Entecavir (monohydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPC6 glypican 6 0.0979411
FNDC3B fibronectin type III domain containing 3B 0.0630782
CSF1 colony stimulating factor 1 (macrophage) 0.0561848
GLS2 glutaminase 2 (liver, mitochondrial) 0.0455537
NRIP1 nuclear receptor interacting protein 1 0.0437342
RUNX1 runt-related transcription factor 1 0.0415064
ATP13A3 ATPase type 13A3 0.041019
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0396399
EXT1 exostosin glycosyltransferase 1 0.0368542
MSN moesin 0.0354816
PTBP3 polypyrimidine tract binding protein 3 0.0328432
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0308589
PDE4D phosphodiesterase 4D, cAMP-specific 0.0308235
SMAD3 SMAD family member 3 0.0303442
P3H2 prolyl 3-hydroxylase 2 0.0279965
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0272026
COG5 component of oligomeric golgi complex 5 0.0270602
DLG1 discs, large homolog 1 (Drosophila) 0.0264304
UBA6 ubiquitin-like modifier activating enzyme 6 0.0247336
SBF2 SET binding factor 2 0.0244359
NAV2 neuron navigator 2 0.0244225
PAX8 paired box 8 0.0241933
KDM6A lysine (K)-specific demethylase 6A 0.0235942
FRMD4A FERM domain containing 4A 0.0234977
METTL15 methyltransferase like 15 0.0232981
PDLIM5 PDZ and LIM domain 5 0.0229231
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0225407
BIRC6 baculoviral IAP repeat containing 6 0.0218196
ARHGAP26 Rho GTPase activating protein 26 0.0209596
ZCCHC7 zinc finger, CCHC domain containing 7 0.0209121
ITGAV integrin, alpha V 0.0206903
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0205443
TXNRD1 thioredoxin reductase 1 0.0205218
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0201424
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0200958
UGCG UDP-glucose ceramide glucosyltransferase 0.019818
PTEN phosphatase and tensin homolog 0.0196122
FNIP1 folliculin interacting protein 1 0.0192865
NBAS neuroblastoma amplified sequence 0.0190111
SLTM SAFB-like, transcription modulator 0.0189975
MSR1 macrophage scavenger receptor 1 0.0189669
ECPAS Ecm29 proteasome adaptor and scaffold 0.0185985
CCNL1 cyclin L1 0.0184966
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0182815
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0182711
NFIB nuclear factor I/B 0.0182498
SNX13 sorting nexin 13 0.0179296
SP3 Sp3 transcription factor 0.0177892
EXOC4 exocyst complex component 4 0.0177598
AVL9 AVL9 homolog (S. cerevisiase) 0.0176674
MBNL1 muscleblind-like splicing regulator 1 0.0175636
STOM stomatin 0.0175562
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0174269
SND1 staphylococcal nuclease and tudor domain containing 1 0.0171771
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0171345
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0171323
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0170728
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0169211
EGFR epidermal growth factor receptor 0.0168892
MBD5 methyl-CpG binding domain protein 5 0.0168804
RTN4 reticulon 4 0.0168322
RNF216 ring finger protein 216 0.0166428
TRIO trio Rho guanine nucleotide exchange factor 0.0165238
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.016295
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0162203
WDR43 WD repeat domain 43 0.0162053
ADAM17 ADAM metallopeptidase domain 17 0.0161791
MAML2 mastermind-like 2 (Drosophila) 0.0160418
NRP1 neuropilin 1 0.0159982
SLC35F5 solute carrier family 35, member F5 0.0158439
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0157449
TNS3 tensin 3 0.0157167
CADPS2 Ca++-dependent secretion activator 2 0.015707
TMEM165 transmembrane protein 165 0.0156889
RB1CC1 RB1-inducible coiled-coil 1 0.0156678
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0155946
NF1 neurofibromin 1 0.0155817
PBX1 pre-B-cell leukemia homeobox 1 0.015539
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0155104
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0154856
USP47 ubiquitin specific peptidase 47 0.0152983
TUSC3 tumor suppressor candidate 3 0.0152703
GOLGA4 golgin A4 0.0150706
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0149407
TTC28 tetratricopeptide repeat domain 28 0.0148593
NOCT nocturnin 0.0145559
ITCH itchy E3 ubiquitin protein ligase 0.0144919
NCEH1 neutral cholesterol ester hydrolase 1 0.0143147
EML4 echinoderm microtubule associated protein like 4 0.0140398
RNF220 ring finger protein 220 0.0139619
ATXN1 ataxin 1 0.0138386
GSK3B glycogen synthase kinase 3 beta 0.0137944
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0137482
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0137283
CYLD cylindromatosis (turban tumor syndrome) 0.0137189
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0137072
RIC1 RAB6A GEF complex partner 1 0.0136528
DOCK5 dedicator of cytokinesis 5 0.0134964
DIAPH3 diaphanous-related formin 3 0.0134082
CNOT1 CCR4-NOT transcription complex, subunit 1 0.013348

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.216898
FTL ferritin, light polypeptide -0.205814
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.204035
TMSB10 thymosin beta 10 -0.18605
ASPH aspartate beta-hydroxylase -0.152497
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125242
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10471
TPT1 tumor protein, translationally-controlled 1 -0.0993013
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0974072
B2M beta-2-microglobulin -0.0945909
PTMA prothymosin, alpha -0.09301
UBC ubiquitin C -0.0886013
HLA-B major histocompatibility complex, class I, B -0.0795081
RPS27A ribosomal protein S27a -0.0755989
RPS8 ribosomal protein S8 -0.074925
CALR calreticulin -0.0747696
HSPB1 heat shock 27kDa protein 1 -0.0715258
RPS6 ribosomal protein S6 -0.0694579
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0691939
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0681358
G0S2 G0/G1 switch 2 -0.0638406
RPL19 ribosomal protein L19 -0.0611979
RPL23 ribosomal protein L23 -0.060962
RPL34 ribosomal protein L34 -0.0599146
RPLP1 ribosomal protein, large, P1 -0.0576867
ICAM1 intercellular adhesion molecule 1 -0.0562832
EIF1 eukaryotic translation initiation factor 1 -0.0527661
IGFBP3 insulin-like growth factor binding protein 3 -0.0520131
MT2A metallothionein 2A -0.0506079
S100A10 S100 calcium binding protein A10 -0.0498977
RPLP2 ribosomal protein, large, P2 -0.0496558
CCL2 chemokine (C-C motif) ligand 2 -0.0490234
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0490138
RPL8 ribosomal protein L8 -0.0490061
LMNA lamin A/C -0.048526
CAVIN1 caveolae associated protein 1 -0.0484043
RPL35A ribosomal protein L35a -0.0480339
DDIT4 DNA-damage-inducible transcript 4 -0.0476367
RPS19 ribosomal protein S19 -0.0473993
RPL12 ribosomal protein L12 -0.0469137
RPS5 ribosomal protein S5 -0.0464671
TPM4 tropomyosin 4 -0.0457549
RPL31 ribosomal protein L31 -0.0452223
RPL26 ribosomal protein L26 -0.044647
RRBP1 ribosome binding protein 1 -0.0422849
RPS24 ribosomal protein S24 -0.0421586
ANXA2 annexin A2 -0.041413
RPL28 ribosomal protein L28 -0.0414049
LOC112694756 uncharaterized LOC112694756 -0.0402585
S100A6 S100 calcium binding protein A6 -0.040088
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0388023
RAD21 RAD21 homolog (S. pombe) -0.0380201
CALU calumenin -0.0374574
RPS4X ribosomal protein S4, X-linked -0.0373461
TKT transketolase -0.0370786
HMGB1 high mobility group box 1 -0.0368607
RACK1 receptor for activated C kinase 1 -0.0365804
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0360471
JUN jun proto-oncogene -0.0356063
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.035538
PKM pyruvate kinase, muscle -0.0352568
GNAS GNAS complex locus -0.0347265
CANX calnexin -0.034266
RPLP0 ribosomal protein, large, P0 -0.0341331
HLA-C major histocompatibility complex, class I, C -0.0339936
MTDH metadherin -0.0339391
GDF15 growth differentiation factor 15 -0.0336182
RPS21 ribosomal protein S21 -0.033407
APOL1 apolipoprotein L, 1 -0.0334036
NAP1L1 nucleosome assembly protein 1-like 1 -0.0331712
RAB1A RAB1A, member RAS oncogene family -0.0323151
RPS13 ribosomal protein S13 -0.0321986
ADM adrenomedullin -0.0320862
RPL35 ribosomal protein L35 -0.0317959
APP amyloid beta (A4) precursor protein -0.0317572
SERF2 small EDRK-rich factor 2 -0.0315937
ACTG1 actin gamma 1 -0.0313482
PFN1 profilin 1 -0.0313349
CP ceruloplasmin (ferroxidase) -0.0313179
HLA-A major histocompatibility complex, class I, A -0.0310862
HLA-E major histocompatibility complex, class I, E -0.0309162
PDIA4 protein disulfide isomerase family A, member 4 -0.0306159
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0303552
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0301467
RPS3 ribosomal protein S3 -0.0301085
RPL37A ribosomal protein L37a -0.0298391
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0295237
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0293592
RPS20 ribosomal protein S20 -0.0290354
ARF1 ADP-ribosylation factor 1 -0.0290286
RPS14 ribosomal protein S14 -0.0290218
S100A9 S100 calcium binding protein A9 -0.0288986
RPL37 ribosomal protein L37 -0.0287929
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0285323
HDLBP high density lipoprotein binding protein -0.0284852
RSL1D1 ribosomal L1 domain containing 1 -0.0281984
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0277628
CD63 CD63 molecule -0.0277161
RPL7A ribosomal protein L7a -0.0277035
RPS16 ribosomal protein S16 -0.027627