Entecavir (monohydrate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.142596
FLNB filamin B, beta 0.111945
ERRFI1 ERBB receptor feedback inhibitor 1 0.0927488
ESYT2 extended synaptotagmin-like protein 2 0.0777997
GRB10 growth factor receptor-bound protein 10 0.0724022
UBA6 ubiquitin-like modifier activating enzyme 6 0.069824
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0672179
ITGA6 integrin, alpha 6 0.0602934
EFNA5 ephrin-A5 0.0585047
TSC22D2 TSC22 domain family, member 2 0.0533129
SPAG9 sperm associated antigen 9 0.0513223
FNDC3B fibronectin type III domain containing 3B 0.0504385
FAM3C family with sequence similarity 3, member C 0.0476982
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.047408
ITPRID2 ITPR interacting domain containing 2 0.0468735
PSD3 pleckstrin and Sec7 domain containing 3 0.0436489
FAM13A family with sequence similarity 13, member A 0.0425457
CORO1C coronin, actin binding protein, 1C 0.0420347
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0410551
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0410004
DOCK5 dedicator of cytokinesis 5 0.038759
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0387561
PICALM phosphatidylinositol binding clathrin assembly protein 0.0369819
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0366192
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0357884
SMAD3 SMAD family member 3 0.0353127
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0351337
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0350875
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0342749
NAMPT nicotinamide phosphoribosyltransferase 0.0341498
GLS2 glutaminase 2 (liver, mitochondrial) 0.0337025
RICTOR RPTOR independent companion of MTOR, complex 2 0.0335969
DPY19L1 dpy-19-like 1 (C. elegans) 0.033069
TRRAP transformation/transcription domain-associated protein 0.0309976
NPTN neuroplastin 0.0308479
ATP13A3 ATPase type 13A3 0.030005
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0293985
EZR ezrin 0.0285274
LMTK2 lemur tyrosine kinase 2 0.0280169
PELI1 pellino E3 ubiquitin protein ligase 1 0.0279878
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0278009
ANXA1 annexin A1 0.0275736
FOXO1 forkhead box O1 0.0272323
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.02709
VCAN versican 0.0262491
ZEB1 zinc finger E-box binding homeobox 1 0.0262444
STK39 serine threonine kinase 39 0.025712
SGMS2 sphingomyelin synthase 2 0.0254504
ZNF292 zinc finger protein 292 0.025422
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0250759
FMNL2 formin-like 2 0.0248008
PTPRR protein tyrosine phosphatase, receptor type, R 0.0245986
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0245753
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0245738
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0244772
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0243718
TRIO trio Rho guanine nucleotide exchange factor 0.0240897
FAM107B family with sequence similarity 107, member B 0.0238988
TGM2 transglutaminase 2 0.0232974
PDE8A phosphodiesterase 8A 0.0228734
MUC17 mucin 17, cell surface associated 0.0227645
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0226003
TMCC3 transmembrane and coiled-coil domain family 3 0.0220526
EGFR epidermal growth factor receptor 0.0218524
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0218342
ARL5B ADP-ribosylation factor-like 5B 0.0218165
APLP2 amyloid beta (A4) precursor-like protein 2 0.0217369
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0216917
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0216619
SEPTIN10 septin 10 0.0213568
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.021323
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0208364
FAT1 FAT atypical cadherin 1 0.0206503
CCNL1 cyclin L1 0.0206408
ARHGAP42 Rho GTPase activating protein 42 0.0204951
EPAS1 endothelial PAS domain protein 1 0.0203076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0202225
ANO6 anoctamin 6 0.0200609
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0200131
IGFBP3 insulin-like growth factor binding protein 3 0.0198726
YAP1 Yes-associated protein 1 0.0197907
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0197153
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0191705
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0191474
AHR aryl hydrocarbon receptor 0.0189193
PPARD peroxisome proliferator-activated receptor delta 0.0188854
PARD3 par-3 family cell polarity regulator 0.0188494
TUFT1 tuftelin 1 0.0187447
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.018683
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0186692
ITGAV integrin, alpha V 0.0185913
SPRED2 sprouty-related, EVH1 domain containing 2 0.018525
TPM3 tropomyosin 3 0.0184814
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0183469
KDM6A lysine (K)-specific demethylase 6A 0.0180965
INSIG2 insulin induced gene 2 0.0180158
MSN moesin 0.0179735
MYH9 myosin, heavy chain 9, non-muscle 0.017778
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0177277
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0173816

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.343897
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.168811
VIM vimentin -0.163724
PTMA prothymosin, alpha -0.142954
TPT1 tumor protein, translationally-controlled 1 -0.135734
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.102247
ACTG1 actin gamma 1 -0.0986976
S100A10 S100 calcium binding protein A10 -0.0810849
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0782818
HMGA1 high mobility group AT-hook 1 -0.0774574
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0768903
EIF1 eukaryotic translation initiation factor 1 -0.0709527
S100A6 S100 calcium binding protein A6 -0.0695556
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0671717
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0663127
FTL ferritin, light polypeptide -0.064442
RPS3 ribosomal protein S3 -0.0630229
S100A4 S100 calcium binding protein A4 -0.061573
RPL35A ribosomal protein L35a -0.0575799
KRT18 keratin 18, type I -0.0566272
RPL12 ribosomal protein L12 -0.056048
LAMB3 laminin, beta 3 -0.0555183
RPS13 ribosomal protein S13 -0.0552278
SLC35F3 solute carrier family 35, member F3 -0.0542948
RPLP2 ribosomal protein, large, P2 -0.0533888
RPL31 ribosomal protein L31 -0.0533564
RPL37A ribosomal protein L37a -0.0531051
GREB1L growth regulation by estrogen in breast cancer-like -0.0528318
B2M beta-2-microglobulin -0.0505428
RPL34 ribosomal protein L34 -0.0505144
RPS8 ribosomal protein S8 -0.0499067
UBC ubiquitin C -0.0495516
RPL8 ribosomal protein L8 -0.0491646
RPL11 ribosomal protein L11 -0.0486798
RPS23 ribosomal protein S23 -0.0484023
S100A11 S100 calcium binding protein A11 -0.046151
RPS27A ribosomal protein S27a -0.04542
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0442807
RPS21 ribosomal protein S21 -0.0439659
RPS14 ribosomal protein S14 -0.0436104
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0424105
RPS27 ribosomal protein S27 -0.0419963
RPLP1 ribosomal protein, large, P1 -0.0419148
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0418542
MYL12B myosin, light chain 12B, regulatory -0.0408468
RPS6 ribosomal protein S6 -0.0406398
RPL32 ribosomal protein L32 -0.0406023
HDLBP high density lipoprotein binding protein -0.0403594
RPL37 ribosomal protein L37 -0.0388311
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0386283
RPL26 ribosomal protein L26 -0.0383371
TMSB4X thymosin beta 4, X-linked -0.0381962
TM4SF1 transmembrane 4 L six family member 1 -0.0376859
RPL7A ribosomal protein L7a -0.0376756
LMO7 LIM domain 7 -0.0372006
KIF5B kinesin family member 5B -0.0371491
CD2AP CD2-associated protein -0.0369481
GNAS GNAS complex locus -0.0367944
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0365808
RPL23 ribosomal protein L23 -0.0363776
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0359946
RPS19 ribosomal protein S19 -0.0359329
F3 coagulation factor III (thromboplastin, tissue factor) -0.035035
GARS1 glycyl-tRNA synthetase 1 -0.0348753
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0346787
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0338779
KRT8 keratin 8, type II -0.0338519
RPL19 ribosomal protein L19 -0.0338248
PGK1 phosphoglycerate kinase 1 -0.0337944
RPS25 ribosomal protein S25 -0.0333969
EPCAM epithelial cell adhesion molecule -0.033247
RASAL2 RAS protein activator like 2 -0.0328114
RPS24 ribosomal protein S24 -0.0327589
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0326982
RPL36A ribosomal protein L36a -0.0325068
PERP PERP, TP53 apoptosis effector -0.0321707
ANXA2 annexin A2 -0.0319973
RPS29 ribosomal protein S29 -0.0318132
RPLP0 ribosomal protein, large, P0 -0.0313528
RRBP1 ribosome binding protein 1 -0.031305
AKAP12 A kinase (PRKA) anchor protein 12 -0.0312076
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0299745
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0296812
EIF5B eukaryotic translation initiation factor 5B -0.0295071
RPL30 ribosomal protein L30 -0.0291695
RPL9 ribosomal protein L9 -0.0291556
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0288862
LY6E lymphocyte antigen 6 complex, locus E -0.0285963
POTEF POTE ankyrin domain family, member F -0.0284773
RPL7 ribosomal protein L7 -0.0281971
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0280004
RPL5 ribosomal protein L5 -0.027988
RACK1 receptor for activated C kinase 1 -0.0275783
NPSR1 neuropeptide S receptor 1 -0.0274138
RPL13A ribosomal protein L13a -0.0270755
RPL36 ribosomal protein L36 -0.02688
RPL10A ribosomal protein L10a -0.0266222
RSL1D1 ribosomal L1 domain containing 1 -0.0264415
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.026335
RPL27A ribosomal protein L27a -0.0261082