Entecavir (monohydrate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYOF myoferlin 0.11356
TIMP3 TIMP metallopeptidase inhibitor 3 0.0927682
NAMPT nicotinamide phosphoribosyltransferase 0.082872
FLNB filamin B, beta 0.0823601
MEF2A myocyte enhancer factor 2A 0.0815046
TRIO trio Rho guanine nucleotide exchange factor 0.0779541
FOXO1 forkhead box O1 0.0764551
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0733918
RBM39 RNA binding motif protein 39 0.0711778
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0666337
OGA O-GlcNAcase 0.058646
AHNAK AHNAK nucleoprotein 0.0583713
EMP1 epithelial membrane protein 1 0.0541409
ESYT2 extended synaptotagmin-like protein 2 0.0537842
RICTOR RPTOR independent companion of MTOR, complex 2 0.0521892
ITCH itchy E3 ubiquitin protein ligase 0.0508798
KIAA1217 KIAA1217 0.050856
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0467199
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0440303
KDM6A lysine (K)-specific demethylase 6A 0.0426459
EZR ezrin 0.0417868
MARCHF6 membrane associated ring-CH-type finger 6 0.0408523
CD44 CD44 molecule (Indian blood group) 0.0406469
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0405683
SMAD3 SMAD family member 3 0.0402507
FNDC3B fibronectin type III domain containing 3B 0.0400882
ITGA6 integrin, alpha 6 0.039995
ANKRD33B ankyrin repeat domain 33B 0.039568
SPAG9 sperm associated antigen 9 0.039206
CUL4B cullin 4B 0.0390649
MYH9 myosin, heavy chain 9, non-muscle 0.0386561
ZNF292 zinc finger protein 292 0.0377457
CAV1 caveolin 1, caveolae protein, 22kDa 0.03726
BCL2L1 BCL2-like 1 0.0370987
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0370812
BHLHE40 basic helix-loop-helix family, member e40 0.03693
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0369162
CTNND1 catenin (cadherin-associated protein), delta 1 0.0365186
LNPEP leucyl/cystinyl aminopeptidase 0.0359004
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0353313
BZW1 basic leucine zipper and W2 domains 1 0.0350131
KMT2C lysine (K)-specific methyltransferase 2C 0.0344267
H1-0 H1.0 linker histone 0.0342214
NEK7 NIMA-related kinase 7 0.0338201
ASPH aspartate beta-hydroxylase 0.0337584
PGK1 phosphoglycerate kinase 1 0.0336835
PTK2 protein tyrosine kinase 2 0.0334396
ANXA2 annexin A2 0.0329469
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0329179
LDHA lactate dehydrogenase A 0.0328308
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0322975
MTSS1 metastasis suppressor 1 0.0318713
KDM3A lysine (K)-specific demethylase 3A 0.0317673
MBNL1 muscleblind-like splicing regulator 1 0.0317257
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0317199
FN1 fibronectin 1 0.0316314
ZNFX1 zinc finger, NFX1-type containing 1 0.0314652
KMT2E lysine (K)-specific methyltransferase 2E 0.0311266
NCOA3 nuclear receptor coactivator 3 0.0309189
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0303775
NPEPPS aminopeptidase puromycin sensitive 0.0302562
SERINC3 serine incorporator 3 0.0301238
SAMD9 sterile alpha motif domain containing 9 0.0300984
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0299993
ANLN anillin, actin binding protein 0.0299764
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0293474
ARRDC3 arrestin domain containing 3 0.0291698
RLF rearranged L-myc fusion 0.0289262
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0288826
PODXL podocalyxin-like 0.0279
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0276648
AOPEP aminopeptidase O (putative) 0.0275683
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026981
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0268916
MATR3 matrin 3 0.0267462
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0265695
SLMAP sarcolemma associated protein 0.0258806
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0254983
PRELID2 PRELI domain containing 2 0.02546
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0254256
SLK STE20-like kinase 0.025358
IQGAP1 IQ motif containing GTPase activating protein 1 0.0252108
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0249803
CDC73 cell division cycle 73 0.0249628
RIN2 Ras and Rab interactor 2 0.0249557
FNIP1 folliculin interacting protein 1 0.0249274
KDM7A lysine (K)-specific demethylase 7A 0.0249231
ANO6 anoctamin 6 0.0248047
ADAM10 ADAM metallopeptidase domain 10 0.0247743
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.024627
GOLGA4 golgin A4 0.0243305
ANXA5 annexin A5 0.0242226
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0242211
RAD21 RAD21 homolog (S. pombe) 0.0242078
PICALM phosphatidylinositol binding clathrin assembly protein 0.0241524
DSTN destrin (actin depolymerizing factor) 0.0241374
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0240651
RAB10 RAB10, member RAS oncogene family 0.0240165
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.023855
USP9X ubiquitin specific peptidase 9, X-linked 0.0238261

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.109235
MT2A metallothionein 2A -0.0893604
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0532841
INTS6 integrator complex subunit 6 -0.0494111
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.04569
IFITM3 interferon induced transmembrane protein 3 -0.0442012
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0412083
FTL ferritin, light polypeptide -0.0395381
RPLP2 ribosomal protein, large, P2 -0.0378904
RPS6 ribosomal protein S6 -0.0365792
RPS13 ribosomal protein S13 -0.0360307
RPS19 ribosomal protein S19 -0.0353186
IFITM1 interferon induced transmembrane protein 1 -0.0346371
RPL11 ribosomal protein L11 -0.0330748
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0311097
ANO1 anoctamin 1, calcium activated chloride channel -0.0309476
RPS21 ribosomal protein S21 -0.0295188
RPL8 ribosomal protein L8 -0.0288963
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0267604
RPL35A ribosomal protein L35a -0.026153
RPS29 ribosomal protein S29 -0.025923
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0257487
EGFR epidermal growth factor receptor -0.0252862
HMGA2 high mobility group AT-hook 2 -0.0251456
RPS8 ribosomal protein S8 -0.0248207
CNRIP1 cannabinoid receptor interacting protein 1 -0.0245298
MT1X metallothionein 1X -0.0240462
S100A2 S100 calcium binding protein A2 -0.0240184
S100A9 S100 calcium binding protein A9 -0.0240014
RPL12 ribosomal protein L12 -0.0239647
HLA-B major histocompatibility complex, class I, B -0.0235449
B2M beta-2-microglobulin -0.0229817
RPL36 ribosomal protein L36 -0.0229481
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0228072
HSPG2 heparan sulfate proteoglycan 2 -0.0223956
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0217339
RPL5 ribosomal protein L5 -0.0216546
LAMA5 laminin, alpha 5 -0.021516
RPL21 ribosomal protein L21 -0.0214143
RPS27 ribosomal protein S27 -0.0210247
RPL23 ribosomal protein L23 -0.0206077
RPL19 ribosomal protein L19 -0.020564
RPS3 ribosomal protein S3 -0.0201637
GUK1 guanylate kinase 1 -0.0197288
EGR1 early growth response 1 -0.0196466
RPL31 ribosomal protein L31 -0.0195127
PDLIM5 PDZ and LIM domain 5 -0.0191612
PTMA prothymosin, alpha -0.0191575
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0184709
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0182355
ZSWIM6 zinc finger, SWIM-type containing 6 -0.018034
S100A10 S100 calcium binding protein A10 -0.0176668
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.017314
SEC61G Sec61 gamma subunit -0.0173016
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0171925
LMNA lamin A/C -0.0169774
RPL7A ribosomal protein L7a -0.0166133
ENO2 enolase 2 (gamma, neuronal) -0.0164155
PRSS23 protease, serine, 23 -0.0163956
RPL32 ribosomal protein L32 -0.0163673
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0162889
RPL37 ribosomal protein L37 -0.0160843
HM13 histocompatibility (minor) 13 -0.0160352
S100A6 S100 calcium binding protein A6 -0.015921
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0158712
RPL9 ribosomal protein L9 -0.0157832
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0156577
MDK midkine (neurite growth-promoting factor 2) -0.0155737
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0154923
RPL27 ribosomal protein L27 -0.0153175
RPL37A ribosomal protein L37a -0.0153146
THSD4 thrombospondin, type I, domain containing 4 -0.0152286
HMGA1 high mobility group AT-hook 1 -0.0151431
ISG15 ISG15 ubiquitin-like modifier -0.0151204
SULF2 sulfatase 2 -0.014883
SETX senataxin -0.0146613
RPLP1 ribosomal protein, large, P1 -0.0145959
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0143364
NUCB2 nucleobindin 2 -0.0142816
EIF1 eukaryotic translation initiation factor 1 -0.0142674
RPL28 ribosomal protein L28 -0.0142292
SERF2 small EDRK-rich factor 2 -0.014157
RPS5 ribosomal protein S5 -0.0140564
ROMO1 reactive oxygen species modulator 1 -0.0140553
PFN1 profilin 1 -0.0140224
RPL35 ribosomal protein L35 -0.0139388
RPS14 ribosomal protein S14 -0.0139148
TMEM258 transmembrane protein 258 -0.0138846
S100A11 S100 calcium binding protein A11 -0.0138833
RPS23 ribosomal protein S23 -0.0135053
DHFR dihydrofolate reductase -0.0132043
RPL18 ribosomal protein L18 -0.0131479
ADIRF adipogenesis regulatory factor -0.012897
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0125613
PALLD palladin, cytoskeletal associated protein -0.0122893
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0122583
PCDH1 protocadherin 1 -0.0122557
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0121455
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0118688
HLA-A major histocompatibility complex, class I, A -0.0118563