Entecavir (monohydrate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.158496
ADGRG6 adhesion G protein-coupled receptor G6 0.112065
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.107681
NPAS3 neuronal PAS domain protein 3 0.094291
USP9X ubiquitin specific peptidase 9, X-linked 0.0904413
JMJD1C jumonji domain containing 1C 0.0875605
SMYD3 SET and MYND domain containing 3 0.0808936
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0723983
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0703522
NUP58 nucleoporin 58 0.0693621
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0665276
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0627679
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0624519
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0616233
LDHA lactate dehydrogenase A 0.0594505
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0569383
ZFAND3 zinc finger, AN1-type domain 3 0.056207
PIAS2 protein inhibitor of activated STAT, 2 0.0553638
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0524487
MATR3 matrin 3 0.0516736
DST dystonin 0.0513574
FMNL2 formin-like 2 0.0510898
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0510692
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0508099
CDH18 cadherin 18, type 2 0.0507535
SETD5 SET domain containing 5 0.0503886
NF1 neurofibromin 1 0.0497555
TOX thymocyte selection-associated high mobility group box 0.0488144
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0475517
SOX5 SRY (sex determining region Y)-box 5 0.0470733
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0469453
AUTS2 autism susceptibility candidate 2 0.046799
FOXO3 forkhead box O3 0.0461672
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0459757
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0455736
WSB1 WD repeat and SOCS box containing 1 0.0455202
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0452315
SHROOM3 shroom family member 3 0.0452183
MED13L mediator complex subunit 13-like 0.045191
ZNF292 zinc finger protein 292 0.0450144
UBA6 ubiquitin-like modifier activating enzyme 6 0.0445241
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0445013
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.044441
CADM2 cell adhesion molecule 2 0.0442357
NALF1 NALCN channel auxiliary factor 1 0.0430201
KMT2C lysine (K)-specific methyltransferase 2C 0.0428162
NAMPT nicotinamide phosphoribosyltransferase 0.0425322
NGLY1 N-glycanase 1 0.040997
COL5A2 collagen, type V, alpha 2 0.0407445
SYAP1 synapse associated protein 1 0.0407393
TET2 tet methylcytosine dioxygenase 2 0.0406867
KDM1A lysine (K)-specific demethylase 1A 0.0402452
TBK1 TANK-binding kinase 1 0.0396857
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0396481
CDC73 cell division cycle 73 0.0394676
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0389996
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0388337
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0387004
KPNB1 karyopherin (importin) beta 1 0.0384636
ZFP36L1 ZFP36 ring finger protein-like 1 0.0379369
BIRC6 baculoviral IAP repeat containing 6 0.0377172
RLF rearranged L-myc fusion 0.0376528
TENM3 teneurin transmembrane protein 3 0.0376099
RAD51B RAD51 paralog B 0.0370612
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0364798
ZNF608 zinc finger protein 608 0.0362447
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0362097
WAC WW domain containing adaptor with coiled-coil 0.0361703
ADAR adenosine deaminase, RNA-specific 0.0359786
PARD3 par-3 family cell polarity regulator 0.0358061
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0352909
ARB2A ARB2 cotranscriptional regulator A 0.0352375
MAP4 microtubule-associated protein 4 0.0348748
TAOK1 TAO kinase 1 0.0346819
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0346436
MIMS1 mitochondrial inner membrane scaffold 1 0.0345795
KDM6A lysine (K)-specific demethylase 6A 0.0344138
ZSWIM6 zinc finger, SWIM-type containing 6 0.0343726
ADNP activity-dependent neuroprotector homeobox 0.0342949
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0342663
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0341658
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0341219
XPO1 exportin 1 0.0340929
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0338147
PTK2 protein tyrosine kinase 2 0.0336229
TM9SF3 transmembrane 9 superfamily member 3 0.0335014
PUM2 pumilio RNA-binding family member 2 0.0333945
SLF1 SMC5-SMC6 complex localization factor 1 0.0332911
WWC2 WW and C2 domain containing 2 0.0332479
KIAA1958 KIAA1958 0.0329284
GRID2 glutamate receptor, ionotropic, delta 2 0.0327947
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0327939
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0321619
TMEM41B transmembrane protein 41B 0.0321147
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0320966
OGA O-GlcNAcase 0.0319961
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0318428
QKI QKI, KH domain containing, RNA binding 0.0317475
VMP1 vacuole membrane protein 1 0.0316329
CLIC4 chloride intracellular channel 4 0.0316271

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.0758677
TMSB10 thymosin beta 10 -0.0728218
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0652887
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.052207
RPL23 ribosomal protein L23 -0.0517392
RPL11 ribosomal protein L11 -0.0506659
RPS21 ribosomal protein S21 -0.0444421
RPS19 ribosomal protein S19 -0.0416555
RPL19 ribosomal protein L19 -0.0382313
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0362186
RPL28 ribosomal protein L28 -0.0352704
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0339519
RPL31 ribosomal protein L31 -0.033597
RPLP1 ribosomal protein, large, P1 -0.0314263
RPS8 ribosomal protein S8 -0.0309223
RPL34 ribosomal protein L34 -0.0307386
RPL32 ribosomal protein L32 -0.0301464
RPS15 ribosomal protein S15 -0.0294156
RPL12 ribosomal protein L12 -0.028849
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.028192
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0279322
RPL35A ribosomal protein L35a -0.0268541
MT2A metallothionein 2A -0.0266258
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0264305
ACTG1 actin gamma 1 -0.0264274
RPL5 ribosomal protein L5 -0.0264087
RPL36 ribosomal protein L36 -0.0262349
RPL38 ribosomal protein L38 -0.0253828
RPS12 ribosomal protein S12 -0.0244936
HDAC4 histone deacetylase 4 -0.0237269
RPLP2 ribosomal protein, large, P2 -0.0233504
PTMA prothymosin, alpha -0.0232522
RPS29 ribosomal protein S29 -0.0231811
CANX calnexin -0.0229163
IGF2 insulin-like growth factor 2 -0.0228831
RPL18 ribosomal protein L18 -0.0226519
COL11A1 collagen, type XI, alpha 1 -0.021861
RPS23 ribosomal protein S23 -0.0212096
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0210234
INTS6 integrator complex subunit 6 -0.0209836
RPL37A ribosomal protein L37a -0.0209256
TRAF3 TNF receptor-associated factor 3 -0.0209058
RPL13A ribosomal protein L13a -0.020676
WLS wntless Wnt ligand secretion mediator -0.0205704
TOM1L2 target of myb1-like 2 (chicken) -0.0196323
RCC1 regulator of chromosome condensation 1 -0.0194506
RPL35 ribosomal protein L35 -0.0190352
RPS27 ribosomal protein S27 -0.0189684
RPS3 ribosomal protein S3 -0.0189337
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0182639
MSH4 mutS homolog 4 -0.0181311
WDR27 WD repeat domain 27 -0.0181075
LAMA5 laminin, alpha 5 -0.018073
CENPE centromere protein E, 312kDa -0.0179891
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0178419
RPS27A ribosomal protein S27a -0.0175498
EIF5B eukaryotic translation initiation factor 5B -0.0169952
TMEM259 transmembrane protein 259 -0.0169247
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0168557
KDM4B lysine (K)-specific demethylase 4B -0.0167121
TMEM117 transmembrane protein 117 -0.0166336
PFN1 profilin 1 -0.0165611
NDUFA4 NDUFA4, mitochondrial complex associated -0.0163354
NUP107 nucleoporin 107kDa -0.0159435
CCAR1 cell division cycle and apoptosis regulator 1 -0.0158846
PTMS parathymosin -0.0158426
CENPF centromere protein F, 350/400kDa -0.0157951
ISG15 ISG15 ubiquitin-like modifier -0.0157559
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0157474
RPS10 ribosomal protein S10 -0.0156324
USO1 USO1 vesicle transport factor -0.0155978
HMGA1 high mobility group AT-hook 1 -0.0149745
VIM vimentin -0.0147686
RPL9 ribosomal protein L9 -0.0147053
DCAF7 DDB1 and CUL4 associated factor 7 -0.014679
RPTOR regulatory associated protein of MTOR, complex 1 -0.0146771
S100A9 S100 calcium binding protein A9 -0.0145287
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0143871
PA2G4 proliferation-associated 2G4, 38kDa -0.0142804
RPS14 ribosomal protein S14 -0.014252
RPS5 ribosomal protein S5 -0.0141712
SON SON DNA binding protein -0.0141585
ATP5MK ATP synthase membrane subunit k -0.0141178
RPL7 ribosomal protein L7 -0.0140704
IFI6 interferon, alpha-inducible protein 6 -0.0140364
TPT1 tumor protein, translationally-controlled 1 -0.013964
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -0.0138794
ATP5F1E ATP synthase F1 subunit epsilon -0.0137738
RPL37 ribosomal protein L37 -0.013772
LYST lysosomal trafficking regulator -0.0137692
PTPRS protein tyrosine phosphatase, receptor type, S -0.0136767
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -0.0136467
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0134984
HINT1 histidine triad nucleotide binding protein 1 -0.0133854
ARMH4 armadillo like helical domain containing 4 -0.0133561
PHF14 PHD finger protein 14 -0.0133399
ZNF395 zinc finger protein 395 -0.0132498
GUK1 guanylate kinase 1 -0.0132476
ATF4 activating transcription factor 4 -0.0131444
PMM2 phosphomannomutase 2 -0.0130859