| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Encorafenib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Encorafenib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.221146 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.201383 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.148491 |
| HDAC9 | histone deacetylase 9 | 0.119916 |
| ANXA1 | annexin A1 | 0.0989876 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0985662 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0981822 |
| MACROD2 | MACRO domain containing 2 | 0.0755732 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0719117 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0716295 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0624495 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0622692 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0618962 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0574304 |
| EFNA5 | ephrin-A5 | 0.0549308 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0508145 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | 0.0505946 |
| PDGFC | platelet derived growth factor C | 0.0499729 |
| EGR1 | early growth response 1 | 0.049058 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0482736 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.0475839 |
| SLC38A2 | solute carrier family 38, member 2 | 0.046201 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0461663 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0461414 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0443358 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0412082 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0401785 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0397546 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0390646 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0387463 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0369623 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0362845 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0337449 |
| VCL | vinculin | 0.0332268 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0321161 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.0310009 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0309703 |
| SESN2 | sestrin 2 | 0.0303598 |
| CLIC4 | chloride intracellular channel 4 | 0.0299652 |
| EGFR | epidermal growth factor receptor | 0.0295087 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0292984 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0291877 |
| JUN | jun proto-oncogene | 0.0279693 |
| PRELID2 | PRELI domain containing 2 | 0.0276171 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0273357 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0272817 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0268426 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0263467 |
| RPS2 | ribosomal protein S2 | 0.0251805 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0247967 |
| RPS12 | ribosomal protein S12 | 0.024669 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0244056 |
| MLIP | muscular LMNA-interacting protein | 0.0240982 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0236685 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0235687 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0234802 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0234354 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0233408 |
| MCL1 | myeloid cell leukemia 1 | 0.0232687 |
| MYO9A | myosin IXA | 0.0229414 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0227615 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0227586 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0217553 |
| BPTF | bromodomain PHD finger transcription factor | 0.0213067 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.02112 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0209557 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0207543 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0207107 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0205951 |
| SMYD3 | SET and MYND domain containing 3 | 0.0205739 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0202533 |
| MYOF | myoferlin | 0.0201 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0196485 |
| MAP4 | microtubule-associated protein 4 | 0.0194552 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0193855 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0192313 |
| DIAPH3 | diaphanous-related formin 3 | 0.0191468 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0190381 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.018762 |
| FHIT | fragile histidine triad | 0.018749 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.018589 |
| APP | amyloid beta (A4) precursor protein | 0.0184755 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0182443 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0179281 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0177117 |
| FNIP1 | folliculin interacting protein 1 | 0.0176328 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0172172 |
| NMD3 | NMD3 ribosome export adaptor | 0.017187 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0169524 |
| ANK2 | ankyrin 2, neuronal | 0.0168959 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0168132 |
| GPHN | gephyrin | 0.0168063 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.016585 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0165146 |
| XPOT | exportin, tRNA | 0.0164923 |
| DST | dystonin | 0.0163216 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0162998 |
| RAD51B | RAD51 paralog B | 0.016256 |
| RPS8 | ribosomal protein S8 | 0.0162407 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0162015 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.205353 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.183298 |
| PKM | pyruvate kinase, muscle | -0.14743 |
| FLNB | filamin B, beta | -0.0954732 |
| TMSB4X | thymosin beta 4, X-linked | -0.0687905 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0678508 |
| AHNAK | AHNAK nucleoprotein | -0.0652576 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0629367 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0522839 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0480895 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0478199 |
| ZNF292 | zinc finger protein 292 | -0.0444313 |
| S100A6 | S100 calcium binding protein A6 | -0.0438851 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0430697 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0408884 |
| ECT2 | epithelial cell transforming 2 | -0.0397917 |
| GOLGA4 | golgin A4 | -0.038901 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0384988 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.036828 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0364846 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0360797 |
| RPS6 | ribosomal protein S6 | -0.0353146 |
| RBM39 | RNA binding motif protein 39 | -0.0351927 |
| GLI3 | GLI family zinc finger 3 | -0.0337666 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0336448 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0335733 |
| LOXL3 | lysyl oxidase-like 3 | -0.0317763 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0305393 |
| NAV2 | neuron navigator 2 | -0.0304103 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0301518 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0293174 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.028759 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0281813 |
| TJP1 | tight junction protein 1 | -0.0281069 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0276322 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0268312 |
| TXNIP | thioredoxin interacting protein | -0.0261918 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0259161 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0254423 |
| PYGB | phosphorylase, glycogen; brain | -0.0244609 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0244334 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0242384 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0241271 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | -0.0240146 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0239786 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0235797 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0235668 |
| PFN1 | profilin 1 | -0.023524 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0235027 |
| AHI1 | Abelson helper integration site 1 | -0.0229885 |
| NBAS | neuroblastoma amplified sequence | -0.0229237 |
| NF1 | neurofibromin 1 | -0.0229083 |
| HJURP | Holliday junction recognition protein | -0.0225904 |
| CDC73 | cell division cycle 73 | -0.0225056 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0224525 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0223391 |
| CENPF | centromere protein F, 350/400kDa | -0.0222347 |
| PGK1 | phosphoglycerate kinase 1 | -0.0221661 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0219762 |
| RNF145 | ring finger protein 145 | -0.0219377 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0211981 |
| RIGI | RNA sensor RIG-I | -0.0208125 |
| SEC24D | SEC24 family member D | -0.0207797 |
| RRBP1 | ribosome binding protein 1 | -0.0206841 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0202413 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0201642 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0201374 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0200911 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0199194 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0198218 |
| EVI5 | ecotropic viral integration site 5 | -0.0194129 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0193932 |
| S100A4 | S100 calcium binding protein A4 | -0.0193743 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | -0.0192673 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0192059 |
| MYO5C | myosin VC | -0.0191365 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0190871 |
| USP34 | ubiquitin specific peptidase 34 | -0.0190806 |
| TFG | TRK-fused gene | -0.0190614 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0190447 |
| RBM25 | RNA binding motif protein 25 | -0.0190225 |
| USP3 | ubiquitin specific peptidase 3 | -0.0189696 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0188381 |
| FOXK1 | forkhead box K1 | -0.0188248 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0188136 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0187332 |
| NUP58 | nucleoporin 58 | -0.0186868 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0183413 |
| WDR45B | WD repeat domain 45B | -0.018107 |
| RBM26 | RNA binding motif protein 26 | -0.0179631 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0179063 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0177537 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0176469 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0175223 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0175208 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0174427 |
| CUL3 | cullin 3 | -0.0173402 |
| NKTR | natural killer cell triggering receptor | -0.0172817 |
| POTEF | POTE ankyrin domain family, member F | -0.0172575 |
| HDLBP | high density lipoprotein binding protein | -0.0172284 |
