Entecavir (monohydrate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.0979679
TXNRD1 thioredoxin reductase 1 0.096938
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0825939
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0626241
GCLC glutamate-cysteine ligase, catalytic subunit 0.0542213
EFNA5 ephrin-A5 0.0539574
LRP1B low density lipoprotein receptor-related protein 1B 0.0528958
PDE4D phosphodiesterase 4D, cAMP-specific 0.0501832
CES1 carboxylesterase 1 0.0435436
RNF213 ring finger protein 213 0.0405895
FAM13A family with sequence similarity 13, member A 0.0375516
PTPRM protein tyrosine phosphatase, receptor type, M 0.03603
NAMPT nicotinamide phosphoribosyltransferase 0.0340153
DOCK5 dedicator of cytokinesis 5 0.0311438
RICTOR RPTOR independent companion of MTOR, complex 2 0.0290649
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0287379
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0284201
SMAD3 SMAD family member 3 0.0283399
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0282689
AHNAK AHNAK nucleoprotein 0.0282196
NCOA3 nuclear receptor coactivator 3 0.0274479
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0270353
IGFBP3 insulin-like growth factor binding protein 3 0.0261978
LIMCH1 LIM and calponin homology domains 1 0.0254742
RNF145 ring finger protein 145 0.0243872
TNS3 tensin 3 0.024342
BIRC3 baculoviral IAP repeat containing 3 0.0241847
AFF1 AF4/FMR2 family, member 1 0.0240706
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0239961
RAB10 RAB10, member RAS oncogene family 0.0239639
LGALS12 lectin, galactoside-binding, soluble, 12 0.0231786
TMEM165 transmembrane protein 165 0.0219796
LPP LIM domain containing preferred translocation partner in lipoma 0.0215963
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0212995
ERRFI1 ERBB receptor feedback inhibitor 1 0.0212744
AKR1C1 aldo-keto reductase family 1, member C1 0.0211547
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0211095
PM20D1 peptidase M20 domain containing 1 0.0210564
MAML3 mastermind-like 3 (Drosophila) 0.0208803
ANKRD10 ankyrin repeat domain 10 0.0207725
TBC1D22A TBC1 domain family, member 22A 0.0207692
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0203961
SLMAP sarcolemma associated protein 0.0196606
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0196517
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0190955
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0190844
SMYD3 SET and MYND domain containing 3 0.018597
CP ceruloplasmin (ferroxidase) 0.0185304
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0184702
RIN2 Ras and Rab interactor 2 0.0184468
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0183626
NRIP1 nuclear receptor interacting protein 1 0.0180474
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0177467
IGF1R insulin-like growth factor 1 receptor 0.0174864
FNDC3B fibronectin type III domain containing 3B 0.0174466
CCSER1 coiled-coil serine-rich protein 1 0.017278
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0172743
GRAMD1B GRAM domain containing 1B 0.0172553
DSPP dentin sialophosphoprotein 0.0169472
DENND5B DENN/MADD domain containing 5B 0.0168897
FOXP1 forkhead box P1 0.0167829
ZMYND8 zinc finger, MYND-type containing 8 0.0167426
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0167382
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0166431
KCMF1 potassium channel modulatory factor 1 0.0164915
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0164256
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0164205
USP34 ubiquitin specific peptidase 34 0.0162482
MED13L mediator complex subunit 13-like 0.0157786
TRIM56 tripartite motif containing 56 0.0154846
MGST1 microsomal glutathione S-transferase 1 0.0154096
STRN3 striatin, calmodulin binding protein 3 0.0152742
MX1 MX dynamin-like GTPase 1 0.0152307
YEATS2 YEATS domain containing 2 0.0151139
LMO7 LIM domain 7 0.015111
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0149764
ARHGAP32 Rho GTPase activating protein 32 0.0148253
PARD3 par-3 family cell polarity regulator 0.0146249
TBC1D5 TBC1 domain family, member 5 0.0145871
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0145759
PRKCA protein kinase C, alpha 0.0144308
MYOF myoferlin 0.0144041
RIMS2 regulating synaptic membrane exocytosis 2 0.0142446
MBNL1 muscleblind-like splicing regulator 1 0.0142013
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0140443
STAT1 signal transducer and activator of transcription 1, 91kDa 0.01397
RAD51B RAD51 paralog B 0.0138333
HELZ helicase with zinc finger 0.0137671
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0137535
JMJD1C jumonji domain containing 1C 0.0136287
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0135447
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0134447
TMEM45B transmembrane protein 45B 0.0133026
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0133009
ADAR adenosine deaminase, RNA-specific 0.0132811
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0131486
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.013062
PER2 period circadian clock 2 0.013042
PUM2 pumilio RNA-binding family member 2 0.0130292
PBX1 pre-B-cell leukemia homeobox 1 0.0129966

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.397348
MT2A metallothionein 2A -0.105918
UBC ubiquitin C -0.0952656
TMSB10 thymosin beta 10 -0.0872636
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0636836
FTL ferritin, light polypeptide -0.0596692
LDHA lactate dehydrogenase A -0.052473
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0472207
TPT1 tumor protein, translationally-controlled 1 -0.0458802
ACTG1 actin gamma 1 -0.0457603
LAMC2 laminin, gamma 2 -0.0437605
RPS27A ribosomal protein S27a -0.0431016
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0430785
SEC61G Sec61 gamma subunit -0.0414233
ENO1 enolase 1, (alpha) -0.0413837
LOC112694756 uncharaterized LOC112694756 -0.0413493
RPS3 ribosomal protein S3 -0.0410665
S100A10 S100 calcium binding protein A10 -0.038849
MCL1 myeloid cell leukemia 1 -0.0369412
EGR1 early growth response 1 -0.0349344
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.034398
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0338775
AREG amphiregulin -0.0335222
PTMA prothymosin, alpha -0.033233
RPL37A ribosomal protein L37a -0.0318345
POTEF POTE ankyrin domain family, member F -0.0305668
NSUN6 NOP2/Sun domain family, member 6 -0.0286783
STC1 stanniocalcin 1 -0.0278083
BLZF1 basic leucine zipper nuclear factor 1 -0.0254787
NDRG1 N-myc downstream regulated 1 -0.0241014
RPL11 ribosomal protein L11 -0.0240653
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0240609
RAB7A RAB7A, member RAS oncogene family -0.0238095
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0236024
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.023358
RPL12 ribosomal protein L12 -0.0233472
RPLP1 ribosomal protein, large, P1 -0.0230506
RPS8 ribosomal protein S8 -0.022909
LAMA4 laminin, alpha 4 -0.0227769
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0225081
SPAG9 sperm associated antigen 9 -0.0223759
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0222848
RPL31 ribosomal protein L31 -0.0218173
PKM pyruvate kinase, muscle -0.0216877
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0210632
ANKRD12 ankyrin repeat domain 12 -0.0210252
RPS12 ribosomal protein S12 -0.0204613
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0202553
BTG1 B-cell translocation gene 1, anti-proliferative -0.0199121
EIF1 eukaryotic translation initiation factor 1 -0.019614
MT1X metallothionein 1X -0.019217
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0185697
SPDYA speedy/RINGO cell cycle regulator family member A -0.0185599
RPS25 ribosomal protein S25 -0.0185111
RPL30 ribosomal protein L30 -0.0185065
MKI67 marker of proliferation Ki-67 -0.0184623
RPL23 ribosomal protein L23 -0.0182904
RPS24 ribosomal protein S24 -0.018266
LOC102724023 ES1 protein homolog, mitochondrial -0.0182349
IER3 immediate early response 3 -0.0179548
RTN4 reticulon 4 -0.0179252
HMGA1 high mobility group AT-hook 1 -0.0178546
RPL9 ribosomal protein L9 -0.0175054
CSTB cystatin B (stefin B) -0.0173999
C15ORF48 chromosome 15 open reading frame 48 -0.0171485
GSK3B glycogen synthase kinase 3 beta -0.0169873
TPM4 tropomyosin 4 -0.0168891
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0168471
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0166114
RPLP0 ribosomal protein, large, P0 -0.0163652
S100A11 S100 calcium binding protein A11 -0.0162657
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0160696
RPS17 ribosomal protein S17 -0.0160257
EEF2 eukaryotic translation elongation factor 2 -0.0159454
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0158952
AKAP12 A kinase (PRKA) anchor protein 12 -0.0157823
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0157802
PFN1 profilin 1 -0.0156519
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0155169
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0152479
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0152406
GSTP1 glutathione S-transferase pi 1 -0.0152252
WDR1 WD repeat domain 1 -0.0152217
MYL12B myosin, light chain 12B, regulatory -0.0151732
PCBP2 poly(rC) binding protein 2 -0.0151685
VCL vinculin -0.0151113
RPL19 ribosomal protein L19 -0.0150843
DOCK4 dedicator of cytokinesis 4 -0.0149377
CAV2 caveolin 2 -0.0148718
CCNI cyclin I -0.0147858
RPS4X ribosomal protein S4, X-linked -0.014626
RPS19 ribosomal protein S19 -0.014335
RPLP2 ribosomal protein, large, P2 -0.0142998
RPS23 ribosomal protein S23 -0.0138685
RPL8 ribosomal protein L8 -0.0134603
RPL36A ribosomal protein L36a -0.0134274
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0132095
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0131945
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.013171
RBM25 RNA binding motif protein 25 -0.0129576