Entecavir (monohydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.14765
ERRFI1 ERBB receptor feedback inhibitor 1 0.127243
FN1 fibronectin 1 0.0842518
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0809991
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0788187
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0635793
SAMD4A sterile alpha motif domain containing 4A 0.0626288
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0621012
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0589608
FNDC3B fibronectin type III domain containing 3B 0.0545539
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0535306
ASPH aspartate beta-hydroxylase 0.0525157
ATXN1 ataxin 1 0.0514029
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0503325
ELL2 elongation factor, RNA polymerase II, 2 0.0457984
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0441412
AFDN afadin, adherens junction formation factor 0.0434044
DSPP dentin sialophosphoprotein 0.0422137
RUNX1 runt-related transcription factor 1 0.040557
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.039654
IGF2 insulin-like growth factor 2 0.0392938
KDM3A lysine (K)-specific demethylase 3A 0.0372402
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0370109
TRIO trio Rho guanine nucleotide exchange factor 0.0359705
DTNA dystrobrevin, alpha 0.0327323
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0324156
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0318559
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0304333
EHBP1 EH domain binding protein 1 0.0297116
FLNB filamin B, beta 0.0286188
VCL vinculin 0.0283999
FRMD5 FERM domain containing 5 0.0279665
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0278184
MSI2 musashi RNA-binding protein 2 0.0272384
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0269098
ZFAND3 zinc finger, AN1-type domain 3 0.0269029
IGF1R insulin-like growth factor 1 receptor 0.0260668
KIAA1217 KIAA1217 0.0252937
KDM4C lysine (K)-specific demethylase 4C 0.025046
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.025036
MACF1 microtubule-actin crosslinking factor 1 0.0243311
PEG3 paternally expressed 3 0.0240704
HOOK2 hook microtubule-tethering protein 2 0.0240228
TBC1D22A TBC1 domain family, member 22A 0.0237309
GPC6 glypican 6 0.023631
PICALM phosphatidylinositol binding clathrin assembly protein 0.0231662
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0227095
GRB10 growth factor receptor-bound protein 10 0.0225919
ARFGEF3 ARFGEF family member 3 0.0222513
LRMDA leucine rich melanocyte differentiation associated 0.0221713
GMDS GDP-mannose 4,6-dehydratase 0.0220716
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0219293
SMAD3 SMAD family member 3 0.0217962
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0216098
ANO6 anoctamin 6 0.0214632
PAWR PRKC, apoptosis, WT1, regulator 0.0211716
TNS1 tensin 1 0.0211178
PRELID2 PRELI domain containing 2 0.0210873
INSIG2 insulin induced gene 2 0.0210778
ESYT2 extended synaptotagmin-like protein 2 0.0209951
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0206716
BIRC6 baculoviral IAP repeat containing 6 0.0205619
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0205429
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0205309
RBM39 RNA binding motif protein 39 0.0205067
DOCK4 dedicator of cytokinesis 4 0.0204302
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.019952
ARHGAP9 Rho GTPase activating protein 9 0.0198493
ARHGAP5 Rho GTPase activating protein 5 0.0196583
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0196043
STRN3 striatin, calmodulin binding protein 3 0.0194244
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0191778
RIGI RNA sensor RIG-I 0.0191124
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0190022
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0189516
CCNY cyclin Y 0.0189358
GSE1 Gse1 coiled-coil protein 0.0188541
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0187594
DST dystonin 0.0185913
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0184744
FOXP1 forkhead box P1 0.0183517
PHF3 PHD finger protein 3 0.0182037
DSCAM Down syndrome cell adhesion molecule 0.018085
ITCH itchy E3 ubiquitin protein ligase 0.0176149
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0176014
MALRD1 MAM and LDL receptor class A domain containing 1 0.0175237
CORO1C coronin, actin binding protein, 1C 0.0171107
CAMTA1 calmodulin binding transcription activator 1 0.0169244
WWC2 WW and C2 domain containing 2 0.0168933
NBAS neuroblastoma amplified sequence 0.0168008
SBF2 SET binding factor 2 0.0167985
ITGAV integrin, alpha V 0.0167897
RNF213 ring finger protein 213 0.0166578
MYH9 myosin, heavy chain 9, non-muscle 0.016491
JMJD1C jumonji domain containing 1C 0.0164326
WAC WW domain containing adaptor with coiled-coil 0.016407
FMNL2 formin-like 2 0.016376
DENND1A DENN/MADD domain containing 1A 0.0163101
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0162859
FAT1 FAT atypical cadherin 1 0.0162838

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.43633
MT2A metallothionein 2A -0.208235
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.181997
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.129488
TIMP1 TIMP metallopeptidase inhibitor 1 -0.118389
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11699
APOA2 apolipoprotein A-II -0.109104
RPS6 ribosomal protein S6 -0.102928
FTL ferritin, light polypeptide -0.100991
TPT1 tumor protein, translationally-controlled 1 -0.0940419
C3 complement component 3 -0.0932447
IGFBP1 insulin-like growth factor binding protein 1 -0.0890984
RPS8 ribosomal protein S8 -0.0791109
RPL11 ribosomal protein L11 -0.0725574
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0673038
RPS19 ribosomal protein S19 -0.0672284
RPL37A ribosomal protein L37a -0.063913
RPLP1 ribosomal protein, large, P1 -0.0638007
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0624993
CCL20 chemokine (C-C motif) ligand 20 -0.0611203
GPC3 glypican 3 -0.0586835
RPL35A ribosomal protein L35a -0.0568027
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0563607
RPS12 ribosomal protein S12 -0.055847
AHSG alpha-2-HS-glycoprotein -0.0540751
APOA1 apolipoprotein A-I -0.0539868
APOB apolipoprotein B -0.0519992
RPLP2 ribosomal protein, large, P2 -0.0510364
RPLP0 ribosomal protein, large, P0 -0.0497494
RPL34 ribosomal protein L34 -0.0485401
RPL31 ribosomal protein L31 -0.047918
APOE apolipoprotein E -0.0467788
FBF1 Fas (TNFRSF6) binding factor 1 -0.0456825
CPE carboxypeptidase E -0.0451277
RPS3 ribosomal protein S3 -0.0448299
RPL32 ribosomal protein L32 -0.0433721
RACK1 receptor for activated C kinase 1 -0.043197
RPL12 ribosomal protein L12 -0.043053
RPS13 ribosomal protein S13 -0.0430116
RPS24 ribosomal protein S24 -0.04295
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0427127
RPS23 ribosomal protein S23 -0.0426117
RPL26 ribosomal protein L26 -0.0404085
RPL23 ribosomal protein L23 -0.0384045
RPL19 ribosomal protein L19 -0.0383337
RPL9 ribosomal protein L9 -0.0376924
ENO1 enolase 1, (alpha) -0.0370754
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0368579
RPS29 ribosomal protein S29 -0.0364397
TMSB10 thymosin beta 10 -0.0364017
PTMA prothymosin, alpha -0.0363299
RPS21 ribosomal protein S21 -0.0363286
RPS14 ribosomal protein S14 -0.0355865
SDC4 syndecan 4 -0.0352714
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0348584
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0347748
RPS27A ribosomal protein S27a -0.0347024
TM4SF1 transmembrane 4 L six family member 1 -0.0346906
RPS5 ribosomal protein S5 -0.0344036
RPL5 ribosomal protein L5 -0.0315221
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0311786
GNAS GNAS complex locus -0.0311632
S100A9 S100 calcium binding protein A9 -0.0307965
RPL36 ribosomal protein L36 -0.0305837
B2M beta-2-microglobulin -0.0298756
IER3 immediate early response 3 -0.0297737
RPS25 ribosomal protein S25 -0.0291406
AMBP alpha-1-microglobulin/bikunin precursor -0.0290662
RPL8 ribosomal protein L8 -0.028991
RPL7A ribosomal protein L7a -0.0286024
LYZ lysozyme -0.0278863
EEF2 eukaryotic translation elongation factor 2 -0.0277102
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0275559
CST3 cystatin C -0.0275323
RPL10A ribosomal protein L10a -0.0264555
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0263446
RPS11 ribosomal protein S11 -0.0255879
RPL37 ribosomal protein L37 -0.0255699
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0253606
TRIM26 tripartite motif containing 26 -0.0246291
RPS10 ribosomal protein S10 -0.0246103
RPL27 ribosomal protein L27 -0.024578
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0241259
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0240379
RPS16 ribosomal protein S16 -0.0234276
RPL35 ribosomal protein L35 -0.0232134
ATP5F1E ATP synthase F1 subunit epsilon -0.0229589
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0229528
RPL28 ribosomal protein L28 -0.0229281
KTN1 kinectin 1 (kinesin receptor) -0.0226523
RPL27A ribosomal protein L27a -0.022247
IL32 interleukin 32 -0.0221458
RPL13A ribosomal protein L13a -0.0221101
EIF5B eukaryotic translation initiation factor 5B -0.0212844
PFN1 profilin 1 -0.0212322
IFITM1 interferon induced transmembrane protein 1 -0.0209609
MT1X metallothionein 1X -0.0209022
ICAM1 intercellular adhesion molecule 1 -0.0208694
RPL15 ribosomal protein L15 -0.0203221
RPL38 ribosomal protein L38 -0.0200511