| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Encorafenib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.153045 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0923384 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0900811 |
| TENM3 | teneurin transmembrane protein 3 | 0.0899637 |
| NTM | neurotrimin | 0.0876056 |
| HDAC9 | histone deacetylase 9 | 0.0872366 |
| ANK2 | ankyrin 2, neuronal | 0.0814594 |
| FOXP2 | forkhead box P2 | 0.0806158 |
| CADM2 | cell adhesion molecule 2 | 0.0755474 |
| GPC3 | glypican 3 | 0.074437 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0741169 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0695183 |
| DST | dystonin | 0.0693736 |
| CDH19 | cadherin 19, type 2 | 0.0685057 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0677872 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0677087 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0662148 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0650072 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0598672 |
| SMYD3 | SET and MYND domain containing 3 | 0.0565696 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0502644 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0497025 |
| PEG10 | paternally expressed 10 | 0.048822 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0486018 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.047887 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0475222 |
| UTRN | utrophin | 0.0474726 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0473814 |
| METAP2 | methionyl aminopeptidase 2 | 0.0471988 |
| COL5A2 | collagen, type V, alpha 2 | 0.0468619 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0455747 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0423545 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.041709 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0414122 |
| MEIS2 | Meis homeobox 2 | 0.0409033 |
| RAD51B | RAD51 paralog B | 0.040163 |
| GLI3 | GLI family zinc finger 3 | 0.0395757 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0390229 |
| TOX | thymocyte selection-associated high mobility group box | 0.0385445 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0382474 |
| SYT1 | synaptotagmin I | 0.037955 |
| FAM171B | family with sequence similarity 171, member B | 0.036775 |
| INTS6 | integrator complex subunit 6 | 0.0367176 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0366124 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0357966 |
| HMGA2 | high mobility group AT-hook 2 | 0.0351995 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0347381 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0347281 |
| SHROOM3 | shroom family member 3 | 0.0338693 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.033749 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0331165 |
| NHSL1 | NHS-like 1 | 0.0327774 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0321272 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0320552 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0315629 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | 0.0311361 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0307941 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0303004 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0286967 |
| RASAL2 | RAS protein activator like 2 | 0.0285173 |
| APP | amyloid beta (A4) precursor protein | 0.0282221 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0282041 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0281723 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0281714 |
| PLCB4 | phospholipase C, beta 4 | 0.0272874 |
| MED13L | mediator complex subunit 13-like | 0.0271476 |
| ATXN1 | ataxin 1 | 0.0268953 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0264106 |
| MED12L | mediator complex subunit 12-like | 0.026283 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0262192 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0255182 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0252589 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0251863 |
| MACROD2 | MACRO domain containing 2 | 0.0250658 |
| SATB2 | SATB homeobox 2 | 0.0249039 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0243909 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0242784 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0242573 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0241955 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0239108 |
| HEATR5A | HEAT repeat containing 5A | 0.0238181 |
| NEBL | nebulette | 0.0236984 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0236097 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0233675 |
| ZNF385D | zinc finger protein 385D | 0.0233461 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0233144 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.023183 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0231637 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.02309 |
| TENM2 | teneurin transmembrane protein 2 | 0.0229519 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0229086 |
| NBEA | neurobeachin | 0.0227688 |
| EXOC4 | exocyst complex component 4 | 0.0227551 |
| WDR70 | WD repeat domain 70 | 0.022415 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0221237 |
| SIK3 | SIK family kinase 3 | 0.0217757 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 0.0216 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0215552 |
| PRTG | protogenin | 0.021449 |
| PHF14 | PHD finger protein 14 | 0.0212213 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.194525 |
| TMSB10 | thymosin beta 10 | -0.19363 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.119259 |
| PTMA | prothymosin, alpha | -0.117043 |
| RPS6 | ribosomal protein S6 | -0.105952 |
| PHIP | pleckstrin homology domain interacting protein | -0.079716 |
| RPS16 | ribosomal protein S16 | -0.0748079 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0696409 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0638455 |
| RPL35A | ribosomal protein L35a | -0.0631083 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0618947 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0618056 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0608951 |
| RPS8 | ribosomal protein S8 | -0.0575273 |
| GNAS | GNAS complex locus | -0.0557376 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0556508 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0555773 |
| RPL11 | ribosomal protein L11 | -0.0523195 |
| COL1A2 | collagen, type I, alpha 2 | -0.0509397 |
| RAI1 | retinoic acid induced 1 | -0.0502161 |
| RPS19 | ribosomal protein S19 | -0.0497844 |
| PFN1 | profilin 1 | -0.0481732 |
| B2M | beta-2-microglobulin | -0.0477426 |
| RPL23 | ribosomal protein L23 | -0.046807 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.046642 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0455931 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0453809 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.044501 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0432683 |
| ITGAV | integrin, alpha V | -0.0423616 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0423046 |
| H3-3B | H3.3 histone B | -0.0419573 |
| RPLP0 | ribosomal protein, large, P0 | -0.0417932 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0406544 |
| RPL12 | ribosomal protein L12 | -0.0399591 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0392772 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0392021 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0390486 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0390089 |
| RTN4 | reticulon 4 | -0.0389591 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0385337 |
| CBX3 | chromobox homolog 3 | -0.0382668 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0369291 |
| RPL9 | ribosomal protein L9 | -0.0362926 |
| TMSB4X | thymosin beta 4, X-linked | -0.0362828 |
| RPL15 | ribosomal protein L15 | -0.0362209 |
| ACTG1 | actin gamma 1 | -0.0359719 |
| PGK1 | phosphoglycerate kinase 1 | -0.0359218 |
| RPLP2 | ribosomal protein, large, P2 | -0.035501 |
| RPS25 | ribosomal protein S25 | -0.0351632 |
| RPL19 | ribosomal protein L19 | -0.0348285 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0344633 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0343571 |
| RPLP1 | ribosomal protein, large, P1 | -0.0337924 |
| FST | follistatin | -0.0337293 |
| SERF2 | small EDRK-rich factor 2 | -0.0336341 |
| THOC2 | THO complex 2 | -0.0335567 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0333088 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0333075 |
| RPL5 | ribosomal protein L5 | -0.0331989 |
| CALR | calreticulin | -0.0329356 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0328113 |
| SETD5 | SET domain containing 5 | -0.0327411 |
| RPS27A | ribosomal protein S27a | -0.0326079 |
| EMP1 | epithelial membrane protein 1 | -0.0325105 |
| S100A9 | S100 calcium binding protein A9 | -0.0322972 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.032239 |
| POTEF | POTE ankyrin domain family, member F | -0.0322231 |
| NRG1 | neuregulin 1 | -0.0321458 |
| ENO1 | enolase 1, (alpha) | -0.0316277 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0315201 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0313769 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0306314 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0302762 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0302346 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0302127 |
| CCN2 | cellular communication network factor 2 | -0.0294313 |
| RPL8 | ribosomal protein L8 | -0.0293142 |
| RPS24 | ribosomal protein S24 | -0.0291192 |
| RBM25 | RNA binding motif protein 25 | -0.0289798 |
| YBX1 | Y box binding protein 1 | -0.0288303 |
| DEK | DEK proto-oncogene | -0.0286862 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0283801 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0279065 |
| RPL34 | ribosomal protein L34 | -0.027745 |
| RPL18 | ribosomal protein L18 | -0.0276621 |
| FTL | ferritin, light polypeptide | -0.0274577 |
| FBL | fibrillarin | -0.0268598 |
| RPL26 | ribosomal protein L26 | -0.0267952 |
| RPL30 | ribosomal protein L30 | -0.0266587 |
| THBS1 | thrombospondin 1 | -0.026585 |
| HMGB1 | high mobility group box 1 | -0.02654 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0265082 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0263095 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0262054 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0260627 |
| MT2A | metallothionein 2A | -0.0256882 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0256636 |
| RPL36A | ribosomal protein L36a | -0.0256361 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0254659 |
