Entecavir (monohydrate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.0770931
LMO7 LIM domain 7 0.0761912
AHNAK AHNAK nucleoprotein 0.0696893
SAMD12 sterile alpha motif domain containing 12 0.0649961
PTK2 protein tyrosine kinase 2 0.0612528
STK24 serine/threonine kinase 24 0.0585664
FNDC3B fibronectin type III domain containing 3B 0.0548818
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.049833
TXNRD1 thioredoxin reductase 1 0.049319
NF1 neurofibromin 1 0.0477268
CCSER1 coiled-coil serine-rich protein 1 0.0472952
ATXN1 ataxin 1 0.0454084
PICALM phosphatidylinositol binding clathrin assembly protein 0.044831
ARHGAP32 Rho GTPase activating protein 32 0.0419135
MBNL1 muscleblind-like splicing regulator 1 0.0404933
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0402735
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0398106
EXT1 exostosin glycosyltransferase 1 0.0396729
CTNND1 catenin (cadherin-associated protein), delta 1 0.0391789
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0379699
DST dystonin 0.0373784
JMJD1C jumonji domain containing 1C 0.037277
PRELID2 PRELI domain containing 2 0.037093
BCL2L1 BCL2-like 1 0.0367572
PLAUR plasminogen activator, urokinase receptor 0.0359146
PDZD8 PDZ domain containing 8 0.0358153
FRY furry homolog (Drosophila) 0.0338808
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0333666
DSCAM Down syndrome cell adhesion molecule 0.0331799
NAMPT nicotinamide phosphoribosyltransferase 0.0331706
ZBTB20 zinc finger and BTB domain containing 20 0.0328078
AKAP13 A kinase (PRKA) anchor protein 13 0.0323255
PDE4D phosphodiesterase 4D, cAMP-specific 0.0321631
ZMYM2 zinc finger, MYM-type 2 0.0318696
GSK3B glycogen synthase kinase 3 beta 0.0318665
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0308276
SMAD3 SMAD family member 3 0.0304585
ERRFI1 ERBB receptor feedback inhibitor 1 0.0300003
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0296513
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.029164
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0290893
ETV6 ets variant 6 0.0287235
VCL vinculin 0.028395
ZFAND3 zinc finger, AN1-type domain 3 0.0279585
SLC45A4 solute carrier family 45, member 4 0.0275986
CYRIB CYFIP related Rac1 interactor B 0.0275402
CD2AP CD2-associated protein 0.027155
MYH9 myosin, heavy chain 9, non-muscle 0.0268691
PATJ PATJ crumbs cell polarity complex component 0.0265061
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0264429
IQGAP1 IQ motif containing GTPase activating protein 1 0.0263211
ARHGAP26 Rho GTPase activating protein 26 0.0262296
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0262145
PRKN parkin RBR E3 ubiquitin protein ligase 0.026199
RAD21 RAD21 homolog (S. pombe) 0.0261706
FAT1 FAT atypical cadherin 1 0.0256185
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0255025
TRAPPC9 trafficking protein particle complex 9 0.0251919
ARL5B ADP-ribosylation factor-like 5B 0.0251115
KDM6A lysine (K)-specific demethylase 6A 0.0246701
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0245302
MBD5 methyl-CpG binding domain protein 5 0.0244961
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0244521
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.024287
FOXO1 forkhead box O1 0.0241779
PTBP3 polypyrimidine tract binding protein 3 0.0241741
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0239286
PTPRK protein tyrosine phosphatase, receptor type, K 0.023887
ZNF292 zinc finger protein 292 0.0237159
ATAD2 ATPase family, AAA domain containing 2 0.0236548
LCOR ligand dependent nuclear receptor corepressor 0.0236351
GMDS GDP-mannose 4,6-dehydratase 0.023511
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0233469
DSPP dentin sialophosphoprotein 0.0233126
AFDN afadin, adherens junction formation factor 0.0231648
CSNK1A1 casein kinase 1, alpha 1 0.0231008
BIRC6 baculoviral IAP repeat containing 6 0.0230395
ITPKC inositol-trisphosphate 3-kinase C 0.0230252
AFF1 AF4/FMR2 family, member 1 0.0229838
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0228446
RBM39 RNA binding motif protein 39 0.0228359
EHF ets homologous factor 0.0225997
TM9SF3 transmembrane 9 superfamily member 3 0.0225073
ERBIN erbb2 interacting protein 0.0224608
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0224292
MECOM MDS1 and EVI1 complex locus 0.022426
ESYT2 extended synaptotagmin-like protein 2 0.0223788
VMP1 vacuole membrane protein 1 0.0222933
SPRED2 sprouty-related, EVH1 domain containing 2 0.0222231
EPS8 epidermal growth factor receptor pathway substrate 8 0.0222078
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0220978
USP3 ubiquitin specific peptidase 3 0.0220056
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0220018
KMT2C lysine (K)-specific methyltransferase 2C 0.0219527
WWC1 WW and C2 domain containing 1 0.0219349
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0218197
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.021616
CDK19 cyclin-dependent kinase 19 0.021364
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0210446
LPP LIM domain containing preferred translocation partner in lipoma 0.0205921

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.29245
RPS6 ribosomal protein S6 -0.14471
RPS19 ribosomal protein S19 -0.13083
TMSB10 thymosin beta 10 -0.121644
TPT1 tumor protein, translationally-controlled 1 -0.120341
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119592
RPLP1 ribosomal protein, large, P1 -0.116003
RPL23 ribosomal protein L23 -0.114662
PTMA prothymosin, alpha -0.108118
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102213
RPS8 ribosomal protein S8 -0.101137
RPLP2 ribosomal protein, large, P2 -0.0941152
RPL35A ribosomal protein L35a -0.0911889
RPS3 ribosomal protein S3 -0.0868302
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0804563
RPS13 ribosomal protein S13 -0.0729698
RPS11 ribosomal protein S11 -0.0717149
RPL12 ribosomal protein L12 -0.06632
RPL31 ribosomal protein L31 -0.0646353
RPL18 ribosomal protein L18 -0.0637337
RPL11 ribosomal protein L11 -0.0621946
RPL28 ribosomal protein L28 -0.0620093
RPL34 ribosomal protein L34 -0.061444
RPS23 ribosomal protein S23 -0.0601025
RPL19 ribosomal protein L19 -0.0594283
RPL9 ribosomal protein L9 -0.0580858
RPS5 ribosomal protein S5 -0.0575397
RPS16 ribosomal protein S16 -0.0556912
RPS21 ribosomal protein S21 -0.0536487
ACTG1 actin gamma 1 -0.0536163
RPS25 ribosomal protein S25 -0.0520163
RPL21 ribosomal protein L21 -0.0518012
RPL37A ribosomal protein L37a -0.0509817
RPL27A ribosomal protein L27a -0.0508381
B2M beta-2-microglobulin -0.0494226
RPS12 ribosomal protein S12 -0.0486833
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0483686
RPL8 ribosomal protein L8 -0.0470083
S100A10 S100 calcium binding protein A10 -0.046809
RPS27A ribosomal protein S27a -0.0446069
FTH1 ferritin, heavy polypeptide 1 -0.0446004
RPL37 ribosomal protein L37 -0.0434728
RPL13A ribosomal protein L13a -0.0431715
RPLP0 ribosomal protein, large, P0 -0.0428869
RPL5 ribosomal protein L5 -0.0423225
RPS27 ribosomal protein S27 -0.040356
RPL7 ribosomal protein L7 -0.0397583
SERF2 small EDRK-rich factor 2 -0.0396433
RPS14 ribosomal protein S14 -0.0395516
RPS29 ribosomal protein S29 -0.0389819
EIF1 eukaryotic translation initiation factor 1 -0.0385565
RPL36 ribosomal protein L36 -0.0384394
HMGA1 high mobility group AT-hook 1 -0.037704
RPL7A ribosomal protein L7a -0.0377007
RPL26 ribosomal protein L26 -0.0373398
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0372289
RPS17 ribosomal protein S17 -0.036886
LYZ lysozyme -0.0362774
ATP5F1E ATP synthase F1 subunit epsilon -0.036184
RPS24 ribosomal protein S24 -0.0360137
EGR1 early growth response 1 -0.0359712
RPL35 ribosomal protein L35 -0.0358566
RPS10 ribosomal protein S10 -0.0358415
RPL36A ribosomal protein L36a -0.0357126
CALR calreticulin -0.0351308
RPL32 ribosomal protein L32 -0.0350914
S100A6 S100 calcium binding protein A6 -0.0333649
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0333378
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329771
VIM vimentin -0.0320152
RPS4X ribosomal protein S4, X-linked -0.0319677
GSTP1 glutathione S-transferase pi 1 -0.0312315
S100P S100 calcium binding protein P -0.0311968
S100A9 S100 calcium binding protein A9 -0.0311941
LOC102724023 ES1 protein homolog, mitochondrial -0.0296833
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0295037
CNRIP1 cannabinoid receptor interacting protein 1 -0.0293971
LMNA lamin A/C -0.0293034
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.029263
RACK1 receptor for activated C kinase 1 -0.0292338
GOLGA4 golgin A4 -0.0290932
ASTN2 astrotactin 2 -0.0284291
RPL10A ribosomal protein L10a -0.0283368
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0282899
YBX1 Y box binding protein 1 -0.0281564
POTEF POTE ankyrin domain family, member F -0.0274506
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0269144
SQSTM1 sequestosome 1 -0.0262261
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0258731
RPL38 ribosomal protein L38 -0.0257283
EEF2 eukaryotic translation elongation factor 2 -0.0255997
RPL27 ribosomal protein L27 -0.0247694
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0246357
GNAS GNAS complex locus -0.0245249
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0242914
ENO1 enolase 1, (alpha) -0.0241924
MT2A metallothionein 2A -0.0241839
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.023761
HMGB1 high mobility group box 1 -0.0233139
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0231391