Encorafenib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Encorafenib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Encorafenib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.120012
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.093641
HDAC9 histone deacetylase 9 0.0906382
CD44 CD44 molecule (Indian blood group) 0.0627052
BICC1 BicC family RNA binding protein 1 0.0605482
RIGI RNA sensor RIG-I 0.0542819
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0515571
SFTPA2 surfactant protein A2 0.0513598
RNF213 ring finger protein 213 0.0510582
FLNA filamin A, alpha 0.0506311
RPS12 ribosomal protein S12 0.0483882
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0421878
HLA-B major histocompatibility complex, class I, B 0.0393483
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0390737
KYNU kynureninase 0.0385616
NFE2L1 nuclear factor, erythroid 2-like 1 0.0365129
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0354962
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0354167
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0316214
SP100 SP100 nuclear antigen 0.0314473
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0301572
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0295307
EXT1 exostosin glycosyltransferase 1 0.0295047
SAMD9 sterile alpha motif domain containing 9 0.0294114
MT2A metallothionein 2A 0.0290976
HLA-E major histocompatibility complex, class I, E 0.028298
PALM2AKAP2 PALM2 and AKAP2 fusion 0.028053
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.028021
C3 complement component 3 0.0263107
RACK1 receptor for activated C kinase 1 0.0261734
EIF1 eukaryotic translation initiation factor 1 0.0257835
NRP1 neuropilin 1 0.0257542
RPL37A ribosomal protein L37a 0.025063
OSBPL8 oxysterol binding protein-like 8 0.022821
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0226477
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.022556
MBNL1 muscleblind-like splicing regulator 1 0.0223357
FTH1 ferritin, heavy polypeptide 1 0.0222696
KLF6 Kruppel-like factor 6 0.0219008
WWTR1 WW domain containing transcription regulator 1 0.0218662
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0216242
PMP22 peripheral myelin protein 22 0.0215614
RPS3 ribosomal protein S3 0.0214135
TLE4 transducin-like enhancer of split 4 0.0208904
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0202941
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0200173
STC2 stanniocalcin 2 0.0199952
AHR aryl hydrocarbon receptor 0.0199716
CALR calreticulin 0.0198876
GPR176 G protein-coupled receptor 176 0.0198577
VCL vinculin 0.0198028
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0196572
BIRC3 baculoviral IAP repeat containing 3 0.0195638
GRN granulin 0.0194025
TUT7 terminal uridylyl transferase 7 0.0191334
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0189749
PCDH7 protocadherin 7 0.0189166
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.01887
CEP112 centrosomal protein 112kDa 0.0187305
ICAM1 intercellular adhesion molecule 1 0.0186557
ZC3H12B zinc finger CCCH-type containing 12B 0.0184027
DOCK1 dedicator of cytokinesis 1 0.0182742
IFIH1 interferon induced with helicase C domain 1 0.018208
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0179168
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0178143
HPCAL1 hippocalcin-like 1 0.0176609
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0171213
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0168765
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0168313
WWOX WW domain containing oxidoreductase 0.0166187
PGK1 phosphoglycerate kinase 1 0.0164335
CXCL8 chemokine (C-X-C motif) ligand 8 0.0164149
ANKRD28 ankyrin repeat domain 28 0.0163074
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0162904
UBAP2L ubiquitin associated protein 2-like 0.016158
RPS2 ribosomal protein S2 0.0159935
PHACTR4 phosphatase and actin regulator 4 0.0159598
NAP1L1 nucleosome assembly protein 1-like 1 0.0158345
BPTF bromodomain PHD finger transcription factor 0.0157814
GADD45B growth arrest and DNA-damage-inducible, beta 0.0157058
ACTG1 actin gamma 1 0.0156512
PTH2R parathyroid hormone 2 receptor 0.0156422
SMYD3 SET and MYND domain containing 3 0.0156249
THBS2 thrombospondin 2 0.015579
NABP1 nucleic acid binding protein 1 0.0154685
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0154372
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0152733
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.0150746
CD164 CD164 molecule, sialomucin 0.0150646
IFI6 interferon, alpha-inducible protein 6 0.0150289
ZNF608 zinc finger protein 608 0.0147456
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0147346
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0146929
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0146595
PCLO piccolo presynaptic cytomatrix protein 0.0144786
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0142442
EPSTI1 epithelial stromal interaction 1 (breast) 0.0142121
NUB1 negative regulator of ubiquitin-like proteins 1 0.0139103
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0139024
SQSTM1 sequestosome 1 0.0138853

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191639
SOD2 superoxide dismutase 2, mitochondrial -0.153144
FRMD4A FERM domain containing 4A -0.133012
TRIO trio Rho guanine nucleotide exchange factor -0.10635
FN1 fibronectin 1 -0.103876
AKAP12 A kinase (PRKA) anchor protein 12 -0.103122
PDE10A phosphodiesterase 10A -0.098956
RPS6 ribosomal protein S6 -0.0870043
CADM1 cell adhesion molecule 1 -0.0869623
IER3 immediate early response 3 -0.08072
VIM vimentin -0.0778368
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0769848
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0742335
ELL2 elongation factor, RNA polymerase II, 2 -0.0704412
FNDC3B fibronectin type III domain containing 3B -0.067997
ZMYND8 zinc finger, MYND-type containing 8 -0.0646591
IGFBP3 insulin-like growth factor binding protein 3 -0.0628995
RAI14 retinoic acid induced 14 -0.0544025
SFRP1 secreted frizzled-related protein 1 -0.0536934
PTMA prothymosin, alpha -0.0523384
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0519859
GOLGA4 golgin A4 -0.0516791
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0494489
MMP12 matrix metallopeptidase 12 -0.0482886
VEGFA vascular endothelial growth factor A -0.0476711
ZNF292 zinc finger protein 292 -0.0476001
MYOF myoferlin -0.0473161
UBC ubiquitin C -0.0472107
MYH9 myosin, heavy chain 9, non-muscle -0.0450772
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0439203
DLG1 discs, large homolog 1 (Drosophila) -0.043679
TMSB10 thymosin beta 10 -0.0434379
CANX calnexin -0.0419775
AHNAK AHNAK nucleoprotein -0.0418545
NAV1 neuron navigator 1 -0.0407002
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0404213
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0389839
SDK1 sidekick cell adhesion molecule 1 -0.0382496
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0381569
MSN moesin -0.0375335
PLIN2 perilipin 2 -0.0375143
FRMPD4 FERM and PDZ domain containing 4 -0.0369868
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0365804
COL1A2 collagen, type I, alpha 2 -0.0353319
SBF2 SET binding factor 2 -0.0351311
TPM1 tropomyosin 1 (alpha) -0.0350439
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0340961
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0335102
ENO1 enolase 1, (alpha) -0.0331376
ADM adrenomedullin -0.0328006
SETD5 SET domain containing 5 -0.0327528
TNS3 tensin 3 -0.0322783
S100A9 S100 calcium binding protein A9 -0.0309052
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0307444
RPS24 ribosomal protein S24 -0.0307318
PKM pyruvate kinase, muscle -0.0304133
RPLP2 ribosomal protein, large, P2 -0.0299313
TENT5A terminal nucleotidyltransferase 5A -0.0296508
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0289464
ADAM12 ADAM metallopeptidase domain 12 -0.0282681
TMSB4X thymosin beta 4, X-linked -0.0282445
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0279387
DIAPH2 diaphanous-related formin 2 -0.0277932
SNX9 sorting nexin 9 -0.0275721
TPM4 tropomyosin 4 -0.027299
NAV2 neuron navigator 2 -0.0271659
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0267918
MORF4L2 mortality factor 4 like 2 -0.0264638
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0263355
COL1A1 collagen, type I, alpha 1 -0.0262542
LOC112694756 uncharaterized LOC112694756 -0.0259165
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0254454
QKI QKI, KH domain containing, RNA binding -0.0249727
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0249244
ARFGEF3 ARFGEF family member 3 -0.0248599
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0245641
RPS21 ribosomal protein S21 -0.0243609
LCORL ligand dependent nuclear receptor corepressor-like -0.0243071
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0239529
EGFR epidermal growth factor receptor -0.0238288
PTBP3 polypyrimidine tract binding protein 3 -0.0237668
NGLY1 N-glycanase 1 -0.0236882
UGCG UDP-glucose ceramide glucosyltransferase -0.0236395
RPL19 ribosomal protein L19 -0.0235985
INSIG1 insulin induced gene 1 -0.0235864
TNIP1 TNFAIP3 interacting protein 1 -0.0234441
PFKP phosphofructokinase, platelet -0.0233446
HELZ helicase with zinc finger -0.023336
PRR16 proline rich 16 -0.0232957
ASTN2 astrotactin 2 -0.0231482
SLC35F3 solute carrier family 35, member F3 -0.0230866
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0230724
PCBP3 poly(rC) binding protein 3 -0.0229739
FLOT1 flotillin 1 -0.022654
HILPDA hypoxia inducible lipid droplet-associated -0.0225599
RRBP1 ribosome binding protein 1 -0.0222782
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0221689
BTG1 B-cell translocation gene 1, anti-proliferative -0.0219832
CDH13 cadherin 13 -0.0218911
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0217698