Endophthalmitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A globe disease that is characterized by inflammation of the inside of the eye. (Human Disease Ontology, DOID_4692)
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Genes

260 genes co-occuring with the disease Endophthalmitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
VEGFB vascular endothelial growth factor B 2.466
PGF placental growth factor 2.396
IL6 interleukin 6 2.327
UBAC1 UBA domain containing 1 2.31
RPE65 retinal pigment epithelium-specific protein 65kDa 2.298
CRP C-reactive protein, pentraxin-related 2.235
IL1B interleukin 1, beta 2.223
TNF tumor necrosis factor 2.134
ALB albumin 2.122
LGALS1 lectin, galactoside-binding, soluble, 1 2.098
TLR2 toll-like receptor 2 2.066
FLT1 fms-related tyrosine kinase 1 2.049
IFNG interferon, gamma 1.966
PLAT plasminogen activator, tissue 1.966
KDR kinase insert domain receptor 1.965
CD4 CD4 molecule 1.964
CXCL8 chemokine (C-X-C motif) ligand 8 1.959
LTF lactotransferrin 1.932
IL10 interleukin 10 1.921
CCL2 chemokine (C-C motif) ligand 2 1.89
INS insulin 1.881
ANGPT2 angiopoietin 2 1.863
FGF2 fibroblast growth factor 2 (basic) 1.858
RBP3 retinol binding protein 3, interstitial 1.854
FN1 fibronectin 1 1.838
ICAM1 intercellular adhesion molecule 1 1.811
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.806
CNTF ciliary neurotrophic factor 1.8
TLR4 toll-like receptor 4 1.792
TGFB2 transforming growth factor, beta 2 1.791
IL1A interleukin 1, alpha 1.768
ARMS2 age-related maculopathy susceptibility 2 1.759
CAMP cathelicidin antimicrobial peptide 1.75
TGFB1 transforming growth factor, beta 1 1.748
IL17A interleukin 17A 1.746
TLR5 toll-like receptor 5 1.741
CRYGS crystallin, gamma S 1.733
RHO rhodopsin 1.723
CARD9 caspase recruitment domain family, member 9 1.721
CFH complement factor H 1.719
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 1.712
FANCC Fanconi anemia, complementation group C 1.704
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 1.701
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 1.679
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.678
ACE angiotensin I converting enzyme 1.665
MYD88 myeloid differentiation primary response 88 1.654
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.654
VEGFC vascular endothelial growth factor C 1.653
COL18A1 collagen, type XVIII, alpha 1 1.64
KRT12 keratin 12, type I 1.638
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.624
C3 complement component 3 1.624
CFI complement factor I 1.623
VEGFD vascular endothelial growth factor D 1.615
OPTC opticin 1.612
CD8A CD8a molecule 1.606
IL2 interleukin 2 1.603
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.59
PLG plasminogen 1.585
TEK TEK tyrosine kinase, endothelial 1.578
FGF7 fibroblast growth factor 7 1.571
ACTB actin, beta 1.571
MMP9 matrix metallopeptidase 9 1.56
CLEC7A C-type lectin domain family 7, member A 1.558
CXCL10 chemokine (C-X-C motif) ligand 10 1.547
FGF16 fibroblast growth factor 16 1.535
EXOC1 exocyst complex component 1 1.535
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.53
FGF22 fibroblast growth factor 22 1.53
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.529
FGF6 fibroblast growth factor 6 1.528
FGF5 fibroblast growth factor 5 1.527
FGF20 fibroblast growth factor 20 1.525
CCL3 chemokine (C-C motif) ligand 3 1.523
FGF17 fibroblast growth factor 17 1.523
TJP1 tight junction protein 1 1.521
FGF18 fibroblast growth factor 18 1.52
FGF9 fibroblast growth factor 9 1.518
FGF3 fibroblast growth factor 3 1.515
FGF4 fibroblast growth factor 4 1.512
FGF8 fibroblast growth factor 8 (androgen-induced) 1.505
PDGFC platelet derived growth factor C 1.501
CSF3 colony stimulating factor 3 (granulocyte) 1.501
FGF10 fibroblast growth factor 10 1.5
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.49
MPO myeloperoxidase 1.489
RLBP1 retinaldehyde binding protein 1 1.482
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 1.469
RPGR retinitis pigmentosa GTPase regulator 1.467
IL4 interleukin 4 1.458
ICE2 interactor of little elongation complex ELL subunit 2 1.454
VIM vimentin 1.454
NGF nerve growth factor (beta polypeptide) 1.449
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 1.436
OCLN occludin 1.435
CCN2 cellular communication network factor 2 1.43
PXDN peroxidasin 1.43
ERV3-1 endogenous retrovirus group 3, member 1 1.424
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.424
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.424
TLR1 toll-like receptor 1 1.421
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 1.42
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.419
FLT4 fms-related tyrosine kinase 4 1.414
PXDNL peroxidasin-like 1.412
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.405
DEFB1 defensin, beta 1 1.389
VTN vitronectin 1.371
PTPRC protein tyrosine phosphatase, receptor type, C 1.364
ERVW-1 endogenous retrovirus group W, member 1 1.36
IREB2 iron-responsive element binding protein 2 1.353
GDNF glial cell derived neurotrophic factor 1.348
CXCL2 chemokine (C-X-C motif) ligand 2 1.342
BDNF brain-derived neurotrophic factor 1.34
JUN jun proto-oncogene 1.34
ANGPT1 angiopoietin 1 1.335
IGF1 insulin-like growth factor 1 (somatomedin C) 1.334
TLR9 toll-like receptor 9 1.332
USH2A Usher syndrome 2A (autosomal recessive, mild) 1.32
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.319
CCL4 chemokine (C-C motif) ligand 4 1.314
IFNB1 interferon, beta 1, fibroblast 1.306
EGF epidermal growth factor 1.298
CCL5 chemokine (C-C motif) ligand 5 1.294
TLR3 toll-like receptor 3 1.291
IL18 interleukin 18 1.289
LACRT lacritin 1.286
IFNA1 interferon, alpha 1 1.284
KERA keratocan 1.277
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.275
CCL11 chemokine (C-C motif) ligand 11 1.275
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.272
CD248 CD248 molecule, endosialin 1.266
RNASE7 ribonuclease, RNase A family, 7 1.266
CFB complement factor B 1.263
CD59 CD59 molecule, complement regulatory protein 1.262
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 1.26
FASLG Fas ligand (TNF superfamily, member 6) 1.257
PAX6 paired box 6 1.256
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.256
KRT3 keratin 3, type II 1.249
PDGFB platelet-derived growth factor beta polypeptide 1.246
C5 complement component 5 1.244
CNGB3 cyclic nucleotide gated channel beta 3 1.244
CCK cholecystokinin 1.241
LY96 lymphocyte antigen 96 1.237
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 1.235
IL5 interleukin 5 1.235
CLEC6A C-type lectin domain family 6, member A 1.233
AIF1 allograft inflammatory factor 1 1.229
RBPMS RNA binding protein with multiple splicing 1.228
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.222
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.221
CEP290 centrosomal protein 290kDa 1.217
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.203
VCAM1 vascular cell adhesion molecule 1 1.202
GUK1 guanylate kinase 1 1.199
C5AR1 complement component 5a receptor 1 1.198
IL13 interleukin 13 1.19
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.189
EPO erythropoietin 1.189
POU4F1 POU class 4 homeobox 1 1.185
ELN elastin 1.183
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 1.183
RCVRN recoverin 1.181
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.181
F2 coagulation factor II (thrombin) 1.178
NECTIN1 nectin cell adhesion molecule 1 1.178
CFP complement factor properdin 1.176
CFD complement factor D (adipsin) 1.175
LCN1 lipocalin 1 1.173
GIMAP5 GTPase, IMAP family member 5 1.172
DEFB4A defensin, beta 4A 1.17
PECAM1 platelet/endothelial cell adhesion molecule 1 1.17
NPR1 natriuretic peptide receptor 1 1.168
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.168
CHM choroideremia (Rab escort protein 1) 1.168
PRTN3 proteinase 3 1.166
CA5B carbonic anhydrase VB, mitochondrial 1.165
CBS cystathionine-beta-synthase 1.162
IFNA2 interferon, alpha 2 1.16
SAG S-antigen; retina and pineal gland (arrestin) 1.158
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.151
FAM120C family with sequence similarity 120C 1.15
TMSB4X thymosin beta 4, X-linked 1.147
RAD51 RAD51 recombinase 1.144
CA13 carbonic anhydrase XIII 1.144
MERTK MER proto-oncogene, tyrosine kinase 1.143
GFAP glial fibrillary acidic protein 1.14
CDH5 cadherin 5, type 2 (vascular endothelium) 1.138
CA5A carbonic anhydrase VA, mitochondrial 1.135
CD101 CD101 molecule 1.133
MMP2 matrix metallopeptidase 2 1.131
CD68 CD68 molecule 1.129
SCG3 secretogranin III 1.125
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.123
CA14 carbonic anhydrase XIV 1.122
MMP8 matrix metallopeptidase 8 1.118
VLDLR very low density lipoprotein receptor 1.116
CNGA3 cyclic nucleotide gated channel alpha 3 1.114
CA7 carbonic anhydrase VII 1.114
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.114
PTX3 pentraxin 3, long 1.114
SORD sorbitol dehydrogenase 1.111
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.105
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.103
CA8 carbonic anhydrase VIII 1.099
CXCL12 chemokine (C-X-C motif) ligand 12 1.094
VIP vasoactive intestinal peptide 1.093
RGS9 regulator of G-protein signaling 9 1.093
CCL20 chemokine (C-C motif) ligand 20 1.091
DCN decorin 1.088
NLRP3 NLR family, pyrin domain containing 3 1.084
AQP5 aquaporin 5 1.083
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.083
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.079
TPI1 triosephosphate isomerase 1 1.076
BEST1 bestrophin 1 1.068
SELE selectin E 1.068
TRAM2 translocation associated membrane protein 2 1.067
TIMP1 TIMP metallopeptidase inhibitor 1 1.067
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.065
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.065
LTA lymphotoxin alpha 1.06
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.059
CXCR2 chemokine (C-X-C motif) receptor 2 1.058
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.058
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 1.058
TLR7 toll-like receptor 7 1.053
NRP1 neuropilin 1 1.052
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.052
TAC1 tachykinin, precursor 1 1.042
PRPH2 peripherin 2 (retinal degeneration, slow) 1.039
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 1.031
MAPK3 mitogen-activated protein kinase 3 1.03
PLB1 phospholipase B1 1.03
TLR6 toll-like receptor 6 1.029
POMC proopiomelanocortin 1.028
ANXA5 annexin A5 1.027
ACE2 angiotensin I converting enzyme 2 1.027
CD80 CD80 molecule 1.025
BMP8A bone morphogenetic protein 8a 1.023
MMP3 matrix metallopeptidase 3 1.022
CA1 carbonic anhydrase I 1.022
F3 coagulation factor III (thromboplastin, tissue factor) 1.022
MSRA methionine sulfoxide reductase A 1.02
CD274 CD274 molecule 1.015
TGFA transforming growth factor, alpha 1.015
HMGB1 high mobility group box 1 1.011
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.01
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.007
CD34 CD34 molecule 1.007
DHFR dihydrofolate reductase 1.006
TOR1B torsin family 1, member B (torsin B) 1.006
CRYAA crystallin, alpha A 1.003
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.002
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 1.001
CALML6 calmodulin-like 6 1.0
CALML4 calmodulin-like 4 1.0