Entecavir (monohydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.145803
PRKG1 protein kinase, cGMP-dependent, type I 0.141698
CADM2 cell adhesion molecule 2 0.117657
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0719185
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0664597
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0642803
JMJD1C jumonji domain containing 1C 0.0630814
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0563887
ZNF292 zinc finger protein 292 0.0531343
ZEB1 zinc finger E-box binding homeobox 1 0.0518235
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0517489
NFIB nuclear factor I/B 0.0512559
ACTG1 actin gamma 1 0.0485681
TMSB4X thymosin beta 4, X-linked 0.046922
MATR3 matrin 3 0.0449197
FGFR1 fibroblast growth factor receptor 1 0.0446975
BBX bobby sox homolog (Drosophila) 0.0441939
NAMPT nicotinamide phosphoribosyltransferase 0.0440566
TRA2A transformer 2 alpha homolog (Drosophila) 0.0411945
PCM1 pericentriolar material 1 0.0381191
GPC6 glypican 6 0.037731
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0377005
SPAG9 sperm associated antigen 9 0.0359462
FNDC3B fibronectin type III domain containing 3B 0.0351158
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0350309
UTRN utrophin 0.034628
USP9X ubiquitin specific peptidase 9, X-linked 0.034137
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0341178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0340394
LPP LIM domain containing preferred translocation partner in lipoma 0.0337971
LDHA lactate dehydrogenase A 0.0327406
SLC38A2 solute carrier family 38, member 2 0.0325662
QKI QKI, KH domain containing, RNA binding 0.0315575
CDC73 cell division cycle 73 0.0315214
BCOR BCL6 corepressor 0.031516
TSHZ2 teashirt zinc finger homeobox 2 0.0311264
MACF1 microtubule-actin crosslinking factor 1 0.0303959
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0303027
SKAP2 src kinase associated phosphoprotein 2 0.0301476
KDM5B lysine (K)-specific demethylase 5B 0.0295499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0287257
WSB1 WD repeat and SOCS box containing 1 0.0282853
ARHGAP5 Rho GTPase activating protein 5 0.0280603
EXOC4 exocyst complex component 4 0.0279353
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0278353
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0275025
AHNAK AHNAK nucleoprotein 0.0273899
EXT1 exostosin glycosyltransferase 1 0.0273739
ZBTB20 zinc finger and BTB domain containing 20 0.0273387
SUCO SUN domain containing ossification factor 0.0272899
RAB1A RAB1A, member RAS oncogene family 0.0271427
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0270825
SMYD3 SET and MYND domain containing 3 0.0267256
TTC17 tetratricopeptide repeat domain 17 0.0266591
FN1 fibronectin 1 0.0265837
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0264351
SSH2 slingshot protein phosphatase 2 0.0263983
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0263672
MARCHF7 membrane associated ring-CH-type finger 7 0.0263147
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0261902
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0261865
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0260151
EIF1 eukaryotic translation initiation factor 1 0.0259784
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0258279
KMT2E lysine (K)-specific methyltransferase 2E 0.0258168
EIF4A1 eukaryotic translation initiation factor 4A1 0.0257433
SIK3 SIK family kinase 3 0.0253803
SFTPA2 surfactant protein A2 0.0252793
PDE4B phosphodiesterase 4B, cAMP-specific 0.0248829
CUX1 cut-like homeobox 1 0.0247054
DST dystonin 0.0245817
ATG10 autophagy related 10 0.0243051
MED13 mediator complex subunit 13 0.0242358
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0240149
STAG2 stromal antigen 2 0.0240083
MYO9A myosin IXA 0.0239595
COL1A2 collagen, type I, alpha 2 0.0239001
AKAP13 A kinase (PRKA) anchor protein 13 0.0238871
SLMAP sarcolemma associated protein 0.0238722
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0238458
RANBP17 RAN binding protein 17 0.0237598
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0236294
FCHSD2 FCH and double SH3 domains 2 0.023608
PUM2 pumilio RNA-binding family member 2 0.0233196
ZFR zinc finger RNA binding protein 0.0230535
ANLN anillin, actin binding protein 0.0229007
FOXP1 forkhead box P1 0.0228777
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0226415
NKTR natural killer cell triggering receptor 0.0225951
TRA2B transformer 2 beta homolog (Drosophila) 0.0225126
CAPRIN1 cell cycle associated protein 1 0.0224529
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0224516
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0224131
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0223984
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0223506
SOX6 SRY (sex determining region Y)-box 6 0.0223177
CCNY cyclin Y 0.0222086
HMGA2 high mobility group AT-hook 2 0.0221203
JAZF1 JAZF zinc finger 1 0.0221141
MICU1 mitochondrial calcium uptake 1 0.0219292

decreased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript -0.214655
VIM vimentin -0.0468511
RPS6 ribosomal protein S6 -0.0458193
FTL ferritin, light polypeptide -0.0299403
RPL19 ribosomal protein L19 -0.0269981
RPS8 ribosomal protein S8 -0.0268352
LOC112694756 uncharaterized LOC112694756 -0.0263348
MGP matrix Gla protein -0.026267
RPS23 ribosomal protein S23 -0.0257178
VEGFA vascular endothelial growth factor A -0.0255063
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0249835
RPS17 ribosomal protein S17 -0.0244822
RPS19 ribosomal protein S19 -0.0241579
PTMA prothymosin, alpha -0.0237268
MSRB3 methionine sulfoxide reductase B3 -0.0229373
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0218559
AKAP9 A kinase (PRKA) anchor protein 9 -0.0217555
PKM pyruvate kinase, muscle -0.0213222
SOX4 SRY (sex determining region Y)-box 4 -0.0212595
CALD1 caldesmon 1 -0.0209325
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0207773
RPLP2 ribosomal protein, large, P2 -0.0202408
UBAP2 ubiquitin associated protein 2 -0.0200756
RPL12 ribosomal protein L12 -0.0198865
TUT4 terminal uridylyl transferase 4 -0.0196576
S100A9 S100 calcium binding protein A9 -0.0196527
RPL5 ribosomal protein L5 -0.0196032
PAIP2 poly(A) binding protein interacting protein 2 -0.0192341
RBM27 RNA binding motif protein 27 -0.0191537
TMSB10 thymosin beta 10 -0.0189277
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0187554
EGR1 early growth response 1 -0.0186719
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0183713
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0182769
LARP1 La ribonucleoprotein domain family, member 1 -0.018265
MDN1 MDN1, midasin homolog (yeast) -0.0180383
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0178239
RPL7A ribosomal protein L7a -0.0173979
PDGFC platelet derived growth factor C -0.0173193
MT2A metallothionein 2A -0.0172504
SRRM1 serine/arginine repetitive matrix 1 -0.0171605
RPS14 ribosomal protein S14 -0.0171593
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.0168108
RPS27 ribosomal protein S27 -0.0167169
LINGO2 leucine rich repeat and Ig domain containing 2 -0.016689
SLK STE20-like kinase -0.0164318
SAMD4B sterile alpha motif domain containing 4B -0.0163991
PFN1 profilin 1 -0.0160897
TSC22D2 TSC22 domain family, member 2 -0.0160198
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -0.0152456
YBX1 Y box binding protein 1 -0.0151285
IGF2 insulin-like growth factor 2 -0.0150289
RPS15 ribosomal protein S15 -0.0148458
TMEM117 transmembrane protein 117 -0.0145933
RPL31 ribosomal protein L31 -0.0145292
SRRM2 serine/arginine repetitive matrix 2 -0.0142264
ATXN2 ataxin 2 -0.0142084
EEF1G eukaryotic translation elongation factor 1 gamma -0.014187
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0141457
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -0.0141115
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.013977
TMEM59 transmembrane protein 59 -0.0139717
MRC2 mannose receptor, C type 2 -0.0139674
PITPNB phosphatidylinositol transfer protein, beta -0.0139542
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -0.0138549
FNBP4 formin binding protein 4 -0.0138178
SKIC3 SKI3 subunit of superkiller complex -0.0137634
SECISBP2L SECIS binding protein 2-like -0.0135469
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0135418
MGA MGA, MAX dimerization protein -0.0134274
OSBPL3 oxysterol binding protein-like 3 -0.013416
RPLP0 ribosomal protein, large, P0 -0.0134095
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0133332
UBB ubiquitin B -0.0132688
RPL13A ribosomal protein L13a -0.013237
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0132292
ZNF695 zinc finger protein 695 -0.0131299
DCAF7 DDB1 and CUL4 associated factor 7 -0.0130951
RPL36AL ribosomal protein L36a-like -0.0130923
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0130675
ZNF207 zinc finger protein 207 -0.0130628
RPL35 ribosomal protein L35 -0.0129949
TBCA tubulin folding cofactor A -0.0129451
NUCB2 nucleobindin 2 -0.0129126
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0128406
RPS2 ribosomal protein S2 -0.0128229
ZNF236 zinc finger protein 236 -0.0127994
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0127429
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0127353
RPS29 ribosomal protein S29 -0.0125755
SUCLG1 succinate-CoA ligase, alpha subunit -0.0125494
RPL36 ribosomal protein L36 -0.0124402
RC3H2 ring finger and CCCH-type domains 2 -0.0124369
RPS11 ribosomal protein S11 -0.0124304
ATP5F1B ATP synthase F1 subunit beta -0.0124022
SRSF3 serine/arginine-rich splicing factor 3 -0.0123807
THBS1 thrombospondin 1 -0.0123415
VKORC1 vitamin K epoxide reductase complex, subunit 1 -0.0123388
ATRN attractin -0.012288
FTH1 ferritin, heavy polypeptide 1 -0.0122542