Entecavir (monohydrate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.282789
NDRG1 N-myc downstream regulated 1 0.207267
COL6A3 collagen, type VI, alpha 3 0.194669
TRIO trio Rho guanine nucleotide exchange factor 0.174413
ATP13A3 ATPase type 13A3 0.144161
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.122072
TIMP3 TIMP metallopeptidase inhibitor 3 0.100342
ELL2 elongation factor, RNA polymerase II, 2 0.0933095
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0919796
CADM1 cell adhesion molecule 1 0.0883545
PDE10A phosphodiesterase 10A 0.0839239
LOXL2 lysyl oxidase-like 2 0.0750424
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0732478
MYH9 myosin, heavy chain 9, non-muscle 0.0715197
FNDC3B fibronectin type III domain containing 3B 0.0667866
ERRFI1 ERBB receptor feedback inhibitor 1 0.0620063
ZNF292 zinc finger protein 292 0.0569247
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0548846
RICTOR RPTOR independent companion of MTOR, complex 2 0.0540142
ARRDC3 arrestin domain containing 3 0.054
PTK2 protein tyrosine kinase 2 0.053692
ASPH aspartate beta-hydroxylase 0.0528571
SPAG9 sperm associated antigen 9 0.0526012
RUNX1 runt-related transcription factor 1 0.0525525
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0522721
PRELID2 PRELI domain containing 2 0.0504467
DLG1 discs, large homolog 1 (Drosophila) 0.0500069
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0499815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0468768
BHLHE40 basic helix-loop-helix family, member e40 0.0465068
ANKRD11 ankyrin repeat domain 11 0.0444659
TRAM2 translocation associated membrane protein 2 0.0443397
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0433738
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0420223
FMNL2 formin-like 2 0.041225
CAMTA1 calmodulin binding transcription activator 1 0.0399703
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0397015
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0394829
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0389139
USP3 ubiquitin specific peptidase 3 0.0388757
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0384314
UBA6 ubiquitin-like modifier activating enzyme 6 0.0382956
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.038144
NAMPT nicotinamide phosphoribosyltransferase 0.0369723
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0368403
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367306
TMEM165 transmembrane protein 165 0.0366035
JARID2 jumonji, AT rich interactive domain 2 0.0359508
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0357782
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0355722
SOD2 superoxide dismutase 2, mitochondrial 0.0355568
KDM7A lysine (K)-specific demethylase 7A 0.0352403
CD109 CD109 molecule 0.0351892
ZFAND3 zinc finger, AN1-type domain 3 0.0348998
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0346185
LDHA lactate dehydrogenase A 0.0345806
NAV2 neuron navigator 2 0.0342357
ANXA5 annexin A5 0.0338174
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0335116
ESYT2 extended synaptotagmin-like protein 2 0.0329497
SETD5 SET domain containing 5 0.0328953
UGCG UDP-glucose ceramide glucosyltransferase 0.0323797
NPEPPS aminopeptidase puromycin sensitive 0.0323193
ADAM17 ADAM metallopeptidase domain 17 0.031998
FAM13A family with sequence similarity 13, member A 0.0317145
QKI QKI, KH domain containing, RNA binding 0.0314368
LOX lysyl oxidase 0.0314091
KMT2C lysine (K)-specific methyltransferase 2C 0.0312819
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0306887
LTBP1 latent transforming growth factor beta binding protein 1 0.0304946
COL5A1 collagen, type V, alpha 1 0.0304254
KDM3A lysine (K)-specific demethylase 3A 0.029987
PICALM phosphatidylinositol binding clathrin assembly protein 0.0298884
CLIC4 chloride intracellular channel 4 0.0297571
SMYD3 SET and MYND domain containing 3 0.0296139
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0288258
OGA O-GlcNAcase 0.0288014
ANXA2 annexin A2 0.0284883
GRB10 growth factor receptor-bound protein 10 0.0278315
HOOK2 hook microtubule-tethering protein 2 0.027655
SDC2 syndecan 2 0.0276303
MED13L mediator complex subunit 13-like 0.0274771
COL1A2 collagen, type I, alpha 2 0.0270946
HELZ helicase with zinc finger 0.0270849
MTSS1 metastasis suppressor 1 0.0269721
RLF rearranged L-myc fusion 0.0268885
COL7A1 collagen, type VII, alpha 1 0.0267088
SMAD3 SMAD family member 3 0.026708
RASA2 RAS p21 protein activator 2 0.0264576
AHNAK AHNAK nucleoprotein 0.0262568
ZEB1 zinc finger E-box binding homeobox 1 0.0260111
HIP1 huntingtin interacting protein 1 0.0257747
MRTFA myocardin related transcription factor A 0.025769
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0256454
CDC73 cell division cycle 73 0.0251435
TFG TRK-fused gene 0.0251234
BBX bobby sox homolog (Drosophila) 0.024794
PDE8A phosphodiesterase 8A 0.0245472
TENT5A terminal nucleotidyltransferase 5A 0.0243869
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0242059

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.211791
MT2A metallothionein 2A -0.188795
TMSB10 thymosin beta 10 -0.11524
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0860598
FTL ferritin, light polypeptide -0.0713758
RPS8 ribosomal protein S8 -0.0606297
RPS6 ribosomal protein S6 -0.0532094
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0525583
RPL35A ribosomal protein L35a -0.0504507
RPS19 ribosomal protein S19 -0.0489095
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0443669
HLA-B major histocompatibility complex, class I, B -0.0443023
ALCAM activated leukocyte cell adhesion molecule -0.043711
ACTG1 actin gamma 1 -0.0436755
CD44 CD44 molecule (Indian blood group) -0.042438
S100A9 S100 calcium binding protein A9 -0.0415491
EGR1 early growth response 1 -0.0402627
PTMA prothymosin, alpha -0.0347736
RPLP2 ribosomal protein, large, P2 -0.0339807
IFITM3 interferon induced transmembrane protein 3 -0.0334358
PALLD palladin, cytoskeletal associated protein -0.0324502
GOLGB1 golgin B1 -0.0315093
RPL8 ribosomal protein L8 -0.031271
IL6 interleukin 6 -0.0292294
RPL37A ribosomal protein L37a -0.0285372
RPS14 ribosomal protein S14 -0.0276348
SQSTM1 sequestosome 1 -0.0275582
RPL36 ribosomal protein L36 -0.0275329
GLIS3 GLIS family zinc finger 3 -0.027505
RPLP1 ribosomal protein, large, P1 -0.0274309
RPL5 ribosomal protein L5 -0.0270856
EEF2 eukaryotic translation elongation factor 2 -0.0265381
RPS13 ribosomal protein S13 -0.0263782
RPL12 ribosomal protein L12 -0.0262753
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0256628
RPL28 ribosomal protein L28 -0.0255701
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0250171
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0248021
RPL31 ribosomal protein L31 -0.0245813
IFI6 interferon, alpha-inducible protein 6 -0.0245508
EIF1 eukaryotic translation initiation factor 1 -0.0243991
RPL7 ribosomal protein L7 -0.0243819
RPS11 ribosomal protein S11 -0.0240334
RACK1 receptor for activated C kinase 1 -0.0235865
HMGA2 high mobility group AT-hook 2 -0.0234373
RPL19 ribosomal protein L19 -0.0232636
RPL37 ribosomal protein L37 -0.0231557
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.021598
ZBTB20 zinc finger and BTB domain containing 20 -0.0215011
RPS3 ribosomal protein S3 -0.0214556
ENO1 enolase 1, (alpha) -0.0214191
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0205196
RPS25 ribosomal protein S25 -0.02047
B2M beta-2-microglobulin -0.0204141
RPL30 ribosomal protein L30 -0.0203877
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0201537
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0200722
RPS29 ribosomal protein S29 -0.0199788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0199742
RPS27A ribosomal protein S27a -0.019741
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0194536
RPL13A ribosomal protein L13a -0.019141
RPL18 ribosomal protein L18 -0.0188488
S100A6 S100 calcium binding protein A6 -0.0187684
RPS15 ribosomal protein S15 -0.0186301
RPL11 ribosomal protein L11 -0.0185997
RPS5 ribosomal protein S5 -0.0185933
RPS27 ribosomal protein S27 -0.0183842
DPYD dihydropyrimidine dehydrogenase -0.0180242
RPL35 ribosomal protein L35 -0.0179889
ZBTB38 zinc finger and BTB domain containing 38 -0.0178836
ISG15 ISG15 ubiquitin-like modifier -0.0178381
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.017683
RPL32 ribosomal protein L32 -0.0175196
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0174638
MYDGF myeloid-derived growth factor -0.0174379
INTS6 integrator complex subunit 6 -0.0172634
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0171955
RPS23 ribosomal protein S23 -0.0170105
CST3 cystatin C -0.0169684
RPL38 ribosomal protein L38 -0.016957
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.016809
YBX1 Y box binding protein 1 -0.0167925
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0167505
RPS16 ribosomal protein S16 -0.0165724
CALR calreticulin -0.0164834
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0161894
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0159621
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0158998
HLA-A major histocompatibility complex, class I, A -0.0158612
DGKI diacylglycerol kinase, iota -0.0157832
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0157379
FOXP1 forkhead box P1 -0.0155582
RPL23 ribosomal protein L23 -0.0155339
PFN1 profilin 1 -0.0153439
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0153049
NABP1 nucleic acid binding protein 1 -0.0150453
RPS10 ribosomal protein S10 -0.0149901
MYADM myeloid-associated differentiation marker -0.0147737
TBCA tubulin folding cofactor A -0.0147711