Entecavir (monohydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0830211
FAM13A family with sequence similarity 13, member A 0.0775076
HELZ helicase with zinc finger 0.0694409
MEF2A myocyte enhancer factor 2A 0.0671723
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0646449
SOS1 son of sevenless homolog 1 (Drosophila) 0.0627646
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0563187
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0562649
MEIS2 Meis homeobox 2 0.0503878
DSCAM Down syndrome cell adhesion molecule 0.0481696
FNDC3B fibronectin type III domain containing 3B 0.0477651
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0432781
BIRC6 baculoviral IAP repeat containing 6 0.0358986
PTEN phosphatase and tensin homolog 0.034484
LIMCH1 LIM and calponin homology domains 1 0.0344054
SPAG9 sperm associated antigen 9 0.0335976
PELI1 pellino E3 ubiquitin protein ligase 1 0.0322443
TRIO trio Rho guanine nucleotide exchange factor 0.031564
YEATS2 YEATS domain containing 2 0.0304558
ZFC3H1 zinc finger, C3H1-type containing 0.0304084
FNBP1 formin binding protein 1 0.0303018
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0300976
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0296257
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0292948
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0292894
ITPRID2 ITPR interacting domain containing 2 0.0290304
DST dystonin 0.0288916
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0288319
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0275878
MBNL2 muscleblind-like splicing regulator 2 0.0271615
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270138
PDE4D phosphodiesterase 4D, cAMP-specific 0.0266759
TPST1 tyrosylprotein sulfotransferase 1 0.0265971
APP amyloid beta (A4) precursor protein 0.0257364
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0257013
RC3H1 ring finger and CCCH-type domains 1 0.0253946
ETNK1 ethanolamine kinase 1 0.0250121
MAP1B microtubule-associated protein 1B 0.0249421
ZBTB20 zinc finger and BTB domain containing 20 0.0249101
CD46 CD46 molecule, complement regulatory protein 0.0241631
SEC31A SEC31 homolog A (S. cerevisiae) 0.023989
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0239853
RUNX1 runt-related transcription factor 1 0.0238828
ZNF148 zinc finger protein 148 0.0237278
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0235248
TENT5A terminal nucleotidyltransferase 5A 0.0233956
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0233309
NREP neuronal regeneration related protein 0.023312
ZNF292 zinc finger protein 292 0.0229773
C1ORF21 chromosome 1 open reading frame 21 0.0229625
PRKD1 protein kinase D1 0.0228827
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0227674
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0226918
HMBOX1 homeobox containing 1 0.0224717
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0220638
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.021775
KMT2C lysine (K)-specific methyltransferase 2C 0.0217295
MYH10 myosin, heavy chain 10, non-muscle 0.0213509
LINGO2 leucine rich repeat and Ig domain containing 2 0.0212939
CDC73 cell division cycle 73 0.0210116
POU2F1 POU class 2 homeobox 1 0.0208397
CENPF centromere protein F, 350/400kDa 0.0207859
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0207029
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0206025
NAMPT nicotinamide phosphoribosyltransferase 0.0205457
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0203993
RAB30 RAB30, member RAS oncogene family 0.0202692
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.020209
ANKRD12 ankyrin repeat domain 12 0.0201317
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0199913
ZFAND3 zinc finger, AN1-type domain 3 0.0198965
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0198143
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0197341
RFC3 replication factor C (activator 1) 3, 38kDa 0.0196817
OGA O-GlcNAcase 0.01962
PCBP3 poly(rC) binding protein 3 0.0195191
FER fer (fps/fes related) tyrosine kinase 0.0194049
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0193964
ARHGAP9 Rho GTPase activating protein 9 0.0192974
AKAP12 A kinase (PRKA) anchor protein 12 0.019255
SLITRK6 SLIT and NTRK-like family, member 6 0.0191335
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0191125
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0189307
KCTD3 potassium channel tetramerization domain containing 3 0.0188934
MARCHF6 membrane associated ring-CH-type finger 6 0.0187329
SSH2 slingshot protein phosphatase 2 0.0187277
RFX7 regulatory factor X, 7 0.0185396
TBCK TBC1 domain containing kinase 0.0183823
BRWD1 bromodomain and WD repeat domain containing 1 0.0183796
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0183011
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0182456
KIDINS220 kinase D-interacting substrate, 220kDa 0.0181853
LCORL ligand dependent nuclear receptor corepressor-like 0.018167
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0180442
SMAD3 SMAD family member 3 0.0180141
MKI67 marker of proliferation Ki-67 0.0180027
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0179279
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0179016
CHD1 chromodomain helicase DNA binding protein 1 0.0178942
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0175002

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.279147
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185776
VIM vimentin -0.144557
PTMA prothymosin, alpha -0.138447
IGF2 insulin-like growth factor 2 -0.136331
RPS6 ribosomal protein S6 -0.122343
VCL vinculin -0.108844
RPL23 ribosomal protein L23 -0.0825423
RPL35A ribosomal protein L35a -0.0810439
NRG1 neuregulin 1 -0.080521
RPL19 ribosomal protein L19 -0.080417
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0802413
RPLP1 ribosomal protein, large, P1 -0.0788178
RPL34 ribosomal protein L34 -0.0737281
ACTG1 actin gamma 1 -0.0712983
LSAMP limbic system-associated membrane protein -0.0694927
RPL38 ribosomal protein L38 -0.0662639
RPS19 ribosomal protein S19 -0.0637822
TPT1 tumor protein, translationally-controlled 1 -0.061685
TMSB10 thymosin beta 10 -0.05708
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0567108
RPL32 ribosomal protein L32 -0.0541951
RPS3 ribosomal protein S3 -0.0511665
HILPDA hypoxia inducible lipid droplet-associated -0.050494
RPL37A ribosomal protein L37a -0.0492027
FTL ferritin, light polypeptide -0.0491445
RPS24 ribosomal protein S24 -0.0489423
RPS12 ribosomal protein S12 -0.0482903
RPL12 ribosomal protein L12 -0.0475444
RPL26 ribosomal protein L26 -0.0447908
RPS27 ribosomal protein S27 -0.0431746
TPM1 tropomyosin 1 (alpha) -0.0430479
RPL31 ribosomal protein L31 -0.0429626
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0421071
RPL37 ribosomal protein L37 -0.0410886
B2M beta-2-microglobulin -0.0398483
THSD4 thrombospondin, type I, domain containing 4 -0.0392496
EGR1 early growth response 1 -0.0387401
S100A9 S100 calcium binding protein A9 -0.03792
EIF1 eukaryotic translation initiation factor 1 -0.0368453
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0356719
RPS8 ribosomal protein S8 -0.0352649
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0350991
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0350944
RPL36 ribosomal protein L36 -0.0348538
RPL28 ribosomal protein L28 -0.0347921
RPL35 ribosomal protein L35 -0.0347648
FERMT2 fermitin family member 2 -0.0344064
RPS14 ribosomal protein S14 -0.0341766
NALF1 NALCN channel auxiliary factor 1 -0.0336655
RACK1 receptor for activated C kinase 1 -0.033203
RNF213 ring finger protein 213 -0.0331707
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.032274
TPM4 tropomyosin 4 -0.0318213
RPL13A ribosomal protein L13a -0.0317649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0317592
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0310207
IER3 immediate early response 3 -0.0307207
RPS25 ribosomal protein S25 -0.0306507
RPLP2 ribosomal protein, large, P2 -0.0301924
RPS17 ribosomal protein S17 -0.0300094
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0299226
RPS23 ribosomal protein S23 -0.0298025
GNAS GNAS complex locus -0.0297592
RPL7 ribosomal protein L7 -0.0293606
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0293078
LPIN1 lipin 1 -0.0289852
RPL27 ribosomal protein L27 -0.0282246
RPS29 ribosomal protein S29 -0.0278435
SP100 SP100 nuclear antigen -0.0277602
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0277197
RPS11 ribosomal protein S11 -0.0276953
RPS13 ribosomal protein S13 -0.0276206
RPS16 ribosomal protein S16 -0.0273189
RPL7A ribosomal protein L7a -0.027012
NDRG1 N-myc downstream regulated 1 -0.0269895
TRIB2 tribbles pseudokinase 2 -0.0268283
MX2 MX dynamin-like GTPase 2 -0.026626
LIMA1 LIM domain and actin binding 1 -0.026598
PRRC2C proline-rich coiled-coil 2C -0.0265149
NACA nascent polypeptide-associated complex alpha subunit -0.026458
KCNIP4 Kv channel interacting protein 4 -0.0260503
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0260434
PFN1 profilin 1 -0.0256749
SERF2 small EDRK-rich factor 2 -0.025241
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0249777
RPL18 ribosomal protein L18 -0.0249392
SOX4 SRY (sex determining region Y)-box 4 -0.0245653
RIGI RNA sensor RIG-I -0.0241264
KTN1 kinectin 1 (kinesin receptor) -0.0235146
RPL9 ribosomal protein L9 -0.0233361
LDHB lactate dehydrogenase B -0.0232849
S100A6 S100 calcium binding protein A6 -0.0232395
FNDC3A fibronectin type III domain containing 3A -0.0230229
RPLP0 ribosomal protein, large, P0 -0.0228191
STK38L serine/threonine kinase 38 like -0.0227598
RPS5 ribosomal protein S5 -0.0227496
GREM2 gremlin 2, DAN family BMP antagonist -0.0225329
KPNB1 karyopherin (importin) beta 1 -0.0224183
CUX1 cut-like homeobox 1 -0.0222757