Entecavir (monohydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0770192
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0655916
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0623687
NUP58 nucleoporin 58 0.0594781
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0557172
SPAG9 sperm associated antigen 9 0.0543935
FNDC3B fibronectin type III domain containing 3B 0.0496396
ELL2 elongation factor, RNA polymerase II, 2 0.0492005
WSB1 WD repeat and SOCS box containing 1 0.0478315
DTNA dystrobrevin, alpha 0.0463852
RUNX1 runt-related transcription factor 1 0.046328
ZNF292 zinc finger protein 292 0.0455974
RBM39 RNA binding motif protein 39 0.0453519
UGCG UDP-glucose ceramide glucosyltransferase 0.0444319
NAMPT nicotinamide phosphoribosyltransferase 0.0432602
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.04261
KDM3A lysine (K)-specific demethylase 3A 0.0417318
TRIO trio Rho guanine nucleotide exchange factor 0.0402185
CD109 CD109 molecule 0.0395704
PICALM phosphatidylinositol binding clathrin assembly protein 0.0386233
HELZ helicase with zinc finger 0.0385854
GLS2 glutaminase 2 (liver, mitochondrial) 0.0377639
ATP13A3 ATPase type 13A3 0.0374398
WAC WW domain containing adaptor with coiled-coil 0.0369293
DST dystonin 0.036585
PTK2 protein tyrosine kinase 2 0.0364914
ADAM9 ADAM metallopeptidase domain 9 0.0361413
MCTP1 multiple C2 domains, transmembrane 1 0.0358913
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0355626
KMT2E lysine (K)-specific methyltransferase 2E 0.0352275
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0342544
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0340676
RNF145 ring finger protein 145 0.0340244
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0325622
QKI QKI, KH domain containing, RNA binding 0.032487
RLF rearranged L-myc fusion 0.0322486
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0320737
WDR43 WD repeat domain 43 0.0319686
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0318479
TSC22D2 TSC22 domain family, member 2 0.0310004
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0300357
ZFAND3 zinc finger, AN1-type domain 3 0.0291808
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0290853
KMT2C lysine (K)-specific methyltransferase 2C 0.0286932
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0282577
CCNL1 cyclin L1 0.0282571
CDC73 cell division cycle 73 0.0282267
SETD5 SET domain containing 5 0.0281527
PUM2 pumilio RNA-binding family member 2 0.0278947
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0278434
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0277054
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0276804
MED13L mediator complex subunit 13-like 0.0276455
MARCHF6 membrane associated ring-CH-type finger 6 0.0275659
WDR45B WD repeat domain 45B 0.0275504
JMJD1C jumonji domain containing 1C 0.0275208
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0274059
BIRC6 baculoviral IAP repeat containing 6 0.0271825
RAB1A RAB1A, member RAS oncogene family 0.0271046
ERRFI1 ERBB receptor feedback inhibitor 1 0.0269833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0267967
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0266958
RTN4 reticulon 4 0.0264554
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0262772
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0261843
NDRG1 N-myc downstream regulated 1 0.0259916
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0259857
UBA6 ubiquitin-like modifier activating enzyme 6 0.0258478
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0256818
PUM1 pumilio RNA-binding family member 1 0.0254442
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0254139
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0253344
TFG TRK-fused gene 0.0253244
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0251829
TXNIP thioredoxin interacting protein 0.0251314
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0249185
TLE4 transducin-like enhancer of split 4 0.0248687
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0242828
PHIP pleckstrin homology domain interacting protein 0.0242661
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0241202
STRN3 striatin, calmodulin binding protein 3 0.0240634
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0240499
CUL3 cullin 3 0.024005
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0236059
APP amyloid beta (A4) precursor protein 0.0234792
TRA2A transformer 2 alpha homolog (Drosophila) 0.0233617
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0233429
CORO1C coronin, actin binding protein, 1C 0.0232618
NF1 neurofibromin 1 0.02324
RICTOR RPTOR independent companion of MTOR, complex 2 0.0231609
USP3 ubiquitin specific peptidase 3 0.0230267
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0229879
PCBP2 poly(rC) binding protein 2 0.0228299
ZMYM2 zinc finger, MYM-type 2 0.0226156
BBX bobby sox homolog (Drosophila) 0.0225762
RYBP RING1 and YY1 binding protein 0.022572
CHD1 chromodomain helicase DNA binding protein 1 0.0223664
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.022366
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0221736
NUP153 nucleoporin 153kDa 0.0220742

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.104459
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0974972
MT2A metallothionein 2A -0.0753073
VIM vimentin -0.0742262
FTL ferritin, light polypeptide -0.0737429
PRKG1 protein kinase, cGMP-dependent, type I -0.0599113
SAMD3 sterile alpha motif domain containing 3 -0.0585475
RPS6 ribosomal protein S6 -0.0452918
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0437159
KIAA1549L KIAA1549-like -0.0421817
RPS19 ribosomal protein S19 -0.0403616
RPL23 ribosomal protein L23 -0.0399994
PHACTR1 phosphatase and actin regulator 1 -0.0399127
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0386792
NTM neurotrimin -0.0379836
SDCCAG8 serologically defined colon cancer antigen 8 -0.0377463
EXT1 exostosin glycosyltransferase 1 -0.0346388
RPL35A ribosomal protein L35a -0.0331394
AKAP12 A kinase (PRKA) anchor protein 12 -0.0327907
LSAMP limbic system-associated membrane protein -0.0313739
CDH13 cadherin 13 -0.0311525
ACTG1 actin gamma 1 -0.0298054
EFNA5 ephrin-A5 -0.0287617
HMGA2 high mobility group AT-hook 2 -0.0286547
RPS8 ribosomal protein S8 -0.0271096
RPL12 ribosomal protein L12 -0.0267867
RPL36 ribosomal protein L36 -0.0259583
ZNF804A zinc finger protein 804A -0.0255316
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0250769
RPL8 ribosomal protein L8 -0.0250763
KIAA1217 KIAA1217 -0.0238663
NALF1 NALCN channel auxiliary factor 1 -0.0236438
RPS3 ribosomal protein S3 -0.0232664
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0229018
RPLP1 ribosomal protein, large, P1 -0.0223718
RPLP2 ribosomal protein, large, P2 -0.0223166
RPL19 ribosomal protein L19 -0.022255
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0208558
RPL32 ribosomal protein L32 -0.0199953
PTPRG protein tyrosine phosphatase, receptor type, G -0.0193168
NAV1 neuron navigator 1 -0.0185434
RPL13A ribosomal protein L13a -0.0183055
RPL35 ribosomal protein L35 -0.0181393
RPL27 ribosomal protein L27 -0.0176392
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0173465
FOXP1 forkhead box P1 -0.0173244
ANTXR2 anthrax toxin receptor 2 -0.0171988
CSTB cystatin B (stefin B) -0.0171419
RPS21 ribosomal protein S21 -0.0170594
RPL5 ribosomal protein L5 -0.0169862
CAVIN1 caveolae associated protein 1 -0.0168919
BMAL2 basic helix-loop-helix ARNT like 2 -0.0164181
MT1X metallothionein 1X -0.0158095
MT1E metallothionein 1E -0.0152369
RPL11 ribosomal protein L11 -0.0149797
ADAM19 ADAM metallopeptidase domain 19 -0.0149674
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0149605
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0147542
MARCHF4 membrane associated ring-CH-type finger 4 -0.0147317
RPL7 ribosomal protein L7 -0.0146315
CDK6 cyclin-dependent kinase 6 -0.0145299
RPL26 ribosomal protein L26 -0.0144285
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0140126
RPS4X ribosomal protein S4, X-linked -0.0137025
PFN1 profilin 1 -0.0136625
RPL18 ribosomal protein L18 -0.0134904
PTPRK protein tyrosine phosphatase, receptor type, K -0.0133698
AHNAK AHNAK nucleoprotein -0.0133509
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0133247
RPS27A ribosomal protein S27a -0.0131083
PCDH11X protocadherin 11 X-linked -0.0128286
RACK1 receptor for activated C kinase 1 -0.0126923
RPS13 ribosomal protein S13 -0.012387
C2CD2 C2 calcium-dependent domain containing 2 -0.012325
RPL34 ribosomal protein L34 -0.0123207
ATP5F1E ATP synthase F1 subunit epsilon -0.0121278
PTPRD protein tyrosine phosphatase, receptor type, D -0.0120608
RPS5 ribosomal protein S5 -0.0118458
HMGA1 high mobility group AT-hook 1 -0.011802
MBD5 methyl-CpG binding domain protein 5 -0.0117204
IFI16 interferon, gamma-inducible protein 16 -0.011704
PCNX4 pecanex 4 -0.0117011
RPL31 ribosomal protein L31 -0.0115898
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0115415
SASH1 SAM and SH3 domain containing 1 -0.0114685
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0114533
CCDC91 coiled-coil domain containing 91 -0.0113714
PTCHD4 patched domain containing 4 -0.0112907
RPLP0 ribosomal protein, large, P0 -0.011259
TPI1 triosephosphate isomerase 1 -0.0112248
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0111796
COL6A2 collagen, type VI, alpha 2 -0.0111029
RPL36A ribosomal protein L36a -0.0110276
HDAC9 histone deacetylase 9 -0.0108201
RPS14 ribosomal protein S14 -0.0104407
GLIS3 GLIS family zinc finger 3 -0.0104312
RPL9 ribosomal protein L9 -0.0103198
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0102534
DOCK4 dedicator of cytokinesis 4 -0.0099986
ENKUR enkurin, TRPC channel interacting protein -0.00996375