Entecavir (monohydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.162555
FAT1 FAT atypical cadherin 1 0.126938
FLNB filamin B, beta 0.121187
THSD4 thrombospondin, type I, domain containing 4 0.103044
EZR ezrin 0.0941964
MYO1E myosin IE 0.0913079
ITGA6 integrin, alpha 6 0.0907146
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0901219
LMO7 LIM domain 7 0.0803677
PDE4D phosphodiesterase 4D, cAMP-specific 0.0801097
ANXA2 annexin A2 0.0784765
MYOF myoferlin 0.07404
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0736834
EPS8 epidermal growth factor receptor pathway substrate 8 0.0733965
PKP2 plakophilin 2 0.0731076
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0714298
VCL vinculin 0.0702576
PTPRG protein tyrosine phosphatase, receptor type, G 0.0689373
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0667645
TXNRD1 thioredoxin reductase 1 0.0667505
RAD51B RAD51 paralog B 0.0667453
AKAP13 A kinase (PRKA) anchor protein 13 0.0665421
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0627236
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0622236
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0590376
PCBP2 poly(rC) binding protein 2 0.0587509
PTPRR protein tyrosine phosphatase, receptor type, R 0.0586425
MX1 MX dynamin-like GTPase 1 0.0581214
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0564327
PTPRK protein tyrosine phosphatase, receptor type, K 0.0558948
TRIM2 tripartite motif containing 2 0.0546579
MUC13 mucin 13, cell surface associated 0.0534794
WWC1 WW and C2 domain containing 1 0.0519124
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0515523
FOXO1 forkhead box O1 0.0500428
POTEF POTE ankyrin domain family, member F 0.0492471
FOXP1 forkhead box P1 0.0486021
CALB1 calbindin 1, 28kDa 0.0480434
DOCK5 dedicator of cytokinesis 5 0.0474788
CEMIP cell migration inducing protein, hyaluronan binding 0.0461266
ITPRID2 ITPR interacting domain containing 2 0.0460729
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0454216
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.045378
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0445445
EPHA2 EPH receptor A2 0.0435101
ARHGAP26 Rho GTPase activating protein 26 0.0432668
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0424391
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0422288
RHPN2 rhophilin, Rho GTPase binding protein 2 0.041214
RIGI RNA sensor RIG-I 0.0412136
RNF213 ring finger protein 213 0.0410834
SHROOM3 shroom family member 3 0.0403892
LPP LIM domain containing preferred translocation partner in lipoma 0.0403569
PATJ PATJ crumbs cell polarity complex component 0.0399583
PRSS3 protease, serine, 3 0.0397483
CLDN4 claudin 4 0.0394736
P3H2 prolyl 3-hydroxylase 2 0.0392569
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0392378
PRELID2 PRELI domain containing 2 0.0384758
OXSR1 oxidative stress responsive 1 0.0383106
RIMKLB ribosomal modification protein rimK-like family member B 0.0375385
CCSER1 coiled-coil serine-rich protein 1 0.0373529
DSG3 desmoglein 3 0.0371427
ASPH aspartate beta-hydroxylase 0.0366262
PLSCR1 phospholipid scramblase 1 0.036333
MSI2 musashi RNA-binding protein 2 0.0352417
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0352079
MPRIP myosin phosphatase Rho interacting protein 0.0351133
SERINC5 serine incorporator 5 0.0349534
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0345216
DSPP dentin sialophosphoprotein 0.0345185
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0340941
TNRC18 trinucleotide repeat containing 18 0.0339526
MAML2 mastermind-like 2 (Drosophila) 0.033821
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0336212
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0326407
TJP1 tight junction protein 1 0.0322012
SH3RF2 SH3 domain containing ring finger 2 0.0321359
KLF3 Kruppel-like factor 3 (basic) 0.032126
MYO1D myosin ID 0.0321106
SLTM SAFB-like, transcription modulator 0.032083
CCNL1 cyclin L1 0.0319345
PARD3 par-3 family cell polarity regulator 0.0315106
CTNND1 catenin (cadherin-associated protein), delta 1 0.0313144
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0310343
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0305831
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0301828
PELI1 pellino E3 ubiquitin protein ligase 1 0.0300871
MACF1 microtubule-actin crosslinking factor 1 0.0299024
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.029637
RAP1B RAP1B, member of RAS oncogene family 0.0293621
RABGAP1L RAB GTPase activating protein 1-like 0.0292939
PARD3B par-3 family cell polarity regulator beta 0.0288951
PKM pyruvate kinase, muscle 0.0288921
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0288196
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0287636
TSC22D2 TSC22 domain family, member 2 0.0287522
TC2N tandem C2 domains, nuclear 0.0285707
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0285142
PDLIM5 PDZ and LIM domain 5 0.0284578

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.210027
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.198259
TPT1 tumor protein, translationally-controlled 1 -0.181859
PTMA prothymosin, alpha -0.132251
RPS6 ribosomal protein S6 -0.0979756
RPLP1 ribosomal protein, large, P1 -0.0972249
TMSB10 thymosin beta 10 -0.0904755
RPS8 ribosomal protein S8 -0.076241
RPL12 ribosomal protein L12 -0.0696775
RPL34 ribosomal protein L34 -0.0686385
CANX calnexin -0.0681698
RPS27A ribosomal protein S27a -0.0615303
RPL35A ribosomal protein L35a -0.0593344
RPLP0 ribosomal protein, large, P0 -0.0584581
RPS19 ribosomal protein S19 -0.0529092
RPS24 ribosomal protein S24 -0.0527361
RPS25 ribosomal protein S25 -0.0424427
RPS13 ribosomal protein S13 -0.0400407
GARS1 glycyl-tRNA synthetase 1 -0.038639
RPL31 ribosomal protein L31 -0.0385631
RPL19 ribosomal protein L19 -0.0381029
HDLBP high density lipoprotein binding protein -0.0380786
RPL8 ribosomal protein L8 -0.0370933
RPS23 ribosomal protein S23 -0.0369543
KDM3A lysine (K)-specific demethylase 3A -0.0366474
RRBP1 ribosome binding protein 1 -0.0364264
GOLGA4 golgin A4 -0.035166
RPL26 ribosomal protein L26 -0.034867
RPL4 ribosomal protein L4 -0.0348599
RPL23 ribosomal protein L23 -0.0347726
AGR2 anterior gradient 2 -0.0343997
RPLP2 ribosomal protein, large, P2 -0.033472
RPL27A ribosomal protein L27a -0.0325468
S100A9 S100 calcium binding protein A9 -0.0323225
RPS27 ribosomal protein S27 -0.0323049
RPL11 ribosomal protein L11 -0.0315464
RPL10A ribosomal protein L10a -0.0299948
PDIA4 protein disulfide isomerase family A, member 4 -0.0293784
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0281645
ACTG1 actin gamma 1 -0.0277888
RPS21 ribosomal protein S21 -0.0276669
RPL37A ribosomal protein L37a -0.0264882
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.026264
RPL37 ribosomal protein L37 -0.0258689
RPL32 ribosomal protein L32 -0.0253697
NAP1L1 nucleosome assembly protein 1-like 1 -0.0248153
RPS3 ribosomal protein S3 -0.0247286
RPL5 ribosomal protein L5 -0.0246864
RPS16 ribosomal protein S16 -0.0246682
SEC61G Sec61 gamma subunit -0.02449
RPL14 ribosomal protein L14 -0.0241796
RPS11 ribosomal protein S11 -0.0237881
RACK1 receptor for activated C kinase 1 -0.0235318
RPL18 ribosomal protein L18 -0.0233638
SERF2 small EDRK-rich factor 2 -0.0232507
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0231542
RPS29 ribosomal protein S29 -0.0231165
RPS14 ribosomal protein S14 -0.0230693
CCNI cyclin I -0.0222093
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0219889
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0214687
RPL13A ribosomal protein L13a -0.0214096
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0211464
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0209119
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.020823
RPL9 ribosomal protein L9 -0.0205188
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0204201
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.02042
RPL38 ribosomal protein L38 -0.0203669
RPL7A ribosomal protein L7a -0.0201996
RPL36A ribosomal protein L36a -0.0201318
H1-0 H1.0 linker histone -0.020129
TMED2 transmembrane emp24 domain trafficking protein 2 -0.0201128
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0199644
GCC2 GRIP and coiled-coil domain containing 2 -0.0195793
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0193024
SRP54 signal recognition particle 54kDa -0.0190252
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0183134
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.018096
CALU calumenin -0.0180919
MXI1 MAX interactor 1, dimerization protein -0.0180749
OGA O-GlcNAcase -0.0178219
YBX3 Y box binding protein 3 -0.017641
RPS5 ribosomal protein S5 -0.0174879
RPL36 ribosomal protein L36 -0.0174739
RPS20 ribosomal protein S20 -0.0173883
RAD21 RAD21 homolog (S. pombe) -0.0172537
RPL36AL ribosomal protein L36a-like -0.0169273
ARF1 ADP-ribosylation factor 1 -0.0169033
TMSB4X thymosin beta 4, X-linked -0.0168235
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0167806
KLF5 Kruppel-like factor 5 (intestinal) -0.016663
RPL6 ribosomal protein L6 -0.0166511
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0165056
DDIT4 DNA-damage-inducible transcript 4 -0.0164631
S100A10 S100 calcium binding protein A10 -0.0163881
RSL1D1 ribosomal L1 domain containing 1 -0.0163709
KRT18 keratin 18, type I -0.0163199
MYL12B myosin, light chain 12B, regulatory -0.0163011
RPL23A ribosomal protein L23a -0.0162257