Entecavir (monohydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0611689
IGFBP3 insulin-like growth factor binding protein 3 0.0504566
FNDC3B fibronectin type III domain containing 3B 0.045807
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0441185
PSD3 pleckstrin and Sec7 domain containing 3 0.0391364
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0334252
HELZ helicase with zinc finger 0.0298727
WDR43 WD repeat domain 43 0.0292785
LPP LIM domain containing preferred translocation partner in lipoma 0.0290986
ZNF292 zinc finger protein 292 0.0288819
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0285176
PTK2 protein tyrosine kinase 2 0.027766
RNF145 ring finger protein 145 0.0264915
CCNL1 cyclin L1 0.0259758
SLMAP sarcolemma associated protein 0.0256924
SVIL supervillin 0.0252708
HMGA2 high mobility group AT-hook 2 0.0243497
PARD3 par-3 family cell polarity regulator 0.0238788
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0225893
ANKRD10 ankyrin repeat domain 10 0.0221433
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0213924
EGFR epidermal growth factor receptor 0.0209933
ANKRD11 ankyrin repeat domain 11 0.0206259
KDM6A lysine (K)-specific demethylase 6A 0.0202859
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0198036
WAC WW domain containing adaptor with coiled-coil 0.0194063
ANXA2 annexin A2 0.0190311
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0188954
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0188901
VCAN versican 0.0188264
IARS1 isoleucyl-tRNA synthetase 1 0.0188078
DLC1 DLC1 Rho GTPase activating protein 0.0187451
TBC1D5 TBC1 domain family, member 5 0.0185855
LAMA4 laminin, alpha 4 0.0184449
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0183893
AFDN afadin, adherens junction formation factor 0.0182584
FXR1 fragile X mental retardation, autosomal homolog 1 0.0182032
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0180652
SBF2 SET binding factor 2 0.0179871
KMT2E lysine (K)-specific methyltransferase 2E 0.0179004
BHLHE40 basic helix-loop-helix family, member e40 0.0176271
OSBPL10 oxysterol binding protein-like 10 0.0175298
TRA2B transformer 2 beta homolog (Drosophila) 0.0175035
FMNL2 formin-like 2 0.0174621
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0174367
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0172156
USP3 ubiquitin specific peptidase 3 0.0171036
FNBP1L formin binding protein 1-like 0.0170895
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0169036
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0166039
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0165437
ZNF148 zinc finger protein 148 0.0162383
MEF2A myocyte enhancer factor 2A 0.0161529
USP24 ubiquitin specific peptidase 24 0.0160697
ANXA1 annexin A1 0.0159029
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0155845
RUNX1 runt-related transcription factor 1 0.0151279
JMJD1C jumonji domain containing 1C 0.0150762
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.014999
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0149714
LRPPRC leucine-rich pentatricopeptide repeat containing 0.014927
SETD5 SET domain containing 5 0.0147258
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0146296
BICD1 bicaudal D homolog 1 (Drosophila) 0.0145933
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0143892
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0143595
HMGA1 high mobility group AT-hook 1 0.0143396
CDC73 cell division cycle 73 0.0142794
AHCTF1 AT hook containing transcription factor 1 0.0142405
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0142185
ARHGAP26 Rho GTPase activating protein 26 0.0140237
TRIM2 tripartite motif containing 2 0.0138813
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0138321
UGCG UDP-glucose ceramide glucosyltransferase 0.013798
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0137732
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0137714
ZNF644 zinc finger protein 644 0.0137533
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0136668
GLS2 glutaminase 2 (liver, mitochondrial) 0.0135581
MATR3 matrin 3 0.0135221
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.0134928
MAML2 mastermind-like 2 (Drosophila) 0.0134615
DOCK4 dedicator of cytokinesis 4 0.0132942
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0132611
DENND1A DENN/MADD domain containing 1A 0.0132446
PDGFC platelet derived growth factor C 0.0132134
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0132037
BRWD1 bromodomain and WD repeat domain containing 1 0.0131544
PUM1 pumilio RNA-binding family member 1 0.013089
CCNT2 cyclin T2 0.0130568
FAM168A family with sequence similarity 168, member A 0.0129628
TFG TRK-fused gene 0.0128038
QKI QKI, KH domain containing, RNA binding 0.0127187
USP9X ubiquitin specific peptidase 9, X-linked 0.0126129
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0125042
PCED1B PC-esterase domain containing 1B 0.0124185
LIMCH1 LIM and calponin homology domains 1 0.0123466
NF1 neurofibromin 1 0.0122157
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.012131
UBE2H ubiquitin-conjugating enzyme E2H 0.0121069

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.217829
MT2A metallothionein 2A -0.13311
TMSB10 thymosin beta 10 -0.131726
FTL ferritin, light polypeptide -0.124228
ACTG1 actin gamma 1 -0.115456
TPT1 tumor protein, translationally-controlled 1 -0.105123
ENO1 enolase 1, (alpha) -0.100443
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.095347
RPS27A ribosomal protein S27a -0.0857915
PTMA prothymosin, alpha -0.0855026
RPS19 ribosomal protein S19 -0.0805843
B2M beta-2-microglobulin -0.0776734
RPS8 ribosomal protein S8 -0.0761308
RPL23 ribosomal protein L23 -0.0745318
RPL31 ribosomal protein L31 -0.0718045
RPL19 ribosomal protein L19 -0.0704969
UBC ubiquitin C -0.0684316
RPL12 ribosomal protein L12 -0.0683503
EEF2 eukaryotic translation elongation factor 2 -0.0674939
RPL32 ribosomal protein L32 -0.065709
MYH9 myosin, heavy chain 9, non-muscle -0.0648611
RPL35A ribosomal protein L35a -0.0617356
RPLP1 ribosomal protein, large, P1 -0.0575805
RPLP2 ribosomal protein, large, P2 -0.0565719
PKM pyruvate kinase, muscle -0.0537129
RPS3 ribosomal protein S3 -0.0514755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0493218
RPL9 ribosomal protein L9 -0.0472456
ASPH aspartate beta-hydroxylase -0.0472175
S100A10 S100 calcium binding protein A10 -0.0470079
AHNAK AHNAK nucleoprotein -0.0440514
CCND1 cyclin D1 -0.0438607
RPS29 ribosomal protein S29 -0.0437571
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0436881
RPL35 ribosomal protein L35 -0.0434603
RPS6 ribosomal protein S6 -0.0427692
MT1X metallothionein 1X -0.0411608
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0402516
RPL34 ribosomal protein L34 -0.0400675
RPL26 ribosomal protein L26 -0.0398563
RPL11 ribosomal protein L11 -0.0393082
FLNA filamin A, alpha -0.0388618
APP amyloid beta (A4) precursor protein -0.0385873
RPL7A ribosomal protein L7a -0.03834
RPL28 ribosomal protein L28 -0.0382215
RPS11 ribosomal protein S11 -0.0376352
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.037369
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0373193
RPS13 ribosomal protein S13 -0.0372433
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.037009
RPS5 ribosomal protein S5 -0.0367033
CALR calreticulin -0.0362499
RPL36 ribosomal protein L36 -0.0361703
RPLP0 ribosomal protein, large, P0 -0.0361271
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0360853
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0351554
S100A6 S100 calcium binding protein A6 -0.0346187
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0346026
RPS14 ribosomal protein S14 -0.0345217
RPS12 ribosomal protein S12 -0.0338555
EIF1 eukaryotic translation initiation factor 1 -0.0325434
LAMB3 laminin, beta 3 -0.0325119
LDHA lactate dehydrogenase A -0.0324874
CANX calnexin -0.0323453
MKI67 marker of proliferation Ki-67 -0.0317448
RPL18 ribosomal protein L18 -0.0317056
TUBB4B tubulin, beta 4B class IVb -0.0313673
RACK1 receptor for activated C kinase 1 -0.0310199
RPS23 ribosomal protein S23 -0.0306524
RPL37A ribosomal protein L37a -0.0303522
SET SET nuclear proto-oncogene -0.0296027
OGA O-GlcNAcase -0.029296
DEK DEK proto-oncogene -0.0289918
ACTN4 actinin, alpha 4 -0.0289388
RPS27 ribosomal protein S27 -0.0285484
MYL12B myosin, light chain 12B, regulatory -0.0283598
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0280058
RPS16 ribosomal protein S16 -0.0279657
RPS15 ribosomal protein S15 -0.0278502
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0278487
RPS4X ribosomal protein S4, X-linked -0.0276748
RPS21 ribosomal protein S21 -0.0275981
RPL38 ribosomal protein L38 -0.0274615
RPS24 ribosomal protein S24 -0.0273875
RPS10 ribosomal protein S10 -0.0271046
SEPTIN7 septin 7 -0.027037
TPM4 tropomyosin 4 -0.0267338
RPS17 ribosomal protein S17 -0.0266478
RPL8 ribosomal protein L8 -0.0261532
RPS25 ribosomal protein S25 -0.0261112
RPL37 ribosomal protein L37 -0.0256906
GSTP1 glutathione S-transferase pi 1 -0.0253361
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0252615
TPI1 triosephosphate isomerase 1 -0.0251346
LOC112694756 uncharaterized LOC112694756 -0.0249424
EGR1 early growth response 1 -0.0248417
CCNI cyclin I -0.0246942
RPL5 ribosomal protein L5 -0.0243655
RPL36A ribosomal protein L36a -0.0238414
RPL15 ribosomal protein L15 -0.02369