molecule (Indian blood group) 0.033748
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0334755
RPL5 ribosomal protein L5 0.0310979
CDH13 cadherin 13 0.0292008
SBF2 SET binding factor 2 0.0286876
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0258873
FNDC3A fibronectin type III domain containing 3A 0.0257968
USP34 ubiquitin specific peptidase 34 0.0257896
EPS8 epidermal growth factor receptor pathway substrate 8 0.0240751
LSAMP limbic system-associated membrane protein 0.0229965
SND1 staphylococcal nuclease and tudor domain containing 1 0.0201177
MCL1 myeloid cell leukemia 1 0.0193319
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0189486
TAS2R14 taste receptor, type 2, member 14 0.0184482
SIK3 SIK family kinase 3 0.0183975
DTNA dystrobrevin, alpha 0.0182864
RACK1 receptor for activated C kinase 1 0.0180776
GSK3B glycogen synthase kinase 3 beta 0.0175775
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0175715
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0170005
NAV1 neuron navigator 1 0.0148613
HLA-B major histocompatibility complex, class I, B 0.0148294
RPL37A ribosomal protein L37a 0.0134324
NIPBL Nipped-B homolog (Drosophila) 0.0120426
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0115883
KDM6A lysine (K)-specific demethylase 6A 0.0115565
PIBF1 progesterone immunomodulatory binding factor 1 0.00802854
RUNX1 runt-related transcription factor 1 0.00798831
TTC3 tetratricopeptide repeat domain 3 0.00759188
SETD5 SET domain containing 5 0.00728627
FNIP1 folliculin interacting protein 1 0.00659848
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.00596224
KMT2C lysine (K)-specific methyltransferase 2C 0.00562386
NAP1L1 nucleosome assembly protein 1-like 1 0.003946
NF1 neurofibromin 1 0.00385517
ANXA2 annexin A2 0.00379737
NSD2 nuclear receptor binding SET domain protein 2 0.00375241
CTBP2 C-terminal binding protein 2 0.00306462
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.00215495
AFF4 AF4/FMR2 family, member 4 0.00194017
RPL26 ribosomal protein L26 0.00128993
MBD5 methyl-CpG binding domain protein 5 3.02532E-4
GOLGA4 golgin A4 2.63512E-4

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.179772
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.171391
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148988
VIM vimentin -0.13763
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.131512
AKAP12 A kinase (PRKA) anchor protein 12 -0.123602
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.102011
LAMA4 laminin, alpha 4 -0.0962974
STC1 stanniocalcin 1 -0.094123
PTMA prothymosin, alpha -0.0906988
SMC5 structural maintenance of chromosomes 5 -0.0809788
RPS6 ribosomal protein S6 -0.0714558
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0674394
EIF1 eukaryotic translation initiation factor 1 -0.0666796
LMAN1 lectin, mannose-binding, 1 -0.0664389
CCNI cyclin I -0.0651339
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0614892
IGFBP3 insulin-like growth factor binding protein 3 -0.0610019
LMNA lamin A/C -0.0572333
RPL11 ribosomal protein L11 -0.0550965
PKM pyruvate kinase, muscle -0.0542079
RB1CC1 RB1-inducible coiled-coil 1 -0.0540298
UBC ubiquitin C -0.0508147
TPM3 tropomyosin 3 -0.0505019
BHLHE40 basic helix-loop-helix family, member e40 -0.049905
PRELID2 PRELI domain containing 2 -0.0497301
TPT1 tumor protein, translationally-controlled 1 -0.0496393
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0478578
SPAG9 sperm associated antigen 9 -0.0474482
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0470649
MYO10 myosin X -0.0457599
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.045065
MAP4 microtubule-associated protein 4 -0.0448442
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.043629
ZMYND8 zinc finger, MYND-type containing 8 -0.0429659
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0429269
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0425954
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.041524
CLTC clathrin, heavy chain (Hc) -0.0392173
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0385033
FN1 fibronectin 1 -0.0345176
RPS3 ribosomal protein S3 -0.0337732
ZFC3H1 zinc finger, C3H1-type containing -0.0337401
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0335844
CANX calnexin -0.0331042
RPL13A ribosomal protein L13a -0.0330265
KTN1 kinectin 1 (kinesin receptor) -0.0326747
NKD1 naked cuticle homolog 1 (Drosophila) -0.0325449
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0324942
OSMR oncostatin M receptor -0.0322925
RPS12 ribosomal protein S12 -0.0312849
FLNB filamin B, beta -0.0312271
OGA O-GlcNAcase -0.0309474
SEC31A SEC31 homolog A (S. cerevisiae) -0.0298688
TMSB10 thymosin beta 10 -0.0298584
GRB10 growth factor receptor-bound protein 10 -0.0293946
SLTM SAFB-like, transcription modulator -0.0289061
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0280366
RPS8 ribosomal protein S8 -0.0276542
RSF1 remodeling and spacing factor 1 -0.0274442
FAM13A family with sequence similarity 13, member A -0.0271975
CNKSR3 CNKSR family member 3 -0.027062
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0269971
RCOR1 REST corepressor 1 -0.0261062
SLC38A1 solute carrier family 38, member 1 -0.0257499
AHNAK AHNAK nucleoprotein -0.0250821
SP100 SP100 nuclear antigen -0.024957
PSD3 pleckstrin and Sec7 domain containing 3 -0.0237346
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0236437
RORA RAR-related orphan receptor A -0.02276
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0221312
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0219164
NAMPT nicotinamide phosphoribosyltransferase -0.0214479
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.021363
RAB7A RAB7A, member RAS oncogene family -0.0210904
S100A6 S100 calcium binding protein A6 -0.020825
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0202927
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0202326
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0197006
PDIA3 protein disulfide isomerase family A, member 3 -0.0195388
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0188308
CALU calumenin -0.0181347
POTEF POTE ankyrin domain family, member F -0.0178693
TXNRD1 thioredoxin reductase 1 -0.0175837
DSCAM Down syndrome cell adhesion molecule -0.0170833
LDHA lactate dehydrogenase A -0.0166162
ANO6 anoctamin 6 -0.0165373
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0160508
MAP1B microtubule-associated protein 1B -0.0156475
GOLGB1 golgin B1 -0.0149065
MACF1 microtubule-actin crosslinking factor 1 -0.0148805
PDE8A phosphodiesterase 8A -0.0148534
MON2 MON2 homolog (S. cerevisiae) -0.0143932
RPL15 ribosomal protein L15 -0.0143343
LOXL2 lysyl oxidase-like 2 -0.0142896
B2M beta-2-microglobulin -0.0141797
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.013874
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0138729
SLC38A2 solute carrier family 38, member 2 -0.0133409
ELL2 elongation factor, RNA polymerase II, 2 -0.0131318