Entecavir (monohydrate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP13A3 ATPase type 13A3 0.10789
UGCG UDP-glucose ceramide glucosyltransferase 0.0742046
TRIO trio Rho guanine nucleotide exchange factor 0.0644147
FNDC3B fibronectin type III domain containing 3B 0.0588934
CCNL1 cyclin L1 0.0481864
NUP58 nucleoporin 58 0.0478235
SOD2 superoxide dismutase 2, mitochondrial 0.0455503
NAMPT nicotinamide phosphoribosyltransferase 0.0420861
UBA6 ubiquitin-like modifier activating enzyme 6 0.0415613
SPAG9 sperm associated antigen 9 0.0328207
NUP153 nucleoporin 153kDa 0.0318254
BHLHE40 basic helix-loop-helix family, member e40 0.0315438
GLS2 glutaminase 2 (liver, mitochondrial) 0.0289503
ELL2 elongation factor, RNA polymerase II, 2 0.0281599
ANXA1 annexin A1 0.0277563
WAC WW domain containing adaptor with coiled-coil 0.0274999
RBM39 RNA binding motif protein 39 0.0270831
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0260176
TFG TRK-fused gene 0.0259406
FAR1 fatty acyl CoA reductase 1 0.0258822
KDM6A lysine (K)-specific demethylase 6A 0.0249742
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0248893
ZFAND3 zinc finger, AN1-type domain 3 0.0245001
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0243738
GOLGA4 golgin A4 0.0239399
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0237008
RICTOR RPTOR independent companion of MTOR, complex 2 0.0236595
PDS5B PDS5 cohesin associated factor B 0.0234405
ADAM9 ADAM metallopeptidase domain 9 0.0232246
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0227831
FXR1 fragile X mental retardation, autosomal homolog 1 0.0225799
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0225264
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0221242
USP3 ubiquitin specific peptidase 3 0.0220732
PICALM phosphatidylinositol binding clathrin assembly protein 0.021925
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0217852
ITCH itchy E3 ubiquitin protein ligase 0.0217332
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0215932
DENND4C DENN/MADD domain containing 4C 0.0212996
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0211045
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0209736
DENND5A DENN/MADD domain containing 5A 0.0208017
NAV2 neuron navigator 2 0.0206324
TNPO1 transportin 1 0.0206215
TPD52 tumor protein D52 0.0205617
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0202292
HELZ helicase with zinc finger 0.0201344
USP12 ubiquitin specific peptidase 12 0.020133
DTNA dystrobrevin, alpha 0.0198308
USP9X ubiquitin specific peptidase 9, X-linked 0.0194258
ANKRD33B ankyrin repeat domain 33B 0.0193588
ARL5B ADP-ribosylation factor-like 5B 0.0193048
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0192946
ZMYM2 zinc finger, MYM-type 2 0.0192292
CNOT1 CCR4-NOT transcription complex, subunit 1 0.019048
QKI QKI, KH domain containing, RNA binding 0.0190349
AFF1 AF4/FMR2 family, member 1 0.0190035
ZNF292 zinc finger protein 292 0.018877
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0186051
NOP58 NOP58 ribonucleoprotein 0.0185749
SMAD3 SMAD family member 3 0.0185478
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0184595
RSRC2 arginine/serine-rich coiled-coil 2 0.018325
TSC22D2 TSC22 domain family, member 2 0.0180497
KMT2E lysine (K)-specific methyltransferase 2E 0.0179262
ZNF841 zinc finger protein 841 0.0177973
PTK2 protein tyrosine kinase 2 0.017758
CHD1 chromodomain helicase DNA binding protein 1 0.0175538
ARL8B ADP-ribosylation factor-like 8B 0.0175485
WTAP Wilms tumor 1 associated protein 0.0174196
GSK3B glycogen synthase kinase 3 beta 0.0173237
OLA1 Obg-like ATPase 1 0.0170536
NCKAP1 NCK-associated protein 1 0.0169419
PCBP2 poly(rC) binding protein 2 0.0169283
RHEB Ras homolog enriched in brain 0.0168496
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0167875
PTBP3 polypyrimidine tract binding protein 3 0.0167719
EPS8 epidermal growth factor receptor pathway substrate 8 0.0167357
PIAS2 protein inhibitor of activated STAT, 2 0.0165855
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0165726
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0165568
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0163988
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0163599
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0162307
MED13L mediator complex subunit 13-like 0.01613
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0161149
AGFG1 ArfGAP with FG repeats 1 0.0160736
DRAM1 DNA-damage regulated autophagy modulator 1 0.0159726
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0159447
RAD23B RAD23 homolog B (S. cerevisiae) 0.0159158
RAB8B RAB8B, member RAS oncogene family 0.015881
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0158135
CXCL8 chemokine (C-X-C motif) ligand 8 0.0157965
MATR3 matrin 3 0.0157821
ANXA5 annexin A5 0.0157081
CD83 CD83 molecule 0.0156747
MBNL1 muscleblind-like splicing regulator 1 0.0153613
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0153055
RLF rearranged L-myc fusion 0.0152102
ELOVL5 ELOVL fatty acid elongase 5 0.0151599

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.285113
HLA-B major histocompatibility complex, class I, B -0.193999
FTL ferritin, light polypeptide -0.191777
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16358
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.16243
MT1X metallothionein 1X -0.0947207
TMSB10 thymosin beta 10 -0.0908387
FN1 fibronectin 1 -0.0817526
ENO1 enolase 1, (alpha) -0.0795444
VIM vimentin -0.0549168
RPS6 ribosomal protein S6 -0.0548982
RPL35A ribosomal protein L35a -0.0547367
ACTG1 actin gamma 1 -0.0503814
RPLP2 ribosomal protein, large, P2 -0.0495535
TPT1 tumor protein, translationally-controlled 1 -0.048338
CD44 CD44 molecule (Indian blood group) -0.0453086
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0450797
HLA-A major histocompatibility complex, class I, A -0.0432297
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.041216
BASP1 brain abundant, membrane attached signal protein 1 -0.0399292
DEK DEK proto-oncogene -0.039821
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393022
PTMA prothymosin, alpha -0.039149
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0386259
NALF1 NALCN channel auxiliary factor 1 -0.0384332
S100A10 S100 calcium binding protein A10 -0.036752
PGK1 phosphoglycerate kinase 1 -0.0363825
RPL12 ribosomal protein L12 -0.0351686
LOC112694756 uncharaterized LOC112694756 -0.0341529
RPS8 ribosomal protein S8 -0.0335253
CAVIN1 caveolae associated protein 1 -0.0329516
S100A6 S100 calcium binding protein A6 -0.0324237
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0320006
EXT1 exostosin glycosyltransferase 1 -0.0318424
CALR calreticulin -0.031046
IFI6 interferon, alpha-inducible protein 6 -0.030634
RPLP1 ribosomal protein, large, P1 -0.0305862
RPS13 ribosomal protein S13 -0.0304507
RPS19 ribosomal protein S19 -0.0304504
F3 coagulation factor III (thromboplastin, tissue factor) -0.0303239
ANXA2 annexin A2 -0.030206
RPL23 ribosomal protein L23 -0.030112
IGFBP3 insulin-like growth factor binding protein 3 -0.0297739
KRT7 keratin 7, type II -0.0296729
GLIS3 GLIS family zinc finger 3 -0.029627
MAP1B microtubule-associated protein 1B -0.029391
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0291845
HMGB1 high mobility group box 1 -0.0282863
RPL11 ribosomal protein L11 -0.0282694
RPL35 ribosomal protein L35 -0.0268408
PFN1 profilin 1 -0.0266605
RHOBTB3 Rho-related BTB domain containing 3 -0.0264219
RPL37 ribosomal protein L37 -0.0263486
TPI1 triosephosphate isomerase 1 -0.0261489
LDHA lactate dehydrogenase A -0.0260388
RPS3 ribosomal protein S3 -0.0260141
PTPRF protein tyrosine phosphatase, receptor type, F -0.0258252
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0255021
PKM pyruvate kinase, muscle -0.0250968
GNAS GNAS complex locus -0.024875
IFITM3 interferon induced transmembrane protein 3 -0.0247245
AKAP12 A kinase (PRKA) anchor protein 12 -0.0244153
TUBB4B tubulin, beta 4B class IVb -0.0239789
RPL8 ribosomal protein L8 -0.0238947
TPM1 tropomyosin 1 (alpha) -0.0238313
RPS21 ribosomal protein S21 -0.0236838
RPL19 ribosomal protein L19 -0.023633
RPL31 ribosomal protein L31 -0.0230522
TMSB4X thymosin beta 4, X-linked -0.0228143
COL5A1 collagen, type V, alpha 1 -0.0227346
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0226613
POTEF POTE ankyrin domain family, member F -0.0223982
S100A9 S100 calcium binding protein A9 -0.022249
TPM4 tropomyosin 4 -0.0221623
TUBB tubulin, beta class I -0.0220739
NDRG1 N-myc downstream regulated 1 -0.0214425
PLCB4 phospholipase C, beta 4 -0.021268
B2M beta-2-microglobulin -0.0211263
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0210242
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0210219
VDAC1 voltage-dependent anion channel 1 -0.0205949
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0205112
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0204247
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0203468
ABI3BP ABI family, member 3 (NESH) binding protein -0.0200632
CENPF centromere protein F, 350/400kDa -0.0198019
RPS14 ribosomal protein S14 -0.0197971
RPL36 ribosomal protein L36 -0.0195525
RPL34 ribosomal protein L34 -0.0189754
RPL7A ribosomal protein L7a -0.0187118
KPNB1 karyopherin (importin) beta 1 -0.0186679
SERF2 small EDRK-rich factor 2 -0.018452
RPL9 ribosomal protein L9 -0.0183184
ZBTB20 zinc finger and BTB domain containing 20 -0.0183168
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0182187
MYL12B myosin, light chain 12B, regulatory -0.018186
RPL32 ribosomal protein L32 -0.0180901
RPS23 ribosomal protein S23 -0.0179726
ZNF432 zinc finger protein 432 -0.017957
RPS27 ribosomal protein S27 -0.0179221