Entecavir (monohydrate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 0.145378
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0920501
EZR ezrin 0.0812008
GMDS GDP-mannose 4,6-dehydratase 0.0804189
ITGA6 integrin, alpha 6 0.0796875
NALF1 NALCN channel auxiliary factor 1 0.0755533
ALCAM activated leukocyte cell adhesion molecule 0.0753399
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0737378
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0717968
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0716621
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0699173
ANXA2 annexin A2 0.0678632
PTPRK protein tyrosine phosphatase, receptor type, K 0.0642941
EMP1 epithelial membrane protein 1 0.062801
FTH1 ferritin, heavy polypeptide 1 0.0608374
CD46 CD46 molecule, complement regulatory protein 0.0608251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0607866
EPS8 epidermal growth factor receptor pathway substrate 8 0.060039
CALB1 calbindin 1, 28kDa 0.0579797
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0574933
GREB1L growth regulation by estrogen in breast cancer-like 0.056683
ANTXR2 anthrax toxin receptor 2 0.0563859
FLNB filamin B, beta 0.0549048
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0531953
LGALS3 lectin, galactoside-binding, soluble, 3 0.0515022
GPHN gephyrin 0.0514627
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0512334
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0490817
EREG epiregulin 0.0469872
VCL vinculin 0.046215
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0461987
MED13L mediator complex subunit 13-like 0.0452834
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0451596
PSD3 pleckstrin and Sec7 domain containing 3 0.0446576
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0443188
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0422024
ESYT2 extended synaptotagmin-like protein 2 0.0421192
FAT1 FAT atypical cadherin 1 0.0418114
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0416172
MBNL1 muscleblind-like splicing regulator 1 0.0410355
BAIAP2L1 BAI1-associated protein 2-like 1 0.0405365
IARS1 isoleucyl-tRNA synthetase 1 0.0405278
GRB10 growth factor receptor-bound protein 10 0.0401009
MSI2 musashi RNA-binding protein 2 0.0397537
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0393706
RNF217 ring finger protein 217 0.0392224
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.039063
LAMA4 laminin, alpha 4 0.038875
ANXA1 annexin A1 0.0384728
PARD3 par-3 family cell polarity regulator 0.0383586
PPARG peroxisome proliferator-activated receptor gamma 0.037979
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0378751
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0376843
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0374168
PDE4D phosphodiesterase 4D, cAMP-specific 0.0373736
LOC102724023 ES1 protein homolog, mitochondrial 0.0367333
MED13 mediator complex subunit 13 0.0363102
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0361941
BIRC6 baculoviral IAP repeat containing 6 0.0361736
ARHGAP6 Rho GTPase activating protein 6 0.0358498
WDR43 WD repeat domain 43 0.0357731
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0356133
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0355827
ANKRD17 ankyrin repeat domain 17 0.0355276
RAP1B RAP1B, member of RAS oncogene family 0.035482
RREB1 ras responsive element binding protein 1 0.0348075
EXT1 exostosin glycosyltransferase 1 0.0346132
WAC WW domain containing adaptor with coiled-coil 0.0344985
PTBP3 polypyrimidine tract binding protein 3 0.0344809
RNF145 ring finger protein 145 0.0344005
JMJD1C jumonji domain containing 1C 0.0343495
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0341438
GDF15 growth differentiation factor 15 0.0338939
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0333951
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0331667
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0328453
MAML3 mastermind-like 3 (Drosophila) 0.0327813
SVIL supervillin 0.0318372
FNDC3B fibronectin type III domain containing 3B 0.0317621
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.031521
PELI1 pellino E3 ubiquitin protein ligase 1 0.0314929
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0311982
EHBP1 EH domain binding protein 1 0.0311824
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0310953
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0308316
SEC31A SEC31 homolog A (S. cerevisiae) 0.0303659
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.030051
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0298817
GSK3B glycogen synthase kinase 3 beta 0.0296867
GLS2 glutaminase 2 (liver, mitochondrial) 0.0295896
PCBP2 poly(rC) binding protein 2 0.028936
FAM13A family with sequence similarity 13, member A 0.0288791
MAML2 mastermind-like 2 (Drosophila) 0.0287075
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0286046
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0284092
KDM6A lysine (K)-specific demethylase 6A 0.028133
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0279177
TES testin LIM domain protein 0.0278842
DIAPH2 diaphanous-related formin 2 0.0275452
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0274587

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.274755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.202624
RPS2 ribosomal protein S2 -0.120339
RPS6 ribosomal protein S6 -0.0799362
PTMA prothymosin, alpha -0.0730862
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0684041
DSPP dentin sialophosphoprotein -0.0675272
RPL12 ribosomal protein L12 -0.0634824
PDIA4 protein disulfide isomerase family A, member 4 -0.0600276
FTL ferritin, light polypeptide -0.057714
RPS19 ribosomal protein S19 -0.0519033
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0507143
RPS12 ribosomal protein S12 -0.0467104
RPS8 ribosomal protein S8 -0.0454597
RPS3 ribosomal protein S3 -0.0452898
TPT1 tumor protein, translationally-controlled 1 -0.041744
VEGFA vascular endothelial growth factor A -0.0414166
DSG2 desmoglein 2 -0.0403135
RPL36 ribosomal protein L36 -0.0392594
B2M beta-2-microglobulin -0.039211
HSPA8 heat shock 70kDa protein 8 -0.0389282
CALR calreticulin -0.0389143
RPL19 ribosomal protein L19 -0.0383953
RPL7 ribosomal protein L7 -0.0373987
RPS29 ribosomal protein S29 -0.0361775
KRT18 keratin 18, type I -0.0358299
TNS4 tensin 4 -0.0345009
RPLP2 ribosomal protein, large, P2 -0.0338555
RPL11 ribosomal protein L11 -0.0337708
CANX calnexin -0.0336604
RPS23 ribosomal protein S23 -0.0331825
CD44 CD44 molecule (Indian blood group) -0.0331536
RPL3 ribosomal protein L3 -0.0325361
RPL32 ribosomal protein L32 -0.0322677
MT2A metallothionein 2A -0.0319296
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0316718
CLTC clathrin, heavy chain (Hc) -0.0314674
CEMIP2 cell migration inducing hyaluronidase 2 -0.0310935
RPLP1 ribosomal protein, large, P1 -0.0309529
RPS27A ribosomal protein S27a -0.0307051
RPL31 ribosomal protein L31 -0.0306162
RPL26 ribosomal protein L26 -0.0297591
PKM pyruvate kinase, muscle -0.0293611
RPS27 ribosomal protein S27 -0.0291546
ENO1 enolase 1, (alpha) -0.0291205
H1-4 H1.4 linker histone, cluster member -0.0291099
NDRG1 N-myc downstream regulated 1 -0.028448
RPS17 ribosomal protein S17 -0.0277913
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0276072
RPL18 ribosomal protein L18 -0.0271763
RPL37A ribosomal protein L37a -0.0270192
RPS13 ribosomal protein S13 -0.0260207
H1-0 H1.0 linker histone -0.0259102
RPS18 ribosomal protein S18 -0.0258855
RPL21 ribosomal protein L21 -0.0249052
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0246309
RPL38 ribosomal protein L38 -0.0245115
ARL15 ADP-ribosylation factor-like 15 -0.0244888
AREG amphiregulin -0.0242829
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0238496
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0235722
PDZD8 PDZ domain containing 8 -0.0235494
RPL7A ribosomal protein L7a -0.0232958
RPS11 ribosomal protein S11 -0.0230085
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0218356
PAPOLA poly(A) polymerase alpha -0.0217211
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0216763
RPL5 ribosomal protein L5 -0.0216482
AGR2 anterior gradient 2 -0.0216323
RPL9 ribosomal protein L9 -0.0210336
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0204947
NEBL nebulette -0.0202026
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0199615
RPL36A ribosomal protein L36a -0.0199045
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0198315
GPSM2 G-protein signaling modulator 2 -0.0198012
KDM3A lysine (K)-specific demethylase 3A -0.0198009
MUC13 mucin 13, cell surface associated -0.0197994
APLP2 amyloid beta (A4) precursor-like protein 2 -0.019758
TMED2 transmembrane emp24 domain trafficking protein 2 -0.0197308
ABHD17C abhydrolase domain containing 17C -0.0193407
ISG15 ISG15 ubiquitin-like modifier -0.019267
KRT19 keratin 19, type I -0.0192443
RPL4 ribosomal protein L4 -0.0191279
RPL34 ribosomal protein L34 -0.0191108
RPL8 ribosomal protein L8 -0.0190785
GOLGB1 golgin B1 -0.0189916
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0186749
RPL15 ribosomal protein L15 -0.0182967
RPL27 ribosomal protein L27 -0.0182375
SET SET nuclear proto-oncogene -0.0181744
PDIA6 protein disulfide isomerase family A, member 6 -0.0180953
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0180046
RSL24D1 ribosomal L24 domain containing 1 -0.0179474
SERF2 small EDRK-rich factor 2 -0.0179374
PIGR polymeric immunoglobulin receptor -0.0178734
CALU calumenin -0.0178555
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.0178042
RPL28 ribosomal protein L28 -0.0176448
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0175049